Alterations in opioid parameters in the hypothalamus of rats with estradiol-induced polycystic ovarian disease.

abstract：:The median eminence (ME), which is the common termination field for adenohypophysiotropic systems, has been shown to produce nitric oxide (NO), a signaling molecule involved in neuroendocrine secretion. Using an ex vivo technique, 17beta-estradiol exposure to ME fragments, including vascular tissues, stimulated NO rel...

journal_title：Endocrinology

authors： Prevot V,Croix D,Rialas CM,Poulain P,Fricchione GL,Stefano GB,Beauvillain JC

更新日期：1999-02-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous endocrine-disrupting chemical. Developmental exposure produces changes in behavior and gene expression in the brain. Here, we examined social recognition behaviors in mice from the third familial generation (F3) after exposure to gestational BPA. Second-generation mice were bred in on...

journal_title：Endocrinology

authors： Wolstenholme JT,Drobná Z,Henriksen AD,Goldsby JA,Stevenson R,Irvin JW,Flaws JA,Rissman EF

更新日期：2019-08-01 00:00:00

abstract：UNLABELLED:The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of action for the anorectic effects produced by peripheral administration of these GLP-1R agonists are not known. Experiments addressed whether food intak...

journal_title：Endocrinology

authors： Kanoski SE,Fortin SM,Arnold M,Grill HJ,Hayes MR

更新日期：2011-08-01 00:00:00

abstract：:The ability of different LH-like hormones, such as hCG, PMSG/equine (e) CG, ovine (o) LH, eLH, and rat (r) LH, to bind to and stimulate steroidogenesis in two types of rat gonadal cells was studied under the same experimental conditions. In both Leydig and granulosa cells, the maximal steroidogenic responses elicited ...

journal_title：Endocrinology

authors： Rani CS,Moudgal NR

更新日期：1985-02-01 00:00:00

abstract：:In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...

journal_title：Endocrinology

authors： Kjos T,Gotoh E,Tkacs N,Shackelford R,Ganong WF

更新日期：1991-08-01 00:00:00

abstract：:Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...

journal_title：Endocrinology

authors： Adamson AD,Friedrichsen S,Semprini S,Harper CV,Mullins JJ,White MR,Davis JR

更新日期：2008-02-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:Poor growth before birth is associated with impaired insulin sensitivity later in life, increasing the risk of type 2 diabetes. The tissue sites at which insulin resistance first develops after intrauterine growth restriction (IUGR), and its molecular basis, are unclear. We have therefore characterized the effects of ...

journal_title：Endocrinology

authors： De Blasio MJ,Gatford KL,Harland ML,Robinson JS,Owens JA

更新日期：2012-05-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:Chemerin is an adipokine with important regulatory roles in adipogenesis. In humans, serum total chemerin (i.e. prochemerin plus chemerin) levels are positively associated with body mass index and metabolic syndrome. However, the mechanisms that increase serum chemerin concentration are unknown. We hypothesized that c...

journal_title：Endocrinology

authors： Parlee SD,Ernst MC,Muruganandan S,Sinal CJ,Goralski KB

更新日期：2010-06-01 00:00:00

abstract：:It is assumed that after complete bilateral adrenalectomy (ADX), no adrenal tissue will redevelop and adrenal hormone levels will remain low and unaffected by stress. However, anecdotal observations in animals and in patients suggest that under some unknown circumstances the opposite can occur. Herein, we studied whet...

journal_title：Endocrinology

authors： Gotlieb N,Albaz E,Shaashua L,Sorski L,Matzner P,Rosenne E,Amram B,Benbenishty A,Golomb E,Ben-Eliyahu S

更新日期：2018-01-01 00:00:00

abstract：:CRF activity of synthetic vasopressins and pitressin was studied in an in vitro system of cultured rat adenohypophyseal cells using direct measurement of ACTH by radioimmunoassay. Pitressin (posterior pituitary extract) induced a dose-related secretion of ACTH whereas synthetic arginine or lysine vasopressin were devo...

