Insulin-like factor 3 promotes wound healing at the ocular surface.

abstract：:DNA damage occurs as a result of environmental insults and aging and, if unrepaired, may lead to chromosomal instability and tumorigenesis. Because GH suppresses ataxia-telangiectasia mutated kinase phosphorylation, decreases DNA repair, and increases DNA damage accumulation, we elucidated whether GH effects on DNA da...

journal_title：Endocrinology

authors： Chesnokova V,Zonis S,Barrett RJ,Gleeson JP,Melmed S

更新日期：2019-06-01 00:00:00

abstract：:We have previously shown that plasma IGF 1 concentration is positively correlated with the rate of antler growth and have proposed that IGF 1 is stimulatory for antler growth in the red deer stag. Therefore to partly resolve the question of whether the IGF 1 was of circulating or local origin in relation to its effect...

journal_title：Endocrinology

authors： Suttie JM,Fennessy PF,Gluckman PD,Corson ID

更新日期：1988-06-01 00:00:00

abstract：:A relationship between the actions of TSH and IGF-1 was first recognized several decades ago. The close physical and functional associations between their respective receptors (TSHR and IGF-1R) has been described more recently in thyroid epithelium and human orbital fibroblasts as has the noncanonical behavior of IGF-...

journal_title：Endocrinology

authors： Atkins SJ,Lentz SI,Fernando R,Smith TJ

更新日期：2015-12-01 00:00:00

abstract：:Heat shock protein (HSP) synthesis increases in cells with a broad range of stress conditions. We recently showed that induction of HSP-70 is associated with inhibition of hormone-sensitive steroidogenesis, but not hormone-sensitive cAMP accumulation, in rat luteal cells by a mechanism associated with interruption of ...

journal_title：Endocrinology

authors： Khanna A,Aten RF,Behrman HR

更新日期：1995-04-01 00:00:00

abstract：:Our previous studies have identified a role for annexin 1 (also called lipocortin 1) in the regulatory actions of glucocorticoids (GCs) on the release of PRL from the rat anterior pituitary gland. In the present study we used antisense and immunoneutralization strategies to extend this work. Exposure of rat anterior p...

journal_title：Endocrinology

authors： Taylor AD,Philip JG,John CD,Cover PO,Morris JF,Flower RJ,Buckingham JC

更新日期：2000-06-01 00:00:00

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:Porcine serum contains five insulin-like growth factor-binding proteins (IGFBPs), whose regulation has been studied by ligand blotting. To more accurately quantify changes in two specific forms of IGFBP a heterologous RIA for porcine (p) IGFBP-2 was developed, and IGFBP-1 levels were analyzed by immunoblotting. By RIA...

journal_title：Endocrinology

authors： McCusker RH,Cohick WS,Busby WH,Clemmons DR

更新日期：1991-11-01 00:00:00

abstract：:The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1 (GLP-1), produced in the intestinal endocrine L cells. We found previously that the bipartite transcription factor beta-catenin/T cell factor (cat/TCF), the major effector of the canonical Wnt signaling pathway, activates intestinal glu ex...

journal_title：Endocrinology

authors： Yi F,Sun J,Lim GE,Fantus IG,Brubaker PL,Jin T

更新日期：2008-05-01 00:00:00

abstract：:Prolactin (PRL) is a vertebrate hormone with diverse actions in osmoregulation, metabolism, reproduction, and in growth and development. Osmoregulation is fundamental to maintaining the functional structure of the macromolecules that conduct the business of life. In teleost fish, PRL plays a critical role in osmoregul...

journal_title：Endocrinology

authors： Yamaguchi Y,Moriyama S,Lerner DT,Grau EG,Seale AP

更新日期：2016-09-01 00:00:00

abstract：:Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the N222D mutation. Me...

journal_title：Endocrinology

authors： Prabhu Y,Blanco EH,Liu M,Peinado JR,Wheeler MC,Gekakis N,Arvan P,Lindberg I

