Estrogen does not increase bone formation in growing rats.

abstract：:Binding of lactogenic hormones to particulate and solubilized microsomal membranes isolated from mammary glands of lactating mice is inhibited by direct addition of 10(-10) M or greater concentrations of triphenylethylene antiestrogens [i.e. tamoxifen (TAM), 4-hydroxy-tamoxifen, and Nafoxidine] to the binding assays. ...

journal_title：Endocrinology

authors： Biswas R,Vonderhaar BK

更新日期：1991-01-01 00:00:00

abstract：:Estrogens play a central role in regulating female reproduction throughout the reproductive axis, and the pituitary is one of the major targets of estrogen action. We hypothesized that estrogen receptor alpha (ERalpha) mediates estrogen action in the pituitary gonadotroph. To test this hypothesis, we generated a mouse...

journal_title：Endocrinology

authors： Gieske MC,Kim HJ,Legan SJ,Koo Y,Krust A,Chambon P,Ko C

更新日期：2008-01-01 00:00:00

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:To assess a possible regulatory influence of opioids upon anterior pituitary function in the chimpanzee, we evaluated the effects of the specific opiate receptor antagonist naloxone and the agonistic enkephalin analog [D-Ala2, MePhe4,Met(o)-ol]enkephalin (FK 33-824; Sandoz) on serum levels of PRL, cortisol, FSH, and L...

journal_title：Endocrinology

authors： Gosselin RE,Blankstein J,Dent DW,Hobson WC,Fuller GB,Reyes FI,Winter JS,Faiman C

更新日期：1983-06-01 00:00:00

abstract：:Previous studies established a positive relationship between oocyte competence and follistatin mRNA abundance. Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis. Treatment of early embryos with follistatin during in vitro culture (befo...

journal_title：Endocrinology

authors： Lee KB,Bettegowda A,Wee G,Ireland JJ,Smith GW

更新日期：2009-05-01 00:00:00

abstract：:The beta-isoform of protein kinase C (PKC) has paradoxically been suggested to be important for both insulin action and insulin resistance as well as for contributing to the pathogenesis of diabetic complications. Presently, we evaluated the effects of knockout of the PKCbeta gene on overall glucose homeostasis and in...

journal_title：Endocrinology

authors： Standaert ML,Bandyopadhyay G,Galloway L,Soto J,Ono Y,Kikkawa U,Farese RV,Leitges M

更新日期：1999-10-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00

abstract：:We tested the hypothesis that depressed duodenal calcium absorption in the streptozotocin diabetic rat is the consequence of diabetes rather than nephrotoxicity of the diabetogenic agent causing abnormal renal vitamin D metabolism. We treated streptozotocin diabetic rats with insulin and compared their duodenal calciu...

journal_title：Endocrinology

authors： Schneider LE,Nowosielski LM,Schedl HP

更新日期：1977-01-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:Studies in mice have identified the ob gene product, leptin, as a signaling factor regulating body weight homeostasis and energy balance. Defective production of the encoded protein may be one of the causes for the development of obesity. Using a high affinity antibody, that in immunohistochemical studies specifically...

journal_title：Endocrinology

authors： McGregor GP,Desaga JF,Ehlenz K,Fischer A,Heese F,Hegele A,Lammer C,Peiser C,Lang RE

更新日期：1996-04-01 00:00:00

abstract：:To test the hypothesis that insulin mediators serve as the signal transduction system for insulin's steroidogenic actions in human placental cytotrophoblasts, we examined the effects of two inositolglycan insulin mediators, the insulin pH 2.0 chiro-inositol mediator (IM-pH 2.0) and the insulin pH 1.3 myo-inositol medi...

journal_title：Endocrinology

authors： Nestler JE,Romero G,Huang LC,Zhang CG,Larner J

更新日期：1991-12-01 00:00:00

abstract：:The direct actions of kit-ligand/stem cell factor (KL) in developing ovarian follicles were investigated. Previous studies have shown that granulosa cells express KL that can support oocyte development. The current study demonstrates that KL can also act directly on theca cells to promote cellular growth and different...

