Inhibin subunit gene expression and distribution in the ovaries of immature, young adult, middle-aged, and old female rats.

abstract：:A highly conserved region in the PTH promoter was identified using the basic local alignment search tool (BLAST) 2 Sequences comparison. Strong specific complexes were observed with a DNA probe that contained much of the computer-derived conserved sequence in the EMSA using bovine parathyroid gland (bPTG) nuclear extr...

journal_title：Endocrinology

authors： Alimov AP,Langub MC,Malluche HH,Koszewski NJ

更新日期：2003-07-01 00:00:00

abstract：:TSH initiates its action by binding to specific membrane receptors' thyroid cells and induces activation of the adenylate cyclase-cAMP cascade. The factors involved in the regulation of TSH receptors are poorly known, except for the TSH dose-dependent regulatory effect. The fact that the thyroid gland of Graves' patie...

journal_title：Endocrinology

authors： Denereaz N,Lemarchand-Beraud T

更新日期：1995-04-01 00:00:00

abstract：:Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR). EMD 21388 also inhibits the binding of T4 to human, dog, and rat serum TTR in vitro and w...

journal_title：Endocrinology

authors： Lueprasitsakul W,Alex S,Fang SL,Pino S,Irmscher K,Köhrle J,Braverman LE

更新日期：1990-06-01 00:00:00

abstract：:Oxytocin receptor (OTR) expression in human myometrium increases over 150-fold from the beginning of pregnancy to the end. In the present studies, we examined potential mechanisms of OTR up-regulation, using myometrial cells in primary culture from women in late gestation. OTR ligand-binding sites and steady-state mRN...

journal_title：Endocrinology

authors： Jeng YJ,Soloff SL,Anderson GD,Soloff MS

更新日期：2003-01-01 00:00:00

abstract：:The factors controlling the synthesis and degradation of the insulin-like growth factor-binding proteins (IGFBPs) during pregnancy are poorly understood. To clarify the roles of nutritional factors in the regulation of fetal and maternal IGFBP production, we examined the effects of fasting, refeeding, and glucose admi...

journal_title：Endocrinology

authors： Osborn BH,Fowlkes J,Han VK,Freemark M

更新日期：1992-10-01 00:00:00

abstract：:Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...

journal_title：Endocrinology

authors： Foradori CD,Whitlock BK,Daniel JA,Zimmerman AD,Jones MA,Read CC,Steele BP,Smith JT,Clarke IJ,Elsasser TH,Keisler DH,Sartin JL

更新日期：2017-10-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:We have previously demonstrated that the gonadotropin-mediated inhibition of apoptosis in ovarian granulosa cells is linked to changes in the expression of several cell death-related genes, including members of the bcl-2 gene family (bcl-2, bax, and bcl-x). Recently, the product of the p53 tumor suppressor gene, a pro...

journal_title：Endocrinology

authors： Tilly KI,Banerjee S,Banerjee PP,Tilly JL

更新日期：1995-04-01 00:00:00

abstract：:Remodeling of maternal spiral arteries during pregnancy requires a subpopulation of extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown to promote trophoblast invasion, but its role in endovascular differ...

journal_title：Endocrinology

authors： Li Y,Zhu H,Klausen C,Peng B,Leung PC

更新日期：2015-11-01 00:00:00

abstract：:Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...

journal_title：Endocrinology

authors： Domann FE,Mitchen JM,Clifton KH

更新日期：1990-12-01 00:00:00

abstract：:Recent evidence indicates that osteopontin (Opn), one of the bone matrix proteins, plays an important role in the attachment of osteoclasts to bone matrix. Besides being elaborated by osteoblasts, this protein is also produced by osteoclasts. The present study was performed to examine the effect of calcitonin (CT) on ...

journal_title：Endocrinology

authors： Kaji H,Sugimoto T,Miyauchi A,Fukase M,Tezuka K,Hakeda Y,Kumegawa M,Chihara K

更新日期：1994-07-01 00:00:00

abstract：:The insulin receptor substrates (IRSs) are key proteins in signal transduction from the insulin receptor. Recently, we discovered a fourth member of this family, designated IRS-4, cloned its complementary DNA from the human embryonic kidney 293 cell line, and characterized its signaling properties in this cell line. A...

journal_title：Endocrinology

authors： Fantin VR,Lavan BE,Wang Q,Jenkins NA,Gilbert DJ,Copeland NG,Keller SR,Lienhard GE

更新日期：1999-03-01 00:00:00

abstract：:Ca2+/calmodulin-dependent processes are altered by manipulations of the hypothalamic-pituitary-adrenal axis. In particular, adrenalectomy (ADX) attenuates hippocampal, but not cortical, calmodulin-dependent adenylate cyclase activity measured during the active (waking) phase of rats. The involvement of calmodulin- and...

journal_title：Endocrinology

authors： Gannon MN,Akompong T,Billingsley ML,McEwen BS

更新日期：1994-02-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:Although Na+/H+ exchange is important to maintenance of pH and volume and thus placental-fetal homeostasis, regulation of the Na+/H+ exchange system is incompletely understood. We previously showed that Na+/H+ exchanger (NHE)1 and -3 and their regulatory factors NHERF1 and -2 were expressed in human and nonhuman prima...

journal_title：Endocrinology

authors： Pepe GJ,Burch MG,Albrecht ED

更新日期：2006-06-01 00:00:00

abstract：:Proteolytic degradation of extracellular matrix components has been suggested to play an essential role in the occurrence of ovulation. Recent studies in our laboratory have indicated that the plasminogen activator and matrix metalloproteinase systems, which were previously believed to be crucial for ovulation, are no...

