Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.

abstract：:Insulin receptor substrate-1 (IRS-1) has an important role as an early intermediary between the insulin and IGF receptors and downstream molecules that participate in insulin and IGF-I signal transduction. Here we employed an antisense oligonucleotide (IRS-1AS) to inhibit whole-body expression of IRS-1 in vivo and eva...

journal_title：Endocrinology

authors： Araújo EP,De Souza CT,Gasparetti AL,Ueno M,Boschero AC,Saad MJ,Velloso LA

更新日期：2005-03-01 00:00:00

abstract：:The multifunctional cytokine, transforming growth factor-beta (TGF beta), is found in many tissues in a latent or inactive form. The nature and composition of the latent complex can vary depending on tissue type. The release of active TGF beta from its latent complex is a potentially important mechanism for regulation...

journal_title：Endocrinology

authors： Bonewald LF,Oreffo RO,Lee CH,Park-Snyder S,Twardzik D,Mundy GR

更新日期：1997-02-01 00:00:00

abstract：:The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragments in the regulatio...

journal_title：Endocrinology

authors： Mazerbourg S,Zapf J,Bar RS,Brigstock DR,Lalou C,Binoux M,Monget P

更新日期：1999-09-01 00:00:00

abstract：:The pancreatic polypeptide cell, the only mature endocrine cell in the fetal pig pancreas, produces equimolar amounts of two peptides, pancreatic polypeptide and pancreatic icosapeptide, from the same precursor. The amino acid sequence of pancreatic polypeptide is more homogeneous among species, whereas pancreatic ico...

journal_title：Endocrinology

authors： Amaratunga A,Tuch BE,Han XG,Georges P,Dean SK,Scott H

更新日期：2001-10-01 00:00:00

abstract：:The effects of FFA on circulating LH and GH concentrations in ovariectomized ewe lambs were investigated. Lambs (n = 14) were weaned at 2.5 months, ovariectomized at 6.5 months, and used at 8.5 months of age. From weaning until day 0 of the experiment, lambs were fed to maintain body weights (23 kg). On day 0, serum F...

journal_title：Endocrinology

authors： Estienne MJ,Schillo KK,Hileman SM,Green MA,Hayes SH,Boling JA

更新日期：1990-04-01 00:00:00

abstract：:The Leydig cells of the testis are known to possess high affinity receptors for luteinizing hormone and human chorionic gonadotropin (hCG), but no information concerning the synthesis of these receptors is available yet. In order to investigate this question, we have purified crude rat interstitial cell preparations o...

journal_title：Endocrinology

authors： Aubry M,Collu R,Ducharme JR,Crine P

更新日期：1982-12-01 00:00:00

abstract：:A1/A2 noradrenergic neurons in the medulla oblongata are well known to mediate stress signals in the central nervous system. Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH. On the other hand, PRL-releasing peptide (PrRP) was recently isolate...

journal_title：Endocrinology

authors： Maruyama M,Matsumoto H,Fujiwara K,Noguchi J,Kitada C,Fujino M,Inoue K

更新日期：2001-05-01 00:00:00

abstract：:The Kiss1 gene and its product kisspeptin are important regulators of reproduction. In rodents, Kiss1 is expressed in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV)/rostral periventricular (PeN) nuclei. In the AVPV/PeN, females have more Kiss1 and tyrosine hydroxylase (TH) neurons than males. ...

journal_title：Endocrinology

authors： Semaan SJ,Murray EK,Poling MC,Dhamija S,Forger NG,Kauffman AS

更新日期：2010-12-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:Progesterone (P(4)) signaling is critical for pregnancy. We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its deficiency leads to P(4) resistance in a pregnancy stage-specific and genetic background-dependent...

journal_title：Endocrinology

authors： Hirota Y,Burnum KE,Acar N,Rabinovich GA,Daikoku T,Dey SK

更新日期：2012-05-01 00:00:00

abstract：:The effect of constant infusions of bovine TSH in different concentrations on the pattern of T4 and T3 secretion was examined in perfused canine thyroids isolated in situ. Each of the thyroid lobes was isolated and perfused in each animal. It was thus possible to examine the effect of two different concentrations of T...

journal_title：Endocrinology

authors： Laurberg P

更新日期：1977-03-01 00:00:00

abstract：:The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...

journal_title：Endocrinology

authors： Daza DO,Sundström G,Bergqvist CA,Duan C,Larhammar D

更新日期：2011-06-01 00:00:00

abstract：:Previously, a human CYP3A4-transgenic (Tg-CYP3A4) mouse line was reported to exhibit enhanced metabolism of midazolam by cytochrome P450 3A4 (CYP3A4) expressed in small intestine. Here we show that expression of CYP3A4 and murine cyp3a and cyp2b was both age and sex dependent. CYP3A4 was expressed in the livers of mal...

journal_title：Endocrinology

authors： Yu AM,Fukamachi K,Krausz KW,Cheung C,Gonzalez FJ

更新日期：2005-07-01 00:00:00

abstract：:The effects of pentobarbital (Pnt) treatment on the progesterone (P)-induced afternoon increase in the medial basal hypothalamic (MBH) LHRH and serum LH and FSH levels in ovariectomized estradiol benzoate-primed rats were studied. Pnt injection before P blocked the afternoon rise in serum gonadotropins but failed to a...

journal_title：Endocrinology

authors： Kalra SP,Simpkins JW,Kalra PS

更新日期：1981-04-01 00:00:00

abstract：:Reports of estrone (E1) and dehydroepiandrosterone (DHEA) sulfatase (sulfohydrolase) activities within many human breast cancers have prompted us to undertake the identification and partial characterization of these enzyme activities within MCF-7 human breast cancer cells. Enzyme assays were performed within subcellul...

