Physiological and pharmacological inhibitors of luteinizing hormone-dependent steroidogenesis induce heat shock protein-70 in rat luteal cells.

abstract：:At micromolar (pharmacological) concentrations, the action of tamoxifen on the proliferation of estrogen-dependent cells can be mediated not only by the estrogen receptor (ER), but also by other target molecules, such as protein kinase-C (PKC), which are easily inhibited by antiestrogens in cell-free experiments. By d...

journal_title：Endocrinology

authors： Astruc ME,Chabret C,Bali P,Gagne D,Pons M

更新日期：1995-03-01 00:00:00

abstract：:Granulosa cells isolated from the ovaries of pregnant mare serum gonadotropin (PMSG)-treated immature rats were cultured with relaxin or FSH. Both hormones increased the secretion of plasminogen activator into the culture medium. Relaxin caused a dose-related rise in plasminogen activator but did not increase cAMP or ...

journal_title：Endocrinology

authors： Too CK,Weiss TJ,Bryant-Greenwood GD

更新日期：1982-10-01 00:00:00

abstract：:The ileal proglucagon-derived peptides (PGDPs) play important roles in the regulation of gastric function and insulin secretion. We have previously demonstrated the existence of a proximal-distal enteroendocrine loop mediated by glucose-dependent insulinotropic peptide (GIP), through which intestinal PGDP secretion is...

journal_title：Endocrinology

authors： Roberge JN,Gronau KA,Brubaker PL

更新日期：1996-06-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...

journal_title：Endocrinology

authors： Yang YW,Robbins AR,Nissley SP,Rechler MM

更新日期：1991-02-01 00:00:00

abstract：:A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...

journal_title：Endocrinology

authors： Xiao J,Sun B,Cai GP

更新日期：2010-07-01 00:00:00

abstract：:PTH, via the PTH/PTH-related protein receptor type 1 that couples to both protein kinase A (PKA) and protein kinase C (PKC) pathways, and the canonical Wnt-beta-catenin signaling pathway play important roles in bone formation. In the present study we have examined the interaction between the PTH and Wnt signaling path...

journal_title：Endocrinology

authors： Tobimatsu T,Kaji H,Sowa H,Naito J,Canaff L,Hendy GN,Sugimoto T,Chihara K

更新日期：2006-05-01 00:00:00

abstract：:The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin...

journal_title：Endocrinology

authors： Nøhr MK,Pedersen MH,Gille A,Egerod KL,Engelstoft MS,Husted AS,Sichlau RM,Grunddal KV,Poulsen SS,Han S,Jones RM,Offermanns S,Schwartz TW

更新日期：2013-10-01 00:00:00

abstract：:Uterine ornithine decarboxylase (ODC) activity is reported to increase after estrogen administration to fetal, neonatal, immature, and adult rats, suggesting that it may be a useful marker in studies of the development of estrogen responsiveness. Standard conditions were validated for enzyme assay of uterine cytosols ...

journal_title：Endocrinology

authors： Olson ME,Sheehan DM,Branham WS

更新日期：1983-11-01 00:00:00

abstract：:We have designed a new experimental system based on in vitro reconstituted thyroid follicles (RTF) to study the relative implication of macropinocytosis and micropinocytosis processes in the internalization of thyroglobulin (Tg). Thyrocytes cultured in the presence of TSH reorganize in histiotypic and functional folli...

journal_title：Endocrinology

authors： Bernier-Valentin F,Kostrouch Z,Rabilloud R,Rousset B

更新日期：1991-10-01 00:00:00

abstract：:Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...

journal_title：Endocrinology

authors： Schreiber NB,Spicer LJ

更新日期：2012-09-01 00:00:00

abstract：:This investigation examined the effects of repeated injections of LH on ovarian function in the immature sheep approximately 12 weeks before the time of the first expected spontaneous ovulation. The frequency of endogenous LH pulses during the pretreatment period was approximately one pulse each 3 h. The first experim...

