Examination of VDR/RXR/DRIP205 Interaction, Intranuclear Localization, and DNA Binding in Ras-Transformed Keratinocytes and Its Implication for Designing Optimal Vitamin D Therapy in Cancer.

abstract：:Stanniocalcin (STC) is a new mammalian polypeptide hormone and appears to be a regulator of neuronal function. We have already shown that the induction of STC mRNA and protein expression by cAMP is integral to neuroblastoma cell differentiation, particularly neurite outgrowth. In this study, we examined the cAMP pathw...

journal_title：Endocrinology

authors： Yeung HY,Chan DK,Mak NK,Wagner GF,Wong CK

更新日期：2003-10-01 00:00:00

abstract：:PTH increases calcium reabsorption exclusively in the distal nephron. Two mechanisms of Ca++ transport through the basolateral membrane (BLM) have been described: the ATP-dependent and the sodium gradient-dependent transport. In the present study, we investigated the effect of PTH and (Bu)2cAMP on these two mechanisms...

journal_title：Endocrinology

authors： Bouhtiauy I,Lajeunesse D,Brunette MG

更新日期：1991-01-01 00:00:00

abstract：:Rats start decreasing their food intake as early as 70 min after the first ingestion of a food deficient in threonine. A decrease of the limiting essential amino acid (EAA) in the plasma was proposed to be the first anorectic signal. Because many hormones regulate feeding behavior, we studied the effect of a meal (46 ...

journal_title：Endocrinology

authors： Feurté S,Nicolaïdis S,Gerozissis K

更新日期：2000-10-01 00:00:00

abstract：:131I therapy is a widely accepted treatment for differentiated thyroid cancers which can accumulate iodide. We evaluated the efficiency of 131I therapy against tumors which are transfected with the Na+/I- symporter (NIS) gene. We transfected the rat NIS cDNA expression vector into malignantly transformed rat thyroid c...

journal_title：Endocrinology

authors： Shimura H,Haraguchi K,Miyazaki A,Endo T,Onaya T

更新日期：1997-10-01 00:00:00

abstract：:Although acute leptin administration in the hypothalamus decreases food intake and increases peripheral energy metabolism, the peripheral actions of central chronic leptin administration are less understood. In this study, we investigated what effects chronic (7 d) intracerebroventricular (ICV) administration of lepti...

journal_title：Endocrinology

authors： Keung W,Palaniyappan A,Lopaschuk GD

更新日期：2011-11-01 00:00:00

abstract：:Current in vivo and in vitro data indicate that progesterone (P) is required for epithelial proliferation in mammary glands of adult mice. P receptors (PgR) in adult mammary glands are under estrogenic regulation. By contrast in immature, pubertal 5-week-old mice, PgR are present only in low concentration and cannot b...

journal_title：Endocrinology

authors： Haslam SZ

更新日期：1988-02-01 00:00:00

abstract：:Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin...

journal_title：Endocrinology

authors： Ismail F,Epstein S,Fallon MD,Thomas SB,Reinhardt TA

更新日期：1988-02-01 00:00:00

abstract：:The type 1 PTH/PTH-related peptide receptor (PTH1R) is a class B G protein-coupled receptor that demonstrates immunoreactivity in the nucleus as well as cytoplasm of target cells. Our previous studies on the PTH1R have shown that it associates with the importin family of transport regulatory proteins. To investigate t...

journal_title：Endocrinology

authors： Pickard BW,Hodsman AB,Fraher LJ,Watson PH

更新日期：2007-05-01 00:00:00

abstract：:Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...

journal_title：Endocrinology

authors： Yang CR,Lowther KM,Lalioti MD,Seli E

更新日期：2016-01-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00

abstract：:Bone marrow-derived cells are major cellular components of human decidua, with macrophages comprising about 30% of the cells in term tissue. Because cytokines released by bone marrow-derived cells are known to affect hormone release in many tissues, we examined whether cytokines affect the release of PRL from human de...

