Parathyroid hormone and calcium: interactions in the control of renin secretion in the isolated, nonfiltering rat kidney.

abstract：:In female mammals, reproduction is sensitive to the availability of metabolic fuels, and food deprivation has been shown to suppress pulsatile LH secretion, attenuate the preovulatory LH surge, and prevent ovulation. It has been suggested that food deprivation impairs fertility by reducing the secretion of GnRH by GnR...

journal_title：Endocrinology

authors： Berriman SJ,Wade GN,Blaustein JD

更新日期：1992-11-01 00:00:00

abstract：:Leptin regulates food intake and other activities through its hypothalamic receptor. Leptin receptors are also found in other organs, including the ovary. Direct effects of leptin in ovarian steroid production were studied in primary rat granulosa cells and in rat and human granulosa cell lines. Leptin (0.6-18 nM) sup...

journal_title：Endocrinology

authors： Barkan D,Jia H,Dantes A,Vardimon L,Amsterdam A,Rubinstein M

更新日期：1999-04-01 00:00:00

abstract：:We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombi...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Carlsson B,Carmignac D,Robinson IC

更新日期：1996-05-01 00:00:00

abstract：:To examine the possibility that the prepubertal hiatus in gonadotropin secretion in primates is occasioned by an endogenous opioid peptide (EOP)-dependent suppression of pulsatile GnRH release, the ability of an EOP receptor antagonist, naloxone (NAL), to elicit GnRH release was examined indirectly in the rhesus monke...

journal_title：Endocrinology

authors： Medhamurthy R,Gay VL,Plant TM

更新日期：1990-02-01 00:00:00

abstract：:Postnatal development of the ovine uterus between birth and postnatal day (PND) 56 involves budding differentiation of the endometrial glandular epithelium from the luminal epithelium (LE) followed by extensive coiling and branching morphogenesis of the tubular glands. To determine the short- and long-term effects of ...

journal_title：Endocrinology

authors： Hayashi K,Carpenter KD,Spencer TE

更新日期：2004-07-01 00:00:00

abstract：:The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

journal_title：Endocrinology

authors： Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

更新日期：2021-03-01 00:00:00

abstract：:Glucocorticoid hormones are involved in functional differentiation of GH-producing somatotrophs. Glucocorticoid treatment prematurely induces GH expression in mammals and birds in a process requiring protein synthesis and Rat sarcoma (Ras) signaling. The objective of this study was to investigate mechanisms through wh...

journal_title：Endocrinology

authors： Ellestad LE,Puckett SA,Porter TE

更新日期：2015-03-01 00:00:00

abstract：:We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and compared the localization of this 10,000 mol wt CaBP with the localization of the 28,000 mol wt vitamin D-dependent CaBP. Antiserum...

journal_title：Endocrinology

authors： Rhoten WB,Bruns ME,Christakos S

更新日期：1985-08-01 00:00:00

abstract：:Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in the ovary, uterus,...

journal_title：Endocrinology

authors： Douglas NC,Tang H,Gomez R,Pytowski B,Hicklin DJ,Sauer CM,Kitajewski J,Sauer MV,Zimmermann RC

更新日期：2009-08-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00

abstract：:Intracellular cargo transport relies on microtubules and motor proteins such as kinesins and dyneins. Currently we have ample knowledge of the mechanisms by which motor proteins propel themselves along the microtubules, but little is known about intracellular factors that regulate motor speed. Here we show that proadr...

journal_title：Endocrinology

authors： Larráyoz IM,Martínez A

更新日期：2012-04-01 00:00:00

abstract：:GH3 cells are a PRL-secreting adenoma cell line derived from pituitary lactotropes. These cells have been stably transfected with rat GnRH receptor complementary DNA to produce four cell lines: GGH(3)1', GGH(3)2', GGH(3)6', and GGH(3)12'. In response to either GnRH or Buserelin (a metabolically stable GnRH agonist), t...

journal_title：Endocrinology

authors： Stanislaus D,Arora V,Awara WM,Conn PM

更新日期：1996-03-01 00:00:00

abstract：:With a recently developed microdissection technique, four circumventricular organs were removed from the rat brain, and their contents of LHRH and TRH were measured. The subfornical organ, the organon vasculosum lamia terminalis, the subcommissural organ, the area postrema all contained significant quantities of both ...

journal_title：Endocrinology

authors： Kizer JS,Palkovits M,Brownstein MJ

更新日期：1976-02-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:In order to compare, in vitro, the TSH suppressive effects of iodothyronines, rat pituitary quarters were first preincubated with T4, T3, rT3, or 3,3'-diiodothyronine (T2) in Gey and Gey buffer containing 1% bovine serum albumin for 2 h at 37 C and then incubated at 37 C for 1 h with the iodothyronine under study and ...

journal_title：Endocrinology

authors： Chopra IJ,Carlson HE,Solomon DH

更新日期：1978-08-01 00:00:00

abstract：:Human thyroperoxidase (hTPO), a type I transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis and plays a major role in thyroid autoimmunity. Whereas hormonosynthesis occurs at the apical membrane of thyroid cells, TPO localizes mainly in the perinuclear membrane and ...

