A 5'-flanking region of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene directs its cell-specific androgen-regulated gene expression in testicular germ cells.

abstract：:GnRH is expressed in first-trimester human placenta and increases cell invasion in extravillous cytotrophoblasts (EVTs). Invasive phenotypes have been reported to be regulated by transcription factor activator protein 1 (AP-1) and mesenchymal cadherin-11. The aim of our study was to investigate the roles of AP-1 compo...

journal_title：Endocrinology

authors： Peng B,Zhu H,Ma L,Wang YL,Klausen C,Leung PC

更新日期：2015-06-01 00:00:00

abstract：:Frequent blood sampling via intraatrial cannula revealed daily rhythms of TSH and thyroid hormones in both male and female Wistar rats. Thermic ablation of the biological clock, i.e. the suprachiasmatic nucleus (SCN), eliminated the diurnal peak in circulating TSH and thyroid hormones. In addition, SCN lesions produce...

journal_title：Endocrinology

authors： Kalsbeek A,Fliers E,Franke AN,Wortel J,Buijs RM

更新日期：2000-10-01 00:00:00

abstract：:Prolactin (PRL) shares several characteristics with growth factors and cytokines, many of which are known to bind to heparan sulfate proteoglycans. In this study we examined the heparin-binding properties of selected members of the PRL/GH family, using heparin affinity columns followed by gel electrophoresis/Western b...

journal_title：Endocrinology

authors： Khurana S,Kuns R,Ben-Jonathan N

更新日期：1999-02-01 00:00:00

abstract：:We have designed a new experimental system based on in vitro reconstituted thyroid follicles (RTF) to study the relative implication of macropinocytosis and micropinocytosis processes in the internalization of thyroglobulin (Tg). Thyrocytes cultured in the presence of TSH reorganize in histiotypic and functional folli...

journal_title：Endocrinology

authors： Bernier-Valentin F,Kostrouch Z,Rabilloud R,Rousset B

更新日期：1991-10-01 00:00:00

abstract：:Pituitary homeobox 1 (Ptx1) is a homeodomain-containing transcription factor acting on transcription of all pituitary hormone genes. Its expression is first detected in the stomodeal ectoderm and is maintained in all derivatives of this structure, including Rathke's pouch. We now show that Ptx1 is expressed in all pit...

journal_title：Endocrinology

authors： Lanctôt C,Gauthier Y,Drouin J

更新日期：1999-03-01 00:00:00

abstract：:Adipokines, cytokines mainly produced by adipocytes, are active participants in the regulation of inflammation. Administration of zymosan (ZY) was used to investigate the regulation and role of adipokines during peritonitis in mice. Injection of ZY led to a significant increase in leptin levels in both serum and perit...

journal_title：Endocrinology

authors： Pini M,Gove ME,Sennello JA,van Baal JW,Chan L,Fantuzzi G

更新日期：2008-08-01 00:00:00

abstract：:GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...

journal_title：Endocrinology

authors： Constantin S,Wray S

更新日期：2016-08-01 00:00:00

abstract：:Immunological and binding methods have been used to demonstrate that acute inflammation induced in the pregnant mouse by a single sc turpentine injection elicits plasma protein responses in the fetal as well as in the maternal compartment. The maternal response involves, along with the classical pattern of positive an...

journal_title：Endocrinology

authors： Vranckx R,Savu L,Maya M,Nunez EA

更新日期：1987-05-01 00:00:00

abstract：:The effects of increasing concentrations of leucine (0.2, 2.0, and 15.0 mmol/liter) on glucagon secretion from the perfused rat pancreas were examined at various glucose levels (0, 3.3, or 8.3 mmol/liter) and in the absence or presence of either arginine (5.0 mmol/liter) or glutamine (10.0 mmol/liter). At a low glucos...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Woussen-Colle MC,Giroix MH,Malaisse WJ

更新日期：1985-03-01 00:00:00

abstract：:Puberty is a developmental period characterized by a broad range of physiologic changes necessary for the acquisition of adult sexual and reproductive maturity. These changes mirror complex modifications within the central nervous system, including within the hypothalamus. These modifications result in the maturation ...

journal_title：Endocrinology

authors： Naulé L,Maione L,Kaiser UB

更新日期：2021-01-01 00:00:00

abstract：:Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...

journal_title：Endocrinology

authors： Hampel U,Klonisch T,Sel S,Schulze U,Garreis F,Seitmann H,Zouboulis CC,Paulsen FP

更新日期：2013-06-01 00:00:00

abstract：:The effects of epidermal growth factor (EGF) on glycogen metabolism and the binding of [125I]iodo-EGF to receptors in fetal rat hepatocytes have been examined. The actions of EGF have been compared with those of insulin-like growth factor I (IGF-I) and insulin. EGF (0.1-45 nM) stimulated dose-dependent increases in [1...

journal_title：Endocrinology

authors： Freemark M

更新日期：1986-08-01 00:00:00

abstract：:We have previously shown that in reaggregate cell cultures of 14-day-old female rat pituitary, LHRH is capable of stimulating lactotrophs to enter the S-phase of the cell cycle, and that this effect is mediated by paracrine growth factors secreted from gonadotrophs. In the present report we describe the isolation, pur...

journal_title：Endocrinology

authors： Tilemans D,Andries M,Proost P,Devreese B,Van Beeumen J,Denef C

更新日期：1994-07-01 00:00:00

abstract：:In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progesterone and pregnenolone in MA-10 cells over a period of 3 h. Steroids were then extracted, separated by...

