Abstract:
:We describe an in vitro system for evaluating the direct effects of catecholamines on the activity of the type II iodothyronine 5'-deiodinase in dispersed rat brown adipocytes. Incubation with norepinephrine or phenylephrine for 3-4 h causes up to a 5-fold increase in deiodinase activity in these cells. As found in vivo studies, the norepinephrine stimulation is blocked by coincubation with the alpha 1-adrenergic antagonist prazosin. The beta-adrenergic antagonist alprenolol either has no effect or increases stimulation by norepinephrine. These results suggest that beta-adrenergic agonists inhibit the activation or synthesis of the deiodinase in these cells.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Obregon MJ,Mills I,Silva JE,Larsen PRdoi
10.1210/endo-120-3-1069subject
Has Abstractpub_date
1987-03-01 00:00:00pages
1069-72issue
3eissn
0013-7227issn
1945-7170journal_volume
120pub_type
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