Microtubules and the intracellular conversion of proparathyroid hormone to parathyroid hormone.

abstract：:Biological actions of natriuretic peptide (NP) are determined by the condition of the receptor as well as that of the hormone. Although we previously demonstrated in hypertensive rats the up-regulation of NP-A receptor that mediates various biological actions of NPs, the pathophysiologic significance of NP-C receptor,...

journal_title：Endocrinology

authors： Yoshimoto T,Naruse M,Naruse K,Shionoya K,Tanaka M,Tanabe A,Hagiwara H,Hirose S,Muraki T,Demura H

更新日期：1996-03-01 00:00:00

abstract：:1Alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is a potent mediator of differentiation and maintenance of specific functions of osteoblasts. To detect novel targets for 1,25-(OH)2D3 action, we applied differential display PCR to human fetal osteoblast-like cells and identified the human analog of murine cystein rich pro...

journal_title：Endocrinology

authors： Schütze N,Lechner A,Groll C,Siggelkow H,Hüfner M,Köhrle J,Jakob F

更新日期：1998-04-01 00:00:00

abstract：:Inhibins and activins are produced by a variety of tissues and may have important endocrine and paracrine roles in development, reproduction, and hematopoiesis. However, little is known regarding the physical properties or concentrations of inhibin and activin in biological fluids. Binding proteins for inhibin or acti...

journal_title：Endocrinology

authors： Krummen LA,Woodruff TK,DeGuzman G,Cox ET,Baly DL,Mann E,Garg S,Wong WL,Cossum P,Mather JP

更新日期：1993-01-01 00:00:00

abstract：:GnRH is detectable in the cerebrospinal fluid (CSF), but its source remains unidentified. Previous studies have harvested CSF for GnRH analysis from the median eminence region, but it is unknown whether GnRH in CSF is restricted to this region. If CSF-GnRH plays a physiological role, through volume transmission, to co...

journal_title：Endocrinology

authors： Caraty A,Skinner DC

更新日期：2008-10-01 00:00:00

abstract：:Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...

journal_title：Endocrinology

authors： Tanaka M,Hayashida Y,Iguchi T,Nakao N,Nakai N,Nakashima K

更新日期：2001-08-01 00:00:00

abstract：:We used the library subtraction technique to identify genes specifically expressed in the rat uterus during early pregnancy. One such gene was that for stathmin, a factor that is associated with tubulin binding and the destabilization of microtubules. Stathmin was expressed at higher levels in implantation sites than ...

journal_title：Endocrinology

authors： Tamura K,Hara T,Yoshie M,Irie S,Sobel A,Kogo H

更新日期：2003-04-01 00:00:00

abstract：:We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...

journal_title：Endocrinology

authors： Globus RK,Patterson-Buckendahl P,Gospodarowicz D

更新日期：1988-07-01 00:00:00

abstract：:Estrogens have been implicated in the regulation of prolactin gene expression in man, although previous studies have not defined the molecular mechanism whereby estradiol activates the human prolactin gene promoter (hPrl). We found that estradiol induced a reproducible 1.8-fold activation of the hPrl gene promoter, us...

journal_title：Endocrinology

authors： Adamson AD,Friedrichsen S,Semprini S,Harper CV,Mullins JJ,White MR,Davis JR

更新日期：2008-02-01 00:00:00

abstract：:In previous studies it was shown that bovine GH (bGH) suppressed and glucagon stimulated the level of 24- and 30- to 34-kilodalton insulin-like growth factor-binding proteins (IGFBPs) in the media of cultured rat hepatocytes. In the present study we have evaluated the regulation of IGFBP-1 gene expression in primary r...

journal_title：Endocrinology

authors： Kachra Z,Yang CR,Murphy LJ,Posner BI

更新日期：1994-11-01 00:00:00

abstract：:Osteoclast precursors have not been well characterized because there are no known markers that can detect them. We have used osteoclast-like cells formed in vitro to develop a panel of specific antibodies that react with mature osteoclasts, osteoclast precursors, and other cells in the osteoclast lineage. Monoclonal a...

