Abstract:
:Spot 14 (S14) is a protein whose mRNA is rapidly up-regulated by lipogenic stimuli including thyroid hormone and a high-carbohydrate diet. Previous investigation into the role of S14 suggested that it is involved in de novo lipogenesis. Knockout of the gene in mice has given further support to this hypothesis. The lack of S14 in different tissues resulted in varying phenotypic effects. In the lactating mammary gland, levels of lipogenesis, specifically the production of medium chain fatty acids, were decreased, whereas hepatic lipogenesis was not decreased. In fact, hepatic lipogenesis was increased, and the increase may be due to compensation by a paralog of S14 called S14-R. S14-R is expressed in the liver but not the mammary gland. Importantly, S14 knockout mice did not have reduced levels of lipogenic enzymes, implying that it does not affect the transcriptional rate of those enzymes. Instead, S14 may act in the cytoplasm to affect lipogenesis.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
LaFave LT,Augustin LB,Mariash CNdoi
10.1210/en.2006-0473subject
Has Abstractpub_date
2006-09-01 00:00:00pages
4044-7issue
9eissn
0013-7227issn
1945-7170pii
en.2006-0473journal_volume
147pub_type
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