Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures.

abstract：:The initial steps involved in mediating the transduction of PTH signal via its G protein-coupled receptors are well understood and occur through the activation of cAMP and phospholipase C pathways. However, the cellular and molecular mechanisms for subsequent receptor desensitization are less well understood. Recently...

journal_title：Endocrinology

authors： Miles RR,Sluka JP,Santerre RF,Hale LV,Bloem L,Boguslawski G,Thirunavukkarasu K,Hock JM,Onyia JE

更新日期：2000-01-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:We have recently demonstrated that 17beta-estradiol (E2) opposes cytokine-dependent increase of inducible nitric oxide synthase (iNOS) activity in rat smooth muscle cells and proposed that this effect might be associated to an antiinflammatory activity of this hormone. In the present study, we examine the E2 effects o...

journal_title：Endocrinology

authors： Cuzzocrea S,Santagati S,Sautebin L,Mazzon E,Calabrò G,Serraino I,Caputi AP,Maggi A

更新日期：2000-04-01 00:00:00

abstract：:Four different GnRHs and one GnRH receptor are reported to be expressed in various mammals, whereas 13 GnRHs and numerous GnRH receptors have been identified in various nonmammalian vertebrates. The nucleotide sequencing of the human genome provided the opportunity to determine which of these peptides and receptors mi...

journal_title：Endocrinology

authors： Neill JD

更新日期：2002-03-01 00:00:00

abstract：:Kallikreins are a multigene subfamily of serine proteases that may have a role in processing precursors of polypeptide hormones and growth factors. The epidermal growth factor (EGF) immunoreactivity in mouse milk is derived from the membrane-bound EGF precursor located on the lumenal border of the alveolar cells in th...

journal_title：Endocrinology

authors： Jahnke GD,Chao J,Walker MP,Diaugustine RP

更新日期：1994-11-01 00:00:00

abstract：:Wortmannin (5-100 nM), a specific phosphatidyinositol 3-kinase inhibitor, augmented 8 mM glucose-induced insulin secretion from control Sprague Dawley rat islets in a dose-dependent manner. This effect persisted after its removal from the perifusion medium; however, this augmenting effect was reduced by the calcium ch...

journal_title：Endocrinology

authors： Zawalich WS,Zawalich KC

更新日期：2000-09-01 00:00:00

abstract：:Starvation depresses thyroid gland function. In addition, the peripheral turnover of thyroxine (T4) is reduced, in part due to decreased fecal elimination of T4. The present studies were performed to determine if starvation also affects the deiodinative pathway for T4 degradation. Rats were isotopically equilibrated w...

journal_title：Endocrinology

authors： Ingbar DH,Galton VA

更新日期：1975-06-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) fed at 0.4% in the diet is known to exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. Three of the major metabolic products of DHEA; DHEA sulfate, alpha-hydroxyetiocholanolone (alpha-ET), and beta-hydroxyetiocholanolone (beta-ET) when fed at 0.1% in th...

journal_title：Endocrinology

authors： Coleman DL,Leiter EH,Applezweig N

更新日期：1984-07-01 00:00:00

abstract：:PTHrP is produced in vessels and acts as a local modulator of tone. We recently reported that PTHrP(1-34) is able to induce vasorelaxation in rat uterine arteries, but in pregnancy, this response is blunted and becomes strictly endothelium dependent. The present study aimed to get insights into the mechanisms involved...

journal_title：Endocrinology

authors： Meziani F,Tesse A,Welsch S,Kremer H,Barthelmebs M,Andriantsitohaina R,Schneider F,Gairard A

更新日期：2008-02-01 00:00:00

abstract：:The developmental patterns of thyroid-stimulating hormone (TSH) was examined in female Long-Evans rats by radioimmunoassay of pituitary and plasma from 5 through 80 days of age. The effects of hypothyroidism on normal TSH levels were examined in animals radiothyroidectomized at birth. Control animals showed a peak in ...

journal_title：Endocrinology

authors： Cons JM,Umezu M,Timiras PS

更新日期：1975-07-01 00:00:00

abstract：:Prolonged exposure to elevated glucocorticoid levels is known to produce insulin resistance (IR), a hallmark of diabetes mellitus. Although not fully elucidated, the underlying molecular mechanisms by which glucocorticoids induce IR may provide potential targets for pharmacological interventions. Here we characterized...

journal_title：Endocrinology

authors： Gounarides JS,Korach-André M,Killary K,Argentieri G,Turner O,Laurent D

更新日期：2008-02-01 00:00:00

abstract：:Addition of somatostatin-14 (SRIF) inhibits corticotropin releasing factor (CRF) and forskolin-stimulated cyclic AMP formation and ACTH release from tumor cells of the mouse anterior pituitary (AtT-20/D16-16). After long-term pretreatment of these cells with SRIF, the ability of SRIF to inhibit CRF and forskolin-stimu...

journal_title：Endocrinology

authors： Reisine T,Axelrod J

更新日期：1983-08-01 00:00:00

abstract：:As we previously showed, we have synthesized a new family of 17β-estradiol-platinum(II) hybrids. Earlier studies revealed the VP-128 hybrid to show high efficiency compared with cisplatin toward hormone-dependent breast cancer cells. In the present research, we have studied the antitumor activity of VP-128 in vitro an...

journal_title：Endocrinology

authors： Brasseur K,Leblanc V,Fabi F,Parent S,Descôteaux C,Bérubé G,Asselin E

更新日期：2013-07-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:The concentration of testosterone (T) and 5alpha-dihydrotestosterone (DHT) in plasma, seminal fluid, and epididymis of male Wistar rats have been determined by radioimmunoassay. The DHT/T ratio rose from 0.1 in blood to 1 in testicular fluid and 4 in epididymal fluid. This ratio is 2 in tissues of "caput" epididymis a...

