Release of glutamate decarboxylase-65 into the circulation by injured pancreatic islet beta-cells.

abstract：:As the regulator of pituitary reproductive hormone synthesis, the hypothalamic neuropeptide GnRH is the central regulator of reproduction. A hallmark of GnRH action is the differential control of gene expression in pituitary gonadotropes through varied pulsatile stimulation. Among other signaling events, GnRH activati...

journal_title：Endocrinology

authors： Nguyen KA,Intriago RE,Upadhyay HC,Santos SJ,Webster NJ,Lawson MA

更新日期：2010-10-01 00:00:00

abstract：:Mouse fibroblast cell lines which secrete bovine (b) GH have been generated. This was accomplished by cotransforming mouse L cells (thymidine kinase-negative [TK-] and adenine phosphoribosyl transferase-negative [APRT-]) with DNA molecules encoding the Rous sarcoma virus-long-terminal repeat and bGH genes along with t...

journal_title：Endocrinology

authors： Leung FC,Jones B,Steelman SL,Rosenblum CI,Kopchick JJ

更新日期：1986-10-01 00:00:00

abstract：:The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...

journal_title：Endocrinology

authors： Youssef A,Iosef C,Han VK

更新日期：2014-04-01 00:00:00

abstract：:Carboxyl-terminal fragments of PTH (C-PTH) appear to have biological properties different from those mediated by the amino-terminal portions of PTH and PTH-related peptide (PTHrP). To characterize a C-PTH receptor that may be involved in mediating these functions, we performed RRAs and affinity cross-linking studies w...

journal_title：Endocrinology

authors： Inomata N,Akiyama M,Kubota N,Jüppner H

更新日期：1995-11-01 00:00:00

abstract：:We have previously reported that the acute injection of interleukin-1 beta (IL-1 beta) into the brain ventricles of intact female rats promptly decreases LHRH release and inhibits gene expression of this peptide in the medial preoptic area (MPOA). The present studies were therefore designed to determine whether contin...

journal_title：Endocrinology

authors： Rivest S,Lee S,Attardi B,Rivier C

更新日期：1993-12-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:L-Asparaginase (ASNase), a drug widely used in the treatment of acute lymphoblastic leukemia, has been reported to decrease serum T4-binding globulin (TBG) levels, while results of serum albumin determinations were conflicting. This effect in vivo has been attributed to depressed liver protein synthesis, but this hypo...

journal_title：Endocrinology

authors： Bartalena L,Martino E,Antonelli A,Pacchiarotti A,Robbins J,Pinchera A

更新日期：1986-09-01 00:00:00

abstract：:The aim of our study was to isolate and identify novel proteins that are involved in the process of ovulation. To achieve this goal we used the technique of proteome analysis. Comparison of ovary protein patterns, obtained by high resolution two-dimensional gel electrophoresis from recombinant FSH (rFSH)- and rFSH + h...

journal_title：Endocrinology

authors： Brockstedt E,Peters-Kottig M,Badock V,Hegele-Hartung C,Lessl M

更新日期：2000-07-01 00:00:00

abstract：:In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...

journal_title：Endocrinology

authors： Khan A,Hong-Lie C,Landau BR

更新日期：1995-05-01 00:00:00

abstract：:This study was conducted to determine the feasibility of using replication-defective adenovirus vectors to express receptors for LH. Two vectors were constructed, one that directs the expression of wild-type human LH receptor (LHr; AdRSVLHrwt) and another that directs the expression of the constitutively activated D57...

journal_title：Endocrinology

authors： Bebia Z,Somers JP,Liu G,Ihrig L,Shenker A,Zeleznik AJ

更新日期：2001-06-01 00:00:00

abstract：:An estrogen-responsive uterine proenzyme of a proteinase in the immature rat uterus has been known for some time. Its mol wt is 77,000, its N-terminal amino acid sequence is the same as prothrombin's for 15 residues, it contains gamma-carboxyl glutamate residues, its biosynthesis is prevented by warfarin, it cross-rea...

journal_title：Endocrinology

authors： Henrikson KP,Jazin EE,Greenwood JA,Dickerman HW

更新日期：1990-01-01 00:00:00

abstract：:Intact 23 kilodalton (kDa), rat PRL is enzymatically cleaved in many target tissues to a 16 kDa (16K PRL) and an 8 kDa fragment. After reduction of an internal disulfide bond the fragments are released. 16K PRL was shown to be a potent mitogen on mammary epithelial cells via PRL receptors. Since estradiol-induced prol...

journal_title：Endocrinology

authors： Ferrara N,Clapp C,Weiner R

更新日期：1991-08-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00

abstract：:Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we...

journal_title：Endocrinology

authors： Iwasaki H,Hirata Y,Iwashina M,Sato K,Marumo F

更新日期：1996-07-01 00:00:00

abstract：:Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the N222D mutation. Me...

journal_title：Endocrinology

authors： Prabhu Y,Blanco EH,Liu M,Peinado JR,Wheeler MC,Gekakis N,Arvan P,Lindberg I