journal_title：Endocrinology

authors： Kukita T,Roodman GD

更新日期：1989-08-01 00:00:00

abstract：:Progesterone (P4) inhibits apoptosis of rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs), which were derived from rat granulosa cells. Defining the mechanism through which P4 mediates its action has been difficult because these cells do not express the classic nuclear P4 receptor. Previous st...

journal_title：Endocrinology

authors： Peluso JJ,Pappalardo A,Fernandez G,Wu CA

更新日期：2004-06-01 00:00:00

abstract：:The effects of L-leucine, D-leucine, and L-isoleucine upon the secretion of glucagon and insulin were investigated using the isolated, perfused rat pancreas. All experiments were conducted in the presence of 5.6 mM D-glucose. Ten-minute perfusions of 2, 5, and 10 mM L-leucine induced the release of glucagon and insuli...

journal_title：Endocrinology

authors： Pek S,Santiago JC,Tai TY

更新日期：1978-10-01 00:00:00

abstract：:The uptake of [125I]T3 in rat skeletal muscle was investigated by incubating intact soleus muscles with a tracer amount of [125I]T3. At 37 C [125I]T3 uptake increased asymptotically; at 60 min the muscle contained 10% of the total [125I]T3 or 0.238 +/- 0.021% per mg wet tissue. At 0 C the [125I]T3 uptake was 1/5 of th...

journal_title：Endocrinology

authors： Pontecorvi A,Robbins J

更新日期：1986-12-01 00:00:00

abstract：:We have studied the changes in thyroid hormone economy that occur in normal pregnant rats between 17-22 days of gestation. T4 and T3 decreased in all extrathyroidal tissues studied, namely plasma, liver, kidney, lung, heart, and skeletal muscle. The exception is the concentration of T3 in cerebral cortex, which remain...

journal_title：Endocrinology

authors： Calvo R,Obregon MJ,Ruiz de Oña C,Ferreiro B,Escobar Del Rey E,Morreale de Escobar G

更新日期：1990-07-01 00:00:00

abstract：:We have investigated the effect of GH on microtubular physiology in Chinese hamster ovary (CHO) cells stably transfected with the complementary DNA for the rat GH receptor (CHO-GHR(1-638)). We show here that after 30 min of human GH (hGH) treatment of CHO-GHR(1-638) cells, there was a significant increase in the level...

journal_title：Endocrinology

authors： Goh EL,Pircher TJ,Lobie PE

更新日期：1998-10-01 00:00:00

abstract：:Hypophysectomized female rats which received renal grafts of anterior pituitary (AP) or weight-matched intact controls were sampled under urethane anesthesia. Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormo...

journal_title：Endocrinology

authors： Udeschini G,Cocchi D,Panerai AE,Gil-Ad I,Rossi GL,Chiodin PG,Liuzzi A,Müller EE

更新日期：1976-03-01 00:00:00

abstract：:The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal...

journal_title：Endocrinology

authors： Engeland WC,Massman L,Mishra S,Yoder JM,Leng S,Pignatti E,Piper ME,Carlone DL,Breault DT,Kofuji P

更新日期：2018-12-01 00:00:00

abstract：:Estrogen sulfotransferase (EST) catalyzes the sulfoconjugation and inactivation of the steroid hormone estrogen. It is known previously that EST is expressed abundantly in Leydig cells of the testis. We recently have shown that male mice with targeted EST gene disruption developed age related Leydig cell and seminifer...

journal_title：Endocrinology

authors： Tong MH,Song WC

更新日期：2002-08-01 00:00:00

abstract：:Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Usi...

journal_title：Endocrinology

authors： Prescott JL,Tindall DJ

更新日期：1998-04-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:Endothelin (ET) and GnRH act through specific receptors to promote Ca2+ mobilization and influx pathways in pituitary gonadotrophs. In the present study cytoplasmic calcium ([Ca2+]i) and secretory responses to these two agonists are compared. In single gonadotrophs, low concentrations of both agonists cause oscillator...