journal_title：Endocrinology

authors： Foster DL,Ryan KD,Papkoff H

更新日期：1984-09-01 00:00:00

abstract：:Angiotensin type 1 receptor blockers are widely used for the treatment of hypertension, and one angiotensin type 1 receptor blocker, telmisartan, specifically activates the peroxisome proliferator-activated receptor (PPAR)-gamma. We studied the impact of PPARgamma mutants on transcriptional control and interaction wit...

journal_title：Endocrinology

authors： Tagami T,Yamamoto H,Moriyama K,Sawai K,Usui T,Shimatsu A,Naruse M

更新日期：2009-02-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) inhibits the embryonic migration of GnRH neurons and regulates hypothalamic GnRH release. A subset of GnRH neurons expresses GABA along their migratory route in the nasal compartment before entering the brain, suggesting that GABA produced by GnRH neurons may help regulate the migratory ...

journal_title：Endocrinology

authors： Heger S,Seney M,Bless E,Schwarting GA,Bilger M,Mungenast A,Ojeda SR,Tobet SA

更新日期：2003-06-01 00:00:00

abstract：:Activating ras point mutations are frequently found in skeletal muscle tumors such as rhabdomyosarcomas. In this study we investigated the impact of two different H-ras mutants in skeletal muscle differentiation: RasV12, a constitutively active form, and RasV12C40, a mutant deficient in Raf1 activation. Stably transfe...

journal_title：Endocrinology

authors： De Alvaro C,Nieto-Vazquez I,Rojas JM,Lorenzo M

更新日期：2008-02-01 00:00:00

abstract：:There is a growing body of evidence that subtle decreases in maternal thyroid hormone during gestation can impact fetal brain development. The present study examined the impact of graded levels of thyroid hormone insufficiency on brain development in rodents. Maternal thyroid hormone insufficiency was induced by expos...

journal_title：Endocrinology

authors： Goodman JH,Gilbert ME

更新日期：2007-06-01 00:00:00

abstract：:Changes in several extracellular matrix proteins, such as fibronectin in fetal membrane and cervical collagens, occur at term and preterm delivery. However, no studies have evaluated changes in extracellular matrix proteins, in relation to myometrial activation recorded using invasive techniques during parturition in ...

journal_title：Endocrinology

authors： Wu WX,Zhang Q,Ma XH,Unno N,Nathanielsz PW

更新日期：1999-05-01 00:00:00

abstract：:The localization of calcitonin gene-related peptide (CGRP)-like immunoreactivity in the adrenal gland of the frog, Rana ridibunda, was examined by the indirect immunofluorescence technique. Using an antiserum directed against rat alpha-CGRP, the presence of a network of positive fibers was observed in the adrenal pare...

journal_title：Endocrinology

authors： Esneu M,Delarue C,Remy-Jouet I,Manzardo E,Fasolo A,Fournier A,Saint-Pierre S,Conlon JM,Vaudry H

更新日期：1994-07-01 00:00:00

abstract：:Around the onset of labor, uterine sensitivity to oxytocin (OT) increases tremendously. Although this is considered to reflect OT receptor (OTR) augmentation in myometrium, neither spatial expression of OTR nor the level of the receptor message during the course of pregnancy have been investigated at the molecular lev...

journal_title：Endocrinology

authors： Kimura T,Takemura M,Nomura S,Nobunaga T,Kubota Y,Inoue T,Hashimoto K,Kumazawa I,Ito Y,Ohashi K,Koyama M,Azuma C,Kitamura Y,Saji F

更新日期：1996-02-01 00:00:00

abstract：:Tunicamycin, an inhibitor of glycosylation, was incubated with ovine thyroid cells in culture to determine the role of glycosylation in the subsequent processing of thyroglobulin to form thyroid hormone. After a 6-h preincubation with tunicamycin (1 microgram/ml), mannose incorporation into glycoproteins in the cell l...

journal_title：Endocrinology

authors： Eggo MC,Burrow GN

更新日期：1983-11-01 00:00:00

abstract：:Gap junctions were observed on the lateral plasma membrane of the typical thyroid epithelial cell in freeze-fracture preparations of rat thyroid gland. The gap junctions were 0.1 to 0.4 mum in diameter and were composed of closely packed, approximately 80 nm particles. They were located from 1 to 6 mum from the apical...

