Abstract:
:The occupancy of atrial natriuretic peptide (ANP) receptors of the ANPA type in human neuroblastoma NB-OK-1 cells elevates cGMP. In this study, ANP concentrations of 10 nM or more increased total K+ uptake. Data obtained in the presence of bumetanide and/or ouabain demonstrated that 1 microM ANP induced a primary stimulation (by 82%) of Na-K-Cl cotransport and a subsequent indirect stimulation (by 15%) of Na,K-ATPase. ANP also inhibited Na/H exchange through an amiloride-sensitive mechanism, as shown by intracellular pH measurement in cells challenged or not by an acid or alkaline load. (Bu)2cGMP mimicked all ANP effects, suggesting that ANP acted through a cGMP-dependent mechanism.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Delporte C,Winand J,Poloczek P,Christophe Jdoi
10.1210/endo.133.1.8391430subject
Has Abstractpub_date
1993-07-01 00:00:00pages
77-82issue
1eissn
0013-7227issn
1945-7170journal_volume
133pub_type
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