journal_title：Endocrinology

authors： Wahlberg P,Nylander A,Ahlskog N,Liu K,Ny T

更新日期：2008-10-01 00:00:00

abstract：:GnRH release in the median eminence (ME) is the central output for control of reproduction. GnRH processes in the preoptic area (POA) also release GnRH. We examined region-specific regulation of GnRH secretion using fast-scan cyclic voltammetry to detect GnRH release in brain slices from adult male mice. Blocking endo...

journal_title：Endocrinology

authors： Glanowska KM,Moenter SM

更新日期：2015-01-01 00:00:00

abstract：:We have compared the influence of insulin-like growth factor 1 (IGF-1) on pituitary gene expression in the rat cell lines GH4C1 and GH3. Incubation with IGF-1 increased PRL messenger RNA (mRNA) levels in GH4C1 cells by 4- to 5-fold but decreased the levels of PRL transcripts in GH3 cells. In addition, the levels of GH...

journal_title：Endocrinology

authors： Castillo AI,Aranda A

更新日期：1997-12-01 00:00:00

abstract：:This study examined the effect of two thirds hepatectomy on rat liver insulin-like growth factor-II (IGF-II) receptors and IGF-II receptor messenger RNA (mRNA) levels. IGF-II receptor levels were determined in liver plasma membrane and Golgi/endosome fractions from sham-operated and hepatectomized rats by ligand bindi...

journal_title：Endocrinology

authors： Scott CD,Ballesteros M,Baxter RC

更新日期：1990-11-01 00:00:00

abstract：:Aldosterone plays a major role in regulating sodium and potassium flux in epithelial tissues such as kidney and colon. Recent evidence suggests that serum- and glucocorticoid-regulated kinase (SGK) is induced by aldosterone and acts as a key mediator of aldosterone action in epithelial tissues. Induction of SGK messen...

journal_title：Endocrinology

authors： Bhargava A,Fullerton MJ,Myles K,Purdy TM,Funder JW,Pearce D,Cole TJ

更新日期：2001-04-01 00:00:00

abstract：:Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat that a 22% reduction in bone mineral density generated by ovariectomy was associated with a 2-fold reduction of transforming growth factor-beta 3 (TGF beta 3) messenger RNA expression in th...

journal_title：Endocrinology

authors： Yang NN,Bryant HU,Hardikar S,Sato M,Galvin RJ,Glasebrook AL,Termine JD

更新日期：1996-05-01 00:00:00

abstract：:The adrenal gland is highly vascularized with tightly regulated blood flow that is closely correlated with steroidogenesis. Mechanisms involved in the regulation of adrenal blood flow and vascular tone are largely unknown. The present study characterizes the contractile responses of isolated small cortical arteries fr...

journal_title：Endocrinology

authors： Zhang DX,Gauthier KM,Campbell WB

更新日期：2004-04-01 00:00:00

abstract：:PGs are important mediators of the ovulatory process and prostaglandin G/H synthase-2 (PGHS-2) is a key rate-limiting enzyme in the PG biosynthetic pathway. To determine whether PGHS-2 is regulated in equine follicles before ovulation and, if so, to characterize its time course of induction, preovulatory follicles wer...

journal_title：Endocrinology

authors： Sirois J,Doré M

更新日期：1997-10-01 00:00:00

abstract：:Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...

journal_title：Endocrinology

authors： Tse A,Lee AK

更新日期：1998-05-01 00:00:00

abstract：:The basal concentration and metabolic clearance of radiolabeled and endogenous thyroglobulin (Tg) were measured in normal male rats. Serum Tg concentrations (by RIA) in Sprague-Dawley adult males ranged from 70-680 ng/ml (mean +/- SD, 218 +/- 177). In male Fisher rats, basal serum Tg concentrations were 32-263 ng/ml. ...

journal_title：Endocrinology

authors： Izumi M,Larsen PR

更新日期：1978-07-01 00:00:00

abstract：:The effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on basal and TRH-induced TSH release, and the effects of IL-1 beta on the uptake of [125I]T3 and [125I]T4 and on nuclear binding of [125I]T3 were examined. Furthermore, the release of other anterior pituitary hormones in the pres...

journal_title：Endocrinology

authors： Wassen FW,Moerings EP,Van Toor H,De Vrey EA,Hennemann G,Everts ME

更新日期：1996-05-01 00:00:00

abstract：:In order to compare, in vitro, the TSH suppressive effects of iodothyronines, rat pituitary quarters were first preincubated with T4, T3, rT3, or 3,3'-diiodothyronine (T2) in Gey and Gey buffer containing 1% bovine serum albumin for 2 h at 37 C and then incubated at 37 C for 1 h with the iodothyronine under study and ...

journal_title：Endocrinology

authors： Chopra IJ,Carlson HE,Solomon DH

更新日期：1978-08-01 00:00:00

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:The adrenergic control of cAMP and 3',5'-cyclic GMP (cGMP) in dispersed adult rat pinealocytes was investigated. Norepinephrine treatment increased cAMP and cGMP content 60- and 400-fold, respectively; both alpha- and beta-adrenoceptors had to be activated for these responses to occur. Beta-Adrenergic stimulation alon...

journal_title：Endocrinology

authors： Vanecek J,Sugden D,Weller J,Klein DC

更新日期：1985-06-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...

journal_title：Endocrinology

authors： Taylor TB,Ramsdell JS

更新日期：1993-09-01 00:00:00