Processing of human growth hormone by rat hepatocytes in monolayer culture.

abstract：:Although the increased expression of Igf-I in liver in response to GH is well characterized, the intracellular signaling pathways that mediate this effect have not been identified. Intracellular signaling molecules belonging to the Janus kinase-signal transducer and activator of transcription 5b (JAK2-STAT5b) pathway ...

journal_title：Endocrinology

authors： Davey HW,Xie T,McLachlan MJ,Wilkins RJ,Waxman DJ,Grattan DR

更新日期：2001-09-01 00:00:00

abstract：:Testicular peritubular cells are myofibroblastic cells, which represent the major cellular components of the wall of the seminiferous tubules. In men their phenotypic characteristics, including possible secretory activity and regulation, are not well known, in neither normal nor pathologically altered testes. Especial...

journal_title：Endocrinology

authors： Schell C,Albrecht M,Mayer C,Schwarzer JU,Frungieri MB,Mayerhofer A

更新日期：2008-04-01 00:00:00

abstract：:We previously described a novel alternatively spliced mRNA transcript of the betacellulin (BTC) gene. This splice isoform, termed BTC-delta4, lacks the C-loop of the epidermal growth factor motif and the transmembrane domain as a result of exon 4 'skipping'. In this study, we expressed BTC-delta4 recombinantly to expl...

journal_title：Endocrinology

authors： Ogata T,Dunbar AJ,Yamamoto Y,Tanaka Y,Seno M,Kojima I

更新日期：2005-11-01 00:00:00

abstract：:The roles of steroids in zebrafish sex differentiation, gonadal development, and function of the adult gonad are poorly understood. Herein, we used ferredoxin 1b (fdx1b) mutant zebrafish to explore such processes. Fdx1b is an essential electron-providing cofactor to mitochondrial steroidogenic enzymes, which are cruci...

journal_title：Endocrinology

authors： Oakes JA,Li N,Wistow BRC,Griffin A,Barnard L,Storbeck KH,Cunliffe VT,Krone NP

更新日期：2019-10-01 00:00:00

abstract：:GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...

journal_title：Endocrinology

authors： Constantin S,Wray S

更新日期：2016-08-01 00:00:00

abstract：:Exposure to testosterone (T) during d 30-90 of fetal life results in low-birth-weight offspring, hypergonadotropism, multifollicular ovaries, and early cessation of cyclicity. The multifollicular phenotype may result from failure of follicles to regress and consequent follicular persistence or, alternatively, increase...

journal_title：Endocrinology

authors： Steckler T,Wang J,Bartol FF,Roy SK,Padmanabhan V

更新日期：2005-07-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:Aromatase-deficient (ArKO) mice are deficient in estrogens due to deletion of the aromatase gene. We hypothesized that there may be changes in the cardiovascular system of ArKO mice because of evidence linking estrogens with improved cardiovascular outcomes and the induction of the glucocorticoid-metabolizing enzyme, ...

journal_title：Endocrinology

authors： Head GA,Obeyesekere VR,Jones ME,Simpson ER,Krozowski ZS

更新日期：2004-09-01 00:00:00

abstract：:A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...

journal_title：Endocrinology

authors： Katz J,Finlay TH,Tom C,Levitz M

更新日期：1980-12-01 00:00:00

abstract：:Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), the predominant IGF carrier protein in circulation, is posttranslationally modified in vivo by IGFBP-3 protease(s) into a number of fragments. Based on the ascertained and predicted recognition sites for known IGFBP-3 proteases, FLAG-epitope tagged intact I...

journal_title：Endocrinology

authors： Devi GR,Yang DH,Rosenfeld RG,Oh Y

更新日期：2000-11-01 00:00:00

abstract：:We have previously demonstrated that CGP 42112 (AT(2) agonist > or =1 nM) markedly reduces catecholamine biosynthesis through AT(2), which is the major angiotensin II (AngII) receptor subtype in cultured porcine chromaffin cells. Also, we have shown that CGP 42112 (> or =1 nM) induces a reduction in cGMP production in...