journal_title：Endocrinology

authors： MacIndoe JH

更新日期：1988-09-01 00:00:00

abstract：:Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR). EMD 21388 also inhibits the binding of T4 to human, dog, and rat serum TTR in vitro and w...

journal_title：Endocrinology

authors： Lueprasitsakul W,Alex S,Fang SL,Pino S,Irmscher K,Köhrle J,Braverman LE

更新日期：1990-06-01 00:00:00

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...

journal_title：Endocrinology

authors： Furman A,Rotmensch S,Kohen F,Mashiach S,Amsterdam A

更新日期：1986-05-01 00:00:00

abstract：:Dopaminergic inhibition of PRL release stimulated by agents that affect cytosolic Ca2+ concentrations, C-kinase activity, and cAMP levels was studied in perifused rat anterior pituitary cells cultured on cytodex beads. We used A23187 (20 microM) to increase intracellular Ca2+, the phorbol ester 12-O-tetradecanoyl-phor...

journal_title：Endocrinology

authors： Delbeke D,Dannies PS

更新日期：1985-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) is a neuropeptide related to vasoactive intestinal peptide-secretin-glucagon which stimulates adenylate cyclase in cultured rat pituitary cells and stimulates LH and FSH release in vitro and in vivo. Because the cAMP-protein kinase-A pathway regulates the...

journal_title：Endocrinology

authors： Tsujii T,Ishizaka K,Winters SJ

更新日期：1994-09-01 00:00:00

abstract：:The brain has traditionally been considered to be a target site of peripheral steroid hormones. By contrast, new findings over the past decade have shown that the brain itself also has the capability of forming steroids de novo, the so-called neurosteroids. De novo neurosteroidogenesis in the brain from cholesterol is...

journal_title：Endocrinology

authors： Tsutsui K

更新日期：2008-06-01 00:00:00

abstract：:This study was designed to investigate the role of dopaminergic mechanisms in the control of aldosterone secretion. Six rhesus monkeys received metoclopramide (1.25 mg, iv), with 5% dextrose (vehicle) or with dopamine (4 micrograms/kg . min) infusions begun 60 min before the administration of the dopamine antagonists....

journal_title：Endocrinology

authors： Sowers JR,Berg G,Martin VS,Mayes DM

更新日期：1982-04-01 00:00:00

abstract：:Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases the risk of endometrial cancer. However, the molecular mechanisms of TAM-induced endometrial carcinoma still remain unclear. In this report, w...

journal_title：Endocrinology

authors： Bai JX,Yan B,Zhao ZN,Xiao X,Qin WW,Zhang R,Jia LT,Meng YL,Jin BQ,Fan DM,Wang T,Yang AG

更新日期：2013-02-01 00:00:00

abstract：:The pharmacokinetics of TRH and its metabolite deamido-TRH (TRH-OH) were evaluated and compared. After a 60- to 90-min infusion of the appropriate peptide into rats, the MCR, half-life of disappearance (t 1/2), and volume of distribution were calculated. The MCR of TRH averaged 4 ml/min, whereas that of TRH-OH was 6.5...

journal_title：Endocrinology

authors： Safran M,Wu CF,Matys R,Alex S,Emerson CH

更新日期：1984-09-01 00:00:00

abstract：:Specific triiodothyronine receptor activity has been detected in rat lung nuclei isolated by Triton X-100, which was sensitive to pH and exhibited temperature-dependent association kinetics. This activity represented a single order of high affinity binding sites, with an apparent dissociation constant for 3,3',5-triio...

journal_title：Endocrinology

authors： Morishige WK,Guernsey DL

更新日期：1978-05-01 00:00:00

abstract：:We investigated the effects of thyroid status on nitric oxide synthase (NOS) gene expression in the rat hypothalamic paraventricular (PVN) and supraoptic nuclei (SON). Propylthiouracil (PTU)-induced hypothyroidism in male rats produced a highly significant reduction in NOS gene transcripts in the PVN and SON, as asses...

journal_title：Endocrinology

authors： Ueta Y,Levy A,Chowdrey HS,Lightman SL

更新日期：1995-10-01 00:00:00

abstract：:Vitamin D deficiency is associated with a range of muscle disorders, including myalgia, muscle weakness, and falls. In humans, polymorphisms of the vitamin D receptor (VDR) gene are associated with variations in muscle strength, and in mice, genetic ablation of VDR results in muscle fiber atrophy and motor deficits. H...

journal_title：Endocrinology

authors： Girgis CM,Mokbel N,Cha KM,Houweling PJ,Abboud M,Fraser DR,Mason RS,Clifton-Bligh RJ,Gunton JE

更新日期：2014-09-01 00:00:00

abstract：:The effects of recombinant human insulin-like growth factor I (IGF-I) on both vasoactive intestinal peptide (VIP) and PRL production and gene expression were studied using rat anterior pituitary cell cultures grown in serum-free defined medium. We also examined whether pituitary VIP could be involved in the PRL respon...

journal_title：Endocrinology

authors： Lara JI,Lorenzo MJ,Cacicedo L,Tolón RM,Balsa JA,López-Fernández J,Sánchez-Franco F

更新日期：1994-12-01 00:00:00

abstract：:Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered i.p. or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hyp...

journal_title：Endocrinology

authors： Fu Y,Matta SG,Valentine JD,Sharp BM

更新日期：1997-05-01 00:00:00