Abstract:
:We have previously shown that plasma IGF 1 concentration is positively correlated with the rate of antler growth and have proposed that IGF 1 is stimulatory for antler growth in the red deer stag. Therefore to partly resolve the question of whether the IGF 1 was of circulating or local origin in relation to its effect on antler growth, we surgically prevented stags from growing antlers. We recorded significantly elevated plasma levels of IGF 1 in the non-antlered stags compared with normal antlered stags during the antler growth periods. This result is consistent with a hypothesis that the antler is a target organ for IGF 1 and that prevention of antler growth removed a population of IGF 1 receptors. IGF 1 is already known to stimulate body growth but this work points strongly to the possibility that plasma IGF 1 may stimulate individual organ growth in an endocrine manner.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Suttie JM,Fennessy PF,Gluckman PD,Corson IDdoi
10.1210/endo-122-6-3005subject
Has Abstractpub_date
1988-06-01 00:00:00pages
3005-7issue
6eissn
0013-7227issn
1945-7170journal_volume
122pub_type
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