Expression, translation, and localization of a novel, small growth hormone variant.

abstract：:Gap junctions were observed on the lateral plasma membrane of the typical thyroid epithelial cell in freeze-fracture preparations of rat thyroid gland. The gap junctions were 0.1 to 0.4 mum in diameter and were composed of closely packed, approximately 80 nm particles. They were located from 1 to 6 mum from the apical...

journal_title：Endocrinology

authors： Tice LW,Carter RC,Wollman SH

更新日期：1976-03-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by peripheral immune cells and also by endocrine cells in the anterior pituitary gland. MIF exerts its proinflammatory actions in the host-defense system by blocking the inhibitory effects of glucocorticoids on the release of other pro...

journal_title：Endocrinology

authors： Tierney T,Patel R,Stead CA,Leng L,Bucala R,Buckingham JC

更新日期：2005-01-01 00:00:00

abstract：:Dynamic bone histomorphometry, [3H]thymidine radioautography, and Northern analysis for bone matrix proteins and insulin-like growth factor-I (IGF-I) were performed in calvariae of ovariectomized (OVX) and estrogen-treated OVX rats. Treatment of OVX rats with diethylstilbestrol (DES) for 2 weeks reduced the periosteal...

journal_title：Endocrinology

authors： Turner RT,Backup P,Sherman PJ,Hill E,Evans GL,Spelsberg TC

更新日期：1992-08-01 00:00:00

abstract：:Permanent effects of postnatal gonads on dopamine (DA)-mediated regulation of PRL secretion were examined in adult male rats of the Wistar-Imamichi strain. Rats were bilaterally orchidectomized at varying postnatal days, i.e. 8 h after birth [neonatal castration (NC)] or at 1, 2, 3, 4, or 6 weeks of age, and subjected...

journal_title：Endocrinology

authors： Watanobe H,Takebe K

更新日期：1987-06-01 00:00:00

abstract：:Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Gremlin, a BMP antagonist, is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. However, its effects in vivo are not known. To investigate the actions of gremlin on bone remodeling in...

journal_title：Endocrinology

authors： Gazzerro E,Pereira RC,Jorgetti V,Olson S,Economides AN,Canalis E

更新日期：2005-02-01 00:00:00

abstract：:We recently reported that chronic 17β-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERα), and independently of ERβ. Here, we have explored the respective roles of membrane vs ...

journal_title：Endocrinology

authors： Valéra MC,Fontaine C,Lenfant F,Cabou C,Guillaume M,Smirnova N,Kim SH,Chambon P,Katzenellenbogen JA,Katzenellenbogen BS,Payrastre B,Arnal JF

更新日期：2015-11-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:We have cloned a type of cDNA for a functional glandular kallikrein, designated as mouse Klk21 (mKlk21), from the adult mouse testis cDNA library. mKlk21 was expressed in the kidney, submaxillary glands, and testis of the mouse. In the testis, mKlk21 mRNA was detectable at 4 wk of postnatal development and became more...

journal_title：Endocrinology

authors： Matsui H,Takahashi T

更新日期：2001-11-01 00:00:00

abstract：:A primary culture system has been established for rainbow trout corpuscles of Stannius (CS). A RIA has also been developed to monitor and characterize the teleocalcin secreted by these cultures. The primary cultured CS cells actively synthesized and secreted teleocalcin for up to 39 days when maintained in amphibian a...

journal_title：Endocrinology

authors： Gellersen B,Wagner GF,Copp DH,Friesen HG

更新日期：1988-08-01 00:00:00

abstract：:Luteinizing hormone/chorionic gonadotropin receptor (LHR) expression in the ovary is regulated by a messenger RNA (mRNA) binding protein, which specifically binds to the coding region of LHR mRNA. We have shown that miR-122, a short noncoding RNA, mediates LHR mRNA levels by modulating the expression of LHR mRNA-bindi...

journal_title：Endocrinology

authors： Menon B,Guo X,Garcia N,Gulappa T,Menon KMJ

更新日期：2018-05-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d...

journal_title：Endocrinology

authors： Chen CY,Kimura H,Landek-Salgado MA,Hagedorn J,Kimura M,Suzuki K,Westra W,Rose NR,Caturegli P

更新日期：2009-01-01 00:00:00

abstract：:The original objective of this study was to use available distribution volume (V) and deca constant (k) estimates for rat LH and FSH to determine the amounts of these hormones synthesized and released during a dynamic secretory event, the postpartum preovulatory surge. The problem was approached by 1) determining the ...

journal_title：Endocrinology

authors： Diebel ND,Bogdanove EM

更新日期：1978-09-01 00:00:00

abstract：:Thyroid hormone produces a prompt, plasma membrane-mediated increase in several metabolic functions in the rat thymocyte. These effects of thyroid hormone require calcium and are inhibited by the beta-adrenergic antagonist alprenolol. In the present study, the interrelationship between thyroid hormone and adrenergic a...

journal_title：Endocrinology

authors： Segal J

更新日期：1988-05-01 00:00:00

abstract：:Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2...

journal_title：Endocrinology

authors： McCallum ML,Pru CA,Niikura Y,Yee SP,Lydon JP,Peluso JJ,Pru JK

更新日期：2016-09-01 00:00:00

abstract：:A RT-PCR approach was used to clone and sequence the full-length growth hormone receptor (GHR) of a teleost fish, the turbot (Scophthalmus maximus). Total liver RNA was amplified by RT-PCR with degenerate primers designed in extracellular and cytoplasmic regions, and a single DNA fragment of 1100 bp was obtained. The ...

