Abstract:
:Historically, much of the research on health effects of environmental pollutants focused on ascertaining whether compounds were carcinogenic. More recent findings show that environmental contaminants also exert insidious effects by disrupting hormone action. Of particular concern are findings that developmental exposure to dioxins, chemicals that act through the aryl hydrocarbon receptor pathway, permanently alters sexually differentiated neural functions in animal models. In this review, we focus on mechanisms through which dioxins disrupt neuroendocrine development as exemplified by effects on a brain region critical for ovulation in rodents. We also provide evidence that dysregulation of GABAergic neural development may be a general mechanism underlying a broad spectrum of effects seen after perinatal dioxin exposure.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Petersen SL,Krishnan S,Hudgens EDdoi
10.1210/en.2005-1157subject
Has Abstractpub_date
2006-06-01 00:00:00pages
S33-42issue
6 Suppleissn
0013-7227issn
1945-7170pii
en.2005-1157journal_volume
147pub_type
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