Glucocorticoid hormones contribute to the adipogenic activity of human serum.

abstract：:Previous studies had suggested that norepinephrine (NE) and its precursors dopamine (DA) and L-DOPA acted similarly on iodine metabolism of isolated thyroid cells. Present studies indicate that this similarity extends to the inhibition by catecholamines of TSH-stimulated T4 release by mouse thyroids incubated in vitro...

journal_title：Endocrinology

authors： Maayan ML,Sellitto RV,Volpert EM

更新日期：1986-02-01 00:00:00

abstract：:The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...

journal_title：Endocrinology

authors： Bianco AC,Silva JE

更新日期：1987-01-01 00:00:00

abstract：:Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis t...

journal_title：Endocrinology

authors： Sikka SC,Swerdloff RS,Rajfer J

更新日期：1985-05-01 00:00:00

abstract：:The pattern of glucagon gene expression and the posttranslational processing of proglucagon was studied in the fetal and neonatal rat. Pancreatic immunoreactive glucagon (IRG) and glucagon-like immunoreactivity (GLI) were low in both fetal pancreas and intestine, respectively. Immediately after birth, pancreatic IRG r...

journal_title：Endocrinology

authors： Lee YC,Brubaker PL,Drucker DJ

更新日期：1990-11-01 00:00:00

abstract：:The structural elements of 19-norprogestogens which may be essential for binding to progesterone and estradiol-17beta(E2) receptors were investigated in the rabbit uterine cytosol. The kinetic study showed that 19-nor-progestogens are competitive inhibitors of progesterone-receptor (8S) binding and E2-receptor binding...

journal_title：Endocrinology

authors： Tamaya T,Nioka S,Furuta N,Shimura T,Takano N

更新日期：1977-06-01 00:00:00

abstract：:We investigated the effect of TSH on calcium transport in mouse thyroid, as well as the influence of iodide thereupon. Thyroid lobes were incubated in Krebs-Ringer bicarbonate buffer containing [45Ca2+] and the time-dependent uptake of [45Ca2+] by the lobes was observed. In the presence of 0.5 mU/ml TSH, the uptake of...

journal_title：Endocrinology

authors： Hashizume K,Ichikawa K,Komiya I,Onaya T

更新日期：1984-05-01 00:00:00

abstract：:Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in the ovary, uterus,...

journal_title：Endocrinology

authors： Douglas NC,Tang H,Gomez R,Pytowski B,Hicklin DJ,Sauer CM,Kitajewski J,Sauer MV,Zimmermann RC

更新日期：2009-08-01 00:00:00

abstract：:[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes. The digestion was performed at 37 C for 24 h under nitr...

journal_title：Endocrinology

authors： Tokuyama T,Yoshinari M,Rawitch AB,Taurog A

更新日期：1987-08-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:The role of calcium in the angiotensin II- or potassium-mediated increase in aldosterone production was analyzed in isolated glomerulosa cells prepared from bovine adrenal glands. The response to potassium was highly dependent on the extracellular calcium concentration, and a maximal response was observed at 0.5 mM ca...

journal_title：Endocrinology

authors： Foster R,Lobo MV,Rasmussen H,Marusic ET

更新日期：1981-12-01 00:00:00

abstract：:Serum levels of progesterone in hysterectomized gilts were determined to evaluate the effects of exogenous 17 beta-estradiol (17 beta-E2) on the secretory activity of aging corpora lutea. Gilts were hysterectomized on day 6 of the estrous cycle and given im injections of 17 beta-E2 to mimic blood levels of endogenous ...

journal_title：Endocrinology

authors： Musah AI,Ford JJ,Anderson LL

更新日期：1984-11-01 00:00:00

abstract：:Previous descriptions of pulsatile LH release in immature female rats have been mostly inaccurate because of infrequent blood sampling, discontinuous and unbalanced blood replacement procedures, and possibly because of the use of a heterologous RIA. The present study was undertaken to circumvent these problems and to ...

journal_title：Endocrinology

authors： Urbanski HF,Ojeda SR

更新日期：1985-08-01 00:00:00

abstract：:It was shown previously that epidermal growth factor (EGF) plays a role in the testosterone-dependent fetal Wolffian duct differentiation. In this communication, the role of EGF was further investigated by determining whether EGF receptor plays a role in mediating the effect of EGF during Wolffian duct (male duct) dif...

journal_title：Endocrinology

authors： Gupta C,Jaumotte J

更新日期：1993-10-01 00:00:00

abstract：:Sex difference in the number of neurons projecting axons from the lateral septum (LS) to the midbrain central gray (MCG) that are concerned with the lordosis-inhibiting system was investigated by injection of Fluoro-Gold (FG), a retrograde tracer, into the rostral MCG on the right side in male and female rats. Immunoh...

journal_title：Endocrinology

authors： Tsukahara S,Yamanouchi K

更新日期：2002-01-01 00:00:00

abstract：:Thyroid hormone action is mediated through its nuclear receptors (TRs), which bind to target DNA sequences [thyroid hormone response element (TRE)] as a homodimer or a heterodimer with 9-cis-retinoic acid receptors. Mutations of TR beta identified in patients with resistance to thyroid hormone (RTH) cluster primarily ...

journal_title：Endocrinology

authors： Nomura Y,Nagaya T,Tsukaguchi H,Takamatsu J,Seo H

更新日期：1996-10-01 00:00:00

abstract：:VEGF is produced by osteoblasts and has been postulated to function as an angiogenic stimulus during normal skeletal development and in fracture repair. In this study, we characterized the molecular mechanisms by which experimental hypoxia increases VEGF mRNA in human MG63 osteoblast-like cells. Exposure of MG63 cells...

