Abstract:
:The molecular forms of GnRH in amphibia have not been characterized structurally. An antiserum to mammalian GnRH that shows appreciable cross-reactivity with chicken GnRH-I ([Gln8]GnRH), chicken GnRH-II ([His5,Trp7,Tyr8]GnRH), and salmon GnRH ([Trp7, Leu8]GnRH) was used in a RIA to detect GnRH-related peptides in an extract of the brain of the European green frog, Rana ridibunda. Two peptides were purified to apparent homogeneity, and determination of their primary structures showed that they are identical to mammalian GnRH and chicken GnRH-II. Salmon GnRH and lamprey GnRH-I ([Tyr3,Leu5,Glu6,Trp7,Lys8]GnRH) were not identified in this species of frog. Immunocytochemical analysis using specific antisera has identified regions of the frog diencephalon and telencephalon in which chicken GnRH-II and mammalian GnRH are localized to different populations of neurons. This differential distribution suggests distinct physiological roles for the two forms of GnRH in amphibia.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Conlon JM,Collin F,Chiang YC,Sower SA,Vaudry Hdoi
10.1210/endo.132.5.8477660subject
Has Abstractpub_date
1993-05-01 00:00:00pages
2117-23issue
5eissn
0013-7227issn
1945-7170journal_volume
132pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Mammary epithelial cells isolated from pregnant, nonlactating heifers were grown in vitro using collagen substrates. Using these systems, the truncated form of insulin growth factor-1 (IGF-1) (des-3-IGF-1), IGF-1, and IGF-2 all stimulated a significant (0.5 to 1 fold) increase in cell proliferation (des-3-IGF-1 greate...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-2-671
更新日期:1991-08-01 00:00:00
abstract::There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/EN.2015-1394
更新日期:2015-10-01 00:00:00
abstract::Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac rem...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1162
更新日期:2015-07-01 00:00:00
abstract::Nitric oxide (NO) is a free radical produced by the action of NO synthases (NOS) and is known to be involved in the regulation of many reproductive events that occur in the oviducts. The oviducts are highly specialized organs that play crucial roles in reproduction by providing an optimal environment for the final mat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1548
更新日期:2006-12-01 00:00:00
abstract::Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1288
更新日期:2011-11-01 00:00:00
abstract::We have measured the concentrations of vasopressin in sequential samples of cerebrospinal fluid (CSF) obtained from fetal lambs between 108 and 130 days gestation. There was a clear and significant (F = 4.46; P less than 0.005) rhythm in vasopressin concentrations in the CSF of nine fetuses, characterized by a mean tr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-6-3095
更新日期:1989-06-01 00:00:00
abstract::The present study was undertaken to identify the mechanisms underlying the effect of insulin-like growth factor (IGF-I) on LH receptor in rat granulosa cells. Treatment with FSH, as expected, produced a substantial increase in LH receptor messenger RNA (mRNA) level, and concurrent treatment with increasing concentrati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.11.7112
更新日期:1999-11-01 00:00:00
abstract::Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Each cDNA contains a signal peptide sequence, the putative CART-like peptide, and a carboxy-terminal extension peptide. Form I encodes a 117...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.12.8519
更新日期:2001-12-01 00:00:00
abstract::We have previously shown that repeated antenatal synthetic glucocorticoid exposure has sex-specific effects on hypothalamic-pituitary-adrenal development in the fetal and adult guinea pig. However, little is known about the mechanisms that underlie these sex-specific outcomes. In the current study we demonstrated that...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-0145
更新日期:2003-07-01 00:00:00
abstract::A central step in the development and sexual differentiation of the brain is the intraneuronal conversion of testosterone to estrogen. This conversion is catalyzed by an enzyme complex comprised of cytochrome P450 aromatase and the ubiquitous NADPH-dependent cytochrome P450 reductase. Brain aromatase activity is devel...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.4.7925130
更新日期:1994-10-01 00:00:00
abstract::Mammalian ovaries contain sympathetic neurons expressing the low affinity neurotropin receptor (p75NTR). To date neither the role these neurons might play in ovarian physiology nor their embryological origin is known. Immunohistochemistry was used to detect postnatal changes in distribution and number of both p75NTR-p...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0394
更新日期:2006-08-01 00:00:00
abstract::Thyroid hormone produces a prompt, plasma membrane-mediated increase in several metabolic functions in the rat thymocyte. These effects of thyroid hormone require calcium and are inhibited by the beta-adrenergic antagonist alprenolol. In the present study, the interrelationship between thyroid hormone and adrenergic a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-5-2240
更新日期:1988-05-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1391
更新日期:2012-09-01 00:00:00
abstract::In dairy goats, treatments associating a progestogen and the equine chorionic gonadotropin (eCG) are the easiest way to induce and synchronize estrus and ovulation and to permit artificial insemination (AI) and/or out of season breeding. From the first treatment, the injection of eCG induces, in some females, the prod...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0595
更新日期:2004-01-01 00:00:00