journal_title：Endocrinology

authors： Jikihara H,Handwerger S

更新日期：1994-01-01 00:00:00

abstract：:Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...

journal_title：Endocrinology

authors： Lecomte MJ,Bertolus C,Ramanantsoa N,Saurini F,Callebert J,Sénamaud-Beaufort C,Ringot M,Bourgeois T,Matrot B,Collet C,Nardelli J,Mallet J,Vodjdani G,Gallego J,Launay JM,Berrard S

更新日期：2018-04-01 00:00:00

abstract：:After 5 days of incubation with 10 nM tritiated dexamethasone, the amount of glucocorticoid displaceably-bound by the ACTH-secreting, glucocorticoid-responsive AtT-20 mouse pituitary tumor cell decreases by 70-80%. This decrease takes place in both the cytosolic and nuclear fractions. Although one might predict that t...

journal_title：Endocrinology

authors： Svec F,Rudis M

更新日期：1982-08-01 00:00:00

abstract：:Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...

journal_title：Endocrinology

authors： Max SR,Toop J

更新日期：1983-07-01 00:00:00

abstract：:The Kiss1 gene and its product kisspeptin are important regulators of reproduction. In rodents, Kiss1 is expressed in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV)/rostral periventricular (PeN) nuclei. In the AVPV/PeN, females have more Kiss1 and tyrosine hydroxylase (TH) neurons than males. ...

journal_title：Endocrinology

authors： Semaan SJ,Murray EK,Poling MC,Dhamija S,Forger NG,Kauffman AS

更新日期：2010-12-01 00:00:00

abstract：:Four different GnRHs and one GnRH receptor are reported to be expressed in various mammals, whereas 13 GnRHs and numerous GnRH receptors have been identified in various nonmammalian vertebrates. The nucleotide sequencing of the human genome provided the opportunity to determine which of these peptides and receptors mi...

journal_title：Endocrinology

authors： Neill JD

更新日期：2002-03-01 00:00:00

abstract：:Recent studies suggest that GH may modulate emotion, behavior, or stress response by its direct actions on the brain, and possible expression of the GH gene in the brain has been predicted. In this study we have investigated whether and where the GH gene is expressed in the brain and how it is regulated. Ribonuclease ...

journal_title：Endocrinology

authors： Yoshizato H,Fujikawa T,Soya H,Tanaka M,Nakashima K

更新日期：1998-05-01 00:00:00

abstract：:Axonal degeneration often leads to the death of neuronal cell bodies. Previous studies demonstrated the substantial protective role of 17β-estradiol (E2) in several types of neuron. However, most studies examined cell body protection, and the role of 17β-E2 in axonal degeneration of retinal ganglion cells (RGC) remain...

journal_title：Endocrinology

authors： Kitaoka Y,Munemasa Y,Hayashi Y,Kuribayashi J,Koseki N,Kojima K,Kumai T,Ueno S

更新日期：2011-07-01 00:00:00

abstract：:Early postnatal exposures to sex steroids have been well recognized to modulate predisposition to diseases of adulthood. There is a complex interplay between timing, duration and dose of endocrine exposures through environmental or dietary sources that may alter the sensitivity of target tissues to the exogenous stimu...

journal_title：Endocrinology

authors： Jang H,Bhasin S,Guarneri T,Serra C,Schneider M,Lee MJ,Guo W,Fried SK,Pencina K,Jasuja R

更新日期：2015-10-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:Serum triiodothyronine (T3) in rats did not change if food intake was restricted without altering the composition of the diet. Feeding a hypocaloric low-protein high-carbohydrate diet caused increases in serum T3, while feeding a hypocaloric high-protein low-carbohydrate diet caused decreases in serum T3. These change...

journal_title：Endocrinology

authors： Glass AR,Mellitt R,Burman KD,Wartofsky L,Swerdloff RS

更新日期：1978-06-01 00:00:00

abstract：:Recent work has implicated stimulatory kisspeptin neurons in the arcuate nucleus (ARC) as important for seasonal changes in reproductive function in sheep, but earlier studies support a role for inhibitory A15 dopaminergic (DA) neurons in the suppression of GnRH (and LH) pulse frequency in the nonbreeding (anestrous) ...

