Sexual differences in the distribution of neurons coexpressing galanin and luteinizing hormone-releasing hormone in the rat brain.

abstract：:Several neuropeptides with the C-terminal RFamide sequence have been identified in the hypothalamus of a variety of vertebrates. Among the RFamide peptide groups, however, only LPXRFamide peptides, including gonadotropin-inhibitory hormone, have been characterized in the avian brain. In the present study, we sought fo...

journal_title：Endocrinology

authors： Ukena K,Tachibana T,Iwakoshi-Ukena E,Saito Y,Minakata H,Kawaguchi R,Osugi T,Tobari Y,Leprince J,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:We have reported that calcitonin (CT) treatment induced downregulation of the CT receptor (CTR) in mouse osteoclast-like cells (OCLs). Here, we studied the features of homologous down-regulation of the CTR in mature mouse OCLs. Treatment with salmon CT (sCT) and human CT (hCT) reduced [125I]sCT specific binding. The d...

journal_title：Endocrinology

authors： Wada S,Udagawa N,Nagata N,Martin TJ,Findlay DM

更新日期：1996-01-01 00:00:00

abstract：:Pineal denervation by superior cervical ganglionectomy (Gx) decreased high affinity binding of estradiol (E2) to the pineal cytosol of female rats and of testosterone to the cytosol of male rats by 40 and 26% and by 75 and 80%, 5 and 14 days after sugery; hormone binding remained unchanged up to 24 h after surgery. Bi...

journal_title：Endocrinology

authors： Cardinali DP,Gómez E,Rosner JM

更新日期：1976-04-01 00:00:00

abstract：:Several lines of indirect evidence suggest that a monocyte family precursor gives rise to the osteoclast, although this hypothesis is controversial. Starting with a uniform population of nonspecific esterase positive, tartrate-sensitive, acid phosphatase-producing, mannose receptor-bearing mononuclear cells, prepared ...

journal_title：Endocrinology

authors： Alvarez JI,Teitelbaum SL,Blair HC,Greenfield EM,Athanasou NA,Ross FP

更新日期：1991-05-01 00:00:00

abstract：:Previously, we demonstrated that excision of the GnRH first intron (intron A) was largely attenuated in non-GnRH-producing tissues but accelerated in GnRH neurons. In the present study, we examined the splicing rate of GnRH pre-mRNA in developing normal mice and adult hypogonadal mice. The preoptic area and cerebral c...

journal_title：Endocrinology

authors： Seong JY,Kim BW,Park S,Son GH,Kim K

更新日期：2001-10-01 00:00:00

abstract：:GH has physiological functions in many tissues, but the cellular targets for direct effects of GH remain ill defined in complex tissues such as the growth plate in which the contribution of direct vs. indirect actions of GH remains controversial. The Janus kinase (Jak)-signal transducer and activator of transcription ...

journal_title：Endocrinology

authors： Gevers EF,Hannah MJ,Waters MJ,Robinson IC

更新日期：2009-08-01 00:00:00

abstract：:Under acute stress conditions in the rat, there is rapid and transient increase in circulating prolactin (PRL). This leads to an elevated expression of the long form of PRLR (PRLR-L) first in the hypothalamus and the choroid plexus. This increase in PRL is involved in the inhibition of stress-induced hypocalcemia and ...

journal_title：Endocrinology

authors： Fujikawa T,Tamura K,Kawase T,Mori Y,Sakai RR,Sakuma K,Yamaguch A,Ogata M,Soya H,Nakashima K

更新日期：2005-08-01 00:00:00

abstract：:Progesterone, which is normally produced in the endoplasmic reticulum, was found to be rapidly degraded in the cytosolic fraction of the guinea pig adrenal cortex in vitro. Assuming this finding reflects what happens in vivo raises a question as to the source of progesterone for interacting with a nuclear progesterone...

journal_title：Endocrinology

authors： Demura T,Driscoll WJ,Strott CA

更新日期：1990-09-01 00:00:00

abstract：:In the present study we used characterized perifusion model for the development of homologous desensitization to GnRH in the pituitary gonadotrope. This system relies on immobilized primary pituitary cultures that are perifused with various pulse patterns and concentrations of GnRH; these patterns and concentrations a...

journal_title：Endocrinology

authors： Janovick JA,Conn PM

更新日期：1996-05-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00

abstract：:Aberrant expression of ectopic G protein-coupled receptors (GPCRs) in adrenal cortex tissue has been observed in several cases of ACTH-independent macronodular adrenal hyperplasias and adenomas associated with Cushing's syndrome. Although there is clear clinical evidence for the implication of these ectopic receptors ...

journal_title：Endocrinology

authors： Mazzuco TL,Chabre O,Sturm N,Feige JJ,Thomas M

更新日期：2006-02-01 00:00:00

abstract：:Glutamate (Glu) is the most prevalent excitatory neurotransmitter in the brain and has been implicated in the regulation of GnRH secretion in several mammalian species, including the monkey. To investigate the neuroanatomical basis for Glu-GnRH interactions, we performed an immunocytochemical study at both the light a...