journal_title：Endocrinology

authors： Takekoshi K,Ishii K,Kawakami Y,Isobe K,Nakai T

更新日期：2001-07-01 00:00:00

abstract：:Interleukin-1 alpha (IL-1 alpha) and IL-1 beta bind to either the p80 type I IL-1 receptor (IL-1RI) or the p68 type II IL-1R (IL-1RII) on both T and B lymphocytes. We and others have previously shown that the anterior pituitary gland also has specific high affinity binding sites for IL-1 alpha (Kd = approximately 1 nM...

journal_title：Endocrinology

authors： French RA,Zachary JF,Dantzer R,Frawley LS,Chizzonite R,Parnet P,Kelley KW

更新日期：1996-09-01 00:00:00

abstract：:Homeostatic control of endocrine systems proceeds via feedforward (agonistic, stimulatory) and feedback (antagonistic, inhibitory) interactions mediated via implicit dose-response functions. However, neither the feedback/feedforward pathways nor the dose-response interfaces are directly observed in vivo. Thus, the goa...

journal_title：Endocrinology

authors： Keenan DM,Clarke IJ,Veldhuis JD

更新日期：2011-12-01 00:00:00

abstract：:To understand the physiological role of ghrelin, it is crucial to study both the actions of ghrelin and the regulation of ghrelin secretion. Although ghrelin actions have been extensively revealed, the direct factors regulating ghrelin secretion by ghrelin-producing cells (X/A-like cells), however, is not fully unders...

journal_title：Endocrinology

authors： Iwakura H,Ariyasu H,Hosoda H,Yamada G,Hosoda K,Nakao K,Kangawa K,Akamizu T

更新日期：2011-07-01 00:00:00

abstract：:We recently identified a novel hypothalamic neuropeptide stimulating GH release in bullfrogs and termed it frog GH-releasing peptide (fGRP). The fGRP precursor encodes fGRP and its related peptides (fGRP-RP-1, -RP-2, and -RP-3), and fGRP-RP-2 also stimulates GH and prolactin (PRL) release. Cell bodies and terminals co...

journal_title：Endocrinology

authors： Chowdhury VS,Yamamoto K,Saeki I,Hasunuma I,Shimura T,Tsutsui K

更新日期：2008-03-01 00:00:00

abstract：:The presence of multiple monomeric forms has been described for estrogen receptor (ER) in different target tissues. Using [3H]tamoxifen aziridine ([3H]TA) to covalently label ER and sodium dodecyl sulfate-polyacrylamide gel electrophoresis to analyze labeled products, ER forms were investigated in pituitary cytosol an...

journal_title：Endocrinology

authors： Geffroy-Roisne S,Duval J,Thieulant ML

更新日期：1992-09-01 00:00:00

abstract：:Perturbing the endoplasmic reticulum homeostasis of thyroid cell lines with thapsigargin, a specific inhibitor of the sarcoendoplasmic reticulum Ca(2+) adenosine triphosphatases, and tunicamycin, an inhibitor of the N-linked glycosylation, blocked Tg in the endoplasmic reticulum. This event was signaled outside the en...

journal_title：Endocrinology

authors： Leonardi A,Vito P,Mauro C,Pacifico F,Ulianich L,Consiglio E,Formisano S,Di Jeso B

更新日期：2002-06-01 00:00:00

abstract：:The effect of an i.v. administration of different doses (250, 500, and 1000 pmol) of ovine CRF (oCRF) on plasma glucose and insulin levels in lean and genetically obese fa/fa rats was investigated. In both phenotypes, i.v. CRF promoted a rapid (peak at 1 min) transient doubling of basal insulin levels without a concom...

journal_title：Endocrinology

authors： Rohner-Jeanrenaud F,Jeanrenaud B

更新日期：1992-04-01 00:00:00

abstract：:Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone. The increase in blood LH produced by IVT NE or iv L...