journal_title：Endocrinology

authors： Goodman RL,Maltby MJ,Millar RP,Hileman SM,Nestor CC,Whited B,Tseng AS,Coolen LM,Lehman MN

更新日期：2012-12-01 00:00:00

abstract：:A rat medullary thyroid carcinoma, which was previously shown to produce high levels of immunoreactive cholecystokinin (CCK), was used to establish a stable cell line. Transplantable tumors were subjected to four series of alternate in vitro and in vivo passages. Cells were prepared from the fourth series of tumors un...

journal_title：Endocrinology

authors： Haun RS,Beinfeld MC,Roos BA,Dixon JE

更新日期：1989-08-01 00:00:00

abstract：:The estrogen receptor-alpha (ERalpha) pituitary-specific variant, TERP-1, is regulated dramatically by physiological status. We examined hormonal regulation of the TERP-1 promoter in transient transfection assays in GH3 somatolactotrope cells. We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenyla...

journal_title：Endocrinology

authors： Bryant WM,Gibson MA,Shupnik MA

更新日期：2006-01-01 00:00:00

abstract：:Exposure of the ileum to nutrients markedly inhibits several upper gastrointestinal functions. Hormonal peptides of the ileal wall, i.e. peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and neurotensin (NT), are thought to play a role in this negative feedback mechanism. The present study was conducted to comparativ...

journal_title：Endocrinology

authors： Dumoulin V,Moro F,Barcelo A,Dakka T,Cuber JC

更新日期：1998-09-01 00:00:00

abstract：:The insulin-, glucagon- and somatostatin-producing cells (beta, alpha, and delta, respectively) in the pancreatic islets derive from a common precursor stem cell and differentiate sequentially during embryonic development. The homeodomain protein islet duodenum HOX (IDX)-1 [insulin promoter factor (IPF)-1/somatostatin...

journal_title：Endocrinology

authors： Lu M,Miller C,Habener JF

更新日期：1996-07-01 00:00:00

abstract：:Reproductive fitness in females is susceptible to obesogenic diets. Energy balance and reproduction are tightly regulated, in part, by hypothalamic neurons in the arcuate nucleus (ARC), and high-fat diet (HFD) can steadily increase estradiol levels in rodents. Estradiol regulates the reproductive axis via negative fee...

journal_title：Endocrinology

authors： Negrón AL,Radovick S

更新日期：2020-10-01 00:00:00

abstract：:IGFs (IGF-I and IGF-II) are essential for development, and their bioactivities are tightly regulated by six related IGF-binding proteins (IGFBPs). IGFBP-5 is the most highly conserved binding protein and is expressed in several key developmental lineages as well as in multiple adult tissues including the mammary gland...

journal_title：Endocrinology

authors： Ning Y,Hoang B,Schuller AG,Cominski TP,Hsu MS,Wood TL,Pintar JE

更新日期：2007-05-01 00:00:00

abstract：:The insulin-like growth factors (IGF)-I and -II are bound to specific carrier proteins in the circulation. For investigation of their physiological role, the acid-stable subunit of the major binding protein (SmBP) was isolated from human plasma Cohn fraction IV. Its effect on the mitogenic activity of IGF-I was studie...

journal_title：Endocrinology

authors： Blum WF,Jenne EW,Reppin F,Kietzmann K,Ranke MB,Bierich JR

更新日期：1989-08-01 00:00:00

abstract：:Constitutive nitric oxide synthase (cNOS) was immunolocalized to study its role in osmotic regulation. Immunoreactivity was observed in all major hypothalamic osmoregulatory structures, the organum vasculosum laminae terminalis, subfornical organ, median preoptic nucleus, and supraoptic and paraventricular nuclei. The...

journal_title：Endocrinology

authors： Wang H,Morris JF

更新日期：1996-05-01 00:00:00