Molecular identification and characterization of the gastrin receptor in guinea pig gastric glands.

abstract：:11 beta-Hydroxysteroid dehydrogenase (11 beta HSI) is an enzyme complex responsible for the conversion of hormonally active cortisol to inactive cortisone; two isoforms of the enzyme have been cloned and characterized. Clinical observations from patients with the hypertensive syndrome apparent mineralocorticoid excess...

journal_title：Endocrinology

authors： Shimojo M,Ricketts ML,Petrelli MD,Moradi P,Johnson GD,Bradwell AR,Hewison M,Howie AJ,Stewart PM

更新日期：1997-03-01 00:00:00

abstract：:In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...

journal_title：Endocrinology

authors： Ikegami K,Atsumi Y,Yorinaga E,Ono H,Murayama I,Nakane Y,Ota W,Arai N,Tega A,Iigo M,Darras VM,Tsutsui K,Hayashi Y,Yoshida S,Yoshimura T

更新日期：2015-02-01 00:00:00

abstract：:The expression of genes encoding key hepatic gluconeogenic enzymes, including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), is regulated at the transcriptional level by a network of transcription factors and cofactors, including cAMP response element-binding protein (CREB). It has been ...

journal_title：Endocrinology

authors： Seo HY,Kim MK,Min AK,Kim HS,Ryu SY,Kim NK,Lee KM,Kim HJ,Choi HS,Lee KU,Park KG,Lee IK

更新日期：2010-02-01 00:00:00

abstract：:The present study was designed to characterize the interaction of calcium and PTH in the control of renin release in isolated rat kidneys perfused in a closed circuit at constant flow. Kidneys were rendered nonfiltering using low perfusion pressures (70 mm Hg) and a hyperoncotic perfusate (100 g/liter BSA). Under thes...

journal_title：Endocrinology

authors： Helwig JJ,Musso MJ,Judes C,Nickols GA

更新日期：1991-09-01 00:00:00

abstract：:Atrial, brain-type, and C-type natriuretic peptides (ANP, BNP, and CNP) act via receptors with intrinsic guanylate cyclase activity. The A-type and B-type ANP receptors are selectively activated by ANP and CNP, respectively. The anterior pituitary is a site of ANP production and action, suggesting a local regulatory f...

journal_title：Endocrinology

authors： McArdle CA,Poch A,Käppler K

更新日期：1993-05-01 00:00:00

abstract：:Basal growth hormone (GH) levels are higher in female than male primates, and estradiol (E) treatment of gonadectomized primates increases serum GH. To determine if the effect of E is mediated at the level of the somatotroph, we verified the effect of E-treatment on serum GH in spayed macaques, and then examined the e...

journal_title：Endocrinology

authors： Bethea CL

更新日期：1991-10-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00

abstract：:Animals maintained on retinol (vitamin A-alcohol)-deficient diets exhibit testicular atrophy and loss of the germinal epithelium. Retinoic acid (vitamin A-acid), when fed to retinol-deficient animals, does not prevent these lesions and had thus been thought not to play a role in the tests. Serum testosterone (T) level...

journal_title：Endocrinology

authors： Appling DR,Chytil F

更新日期：1981-06-01 00:00:00

abstract：:The feedback sites of estrogen within the hypothalamus and lower brain stem involved in the suppression of pulsatile LH secretion during 48-h fasting were examined in ovariectomized rats with local estradiol (E2) implants. The animals were ovariectomized and immediately implanted stereotaxically with stainless steel c...

journal_title：Endocrinology

authors： Nagatani S,Tsukamura H,Maeda K

更新日期：1994-09-01 00:00:00

abstract：:The beta-isoform of protein kinase C (PKC) has paradoxically been suggested to be important for both insulin action and insulin resistance as well as for contributing to the pathogenesis of diabetic complications. Presently, we evaluated the effects of knockout of the PKCbeta gene on overall glucose homeostasis and in...

journal_title：Endocrinology

authors： Standaert ML,Bandyopadhyay G,Galloway L,Soto J,Ono Y,Kikkawa U,Farese RV,Leitges M

更新日期：1999-10-01 00:00:00

abstract：:Members of the winged helix transcription factor family are known to regulate epithelial cell differentiation by regulating cell-specific gene expression. rWIN is a newly discovered member of the winged helix family shown to be present in the adult rat testis. In the testis the human homolog of rWIN, HFH-11, was local...

journal_title：Endocrinology

authors： Chaudhary J,Mosher R,Kim G,Skinner MK

更新日期：2000-08-01 00:00:00

abstract：:The enzyme glutamate decarboxylase-65 (GAD65) is a major autoantigen in autoimmune diabetes. The mechanism whereby autoreactivity to GAD65, an intracellular protein, is triggered is unknown, and it is possible that immunoreactive GAD65 is released by injured pancreatic islet beta-cells. There is a great need for metho...

journal_title：Endocrinology

authors： Waldrop MA,Suckow AT,Marcovina SM,Chessler SD

更新日期：2007-10-01 00:00:00

abstract：:We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet beta-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. The effects of 1-2 d culture of both rat INS 832/13 cells and hu...