journal_title：Endocrinology

authors： Steele MK,Ganong WF

更新日期：1986-12-01 00:00:00

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:Studies show that a subset of transgender men desire children; however, there is a paucity of literature on the effect of gender-affirming testosterone therapy on reproductive function. In this manuscript, we will review the process of gender-affirming hormone therapy for transgender men and what is known about ovaria...

journal_title：Endocrinology

authors： Moravek MB,Kinnear HM,George J,Batchelor J,Shikanov A,Padmanabhan V,Randolph JF

更新日期：2020-03-01 00:00:00

abstract：:Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...

journal_title：Endocrinology

authors： Roth JD,Coffey T,Jodka CM,Maier H,Athanacio JR,Mack CM,Weyer C,Parkes DG

更新日期：2007-12-01 00:00:00

abstract：:Properties of cyclic 3',5'-nucleotide phosphodiesterase in the 100,500 X g supernatant of the bovine thyroid were investigated. The enzyme activity was measured by a radioisotopic method using an anionic-exchange resin, and it was found that the activity was stimulated by Mg2+. Sephadex G-200 gel filtration separated ...

journal_title：Endocrinology

authors： Yagura T,Azuma Y,Akazawa Y,Nagata I,Uchino H

更新日期：1978-11-01 00:00:00

abstract：:GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...

journal_title：Endocrinology

authors： King JA,Mehl AE,Tyndale-Biscoe CH,Hinds L,Millar RP

更新日期：1989-11-01 00:00:00

abstract：:Multiple forms of PRL differing in their physicochemical and biological characteristics have been described. We have analyzed the molecular forms of human (h) PRL released in culture by pure hPRL-secreting tumors with a particular attention to glycosylated hPRL. The prolactinoma cells from six different tumors release...

journal_title：Endocrinology

authors： Pellegrini I,Gunz G,Ronin C,Fenouillet E,Peyrat JP,Delori P,Jaquet P

更新日期：1988-06-01 00:00:00

abstract：:An in vitro system which uses perifused pieces from the antrum of rat stomach has been used to study the effect of dihydrosomatostatin on gastrin release. The gastrin concentration in fractions of the perfusate was measured by radioimmunoassay. Dihydrosomatostatin (2 x 10-7M) had no effect on basal gastrin levels but ...

journal_title：Endocrinology

authors： Hayes JR,Johnson DG,Koerker D,Williams RH

更新日期：1975-06-01 00:00:00

abstract：:Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids) and some unique brain-specific steroids. Neurosteroids are thought to mediate their action through ion gated channel receptors such as gamma-aminobutyric acid(A) and N-methyl-D-aspartate rathe...

journal_title：Endocrinology

authors： Compagnone NA,Bulfone A,Rubenstein JL,Mellon SH

更新日期：1995-11-01 00:00:00

abstract：:The physicochemical and immunological properties of androgen receptors from kidney and brain of testicular-feminized (Tfm) mutant mice and wild-type mice were compared. Analysis by gel filtration and sucrose density gradients revealed that the mol wt of the mutant receptor was 66K (38A; 3.8S) which was significantly s...

journal_title：Endocrinology

authors： Young CY,Johnson MP,Prescott JL,Tindall DJ

更新日期：1989-02-01 00:00:00

abstract：:Two corticotropin-releasing factor 2 receptor (CRF2R)-selective peptides have been recently described, urocortin II (also known as stresscopin-related peptide) and urocortin III (stresscopin). We have used urocortin II to evaluate the effects of activation of the CRF2R on skeletal muscle-related physiological processe...

journal_title：Endocrinology

authors： Hinkle RT,Donnelly E,Cody DB,Bauer MB,Isfort RJ

更新日期：2003-11-01 00:00:00

abstract：:Stimulation of rat granulosa cell aromatase activity by FSH has recently been used as a sensitive biological end point to develop an in vitro FSH bioassay. The present report provides a detailed validation and application of this assay. In the presence of androstenedione and diethylstilbestrol, FSH stimulated estrogen...

journal_title：Endocrinology

authors： Jia XC,Hsueh AJ

更新日期：1986-10-01 00:00:00