journal_title：Endocrinology

authors： Stojilković SS,Iida T,Cesnjaj M,Catt KJ

更新日期：1992-12-01 00:00:00

abstract：:We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...

journal_title：Endocrinology

authors： Suttie JM,Gluckman PD,Butler JH,Fennessy PF,Corson ID,Laas FJ

更新日期：1985-02-01 00:00:00

abstract：:The present study employed the dehydroepiandrosterone (DHA) loading test to determine if the placenta in baboons remains functional following fetectomy. A bolus iv injection of 100 mg DHA was given to 4 baboons prior to and at various intervals following fetectomy at midgestation. Blood samples were withdrawn over a 4...

journal_title：Endocrinology

authors： Albrecht ED,Pepe GJ

更新日期：1985-02-01 00:00:00

abstract：:Proglucagon, synthesized in the pancreatic islets and the intestinal L-cells, contains in its precursor structure glucagon, glicentin, and two glucagon-like peptides (GLP-I and GLP-II) separated by an intervening peptide (IP-II). We have cloned a stable rat islet cell line expressing the glucagon gene at high levels, ...

journal_title：Endocrinology

authors： Philippe J,Mojsov S,Drucker DJ,Habener JF

更新日期：1986-12-01 00:00:00

abstract：:Remodeling of maternal spiral arteries during pregnancy requires a subpopulation of extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown to promote trophoblast invasion, but its role in endovascular differ...

journal_title：Endocrinology

authors： Li Y,Zhu H,Klausen C,Peng B,Leung PC

更新日期：2015-11-01 00:00:00

abstract：:Human osteoblast-like cells (HOB) produce vascular endothelial growth factor (VEGF), the steady state level of which is stimulated by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. As osteoblasts and endothelial cells are proximally located in skeletal tissue, we investigated the anabolic effects of 1,25-(OH)2D3 and VEGF on...

journal_title：Endocrinology

authors： Wang DS,Miura M,Demura H,Sato K

更新日期：1997-07-01 00:00:00

abstract：:The development of acquired resistance to antihormonal agents in breast cancer is a major therapeutic problem. We have developed a tamoxifen-resistant (TAM-R) MCF-7 breast cancer cell line to investigate the mechanisms behind this condition. Both epidermal growth factor receptor (EGFR) and c-erbB2 mRNA and protein exp...

journal_title：Endocrinology

authors： Knowlden JM,Hutcheson IR,Jones HE,Madden T,Gee JM,Harper ME,Barrow D,Wakeling AE,Nicholson RI

更新日期：2003-03-01 00:00:00

abstract：:Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered iron regulation hormone is predominantly expressed in the liver, and regulated by iron and hypoxia. As an antimicrobial peptide, this hormone is also elevated during infections and inflammation. In this ...

journal_title：Endocrinology

authors： Wang Q,Du F,Qian ZM,Ge XH,Zhu L,Yung WH,Yang L,Ke Y

更新日期：2008-08-01 00:00:00

abstract：:The present study was designed to investigate the effect of PTH on calcium (Ca2+) transport through the luminal membrane of proximal and distal rabbit tubule segments. Proximal tubule and distal tubule segment suspensions were incubated with the hormone, and the luminal membranes were subsequently purified. Incubation...

journal_title：Endocrinology

authors： Lajeunesse D,Bouhtiauy I,Brunette MG

更新日期：1994-01-01 00:00:00

abstract：:A perifusion system has been developed in which a dose-dependent response of isolated Leydig tumor cells to steroidogenic stimuli, as assessed by the rates of steroid production, can be measured as a function of time. In response to a continuous perifusion for 340 min with a saturating concentration of hCG, ovine LH (...

journal_title：Endocrinology

authors： Segaloff DL,Puett D,Ascoli M

更新日期：1981-02-01 00:00:00