更新日期：2014-07-01 00:00:00

abstract：:Studies were undertaken to investigate the effects of synthetic 1-24 adrenocorticotropin (ACTH), bovine alpha melanocyte-stimulating hormone (alpha-MSH), and ovine beta lipotropin (beta-LPH) on plasma calcium and phosphate in rabbits. Equimolar concentrations of these hormones were infused intravenously in intact and ...

journal_title：Endocrinology

authors： Gildersleeve DL,Pearson TA,Baghdiantz A,Foster GV

更新日期：1975-12-01 00:00:00

abstract：:We have compared the physicochemical properties of rat uterine nuclear estrogen receptors (ER) labeled with (E2) or the high affinity antiestrogen 4-hydroxytamoxifen [OH Tam; 1-[4-(2-dimethylaminoethoxy)phenyl]-1-(4-hydroxyphenyl) 2-phenyl-but-1-(Z)ene]. Nuclear ER labeled in vivo with either ligand had sedimentation ...

journal_title：Endocrinology

authors： Attardi B,Happe HK

更新日期：1986-08-01 00:00:00

abstract：:We recently identified a 32 K mol wt insulin-like growth factor (IGF)-binding protein (BP) which is markedly increased in the serum of streptozotocin-diabetic rats and recognized by antiserum against the human amniotic fluid IGFBP (hIGFBP-1). In the present study we sought to confirm that this protein represents the r...

journal_title：Endocrinology

authors： Unterman TG,Oehler DT,Gotway MB,Morris PW

更新日期：1990-08-01 00:00:00

abstract：:High-fat diet and intrauterine growth retardation may predispose to obesity, insulin resistance, and type 2 diabetes. Because prenatal ethanol (ETOH) exposure causes intrauterine growth retardation, we investigated its interactions with postnatal high-fat diet on glucose tolerance and adipocyte-derived hormones in the...

journal_title：Endocrinology

authors： Chen L,Nyomba BL

更新日期：2003-02-01 00:00:00

abstract：:Ovarian steroids act on unidentified neurons to trigger preovulatory secretion of GnRH. In the rat, important steroid target cells reside in the anterior medial preoptic nucleus (AMPN), a sexually dimorphic structure essential for stimulatory effects of ovarian steroids on LH secretion. The AMPN contains neurotensin (...

journal_title：Endocrinology

authors： Alexander MJ,Dobner PR,Miller MA,Bullock BP,Dorsa DM,Leeman SE

更新日期：1989-10-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:To investigate the respective role in PRL secretion of gamma-aminobutyric acid (GABA), either derived from the central nervous system or circulating in plasma, experiments were performed using ethanolamine-O-sulfate (EOS), a specific inhibitor of GABA catabolism. Intracerebroventricular injection of EOS (2 mg/kg) indu...

journal_title：Endocrinology

authors： Apud JA,Racagni G,Iuliano E,Cocchi D,Casanueva F,Müller EE

更新日期：1981-04-01 00:00:00

abstract：:Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...

journal_title：Endocrinology

authors： Li MH,Yang HH,Li MR,Sun YL,Jiang XL,Xie QP,Wang TR,Shi HJ,Sun LN,Zhou LY,Wang DS

更新日期：2013-12-01 00:00:00

abstract：:The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...

journal_title：Endocrinology

authors： Walker WH,Fucci L,Habener JF

更新日期：1995-08-01 00:00:00

abstract：:In the present study, we report that ACTH induces a transient chloride current. The lack of correlation between ACTH-induced cAMP production and amplitude of the Cl- current, as well as the absence of stimulation by forskolin or 8Br-cAMP indicated that the ACTH-induced current was not cAMP-dependent. We explored the p...

journal_title：Endocrinology

authors： Chorvátová A,Gendron L,Bilodeau L,Gallo-Payet N,Payet MD

更新日期：2000-02-01 00:00:00

abstract：:The conversion of T4 to T3 in the brain and anterior pituitary gland contributes significantly to the T3 content of these tissues and appears to be an important modulator of thyroid hormone action. In the present study, the antimanic agent lithium was demonstrated in cultured neural and pituitary tissue to have a sign...

journal_title：Endocrinology

authors： St Germain DL

更新日期：1987-04-01 00:00:00

abstract：:Testicular peritubular cells are myofibroblastic cells, which represent the major cellular components of the wall of the seminiferous tubules. In men their phenotypic characteristics, including possible secretory activity and regulation, are not well known, in neither normal nor pathologically altered testes. Especial...

journal_title：Endocrinology

authors： Schell C,Albrecht M,Mayer C,Schwarzer JU,Frungieri MB,Mayerhofer A

更新日期：2008-04-01 00:00:00

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:In rat uterus and prostate, 7 alpha, 17 alpha-dimethyl-19-nortestosterone (DMNT) binds to the androgen receptor specifically and with high affinity. However, this steroid does not bind to glucocorticoid receptors, since it does not displace binding of [3H]triamcinolone acetonide in calf thymus cytosol. In calf uterine...

journal_title：Endocrinology

authors： Traish AM,Müller RE,Wotiz HH

更新日期：1986-04-01 00:00:00