Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.

abstract：:Telomerase activity is essential for protection of cells against the telomere erosion that occurs with each round of cell replication, and thus appears to play a role in the indefinite replication potential of some, but not all, eukaryotic cells. In this regard, some tissues contain stem cells that have a long prolife...

journal_title：Endocrinology

authors： Banerjee PP,Banerjee S,Zirkin BR,Brown TR

更新日期：1998-03-01 00:00:00

abstract：:GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...

journal_title：Endocrinology

authors： King JA,Mehl AE,Tyndale-Biscoe CH,Hinds L,Millar RP

更新日期：1989-11-01 00:00:00

abstract：:Synthetic glucocorticoids (GCs), including dexamethasone (DEX), are powerful anti-inflammatory drugs. Long-term use of GCs, however, can result in metabolic side effects such as hyperglycemia, hepatosteatosis, and insulin resistance. The GC receptor (GR) and liver X receptors (LXRα and LXRβ) regulate overlapping genes...

journal_title：Endocrinology

authors： Patel R,Magomedova L,Tsai R,Angers S,Orellana A,Cummins CL

更新日期：2017-04-01 00:00:00

abstract：:The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity. Several antagonists have been developed to decrease the orexigenic signaling, but none of these have been approved for the treatment of obesit...

journal_title：Endocrinology

authors： Hedegaard MA,Holst B

更新日期：2020-04-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:Hormonal induction of steroidogenesis in the adrenal and gonads is dependent on the synthesis and function of the steroidogenic acute regulatory protein (StAR). As a first approach to investigate the role of translation in the control of StAR expression, we examined StAR protein synthesis and steroid production in MA-...

journal_title：Endocrinology

authors： Clark BJ,Combs R,Hales KH,Hales DB,Stocco DM

更新日期：1997-11-01 00:00:00

abstract：:Bone marrow-derived cells are major cellular components of human decidua, with macrophages comprising about 30% of the cells in term tissue. Because cytokines released by bone marrow-derived cells are known to affect hormone release in many tissues, we examined whether cytokines affect the release of PRL from human de...

journal_title：Endocrinology

authors： Jikihara H,Handwerger S

更新日期：1994-01-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes. Hepatocytes were freshly isolated from Sprague-Dawley rats treated with dexamethasone (1 mg/kg) for 4 days and from untreated littermates. Dexamet...

journal_title：Endocrinology

authors： Karasik A,Kahn CR

更新日期：1988-11-01 00:00:00

abstract：:Uterine estrogen receptor (ER) and ER mRNA were measured in cycling and ovariectomized (OVX) estrogen-treated mice to probe the physiological regulation of the intracellular distribution and biosynthesis of ER. On proestrus, when plasma estradiol (E2) levels are highest, the cell nuclear ER concentration was 2.4-fold ...

journal_title：Endocrinology

authors： Bergman MD,Schachter BS,Karelus K,Combatsiaris EP,Garcia T,Nelson JF

更新日期：1992-04-01 00:00:00

abstract：:Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2...

journal_title：Endocrinology

authors： McCallum ML,Pru CA,Niikura Y,Yee SP,Lydon JP,Peluso JJ,Pru JK

更新日期：2016-09-01 00:00:00

abstract：:Dog thyroid slices released in their incubation medium prostaglandins E2 (PGE2), F2 alpha (PGF2 alpha), 15-keto-13,14-dihydro-F2 alpha, and thromboxane B2 (TxB2), as measured by direct RIA. This release could be inhibited by indomethacin and naproxen, indicating that it corresponded to a neosynthesis. Carbamylcholine ...

journal_title：Endocrinology

authors： Boeynaems JM,Waelbroeck M,Dumont JE

更新日期：1979-10-01 00:00:00

abstract：:Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene. Three human breast carcinoma cell lines, in which endogenous ERalpha is expressed ...

journal_title：Endocrinology

authors： Lin KH,Wang WJ,Wu YH,Cheng SY

更新日期：2002-02-01 00:00:00

abstract：:The disappearance of 125-I-ACTH from the circulation of 4 pregnant and fetal sheep has been followed after a single injection to the ewe or fetus. The mean metabolic clearance rate for the fetus and the ewe was 55 and 34 ml/min/kg respectively, giving a half-life in each case of about 1 min. The higher fetal than mate...

journal_title：Endocrinology

authors： Jones CT,Luther E,Ritchie JW,Worthington D

更新日期：1975-01-01 00:00:00

abstract：:Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in mammalian serum, but the source of the circulating enzyme is unknown. Pancreatic islets have been reported to contain and secrete GPI-PLD. In this report we examined the regulation of GPI-PLD secretion from beta TC3 cells, a mouse insulinom...

journal_title：Endocrinology

authors： Deeg MA,Verchere CB

更新日期：1997-02-01 00:00:00

abstract：:Autoradiographs of thyroid glands of aging mice demonstrate the gradual appearance of "cold" follicles which fail to iodinate the intraluminar iodoproteins even after intense exogeneous or endogeneous TSH stimulation. "Cold" follicles first appear at the age of 5 months. They may account for 80% of all thyroid follicl...