journal_title：Endocrinology

authors： El-Assaad W,Buteau J,Peyot ML,Nolan C,Roduit R,Hardy S,Joly E,Dbaibo G,Rosenberg L,Prentki M

更新日期：2003-09-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:The impact of clinical progestins used in contraception and hormone therapies on the metabolic capacity of the brain has long-term implications for neurological health in pre- and postmenopausal women. Previous analyses indicated that progesterone and 17β-estradiol (E2) sustain and enhance brain mitochondrial energy-t...

journal_title：Endocrinology

authors： Irwin RW,Yao J,Ahmed SS,Hamilton RT,Cadenas E,Brinton RD

更新日期：2011-02-01 00:00:00

abstract：:During the purification of skeletal growth factor/insulin-like growth factor-II and transforming growth factor-beta (TGF beta) from EDTA extracts of bovine bone matrix significant mitogenic activity for cultured osteoblast (Ob)-like cells eluted in fractions that contained a nearly homogeneous peptide with a mol wt of...

journal_title：Endocrinology

authors： Jennings JC,Mohan S,Baylink DJ

更新日期：1989-07-01 00:00:00

abstract：:The primary culture of rat luteal cells and their long-term maintenance have been difficult. Low cellular yields have limited the possibility for the study of gene regulation in luteal cells. The goal of this study was to develop a cell line to serve as a model by which to study the expression and regulation of variou...

journal_title：Endocrinology

authors： Sugino N,Zilberstein M,Srivastava RK,Telleria CM,Nelson SE,Risk M,Chou JY,Gibori G

更新日期：1998-04-01 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is one of the most important neurotransmitters that regulate the excitability of GnRH neurons. Numerous studies have shown that GABA activates Cl(-) currents in GnRH neurons, and these effects are antagonized by GABA(A) receptor antagonists. The GABA(B) receptor is a heterodimer composed...

journal_title：Endocrinology

authors： Zhang C,Bosch MA,Rønnekleiv OK,Kelly MJ

更新日期：2009-05-01 00:00:00

abstract：:GH and IGF-I are potent regulators of muscle growth and function. Although IGF-I is known to mediate many of the effects of GH, it is not yet clear whether all effects of GH are completely dependent on the IGF-I system. To evaluate the biological effects of the GH/IGF-I axis on muscle growth, we administrated recombin...

journal_title：Endocrinology

authors： Kim H,Barton E,Muja N,Yakar S,Pennisi P,Leroith D

更新日期：2005-04-01 00:00:00

abstract：:Immunohistochemical (immunoperoxidase) studies were performed on 478 sections from 97 rat pituitary glands with rabbit antisera to unconjugated human synthetic calcitonin beta-endorphin, and/or ACTH-(17--39). Calcitonin-positive cells were present in a majority of the anterior lobes studied, whereas they were present ...

journal_title：Endocrinology

authors： Watkins WB,Moore RY,Burton D,Bone HG 3rd,Catherwood BD,Deftos LJ

更新日期：1980-06-01 00:00:00

abstract：:The DHCR24 gene encodes an enzyme catalyzing the last step of cholesterol biosynthesis, the conversion of desmosterol to cholesterol. To elucidate the physiological significance of cholesterol biosynthesis in mammalian cells, we investigated proliferation of mouse embryonic fibroblasts (MEFs) prepared from DHCR24(-/-)...

journal_title：Endocrinology

authors： Lu X,Kambe F,Cao X,Yoshida T,Ohmori S,Murakami K,Kaji T,Ishii T,Zadworny D,Seo H

更新日期：2006-06-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:A novel transcript of the GH gene has been identified in ocular tissues of chick embryos. It is, however, unknown whether this transcript (small chicken GH, scGH) is translated. This possibility was therefore assessed. The expression of scGH mRNA was confirmed by RT-PCR, using primers that amplified a 426-bp cDNA of i...

journal_title：Endocrinology

authors： Baudet ML,Martin B,Hassanali Z,Parker E,Sanders EJ,Harvey S

更新日期：2007-01-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:Reduced and S-carbamidomethylated human GH (RCAM-hGH) was digested with human plasmin, yielding a mixture of products. These were partially separated by chromatography on DEAE-cellulose, yielding three major fractions: Da and Db, which were equipotent with native hGH in the weight gain test; and Dc, which was about ha...

journal_title：Endocrinology

authors： Mills JB,Kostyo JL,Moseley MH,Reagan CR,Wilhelmi AE

更新日期：1978-05-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:Purinergic G protein-coupled receptors (P2YR) and ion-conducting receptor-channels (P2XR) are present in the pituitary. However, their identification, expression within pituitary cell subpopulations, and the ability to elevate intracellular Ca2+ concentration ([Ca2+]i) in response to ATP stimulation were incompletely ...

journal_title：Endocrinology

authors： Koshimizu TA,Tomić M,Wong AO,Zivadinovic D,Stojilkovic SS

更新日期：2000-11-01 00:00:00

abstract：:There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. ...

journal_title：Endocrinology

authors： França LR,Suescun MO,Miranda JR,Giovambattista A,Perello M,Spinedi E,Calandra RS

更新日期：2006-03-01 00:00:00