journal_title：Endocrinology

authors： Yasuda N,Greer MA

更新日期：1976-04-01 00:00:00

abstract：:We performed an electrophysiological study to investigate ion transport of pendrin and thereby understand the pathogenesis of Pendred syndrome. Using pendrin-transfected COS-7 cells, we could show that pendrin transports both iodide and chloride measured as voltage-dependent inward and outward membrane currents. Chlor...

journal_title：Endocrinology

authors： Yoshida A,Hisatome I,Taniguchi S,Sasaki N,Yamamoto Y,Miake J,Fukui H,Shimizu H,Okamura T,Okura T,Igawa O,Shigemasa C,Green ED,Kohn LD,Suzuki K

更新日期：2004-09-01 00:00:00

abstract：:The hepatic extractions of gastric inhibitory polypeptide (GIP) and insulin were determined using in vitro and in vivo methods to assess the role of the liver in GIP metabolism and the possible effect of GIP on the hepatic extraction of insulin. During in vitro studies using the isolated perfused rat liver, infusion o...

journal_title：Endocrinology

authors： Hanks JB,Andersen DK,Wise JE,Putnam WS,Meyers WC,Jones RS

更新日期：1984-09-01 00:00:00

abstract：:Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Since low mol wt GTP-binding proteins (LMW-GTP-binding proteins) have been implicated in the regulation of vesicular trafficking, we have analyzed these proteins in adipocyt...

journal_title：Endocrinology

authors： Cormont M,Tanti JF,Grémeaux T,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1991-12-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:GnRH neurons are central regulators of reproduction and respond to factors affecting fertility, such as stress. Corticotropin-releasing hormone (CRH) is released during stress response. In brain slices from unstressed controls, CRH has opposite, estradiol-dependent effects on GnRH neuron firing depending on the CRH re...

journal_title：Endocrinology

authors： Phumsatitpong C,De Guzman RM,Zuloaga DG,Moenter SM

更新日期：2020-11-01 00:00:00

abstract：:Carboxyl-terminal fragments of PTH (C-PTH) appear to have biological properties different from those mediated by the amino-terminal portions of PTH and PTH-related peptide (PTHrP). To characterize a C-PTH receptor that may be involved in mediating these functions, we performed RRAs and affinity cross-linking studies w...

journal_title：Endocrinology

authors： Inomata N,Akiyama M,Kubota N,Jüppner H

更新日期：1995-11-01 00:00:00

abstract：:Although tamoxifen (TAM), which is widely used in the treatment of breast cancer, also has a beneficial effect on cisplatin-refractory ovarian cancer, the biological mechanism of this effect has remained obscure. TAM, besides its action as an antiestrogen, also inhibits cell proliferation of estrogen receptor (ER)-neg...

journal_title：Endocrinology

authors： Mabuchi S,Ohmichi M,Kimura A,Ikebuchi Y,Hisamoto K,Arimoto-Ishida E,Nishio Y,Takahashi K,Tasaka K,Murata Y

更新日期：2004-03-01 00:00:00

abstract：:Long-term glucocorticoid treatment impairs the survival and bone formation of osteogenic cells, leading to bone mass loss. The Wnt inhibitor Dickkopf-1 (DKK1) acts as a potent bone-remodeling factor that mediates several types of skeletal disorders. Whereas excess glucocorticoid is known to disturb Wnt signaling in os...

journal_title：Endocrinology

authors： Wang FS,Ko JY,Yeh DW,Ke HC,Wu HL

更新日期：2008-04-01 00:00:00

abstract：:Covalent adduction of a nitrosyl group to cysteines [S-nitrosylation (S-NO)] is emerging as a key route for nitric oxide (NO) to directly modulate protein functions. Here, we studied the effects of estrogens on endothelial protein S-NO and analyzed the nitrosyl-proteomes by biotin/CyDye switch technique combined with ...

journal_title：Endocrinology

authors： Zhang HH,Feng L,Livnat I,Hoh JK,Shim JY,Liao WX,Chen DB

更新日期：2010-08-01 00:00:00

abstract：:Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...

