Central kappa- and mu-opiate receptors mediate ACTH-release in rats.

abstract：:We studied the interactions of two natural thyroid hormone receptor (TR) mutants from patients with resistance to thyroid hormone (RTH) and an artificial TR mutant with a nuclear receptor corepressor, N-CoR, and a steroid receptor coactivator, SRC-1. In electrophoretic mobility shift assays, wild-type TRbeta-1 interac...

journal_title：Endocrinology

authors： Liu Y,Takeshita A,Misiti S,Chin WW,Yen PM

更新日期：1998-10-01 00:00:00

abstract：:We have investigated the production and actions of a growth regulatory protein, insulin-like growth factor binding protein (IGFBP)-3, in the androgen-responsive prostate carcinoma cell line LNCaP. Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,2...

journal_title：Endocrinology

authors： Martin JL,Pattison SL

更新日期：2000-07-01 00:00:00

abstract：:Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Since low mol wt GTP-binding proteins (LMW-GTP-binding proteins) have been implicated in the regulation of vesicular trafficking, we have analyzed these proteins in adipocyt...

journal_title：Endocrinology

authors： Cormont M,Tanti JF,Grémeaux T,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1991-12-01 00:00:00

abstract：:Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding...

journal_title：Endocrinology

authors： MacKay H,Patterson ZR,Abizaid A

更新日期：2017-04-01 00:00:00

abstract：:Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stim...

journal_title：Endocrinology

authors： Zmora N,Stubblefield J,Golan M,Servili A,Levavi-Sivan B,Zohar Y

更新日期：2014-05-01 00:00:00

abstract：:Gonadal differentiation is dependent upon a cascade of molecular and morphological events. Steroidogenic factor 1 (SF-1) and DAX-1 have been implicated in this process. A SF-1 binding site has been reported to be present on the DAX-1 gene. We therefore used immunocytochemistry to determine whether these two transcript...

journal_title：Endocrinology

authors： Majdic G,Saunders PT

更新日期：1996-08-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:GnRH neurons are the central regulators of fertility, and their activity is modulated by steroid feedback. In women with hyperandrogenemic infertility and in animal models of these disorders, elevated androgen levels interfere with progesterone (P) negative feedback. Our previous work showed that steroids altered the ...

journal_title：Endocrinology

authors： Pielecka J,Quaynor SD,Moenter SM

更新日期：2006-03-01 00:00:00

abstract：:In seasonally breeding species, an animal's photoperiodic history (the daylength or photoperiod previously experienced) influences the reproductive response to new photoperiods. However, this has only been examined over a relatively narrow range of photoperiods. We assessed whether Djungarian hamsters (Phodopus sungor...

journal_title：Endocrinology

authors： Rivkees SA,Hall DA,Weaver DR,Reppert SM

更新日期：1988-06-01 00:00:00

abstract：:We examined the effects of bombesin on rat pancreatic digestive enzyme gene expression using cloned complementary DNA probes for amylase, trypsinogen I, chymotrypsinogen B, and lysophospholipase. Rats were injected sc three times daily with 5 nmol/kg body wt bombesin. Pancreata were investigated after 6, 12, 24, 48, a...

journal_title：Endocrinology

authors： Rosewicz S,Liehr RM,Solomon TE,Riecken EO,Logsdon CD

更新日期：1992-03-01 00:00:00

abstract：:Cultured pineal ependymal cells from rat fetuses aged 17 to 19 days post-coitum release into their media a substance that has hydroosmotic, antidiuretic and rat uterine activities. Paper chromatography of concentrates from culture media demonstrates that the substance possessing all the above activities was eluted fro...

journal_title：Endocrinology

authors： Pavel S,Goldstein R,Ghinea E,Calb M

更新日期：1977-01-01 00:00:00

abstract：:A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...

journal_title：Endocrinology

authors： Clark SA,Chick WL

更新日期：1990-04-01 00:00:00

abstract：:We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...

journal_title：Endocrinology

authors： Neufeld DS,Platzer M,Davies TF

更新日期：1989-01-01 00:00:00

abstract：:Pulsatile release of GnRH-1 is critical to stimulate gonadotropes of the anterior pituitary. This secretory pattern seems to be inherent to GnRH-1 neurons, however, the mechanisms underlying such episodical release remain unknown. In monkey nasal explants, the GnRH-1 population exhibits synchronized calcium events wit...

journal_title：Endocrinology

authors： Constantin S,Caraty A,Wray S,Duittoz AH

更新日期：2009-07-01 00:00:00

abstract：:Bovine placental lactogen (bPL) has been isolated from bovine trophoblast and characterized as a 32 K mol wt protein which exists in three different forms which differ in their isoelectric point values and their amino acid compositions. Two of the three forms have been shown to have both bovine GH (bGH)- and bovine PR...