journal_title：Endocrinology

authors： Akeno N,Czyzyk-Krzeska MF,Gross TS,Clemens TL

更新日期：2001-02-01 00:00:00

abstract：:Leptin has been postulated to comprise part of an adipostat, whereby during states of excessive energy storage, elevated levels of the hormone prevent further weight gain by inhibiting appetite. A physiological role for leptin in this regard remains unclear because the presence of excessive food, and therefore the nee...

journal_title：Endocrinology

authors： Jeong KH,Sakihara S,Widmaier EP,Majzoub JA

更新日期：2004-07-01 00:00:00

abstract：:Basal or hypothalamic extract-induced ACTH or TSH secretory capacity as well as intracellular ACTH content were assessed in cultured rat adenohypophyseal cells after various pretreatments of the donor animals. Medium and intracellular ACTH or TSH were measured by radioimmunoassay. Ten-day to 2-month adrenalectomy enha...

journal_title：Endocrinology

authors： Yasuda N,Takebe K,Greer MA

更新日期：1976-03-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) is specifically and reversibly bound by particulate fractions from adrenals from fetal calves and lambs. These binding sites appear to be located primarily in the adrenal medulla and have properties very similar to those which we have detected in adult human, bovine, and ovine adrenal medulla. ...

journal_title：Endocrinology

authors： Karaplis AC,Powell WS

更新日期：1981-12-01 00:00:00

abstract：:The study of epigenetics allows for the understanding of gene × environmental interactions and provides a mechanism by which brief internal or external environmental changes can shape lasting differences in gene function and behavior. Epigenetic processes appear to impact a wide variety of physiological processes with...

journal_title：Endocrinology

authors： Auger AP,Auger CJ

更新日期：2011-02-01 00:00:00

abstract：:Treatment of inflammation is often accomplished through the use of glucocorticoids. However, their use is limited by side effects. We have examined the activity of a novel glucocorticoid receptor ligand that binds the receptor efficiently and strongly represses inflammatory gene expression. This compound has potent an...

journal_title：Endocrinology

authors： López FJ,Ardecky RJ,Bebo B,Benbatoul K,De Grandpre L,Liu S,Leibowitz MD,Marschke K,Rosen J,Rungta D,Viveros HO,Yen WC,Zhi L,Negro-Vilar A,Miner JN

更新日期：2008-05-01 00:00:00

abstract：:The present study was designed to evaluate the relative contribution of endogenous excitatory amino acids to the control of the estradiol-induced LH surge using specific blockers for N-methyl-D-aspartic acid (NMDA) and non-NMDA receptor types. Adult female rats ovariectomized for 2-3 weeks were implanted with third ve...

journal_title：Endocrinology

authors： López FJ,Donoso AO,Negro-Vilar A

更新日期：1990-03-01 00:00:00

abstract：:In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After rec...

journal_title：Endocrinology

authors： Anderson ST,Sawangjaroen K,Curlewis JD

更新日期：1996-08-01 00:00:00

abstract：:This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16...

journal_title：Endocrinology

authors： Tilbrook AJ,de Kretser DM,Cummins JT,Clarke IJ

更新日期：1991-12-01 00:00:00

abstract：:For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells tha...

journal_title：Endocrinology

authors： Ducy P

更新日期：2020-10-01 00:00:00

abstract：:The rate of internalization and degradation of radioiodinated hCG and ovine LH (oLH) as well as homologous and heterologous recombinants of their subunits was studied in suspensions of ovine luteal cells. Hormone bound to the plasma membrane was quantified by treating the cells with acidic buffer (pH 3.0) and quantifi...

journal_title：Endocrinology

authors： Mock EJ,Papkoff H,Niswender GD

更新日期：1983-07-01 00:00:00

abstract：:Oxytocin (OT) is released by the posterior pituitary during male orgasm and is supposed to participate in the ejaculatory process. We now report evidence demonstrating the presence of an OT receptor gene (real-time RT-PCR and Northern blot) and protein (immunohistochemistry, Western blot, and binding studies) expressi...

journal_title：Endocrinology

authors： Vignozzi L,Filippi S,Luconi M,Morelli A,Mancina R,Marini M,Vannelli GB,Granchi S,Orlando C,Gelmini S,Ledda F,Forti G,Maggi M

更新日期：2004-04-01 00:00:00

abstract：:Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease ...

journal_title：Endocrinology

authors： Yoshizato H,Fujikawa T,Soya H,Tanaka M,Nakashima K

更新日期：1998-05-01 00:00:00

abstract：:The mechanism of the inhibitory effect of long term treatment with estradiol on dopamine synthesis in tuberoinfundibular dopaminergic (TIDA) neurons was studied by using hypothalamic slices from ovariectomized rats. Treatment with 2 mg estradiol valerate (EV) at a 3-week interval increased the weight of the anterior p...

journal_title：Endocrinology

authors： Arita J,Kimura F

更新日期：1987-08-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase 2 (11 beta-HSD2) protects mineralocorticoid receptors from high circulating levels of glucocorticoids and cDNAs for 11 beta-HSD2 from human and sheep have been recently cloned. We have isolated the gene for mouse 11 beta-HSD2, which spans 7 kilobases and is composed of 5 exons. In ...

journal_title：Endocrinology

authors： Cole TJ

更新日期：1995-10-01 00:00:00