Abstract:
:Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease protection assay and 5'-rapid amplification of complementary DNA ends-PCR analyses indicated that the GH gene was expressed in rat brain, initiating at the identical transcription start point as that for pituitary GH gene expression. The brain GH messenger RNA was predominantly detected in the lateral hypothalamus (lh) by in situ reverse transcription-PCR analysis. GH gene expression in the brain was significantly enhanced by GH-releasing hormone administration and was rapidly repressed by exposure to restraint stress in the water, whereas the changes in pituitary GH messenger RNA contents in these circumstances were relatively smaller. The results of the present study suggest that the brain GH is predominantly expressed in lh under the control of physiological conditions to play a role in the modulation of brain functions.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Yoshizato H,Fujikawa T,Soya H,Tanaka M,Nakashima Kdoi
10.1210/endo.139.5.6009subject
Has Abstractpub_date
1998-05-01 00:00:00pages
2545-51issue
5eissn
0013-7227issn
1945-7170journal_volume
139pub_type
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