更新日期：2014-07-01 00:00:00

abstract：:Intracellular cargo transport relies on microtubules and motor proteins such as kinesins and dyneins. Currently we have ample knowledge of the mechanisms by which motor proteins propel themselves along the microtubules, but little is known about intracellular factors that regulate motor speed. Here we show that proadr...

journal_title：Endocrinology

authors： Larráyoz IM,Martínez A

更新日期：2012-04-01 00:00:00

abstract：:New insulin-secreting cell lines (INS-1 and INS-2) were established from cells isolated from an x-ray-induced rat transplantable insulinoma. The continuous growth of these cells was found to be dependent on the reducing agent 2-mercaptoethanol. Removal of this thiol compound caused a 15-fold drop in total cellular glu...

journal_title：Endocrinology

authors： Asfari M,Janjic D,Meda P,Li G,Halban PA,Wollheim CB

更新日期：1992-01-01 00:00:00

abstract：:To elucidate the metabolic fate and possible role of androgens and their derivatives during primate fetal development, aromatase (AROM), 5 alpha-reductase (5 alpha R), and androgen receptor (AR; cytosolic) levels were assessed in the brain, heart (HRT), lung (LNG), and skeletal muscle (MUS) of fetal rhesus monkeys. An...

journal_title：Endocrinology

authors： Sholl SA,Goy RW,Kim KL

更新日期：1989-02-01 00:00:00

abstract：:The expression of cholesterol side-chain cleavage cytochrome P450 (P450scc), 17 alpha-hydroxylase cytochrome P450 (P45017 alpha), and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) was studied in bovine placenta and fetal adrenal glands throughout gestation. The levels of expression of these enzymes were much lower ...

journal_title：Endocrinology

authors： Conley AJ,Head JR,Stirling DT,Mason JI

更新日期：1992-05-01 00:00:00

abstract：:It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and sh...

journal_title：Endocrinology

authors： Bartke A,Siler-Khodr TM,Hogan MP,Roychoudhury P

更新日期：1981-01-01 00:00:00

abstract：:We have recently disclosed sustained episodes of LH release (minisurges) during the afternoons of the juvenile-peripubertal transition period in the female rat. To determine if these LH minisurges are gonad independent, i.e. develop in the absence of the ovaries, animals were ovariectomized when neonates, and the mode...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1986-03-01 00:00:00

abstract：:7B2 is a novel neuroendocrine polypeptide which belongs to an entirely new superfamily of proteins. In extension of previous reports on 7B2, these studies concern its expression in endocrine pancreatic tissue. They have been performed using specific antibodies prepared against two distinct synthetic fragments of 7B2 c...

journal_title：Endocrinology

authors： Benjannet S,Marcinkiewicz M,Falgueyret JP,Johnson DE,Seidah NG,Chrétien M

更新日期：1988-08-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:Women with type 1 diabetes are subfertile. Diabetes negatively affects pregnancy by causing early miscarriage and poor prenatal outcomes. In this study we examine consequences of maternal type 1 diabetes on early embryo development, metabolic gene expression, and the pattern of insulin receptor (IR) and IGF-I receptor...

journal_title：Endocrinology

authors： Ramin N,Thieme R,Fischer S,Schindler M,Schmidt T,Fischer B,Navarrete Santos A

更新日期：2010-09-01 00:00:00

abstract：:The role of vasopressin (VP) in the regulation of pituitary corticotropin-releasing factor (CRF) receptors was studied by examining the effects of adrenalectomy and VP infusion on pituitary CRF receptors in genetically VP-deficient rats (di/di) and Long-Evans control rats. Binding studies with [125I]Tyr-ovine CRF in 3...

journal_title：Endocrinology

authors： Holmes MC,Catt KJ,Aguilera G

更新日期：1987-12-01 00:00:00

abstract：:To elucidate the temporal profile of adaptive changes of the islets of Langerhans to the increased insulin demands of pregnancy, we have studied islet cell proliferation and insulin secretion during gestation in the rat. 5-Bromo-2'-deoxyuridine incorporation into dividing islet cells was significantly (P less than 0.0...