journal_title：Endocrinology

authors： Fayadat L,Niccoli-Sire P,Lanet J,Franc JL

更新日期：1998-10-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00

abstract：:Most of the constitutive hepatic P450 isoforms expressed in the rat exhibit dramatic gender differences. Whereas only male hepatocytes contain CYP2A2, 2C11, and 3A2, only female hepatocytes express CYP2C12 and 3- to 4-fold greater levels of CYP2C7. This sexually dimorphic expression of hepatic P450 isoforms is regulat...

journal_title：Endocrinology

authors： Pampori NA,Shapiro BH

更新日期：1999-03-01 00:00:00

abstract：:In the present study, we report that ACTH induces a transient chloride current. The lack of correlation between ACTH-induced cAMP production and amplitude of the Cl- current, as well as the absence of stimulation by forskolin or 8Br-cAMP indicated that the ACTH-induced current was not cAMP-dependent. We explored the p...

journal_title：Endocrinology

authors： Chorvátová A,Gendron L,Bilodeau L,Gallo-Payet N,Payet MD

更新日期：2000-02-01 00:00:00

abstract：:The regulation of delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase (3 beta-HSD) was studied in primary cultures of rat adrenocortical cells. In the absence of ACTH, this enzymic activity was found to decay with a half-life of 3.1 days, which was similar to the half-life of the enzyme activity induced by ACTH in v...

journal_title：Endocrinology

authors： Rybak SM,Ramachandran J

更新日期：1982-08-01 00:00:00

abstract：:In healthy individuals, peripheral insulin resistance evoked by dietary saturated lipid can be accompanied by increased insulin secretion such that glucose tolerance is maintained. Substitution of long-chain omega-3 fatty acids for a small percentage of dietary saturated fat prevents insulin resistance in response to ...

journal_title：Endocrinology

authors： Holness MJ,Greenwood GK,Smith ND,Sugden MC

更新日期：2003-09-01 00:00:00

abstract：:The present work aimed to determine the role played by protein kinase-C (PKC) in the alpha 1-adrenoceptor-induced activation of hepatic metabolism. The following observations indicate that activation of PKC is a condition necessary for alpha 1-adrenoceptor activation of hepatic functions, but not sufficient to mimic t...

journal_title：Endocrinology

authors： Urcelay E,Butta N,Manchón CG,Ciprés G,Requero AM,Ayuso MS,Parrilla R

更新日期：1993-11-01 00:00:00

abstract：:Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...

journal_title：Endocrinology

authors： Wira CR,Roche MA,Rossoll RM

更新日期：2002-08-01 00:00:00

abstract：:To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...

journal_title：Endocrinology

authors： Vincent M,Guz Y,Rozenberg M,Webb G,Furuta M,Steiner D,Teitelman G

更新日期：2003-09-01 00:00:00

abstract：:A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...

journal_title：Endocrinology

authors： Katz J,Finlay TH,Tom C,Levitz M

更新日期：1980-12-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Using a Leydig tumor cell line (MA-10) transiently transfected with the human lutropin receptor (hLHR) and mutants thereof, we examined the identity of the G proteins activated by the agonist-engaged hLHR-wild type (wt) and by three of its naturally occurring constitutively active mutants. Two of the mutants examined,...

journal_title：Endocrinology

authors： Hirakawa T,Ascoli M

更新日期：2003-09-01 00:00:00

abstract：:The vertebrate adenohypophysis forms as a placode at the anterior margin of the neural plate, requiring both hedgehog (Hh) and fibroblast growth factor (Fgf) mediated cell-cell signaling for induction and survival of endocrine cell types. Using small molecule inhibitors to modulate signaling levels during zebrafish de...

journal_title：Endocrinology

authors： Guner B,Ozacar AT,Thomas JE,Karlstrom RO

更新日期：2008-09-01 00:00:00

abstract：:Uterine epithelial cells (UEC) isolated from 6-week-old CF-1 mice were immortalized using retroviral-mediated transfection of SV40 large T-antigen. One line, WEG-1, retained epithelial morphology and reacted with antibodies to cytokeratins 18, 19, laminin, fibronectin, and beta-catenin. In addition, WEG-1 cells displa...

journal_title：Endocrinology

authors： Wegner CC,Cherington V,Clemens JW,Jacobs AL,Julian J,Surveyor GA,Bell EC,Carson DD

更新日期：1996-01-01 00:00:00

abstract：:Three transforming growth factor-beta protein isoforms (TGFbeta1, TGFbeta2, and TGFbeta3) have been identified in mammals. These isoforms appear to have similar actions on cell growth in various tissues. In rat pituitary tissue, TGFbeta1 is localized in PRL-secreting lactotropes and has been shown to act on lactotrope...

journal_title：Endocrinology

authors： Hentges S,Pastorcic M,De A,Boyadjieva N,Sarkar DK

更新日期：2000-04-01 00:00:00