journal_title：Endocrinology

authors： Tice LW,Carter RC,Wollman SH

更新日期：1976-03-01 00:00:00

abstract：:The presence of estrogen receptors (ERs) in nonneural cells in brain, including glia, ependyma, and endothelia, has not previously been documented with electron microscopy. This study employed immunocytochemistry to investigate whether ER immunoreactivity (ER-ir) is present in glial, ependymal, or endothelial cells in...

journal_title：Endocrinology

authors： Langub MC Jr,Watson RE Jr

更新日期：1992-01-01 00:00:00

abstract：:We have investigated the interaction of estrogen with GnRH on the regulation of LH subunit mRNA in female hypogonadal (hpg) mice receiving constant frequency and amplitude pulsatile GnRH treatment for up to 18 days. The level of cytosolic common alpha mRNA in female hpg mouse pituitaries was 45 +/- 6% of normal female...

journal_title：Endocrinology

authors： Saade G,London DR,Clayton RN

更新日期：1989-04-01 00:00:00

abstract：:Photoaffinity labeling with underivatized T3 was used to identify T3-binding proteins in the membrane of rat erythrocytes. UV irradiation of ghosts and peripheral protein-depleted membranes in the presence of [125I]T3 resulted in the covalent attachment of 125I to membrane proteins (analyzed by polyacrylamide gel elec...

journal_title：Endocrinology

authors： Samson M,Osty J,Blondeau JP

更新日期：1993-06-01 00:00:00

abstract：:Recently, we reported that ovariectomy (OVX)-induced FSH hypersecretion can be elicited in hypophysectomized rats bearing renal pituitary allografts isolated from direct hypothalamic intervention. The possible role of the FSH-stimulating protein, activin-B, in eliciting this response was investigated using passive imm...

journal_title：Endocrinology

authors： DePaolo LV,Bald LN,Fendly BM

更新日期：1992-03-01 00:00:00

abstract：:We investigated whether genetic selection for growth influences pituitary GH secretion in two strains of rats, LL (large) and SS (small). Animals were bled every 15 min for 6 h via an indwelling atrial Silastic catheter, and GH levels were determined by RIA. LL and SS males displayed a low frequency, high amplitude ep...

journal_title：Endocrinology

authors： O'Sullivan D,Millard WJ,Badger TM,Martin JB,Martin RJ

更新日期：1986-11-01 00:00:00

abstract：:Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...

journal_title：Endocrinology

authors： Ashkenazi H,Cao X,Motola S,Popliker M,Conti M,Tsafriri A

更新日期：2005-01-01 00:00:00

abstract：:The effects of human pancreatic GH-releasing factor-40 (hpGRF-40; 0.01-100 nM) and (Bu)2cAMP (0.015-1.5 mM) on GH release from primary monolayer cultures of pituitary cells were evaluated in rats of three age groups: postnatal days 2 and 12, and young adult males (3-4 months). Both hpGRF-40 and (Bu)2cAMP elicited a do...

journal_title：Endocrinology

authors： Szabo M,Cuttler L

更新日期：1986-01-01 00:00:00

abstract：:Activation of the leptin receptor, LepRb, by the adipocytokine/neurotrophic factor leptin in the central nervous system has procognitive and antidepressive effects. Leptin has been shown to increase glutamatergic synaptogenesis in multiple brain regions. In contrast, mice that have a mutation in the LepRb gene show ab...

journal_title：Endocrinology

authors： Bland T,Zhu M,Dillon C,Sahin GS,Rodriguez-Llamas JL,Appleyard SM,Wayman GA

更新日期：2020-02-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00

abstract：:Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents. The reduction in adiposity is related to decreased food intake and increased energy expenditure. However, the molecular mechanisms through which TPM induces weight loss are contradictory and remain to be clarified. Whether TPM treatme...

journal_title：Endocrinology

authors： Caricilli AM,Penteado E,de Abreu LL,Quaresma PG,Santos AC,Guadagnini D,Razolli D,Mittestainer FC,Carvalheira JB,Velloso LA,Saad MJ,Prada PO

更新日期：2012-09-01 00:00:00