journal_title：Endocrinology

authors： Duello TM,Byatt JC,Bremel RD

更新日期：1986-09-01 00:00:00

abstract：:Calcitonin (CT) and related peptides, such as CT gene-related peptide and salmon CT (sCT)-like peptide, are present in the rat nervous system and the pituitary gland, and sCT markedly inhibits basal and TRH-stimulated PRL release from anterior pituitary (AP) cells. Because TRH-induced PRL release is known to involve i...

journal_title：Endocrinology

authors： Shah GV,Kennedy D,Dockter ME,Crowley WR

更新日期：1990-08-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. In the present studi...

journal_title：Endocrinology

authors： Li M,Li J,Hoodless PA,Tzukazaki T,Wrana JL,Attisano L,Tsang BK

更新日期：1997-09-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:The estrogen receptor-alpha (ERalpha) pituitary-specific variant, TERP-1, is regulated dramatically by physiological status. We examined hormonal regulation of the TERP-1 promoter in transient transfection assays in GH3 somatolactotrope cells. We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenyla...

journal_title：Endocrinology

authors： Bryant WM,Gibson MA,Shupnik MA

更新日期：2006-01-01 00:00:00

abstract：:After incubation with 0.5 mM isobutylmethylxanthine, 1 microM dexamethasone, and 1 microM insulin for 72 h, 3T3-L1 cells acquire the phenotypic characteristics of mature adipocytes, including a hormone-sensitive particulate cAMP phosphodiesterase activity. In addition, adipocytes contain soluble cAMP and calmodulin-se...

journal_title：Endocrinology

authors： Elks ML,Manganiello VC,Vaughan M

更新日期：1984-10-01 00:00:00

abstract：:Kisspeptin is the product of the Kiss1 gene that regulates GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the preoptic area (POA) and arcuate nucleus (ARC), and expression is up-regulated in the caudal ARC during the periovulatory period. We hypothesized that kisspeptin neurons in the ARC are activ...

journal_title：Endocrinology

authors： Smith JT,Li Q,Pereira A,Clarke IJ

更新日期：2009-12-01 00:00:00

abstract：:The mechanisms whereby tissue sensitivity to PRL is controlled are not well understood. Here we report that expression of mRNA and protein for members of the SOCS/CIS/JAB family of cytokine signaling inhibitors is increased by PRL administration in ovary and adrenal gland of the lactating rat deprived of circulating P...

journal_title：Endocrinology

authors： Tam SP,Lau P,Djiane J,Hilton DJ,Waters MJ

更新日期：2001-11-01 00:00:00

abstract：:Concern that some chemicals in our environment may affect human health by disrupting normal endocrine function has prompted research on interactions of environmental contaminants with steroid hormone receptors. We compared the activity of 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), an estrogenic metabolite...

journal_title：Endocrinology

authors： Gaido KW,Leonard LS,Maness SC,Hall JM,McDonnell DP,Saville B,Safe S

更新日期：1999-12-01 00:00:00

abstract：:Apolipoprotein A-IV (apo A-IV) is a satiety factor involved in the control of food intake and body weight. Our previous studies demonstrated that apo A-IV is present in areas of the hypothalamus where leptin acts to influence energy homeostasis. In the present studies, we found that leptin-deficient obese (ob/ob) mice...

journal_title：Endocrinology

authors： Shen L,Tso P,Woods SC,Sakai RR,Davidson WS,Liu M

更新日期：2007-06-01 00:00:00

abstract：:Oxytocin receptor (OTR) expression in human myometrium increases over 150-fold from the beginning of pregnancy to the end. In the present studies, we examined potential mechanisms of OTR up-regulation, using myometrial cells in primary culture from women in late gestation. OTR ligand-binding sites and steady-state mRN...

journal_title：Endocrinology

authors： Jeng YJ,Soloff SL,Anderson GD,Soloff MS

更新日期：2003-01-01 00:00:00

abstract：:The rate-limiting event for combination of hCG alpha- and beta-subunits in JAR choriocarcinoma cells is the rate of disulfide bond formation in the beta-subunit. This is accompanied by a conformational change that produces a combination-competent form of the beta-subunit. The combination reaction, however, is incomple...

journal_title：Endocrinology

authors： Beebe JS,Huth JR,Ruddon RW

更新日期：1990-01-01 00:00:00

abstract：:Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...

journal_title：Endocrinology

authors： Oshima H,Simons SS Jr

更新日期：1992-04-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00