journal_title：Endocrinology

authors： Pujol A,Bayard F,Louvet JP,Boulard C

更新日期：1976-01-01 00:00:00

abstract：:Adiponectin (ApN) is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. Chronic repercussions of ApN treatment or overexpression on adiposity and body weight are still controversial. Here, we generated a transgenic (Tg) mouse model allowing persistent and mod...

journal_title：Endocrinology

authors： Bauche IB,El Mkadem SA,Pottier AM,Senou M,Many MC,Rezsohazy R,Penicaud L,Maeda N,Funahashi T,Brichard SM

更新日期：2007-04-01 00:00:00

abstract：:Interleukin-6 (IL-6) stimulates the release of hCG from syncytiotrophoblast cells, but the effects of IL-6 and other cytokines on the release of placental lactogen (hPL) are unknown. To determine the effect of IL-6 on hPL release, we exposed an enriched fraction of trophoblast cells (prepared by the isopycnic centrifu...

journal_title：Endocrinology

authors： Stephanou A,Handwerger S

更新日期：1994-08-01 00:00:00

abstract：:Prepubertal reproductive development in juvenile male Siberian hamsters can be strongly influenced by photoperiod information received during gestation. Information transmitted from the mother hamster to her fetuses appears to modify the photoperiodic mechanism of the developing hamsters so that they may respond diffe...

journal_title：Endocrinology

authors： Shaw D,Goldman BD

更新日期：1995-10-01 00:00:00

abstract：:In adult rats hysterectomized on day 8 of pseudopregnancy, the mean serum progesterone (P) level fell from 88 ng/ml on day 8 to 44 ng/ml on day 15 (n = 61). In response to a single sc injection of 0.5 ml of a specific antiserum to LH (LHAS) on day 10, the P level fell to less than 10 by day 15 in 29 of 33 rats; howeve...

journal_title：Endocrinology

authors： Sanchez-Criado J,Rothchild I

更新日期：1986-10-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has been shown to induce insulin resistance in cultured cells as well as in animal models. The aim of this study was to map the in vivo mechanism whereby TNF-alpha contributes to the pathogenesis of impaired insulin signaling, using obese and lean Zucker rats in which TNF-alpha ...

journal_title：Endocrinology

authors： Cheung AT,Ree D,Kolls JK,Fuselier J,Coy DH,Bryer-Ash M

更新日期：1998-12-01 00:00:00

abstract：:The p44/p42 MAPKs (ERK1/2) cascade regulates beta-cell nuclear events, which modulates cell differentiation and gene transcription, whereas its implication in processes occurring in the cytoplasm, such as activation of the exocytotic machinery, is still unclear. Using the MIN6 beta-cell line and isolated rat islets of...

journal_title：Endocrinology

authors： Longuet C,Broca C,Costes S,Hani EH,Bataille D,Dalle S

更新日期：2005-02-01 00:00:00

abstract：:GH is an important regulator of body growth and composition as well as numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the majority of circulating "endocrine" IGF-I results from GH-stimulated liver IGF-I production. To develop a better understanding of the role o...

journal_title：Endocrinology

authors： List EO,Berryman DE,Funk K,Jara A,Kelder B,Wang F,Stout MB,Zhi X,Sun L,White TA,LeBrasseur NK,Pirtskhalava T,Tchkonia T,Jensen EA,Zhang W,Masternak MM,Kirkland JL,Miller RA,Bartke A,Kopchick JJ

更新日期：2014-05-01 00:00:00

abstract：:Maintenance of FSH biosynthesis requires ongoing exposure to pulsatile GnRH. Recent data demonstrate that activin also stimulates FSH biosynthesis. We used a perifused pituitary system to examine regulation of FSH beta mRNA levels by pulsatile GnRH and activin. Hourly pulses of 10 nM GnRH increased FSH beta mRNA level...

journal_title：Endocrinology

authors： Weiss J,Harris PE,Halvorson LM,Crowley WF Jr,Jameson JL

更新日期：1992-09-01 00:00:00

abstract：:Mammary gland is an organ that undergoes cycles of growth, differentiation, and function during pregnancy and lactation. Although it is known that the gland enhances its sensitivity to insulin during lactation, it remains to be investigated whether this increased sensitivity develops during pregnancy and which are the...

journal_title：Endocrinology

authors： Carrascosa JM,Ramos P,Molero JC,Herrera E

更新日期：1998-02-01 00:00:00

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5'-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent each of the 5'-dei...

journal_title：Endocrinology

authors： Liao XH,Di Cosmo C,Dumitrescu AM,Hernandez A,Van Sande J,St Germain DL,Weiss RE,Galton VA,Refetoff S

更新日期：2011-03-01 00:00:00

abstract：:Previously, we reported that testicular macrophages constitutively release tumor necrosis factor (TNF) in vitro and are unresponsive to bacterial endotoxins [lipopolysaccharides (LPS)]. These properties are not typical of other tissue macrophages. The goals of the present study were, therefore, to establish 1) if test...

journal_title：Endocrinology

authors： Moore C,Hutson JC

更新日期：1994-01-01 00:00:00

abstract：:Human decidual cells synthesize and release decidual PRL (dPRL) immunologically and biochemically identical to human pituitary PRL. However, stimulators and inhibitors of PRL secretion such as TRH, bromocriptine or dopamine have no effect on dPRL release. The evidence for the involvement of Ca2+ in dPRL release is bas...

journal_title：Endocrinology

authors： Sartor P,Couderc B,Corcuff JB,Odessa MF,Mayer G,Dufy B

更新日期：1992-06-01 00:00:00