journal_title：Endocrinology

authors： Parsons JA,Brelje TC,Sorenson RL

更新日期：1992-03-01 00:00:00

abstract：:Regulation of MUC1 expression and removal is a salient feature of embryo implantation, bacterial clearance, and tumor progression. In some species, embryo implantation is accompanied by a transcriptional decline in uterine epithelial expression of MUC1. In other species, MUC1 is locally removed at blastocyst attachmen...

journal_title：Endocrinology

authors： Thathiah A,Brayman M,Dharmaraj N,Julian JJ,Lagow EL,Carson DD

更新日期：2004-09-01 00:00:00

abstract：:We studied the structural and functional characteristics of insulin receptors from rat brain and liver from late gestation through adulthood as well as from cultured neuronal and glial cells from neonatal rats. Specific insulin binding was present on membrane preparations from brain and liver at all stages of developm...

journal_title：Endocrinology

authors： Lowe WL Jr,Boyd FT,Clarke DW,Raizada MK,Hart C,LeRoith D

更新日期：1986-07-01 00:00:00

abstract：:Linear growth results from proliferation and differentiation of chondrocytes within the growth plates and is regulated, in part, by the insulin-like growth factors (IGFs). IGF binding proteins (IGFBPs) also appear to play a significant, but yet unclear, role. To examine IGFBP production by chondrocytes, we isolated bo...

journal_title：Endocrinology

authors： Olney RC,Smith RL,Kee Y,Wilson DM

更新日期：1993-08-01 00:00:00

abstract：:Two different types of corticoid receptor molecules bind circulating corticosterone in brain: mineralocorticoid receptors (MR) and glucocorticoid receptors. MR exhibit the highest affinity for the endogenous glucocorticoid in the rat, corticosterone. During development, low corticosterone levels influence neurogenesis...

journal_title：Endocrinology

authors： Vázquez DM,López JF,Morano MI,Kwak SP,Watson SJ,Akil H

更新日期：1998-07-01 00:00:00

abstract：:Recent studies have demonstrated that passive immunization of neonatal rats to GRF inhibited their somatic growth through the suppression of GH secretion. In this study, we investigated the changes in pituitary GRF receptor (GRFR) expression in GRF antibody (GRF-ab) treated rats. Neonatal rats were treated from day 1 ...

journal_title：Endocrinology

authors： Horikawa R,Hellmann P,Cella SG,Torsello A,Day RN,Muller EE,Thorner MO

更新日期：1996-06-01 00:00:00

abstract：:LH supplementation in assisted reproductive technology cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral fol...

journal_title：Endocrinology

authors： Hattori K,Orisaka M,Fukuda S,Tajima K,Yamazaki Y,Mizutani T,Yoshida Y

更新日期：2018-06-01 00:00:00

abstract：:Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...

journal_title：Endocrinology

authors： Ahluwalia A,Hoa N,Ge L,Blumberg B,Levin ER

更新日期：2020-11-01 00:00:00

abstract：:We previously found that the sustained rise in active sodium transport by the toad urinary bladder after exposure to insulin is associated with the synthesis of a membrane protein with a molecular weight of 25,000. Studying the effects of insulin on the incorporation of uridine into RNA of epithelial cells of the blad...

journal_title：Endocrinology

authors： Cobb MH,Yang CP,Scott WN

更新日期：1981-12-01 00:00:00

abstract：:Telomerase activity is essential for protection of cells against the telomere erosion that occurs with each round of cell replication, and thus appears to play a role in the indefinite replication potential of some, but not all, eukaryotic cells. In this regard, some tissues contain stem cells that have a long prolife...

journal_title：Endocrinology

authors： Banerjee PP,Banerjee S,Zirkin BR,Brown TR

更新日期：1998-03-01 00:00:00