abstract::A detailed understanding of the mechanism of action of estrogen on bones is still lacking. The present study was designed to examine possible modulation by 17 beta-estradiol (E2) on the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and on vitamin D receptors (VDR) in the ROS 17/2.8 osteoblast-like cell line. Cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.5.1315250
更新日期:1992-05-01 00:00:00
abstract::Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.12.8940340
更新日期:1996-12-01 00:00:00
abstract::Previous studies indicate that magnesium, like calcium, stimulates the release of calcitonin (CT) from the thyroid gland. On the other hand, C-cell hyperplasia has been noted in magnesium-deficient dogs and rats. To explore further possible interrelationships between magnesium and CT, 21-day-old Sprague-Dawley male ra...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-6-2232
更新日期:1985-06-01 00:00:00
abstract::Decidualization, the process by which fibroblastic human endometrial stromal cells (HESC) differentiate into secretory decidual cells, is a critical event during the establishment of pregnancy. It is dependent on the steroid hormone progesterone acting through the nuclear progesterone receptor (PR). Previously, we ide...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqz021
更新日期:2020-01-01 00:00:00
abstract::Recent studies from our laboratory (Endocrinology 136:4762-4768, 1995) demonstrating that the expression of cAMP-dependent nuclear transcription factor CREB (cAMP response element binding protein) is lost following ovulation in macaques has revealed a novel mechanism by which the cytoplasmic and nuclear actions the cA...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.8.5346
更新日期:1997-08-01 00:00:00
abstract::Fetal pancreatic islets (21.5 days old) were cultured in RPMI 1640 containing either 2.8 or 11.1 mM glucose for 7 days. After the 7-day culture period, islets cultured in 2.8 mM glucose demonstrated a minimal first phase of insulin secretion in response to acute glucose stimulation, whereas islets cultured in 11.1 mM ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-2-582
更新日期:1984-02-01 00:00:00
abstract::The effects of recombinant human insulin-like growth factor I (IGF-I) on both vasoactive intestinal peptide (VIP) and PRL production and gene expression were studied using rat anterior pituitary cell cultures grown in serum-free defined medium. We also examined whether pituitary VIP could be involved in the PRL respon...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.6.7988440
更新日期:1994-12-01 00:00:00
abstract::Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1090
更新日期:2009-03-01 00:00:00
abstract::The perinatal rat exhibits low serum TSH levels in the presence of very low concentrations of T3 and T4. We had reported previously that this animal does not require endogenous TRH for TSH release. We investigated here whether the inhibitory hormone somatostatin (SS) has a role in maintaining the low TSH secretory set...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-4-1683
更新日期:1985-10-01 00:00:00
abstract::Maternal obesity at conception increases the risk of offspring obesity, thus propagating an intergenerational vicious cycle. Male offspring born to obese dams are hyperresponsive to high fat-diets, gaining greater body weight, fat mass, and additional metabolic sequelae compared to lean controls. In this report, we id...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1078
更新日期:2011-11-01 00:00:00
abstract::The structural elements of 19-norprogestogens which may be essential for binding to progesterone and estradiol-17beta(E2) receptors were investigated in the rabbit uterine cytosol. The kinetic study showed that 19-nor-progestogens are competitive inhibitors of progesterone-receptor (8S) binding and E2-receptor binding...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-100-6-1579
更新日期:1977-06-01 00:00:00
abstract::The beta-isoform of protein kinase C (PKC) has paradoxically been suggested to be important for both insulin action and insulin resistance as well as for contributing to the pathogenesis of diabetic complications. Presently, we evaluated the effects of knockout of the PKCbeta gene on overall glucose homeostasis and in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.10.7073
更新日期:1999-10-01 00:00:00
abstract::We have investigated the activation of ERK2, a serine/threonine kinase necessary for transmission of mitogenic signals, in cells derived from mouse embryos homozygous for a null mutation of the insulin-like growth factor (IGF)-1R gene (R- cells) and from wild-type littermates (W cells), respectively. Stimulation of qu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.7.6766
更新日期:1999-07-01 00:00:00
abstract::Interaction between Sertoli cells and germ cells is likely to be critical for normal development of the testis. We have established and characterized cocultures of neonatal Sertoli cells and gonocytes and have begun to study the physical and functional relationship between these cells in vitro. Cells were isolated fro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-2812
更新日期:1990-12-01 00:00:00
abstract::New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in total cellular glu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.1.1370150
更新日期:1992-01-01 00:00:00
abstract::Three members of the progestin and adipoQ receptor (PAQR) family, PAQR-7, PAQR-8, and PAQR-5 [membrane progesterone (P4) receptor (PR) (mPR)α, mPRβ, and mPRγ], function as plasma mPRs coupled to G proteins in mammalian cells, but the characteristics of two other members, PAQR6 and PAQR9 (mPRδ and mPRε), remain unclear...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1772
更新日期:2013-01-01 00:00:00