Abstract:
:Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Thaler JP,Schwartz MWdoi
10.1210/en.2010-0336subject
Has Abstractpub_date
2010-09-01 00:00:00pages
4109-15issue
9eissn
0013-7227issn
1945-7170pii
en.2010-0336journal_volume
151pub_type
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