journal_title：Endocrinology

authors： Goldsmith PC,Thind KK,Perera AD,Plant TM

更新日期：1994-02-01 00:00:00

abstract：:Beta-adrenergic agonists and antagonists are widely used in many clinical situations to regulate beta-adrenergic stimulation. However, responsiveness to beta-stimulation may be reduced by the process of desensitization. We have established an in vivo mammalian model system, the rat lung, to study the cellular and bioc...

journal_title：Endocrinology

authors： Strasser RH,Stiles GL,Lefkowitz RJ

更新日期：1984-10-01 00:00:00

abstract：:Up-regulation of maternal islet function is essential to accommodate the increased demand for insulin during pregnancy. Previously, we suggested that lactogenic activity regulates islet function during pregnancy. However, this hypothesis was based on the effect of homologous PRLs on islets, since the homologous placen...

journal_title：Endocrinology

authors： Brelje TC,Scharp DW,Lacy PE,Ogren L,Talamantes F,Robertson M,Friesen HG,Sorenson RL

更新日期：1993-02-01 00:00:00

abstract：:Insulin-like growth factor (IGF) I, a polypeptide synthesized by skeletal cells, and its amino terminus truncated derivative desamino-(1-3)-IGF I (des-IGF I) were compared for their effects on bone formation in vitro. Des-IGF I and IGF I were studied for their effects on DNA and collagen synthesis in cultures of intac...

journal_title：Endocrinology

authors： Canalis E,McCarthy TL,Centrella M

更新日期：1991-07-01 00:00:00

abstract：:We previously demonstrated that the mitochondrial peripheral-type benzodiazepine receptor (PBR) is coupled to hormone-activated steroidogenesis by regulating the intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. In the present study we examined whether PBR is the site of horm...

journal_title：Endocrinology

authors： Boujrad N,Gaillard JL,Garnier M,Papadopoulos V

更新日期：1994-10-01 00:00:00

abstract：:Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a posttranscriptional regulator of genes that are essential for spermatid elongation and completion of spermatogenesis. It also prevents Leydig cells (LCs) from gonadotropin overstimulation of androgen production. In transgenic (Tg) mice carrying deletions...

journal_title：Endocrinology

authors： Kavarthapu R,Tsai-Morris CH,Fukushima M,Pickel J,Dufau ML

更新日期：2013-06-01 00:00:00

abstract：:Enhanced epinephrine secretion from adrenal chromaffin cells (ACCs) is an important homeostatic response to severe systemic inflammation during sepsis. Evidence suggests that increased activation of ACCs by preganglionic sympathetic neurons and direct alterations in ACC function contribute to this response. However, t...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2014-01-01 00:00:00

abstract：:The monocarboxylate transporter Mct10 (Slc16a10; T-type amino acid transporter) facilitates the cellular transport of thyroid hormone (TH) and shows an overlapping expression with the well-established TH transporter Mct8. Because Mct8 deficiency is associated with distinct tissue-specific alterations in TH transport a...

journal_title：Endocrinology

authors： Müller J,Mayerl S,Visser TJ,Darras VM,Boelen A,Frappart L,Mariotta L,Verrey F,Heuer H

更新日期：2014-01-01 00:00:00

abstract：:Experiments were conducted to obtain information on the possible transfer of TSH and thyroid hormones from mother rats to their infants via milk. The mothers were thyroidectomized by surgical or chemical (tapazole) means to eliminate maternal thyroid hormones from milk while increasing its content of TSH. Their pups w...

journal_title：Endocrinology

authors： Glasscock GF,Nicoll CS

更新日期：1983-03-01 00:00:00

abstract：:Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...

journal_title：Endocrinology

authors： Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

更新日期：2001-01-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:31P nuclear magnetic resonance (NMR) was used to study the effects of 17 beta-estradiol on the content of phosphates and on the flux catalyzed by creatine kinase in immature rat uteri. Perifusion with oxygenated medium at 36 C maintained the uteri in a viable state for at least 10 h in vitro during 31P NMR measurement...

journal_title：Endocrinology

authors： Degani H,Victor TA,Kaye AM

更新日期：1988-04-01 00:00:00

abstract：:The effects of increasing concentrations of leucine (0.2, 2.0, and 15.0 mmol/liter) on glucagon secretion from the perfused rat pancreas were examined at various glucose levels (0, 3.3, or 8.3 mmol/liter) and in the absence or presence of either arginine (5.0 mmol/liter) or glutamine (10.0 mmol/liter). At a low glucos...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Woussen-Colle MC,Giroix MH,Malaisse WJ

更新日期：1985-03-01 00:00:00

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:Although GH plays a key role in postnatal growth, prenatal growth is thought to be GH independent. However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetal tissues as early as fetal stage E12. The aim of the present study was to investigate tissue-specific production of the GHR/BP...

journal_title：Endocrinology

authors： Edmondson SR,Werther GA,Russell A,LeRoith D,Roberts CT Jr,Beck F

更新日期：1995-10-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or genetic disruption of sympathetic outflow to bone induces bone gain in rodents. These recent findings implied that ...

journal_title：Endocrinology

authors： Ma Y,Nyman JS,Tao H,Moss HH,Yang X,Elefteriou F

更新日期：2011-04-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00