journal_title：Endocrinology

authors： Studer H,Forster R,Conti A,Kohler H,Haeberli A,Engler H

更新日期：1978-05-01 00:00:00

abstract：:On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...

journal_title：Endocrinology

authors： Galbiati M,Zanisi M,Messi E,Cavarretta I,Martini L,Melcangi RC

更新日期：1996-12-01 00:00:00

abstract：:Gene expression of fibroblast growth factor-9 (FGF9) is decreased in granulosa cells (GC) of cystic follicles compared with normal dominant follicles in cattle. The objectives of this study were to investigate the effects of FGF9 on GC steroidogenesis, gene expression, and cell proliferation and to determine the hormo...

journal_title：Endocrinology

authors： Schreiber NB,Spicer LJ

更新日期：2012-09-01 00:00:00

abstract：:It is well established that in the pituitary gland corticotropin-releasing hormone (CRH) stimulates the release of beta-endorphin (beta-E) via a cAMP-linked mechanism. Studies of the mechanisms underlying the CRH stimulation of beta-E release from rat hypothalamic slices perifused in vitro are reported in this paper. ...

journal_title：Endocrinology

authors： Burns G,Almeida OF,Passarelli F,Herz A

更新日期：1989-09-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:Epidermal growth factor (EGF) and TGFalpha are well known for their activities in the ovary. Both factors initiate signal transduction by binding to the common EGF receptor that has been demonstrated in the ovary across vertebrates from fish to humans. Using zebrafish as the model, we demonstrated in the present study...

journal_title：Endocrinology

authors： Pang Y,Ge W

更新日期：2002-01-01 00:00:00

abstract：:A heterologous RIA for rat GH-releasing factor (rGRF) was established using synthetic rGRF-(1-43)OH for both standard reference and radioiodination with the antiserum produced against human GRF-(1-44) NH2. The regional distribution of rGRF-like immunoreactivity (LI) in rat hypothalamus was examined according to the Pa...

journal_title：Endocrinology

authors： Kita T,Chihara K,Abe H,Minamitani N,Kaji H,Kodama H,Kashio Y,Okimura Y,Fujita T,Ling N

更新日期：1985-01-01 00:00:00

abstract：:Starvation depresses thyroid gland function. In addition, the peripheral turnover of thyroxine (T4) is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were isotopically equilibrated w...

journal_title：Endocrinology

authors： Ingbar DH,Galton VA

更新日期：1975-06-01 00:00:00

abstract：:We have previously shown that placental protein 12 (PP12) is synthesized and secreted by human term pregnancy decidua in vitro. In the present study, fragments of proliferative and secretory phase endometrium were cultured in media in the presence and absence of progesterone (P) and 17 beta-estradiol (E2) for 96 h. Th...

journal_title：Endocrinology

authors： Rutanen EM,Koistinen R,Sjöberg J,Julkunen M,Wahlström T,Bohn H,Seppälä M

更新日期：1986-03-01 00:00:00

abstract：:Pancreatic glucokinase (GK) is considered an important element of the glucose-sensing unit in pancreatic beta-cells. It is possible that the brain uses similar glucose-sensing units, and we employed GK immunohistochemistry and confocal microscopy to examine the anatomical distribution of GK-like immunoreactivities in ...

journal_title：Endocrinology

authors： Maekawa F,Toyoda Y,Torii N,Miwa I,Thompson RC,Foster DL,Tsukahara S,Tsukamura H,Maeda K

更新日期：2000-01-01 00:00:00

abstract：:Calcineurin-nuclear factor of activated T cells signaling controls the differentiation and function of osteoclasts and osteoblasts, and regulator of calcineurin-2 (Rcan2) is a physiological inhibitor of this pathway. Rcan2 expression is regulated by T(3), which also has a central role in skeletal development and bone ...

journal_title：Endocrinology

authors： Bassett JH,Logan JG,Boyde A,Cheung MS,Evans H,Croucher P,Sun XY,Xu S,Murata Y,Williams GR

更新日期：2012-07-01 00:00:00

abstract：:Differentiation of endometrial stromal cells into decidual cells is a prerequisite for successful embryo implantation. Our previous studies in the mouse have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ superfamily, is essential for this differentiation process. BMP2 is markedly in...

journal_title：Endocrinology

authors： Li Q,Kannan A,Das A,Demayo FJ,Hornsby PJ,Young SL,Taylor RN,Bagchi MK,Bagchi IC

更新日期：2013-01-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:Several studies have revealed a variety of interactions between PTH and ACTH. The existence of a significant area of homology in the bioactive regions of the two molecules has been proposed as a possible reason for such interactions. To clarify the relationship, corticosteroidogenic and cAMP accumulative effects of bo...

journal_title：Endocrinology

authors： Rafferty B,Zanelli JM,Rosenblatt M,Schulster D

更新日期：1983-09-01 00:00:00