Deoxyribonucleic acid synthesis-dependent casein gene expression: species differences.

abstract：:Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat that a 22% reduction in bone mineral density generated by ovariectomy was associated with a 2-fold reduction of transforming growth factor-beta 3 (TGF beta 3) messenger RNA expression in th...

journal_title：Endocrinology

authors： Yang NN,Bryant HU,Hardikar S,Sato M,Galvin RJ,Glasebrook AL,Termine JD

更新日期：1996-05-01 00:00:00

abstract：:Previous studies from our laboratory have shown that messenger RNAs (mRNAs) coding for a cAMP-specific phosphodiesterase (PDE4A) are present in mature rat and mouse germ cells. However, no information is available about the properties of the expressed proteins. To determine their structure and regulation, the PDE4A is...

journal_title：Endocrinology

authors： Naro F,Zhang R,Conti M

更新日期：1996-06-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:Androgens are the primary regulators of epididymal structure and functions. Principal cells are the major cell type of the tissue and are particularly sensitive to androgen removal. To distinguish the direct effects of androgens on this cell type, DNA microarrays were used to identify androgen-regulated genes in the m...

journal_title：Endocrinology

authors： Seenundun S,Robaire B

更新日期：2007-01-01 00:00:00

abstract：:Exposure of FRTL-5 thyroid cells to ATP (1 microM to 1 mM) resulted in the stimulation of I- efflux in association with the induction of inositol trisphosphate production and intracellular Ca2+ mobilization. Nonhydrolyzable ATP derivatives, ADP and GTP, were also as effective in magnitude as ATP, whereas neither AMP n...

journal_title：Endocrinology

authors： Okajima F,Sho K,Kondo Y

更新日期：1988-08-01 00:00:00

abstract：:Previous studies indicate that magnesium, like calcium, stimulates the release of calcitonin (CT) from the thyroid gland. On the other hand, C-cell hyperplasia has been noted in magnesium-deficient dogs and rats. To explore further possible interrelationships between magnesium and CT, 21-day-old Sprague-Dawley male ra...

journal_title：Endocrinology

authors： Anast CS,Gardner DW

更新日期：1985-06-01 00:00:00

abstract：:We investigated the effect of TSH on calcium transport in mouse thyroid, as well as the influence of iodide thereupon. Thyroid lobes were incubated in Krebs-Ringer bicarbonate buffer containing [45Ca2+] and the time-dependent uptake of [45Ca2+] by the lobes was observed. In the presence of 0.5 mU/ml TSH, the uptake of...

journal_title：Endocrinology

authors： Hashizume K,Ichikawa K,Komiya I,Onaya T

更新日期：1984-05-01 00:00:00

abstract：:Apoptosis is the process of cellular self-destruction, and genes such as bcl-2 and bax are known to inhibit and promote apoptosis, respectively. In this study, we show that apoptosis can be induced in pancreatic beta-cell lines, and we investigate the apoptotic pathways through the bcl-2 and bax genes and intracellula...

journal_title：Endocrinology

authors： Mizuno N,Yoshitomi H,Ishida H,Kuromi H,Kawaki J,Seino Y,Seino S

更新日期：1998-03-01 00:00:00

abstract：:The effects of estradiol valerate and constant light exposure on the histological appearance of the arcuate nucleus were assessed in female rats. Both of these treatments caused significant increases in the numbers of reactive microglial cells and astrocytic granules in the nucleus. Ovariectomy before either treatment...

journal_title：Endocrinology

authors： Brawer JR,Schipper H,Naftolin F

更新日期：1980-07-01 00:00:00

abstract：:Basal hypothalamic deafferentation abolished the nycthemeral rhythm of both plasma TSH and corticosterone. ...

journal_title：Endocrinology

authors： Fukuda H,Greer MA

更新日期：1975-09-01 00:00:00

abstract：:GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor. Whereas GnRH inhibits the activity of the M-current in peripheral neurons, there is no direct evidence that the M-current is involved in the autoregulatory ...

journal_title：Endocrinology

authors： Xu C,Roepke TA,Zhang C,Rønnekleiv OK,Kelly MJ

更新日期：2008-05-01 00:00:00

abstract：:Split hand/foot malformation (SHFM) is syndromic ectrodactyly often associated with mental retardation and/or craniofacial defects. Several clinical reports previously described urogenital dysplasia such as micropenis, hypospadias, and small testis in SHFM patients. Genetic lesions in the Dlx5 and Dlx6 (Dlx5/6) locus ...

journal_title：Endocrinology

authors： Nishida H,Miyagawa S,Vieux-Rochas M,Morini M,Ogino Y,Suzuki K,Nakagata N,Choi HS,Levi G,Yamada G

更新日期：2008-05-01 00:00:00

abstract：:To address controversies of estrogen therapy, in vitro models of perimenopause and prevention vs. treatment modes of 17beta-estradiol (E(2)) exposure were developed and used to assess the neuroprotective efficacy of E(2) against beta-amyloid-1-42 (Abeta(1-42))-induced neurodegeneration in rat primary hippocampal neuro...

journal_title：Endocrinology

authors： Chen S,Nilsen J,Brinton RD

更新日期：2006-11-01 00:00:00

abstract：:To investigate the participation of cyclic nucleotides in LHRH-mediated gonadotropin release, cells from the anterior pituitaries of 15-day-old female rats were fractionated on an albumin gradient by sedimentation at unit gravity. gonadotrophs and somatotrophs were detected in the fractions by histology and RIA of hor...

journal_title：Endocrinology

authors： Snyder G,Naor Z,Fawcett CP,McCann SM

更新日期：1980-11-01 00:00:00

abstract：:Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the consumption of caffeine during pregnancy may increase the risk of pregnancy loss; however, little is known about the direct effect of caffeine on normal trophoblast ...