journal_title：Endocrinology

authors： Rommerts FF,King SR,Span PN

更新日期：2001-12-01 00:00:00

abstract：:The metabolism of [3H]progesterone by the fetal calf adrenal was examined in homogenates and microsomal fractions of adrenals obtained from mid- or late gestational fetal calves. Throughout the course of gestation, there was no detectable difference in the formation of corticosterone from progesterone by adrenal homog...

journal_title：Endocrinology

authors： Kan KW,Baird A,Solomon S

更新日期：1983-09-01 00:00:00

abstract：:T(4) must be activated by its monodeiodination to T(3) by type 1 or 2 iodothyronine deiodinase (D1 and D2). Recent studies show that despite an approximately 2000-fold higher Michaelis constant (K(m); T(4)) for D1 than for D2 using dithiothreitol (DTT) as cofactor, D1 expressed in intact cells produces T(3) at free T(...

journal_title：Endocrinology

authors： Goemann IM,Gereben B,Harney JW,Zhu B,Maia AL,Larsen PR

更新日期：2010-02-01 00:00:00

abstract：:Osteocalcin (OC) is one of the abundant non-collagenous bone matrix proteins produced exclusively by osteoblasts, and its serum level is used as an indicator of bone metabolism in patients. Transforming growth factor-beta (TGF beta) is abundant in bones and platelets, promotes wound healing in vivo, and is a potent st...

journal_title：Endocrinology

authors： Noda M

更新日期：1989-02-01 00:00:00

abstract：:In the present study the effects of stimulus deprivation on vasoactive intestinal peptide (VIP)- and alpha 1-adrenergically mediated amplification of VIP-stimulated cAMP and cGMP accumulation were examined. Dispersed pinealocytes were prepared from either Sprague-Dawley rats maintained for 2 weeks in a normal lighting...

journal_title：Endocrinology

authors： Chik CL,Ho AK

更新日期：1991-02-01 00:00:00

abstract：:Leptin enhances the glucose utilization in most insulin target tissues and paradoxically decreases it in white adipose tissue (WAT), but knowledge of the mechanisms underlying the inhibitory effect of central leptin on the insulin-dependent glucose uptake in WAT is limited. After 7 d intracerebroventricular leptin tre...

journal_title：Endocrinology

authors： Bonzón-Kulichenko E,Fernández-Agulló T,Moltó E,Serrano R,Fernández A,Ros M,Carrascosa JM,Arribas C,Martínez C,Andrés A,Gallardo N

更新日期：2011-04-01 00:00:00

abstract：:The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain express...

journal_title：Endocrinology

authors： Couse JF,Yates MM,Rodriguez KF,Johnson JA,Poirier D,Korach KS

更新日期：2006-08-01 00:00:00

abstract：:Bovine granulosa cells seeded in the presence of serum on extracellular matrix-coated dishes proliferate actively when exposed to serum-free medium supplemented with insulin (2 microgram/ml), fibroblast growth factor (FGF, 100 ng/ml), and high density lipoprotein (HDL, 30 microgram protein/ml). The final density of th...

journal_title：Endocrinology

authors： Savion N,Lui GM,Laherty R,Gospodarowicz D

更新日期：1981-08-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...

journal_title：Endocrinology

authors： Dover AR,Hadoke PW,Macdonald LJ,Miller E,Newby DE,Walker BR

更新日期：2007-01-01 00:00:00

abstract：:The study of epigenetics allows for the understanding of gene × environmental interactions and provides a mechanism by which brief internal or external environmental changes can shape lasting differences in gene function and behavior. Epigenetic processes appear to impact a wide variety of physiological processes with...

journal_title：Endocrinology

authors： Auger AP,Auger CJ

更新日期：2011-02-01 00:00:00

abstract：:Adrenomedullin (ADM) is a potent vasorelaxant peptide that plays important roles in cardiovascular homeostasis and inflammatory response. ADM derived from macrophages is one of the major sources of ADM that is produced in the inflammatory process. To assess the functions of ADM in inflammation, we studied the temporal...

journal_title：Endocrinology

authors： Wong LY,Cheung BM,Li YY,Tang F

更新日期：2005-03-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00

abstract：:Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...

journal_title：Endocrinology

authors： Martinez-Arguelles DB,Papadopoulos V

更新日期：2015-01-01 00:00:00

abstract：:We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene expression. CYP2C11 is an enzyme expressed in the liver of male rats and is regulated by a pulsatile pattern of GH secretion. We have previously shown that MC atte...

journal_title：Endocrinology

authors： Timsit YE,Riddick DS

更新日期：2002-09-01 00:00:00

abstract：:Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central aspect in the development of pathological conditions. Testosterone can act through the classic androgen receptor (AR) in the cytoplasm, eliciting genomic signaling,...

journal_title：Endocrinology

authors： Peinetti N,Scalerandi MV,Cuello Rubio MM,Leimgruber C,Nicola JP,Torres AI,Quintar AA,Maldonado CA

更新日期：2018-02-01 00:00:00

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:Posttranslational processing of proadrenomedullin generates two biologically active peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Sequence comparison of homologous proadrenomedullin genes in vertebrate evolution shows a high degree of stability in the reading frame for AM, whereas P...

journal_title：Endocrinology

authors： Martínez A,Bengoechea JA,Cuttitta F

更新日期：2006-07-01 00:00:00