journal_title：Endocrinology

authors： Kandola MK,Sykes L,Lee YS,Johnson MR,Hanyaloglu AC,Bennett PR

更新日期：2014-02-01 00:00:00

abstract：:The ontogeny of expression of the CRF gene in the paraventricular hypothalamic nucleus and POMC gene in the pituitary was studied in rats using in situ hybridization histochemistry and Northern blotting techniques, respectively. CRF mRNA was first detected on day 17 of gestation (E17) in the paraventricular nucleus of...

journal_title：Endocrinology

authors： Grino M,Young WS 3rd,Burgunder JM

更新日期：1989-01-01 00:00:00

abstract：:As the regulator of pituitary reproductive hormone synthesis, the hypothalamic neuropeptide GnRH is the central regulator of reproduction. A hallmark of GnRH action is the differential control of gene expression in pituitary gonadotropes through varied pulsatile stimulation. Among other signaling events, GnRH activati...

journal_title：Endocrinology

authors： Nguyen KA,Intriago RE,Upadhyay HC,Santos SJ,Webster NJ,Lawson MA

更新日期：2010-10-01 00:00:00

abstract：:Uterine estrogen receptor (ER) and ER mRNA were measured in cycling and ovariectomized (OVX) estrogen-treated mice to probe the physiological regulation of the intracellular distribution and biosynthesis of ER. On proestrus, when plasma estradiol (E2) levels are highest, the cell nuclear ER concentration was 2.4-fold ...

journal_title：Endocrinology

authors： Bergman MD,Schachter BS,Karelus K,Combatsiaris EP,Garcia T,Nelson JF

更新日期：1992-04-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a newly discovered neuropeptide that is present in high amounts in hypothalamic neuroendocrine neurons and potently stimulates the accumulation of cAMP within cells of the anterior pituitary. We have employed several specific antisera recognizing different ...

journal_title：Endocrinology

authors： Hannibal J,Mikkelsen JD,Fahrenkrug J,Larsen PJ

更新日期：1995-09-01 00:00:00

abstract：:The role of calcium in the angiotensin II- or potassium-mediated increase in aldosterone production was analyzed in isolated glomerulosa cells prepared from bovine adrenal glands. The response to potassium was highly dependent on the extracellular calcium concentration, and a maximal response was observed at 0.5 mM ca...

journal_title：Endocrinology

authors： Foster R,Lobo MV,Rasmussen H,Marusic ET

更新日期：1981-12-01 00:00:00

abstract：:Otsuka Long-Evans Tokushima fatty (OLETF) rats lacking cholecystokinin-A receptors are hyperphagic, obese, and diabetic. Although exercise attenuates OLETF rats' obesity, the mechanisms underlying the effects of exercise are unclear. In this study, we determined the effects of running wheel activity on patterns of bod...

journal_title：Endocrinology

authors： Bi S,Scott KA,Hyun J,Ladenheim EE,Moran TH

更新日期：2005-04-01 00:00:00

abstract：:Mineralocorticoid and glucocorticoid hormones are metabolized as glucuronide conjugates. Using labeled [(14)C]uridine diphosphate glucuronic acid and microsomal preparations from human embryonic kidney 293 cells stably expressing the different human and monkey uridine diphosphate glucuronosyltransferase (UGT)2B enzyme...

journal_title：Endocrinology

authors： Girard C,Barbier O,Veilleux G,El-Alfy M,Bélanger A

更新日期：2003-06-01 00:00:00

abstract：:A rat medullary thyroid carcinoma, which was previously shown to produce high levels of immunoreactive cholecystokinin (CCK), was used to establish a stable cell line. Transplantable tumors were subjected to four series of alternate in vitro and in vivo passages. Cells were prepared from the fourth series of tumors un...

journal_title：Endocrinology

authors： Haun RS,Beinfeld MC,Roos BA,Dixon JE

更新日期：1989-08-01 00:00:00