journal_title：Endocrinology

authors： Grant I,Cartwright JE,Lumicisi B,Wallace AE,Whitley GS

更新日期：2012-09-01 00:00:00

abstract：:Open pig thyroid follicles in which the apical surface of the follicle cells is in direct contact with the incubation medium were used to study the effect of stimulated exocytosis and stimulated H2O2 generation on the iodination of protein in the incubation medium. In previous studies on this system of follicles we ha...

journal_title：Endocrinology

authors： Björkman U,Ekholm R

更新日期：1988-02-01 00:00:00

abstract：:GH secretion is altered by exercise in humans. In an attempt to investigate the underlying mechanisms, we developed a rodent model. GH secretion was assayed in male and female rats that were sedentary (not exercised), acutely exercised, and chronically exercised. Sedentary males showed typical pulsatile GH secretion. ...

journal_title：Endocrinology

authors： Butkus JA,Brogan RS,Giustina A,Kastello G,Sothmann M,Wehrenberg WB

更新日期：1995-06-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:Despite understanding the molecular basis of activin/TGF beta and bone morphogenetic protein (BMP) signaling, this study is the first to characterize multiple, sequential elements of these pathways in the ovary concurrently. The expression of activin/BMP receptor, Smad, and beta glycan mRNAs by postnatal rat ovaries w...

journal_title：Endocrinology

authors： Drummond AE,Le MT,Ethier JF,Dyson M,Findlay JK

更新日期：2002-04-01 00:00:00

abstract：:The procession of round spermatids through stages VII and VIII of the rat spermatogenic cycle is critically dependent on testosterone (T). When intratesticular T levels are reduced, round spermatids appear to slough from the seminiferous epithelium, resulting in the disappearance of elongated spermatids. We hypothesiz...

journal_title：Endocrinology

authors： Perryman KJ,Stanton PG,Loveland KL,McLachlan RI,Robertson DM

更新日期：1996-09-01 00:00:00

abstract：:The rat prostate is dependent on androgen for normal growth and differentiation. In addition, the organ undergoes rapid cell death upon withdrawal of androgen on castration, and the atrophied tissue is capable of regrowth after androgen replacement in adult animals. In our search for novel factor(s) that participate i...

journal_title：Endocrinology

authors： Nishi N,Shoji H,Miyanaka H,Nakamura T

更新日期：2000-09-01 00:00:00

abstract：:To examine further the relationship between developmental changes in LH release and the onset of puberty, effects of posterior hypothalamic lesions were tested in ovariectomized (OVX), sexually immature female monkeys. In OVX females (n = 3) with sham hypothalamic lesions basal LH levels were suppressed during the pre...

journal_title：Endocrinology

authors： Schultz NJ,Terasawa E

更新日期：1988-07-01 00:00:00

abstract：:Extensive remodeling of the follicular extracellular matrix occurs during the process of ovulation. This remodeling involves the breakdown of collagen, which is regulated, in part, by the action of the metalloproteinase collagenase and its associated inhibitors. In the present study, follicular metalloproteinase inhib...

journal_title：Endocrinology

authors： Curry TE Jr,Mann JS,Estes RS,Jones PB

更新日期：1990-07-01 00:00:00

abstract：:Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in mammalian serum, but the source of the circulating enzyme is unknown. Pancreatic islets have been reported to contain and secrete GPI-PLD. In this report we examined the regulation of GPI-PLD secretion from beta TC3 cells, a mouse insulinom...

journal_title：Endocrinology

authors： Deeg MA,Verchere CB

更新日期：1997-02-01 00:00:00

abstract：:We previously have described molecular mechanisms converging at the Nur response element-signal transducer and activator of transcription (STAT) composite site responsible for synergistic activation of the proopiomelanocortin (POMC) gene promoter by leukemia inhibitory factor (LIF) and CRH. In this study, we asked how...

journal_title：Endocrinology

authors： Latchoumanin O,Mynard V,Devin-Leclerc J,Dugué MA,Bertagna X,Catelli MG

更新日期：2007-01-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:In this study, we investigated the transcriptional regulation of the adrenergic induction of type II iodothyronine deiodinase (Dio2) in rat pinealocytes. Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and...

journal_title：Endocrinology

authors： Chik CL,Wloka MT,Price DM,Ho AK

更新日期：2007-07-01 00:00:00

abstract：:In previous studies we have shown that aromatase cytochrome P450 (P450arom) mRNA and protein increase markedly in luteal tissue between days 10-19 of gestation, whereas cholesterol side-chain cleavage cytochrome P450 (P450scc) appears to be constitutively maintained regardless of hormonal changes occurring during preg...

journal_title：Endocrinology

authors： Hickey GJ,Oonk RB,Hall PF,Richards JS

更新日期：1989-09-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF alpha), a product of activated monocytes, induces tissue wasting in certain solid tumors in vivo and in in vitro model systems. Recent studies indicate that TNF alpha also regulates cell replication and expression of differentiated function in a variety of nonneoplastic cell systems. S...

journal_title：Endocrinology

authors： Centrella M,McCarthy TL,Canalis E

更新日期：1988-09-01 00:00:00

abstract：:For successful human placentation, invasion of trophoblast cells into the uterus and its associated vasculature is essential, and the regulation of this process is controlled by many factors at the fetal-maternal interface. N-acetylglucosaminyltransferase V (GnT-V) is a key enzyme that catalyzes beta1, 6-N-acetylgluco...

journal_title：Endocrinology

authors： Yamamoto E,Ino K,Miyoshi E,Inamori K,Abe A,Sumigama S,Iwase A,Kajiyama H,Shibata K,Nawa A,Kikkawa F

更新日期：2009-02-01 00:00:00