journal_title：Endocrinology

authors： Calduch-Giner J,Duval H,Chesnel F,Boeuf G,Pérez-Sánchez J,Boujard D

更新日期：2001-07-01 00:00:00

abstract：:The uterotropic response of the uterus to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous genetic studies from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 led to the identification of q...

journal_title：Endocrinology

authors： Wall EH,Case LK,Hewitt SC,Nguyen-Vu T,Candelaria NR,Teuscher C,Lin CY

更新日期：2014-08-01 00:00:00

abstract：:The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the endogenous GnRH signal required to induce and maintain a LH surge of full amplitude and duration. For this purpose, we assessed the effect of a competitive GnRH...

journal_title：Endocrinology

authors： Evans NP,Dahl GE,Caraty A,Padmanabhan V,Thrun LA,Karsch FJ

更新日期：1996-11-01 00:00:00

abstract：:Women with type 1 diabetes are subfertile. Diabetes negatively affects pregnancy by causing early miscarriage and poor prenatal outcomes. In this study we examine consequences of maternal type 1 diabetes on early embryo development, metabolic gene expression, and the pattern of insulin receptor (IR) and IGF-I receptor...

journal_title：Endocrinology

authors： Ramin N,Thieme R,Fischer S,Schindler M,Schmidt T,Fischer B,Navarrete Santos A

更新日期：2010-09-01 00:00:00

abstract：:Cellular distribution of progestin receptor immunoreactivity (PR-IR) in paraffin-embedded rabbit oviduct tissue was determined using a monoclonal antibody and the indirect immunoperoxidase method. Ampullar and isthmic tissue from ovariectomized animals primed with 17 beta-estradiol or vehicle alone was examined. As ex...

journal_title：Endocrinology

authors： Hyde BA,Blaustein JD,Black DL

更新日期：1989-09-01 00:00:00

abstract：:Interleukin-1 (IL-1), one of the mediators of the interaction between the immune and the neuroendocrine system, is well known to modulate anterior pituitary hormone secretion. As IL-1 influences growth of various cell types, we investigated whether IL-1 is also a growth factor of pituitary cells. We demonstrate that I...

journal_title：Endocrinology

authors： Renner U,Newton CJ,Pagotto U,Sauer J,Arzt E,Stalla GK

更新日期：1995-08-01 00:00:00

abstract：:Insulin radioreceptor assays were developed using splenic leukocytes and peripheral erythrocytes from individual mice. Splenic leukocytes were prepared using an NH4Cl buffer which did not alter insulin binding, but gave much higher yields than density gradient methods. Mouse erythrocytes were isolated from heparinized...

journal_title：Endocrinology

authors： Shimizu F,Kahn CR

更新日期：1982-02-01 00:00:00

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:Coordinating the activities of neighboring cells during development in multicellular organisms requires complex cellular interactions involving secreted, cell surface, and extracellular matrix components. Although most cloning efforts have concentrated on secreted molecules, recent work has emphasized the importance o...

journal_title：Endocrinology

authors： Stephan JP,Roberts PE,Bald L,Lee J,Gu Q,Devaux B,Mather JP

更新日期：1999-12-01 00:00:00

abstract：:The median eminence (ME) region of the hypothalamus was electrically stimulated through permanently implanted electrodes in 1 unanesthetized sheep. Plasma concentrations of GH and prolactin (PRL) were measured at 10-min intervals before, during and after 30-min periods of electrical stimulation or sham procedures. The...

journal_title：Endocrinology

authors： Malven PV

更新日期：1975-10-01 00:00:00

abstract：:We have previously reported that the acute injection of interleukin-1 beta (IL-1 beta) into the brain ventricles of intact female rats promptly decreases LHRH release and inhibits gene expression of this peptide in the medial preoptic area (MPOA). The present studies were therefore designed to determine whether contin...

journal_title：Endocrinology

authors： Rivest S,Lee S,Attardi B,Rivier C

更新日期：1993-12-01 00:00:00

abstract：:To identify genes involved in regulated insulin secretion, we have established and characterized two sublines derived from the mouse pancreatic beta-cell line MIN6, designated B1 and C3. They have a similar insulin content, but differ in their secretory properties. B1 responded to glucose in a concentration- and cell ...

journal_title：Endocrinology

authors： Lilla V,Webb G,Rickenbach K,Maturana A,Steiner DF,Halban PA,Irminger JC

更新日期：2003-04-01 00:00:00

abstract：:Dysregulation of the hypothalamic-pituitary-adrenocortical axis has been theoretically linked to the processes of aging for decades. To investigate the effects of age on high frequency rhythms of plasma ACTH at the time of circadian activation, integrated 2-min blood samples were collected over 4 h in 10 young and 14 ...

journal_title：Endocrinology

authors： Carnes M,Goodman BM,Lent SJ,Vo H

更新日期：1993-08-01 00:00:00

abstract：:The roles of growth hormone and somatomedin in stimulating muscle cell proliferation were investigated in a series of experiments on myoblast growth in culture. At levels 100 times normal circulating concentrations, neither growth hormone nor insulin stimulated growth of rat muscle cells in serum-free medium. In contr...

journal_title：Endocrinology

authors： Florini JR,Nicholson ML,Dulak NC

更新日期：1977-07-01 00:00:00

abstract：:31P nuclear magnetic resonance (NMR) was used to study the effects of 17 beta-estradiol on the content of phosphates and on the flux catalyzed by creatine kinase in immature rat uteri. Perifusion with oxygenated medium at 36 C maintained the uteri in a viable state for at least 10 h in vitro during 31P NMR measurement...

journal_title：Endocrinology

authors： Degani H,Victor TA,Kaye AM

更新日期：1988-04-01 00:00:00