journal_title：Endocrinology

authors： Parrott JA,Skinner MK

更新日期：1997-09-01 00:00:00

abstract：:To analyze the roles of insulin receptor substrate (IRS) proteins in insulin-stimulated cell cycle progression, we examined the functions of rat IRS-1 and IRS-3 in Chinese hamster ovary cells overexpressing the human insulin receptor. In this type of cell overexpressing IRS-1 or IRS-3, we showed that: 1) overexpressio...

journal_title：Endocrinology

authors： Kaburagi Y,Yamashita R,Ito Y,Okochi H,Yamamoto-Honda R,Yasuda K,Sekihara H,Sasazuki T,Kadowaki T,Yazaki Y

更新日期：2004-12-01 00:00:00

abstract：:Although prolactinomas can be effectively treated with dopamine agonists, about 20% of patients develop dopamine resistance or tumor recurrence after surgery, indicating a need for better understanding of underlying disease mechanisms. Although estrogen-induced rat prolactinomas have been widely used to investigate th...

journal_title：Endocrinology

authors： Tong Y,Zheng Y,Zhou J,Oyesiku NM,Koeffler HP,Melmed S

更新日期：2012-08-01 00:00:00

abstract：:The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself. In this study, we have cloned and characterized the mouse promoter of PTG. We identified multiple FoxA2...

journal_title：Endocrinology

authors： Cheng A,Zhang M,Crosson SM,Bao ZQ,Saltiel AR

更新日期：2006-07-01 00:00:00

abstract：:GH receptor (GHR) mediates the anabolic and metabolic effects of GH. We previously characterized a monoclonal antibody (anti-GHR(ext-mAb)) that reacts with subdomain 2 of the rabbit GHR extracellular domain (ECD) and is a conformation-specific inhibitor of GH signaling in cells bearing rabbit or human GHR. Notably, th...

journal_title：Endocrinology

authors： Jiang J,Wan Y,Wang X,Xu J,Harris JM,Lobie PE,Zhang Y,Zinn KR,Waters MJ,Frank SJ

更新日期：2011-12-01 00:00:00

abstract：:Cripto-1 (TDGF1) is a multifunctional signaling factor that stimulates cellular effects, including proliferation, migration, survival, epithelial-to-mesenchymal transition, and angiogenesis, to regulate embryogenesis, tissue homeostasis, and tumorigenesis. Those cell behaviors are also associated with implantation of ...

journal_title：Endocrinology

authors： Gershon E,Hadas R,Elbaz M,Booker E,Muchnik M,Kleinjan-Elazary A,Karasenti S,Genin O,Cinnamon Y,Gray PC

更新日期：2018-04-01 00:00:00

abstract：:The effects of increasing concentrations of leucine (0.2, 2.0, and 15.0 mmol/liter) on glucagon secretion from the perfused rat pancreas were examined at various glucose levels (0, 3.3, or 8.3 mmol/liter) and in the absence or presence of either arginine (5.0 mmol/liter) or glutamine (10.0 mmol/liter). At a low glucos...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Woussen-Colle MC,Giroix MH,Malaisse WJ

更新日期：1985-03-01 00:00:00

abstract：:Osteocalcin (OC), a bone specific protein expressed during differentiation and mineralization of the bone extracellular matrix, is down-regulated upon treatment with transforming growth factor (TGF)-beta 1. To address the potential role of OC gene expression in relation to TGF-beta 1 regulation of bone formation and r...

journal_title：Endocrinology

authors： Banerjee C,Stein JL,Van Wijnen AJ,Frenkel B,Lian JB,Stein GS

更新日期：1996-05-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks....

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-11-01 00:00:00

abstract：:A RT-PCR approach was used to clone and sequence the full-length growth hormone receptor (GHR) of a teleost fish, the turbot (Scophthalmus maximus). Total liver RNA was amplified by RT-PCR with degenerate primers designed in extracellular and cytoplasmic regions, and a single DNA fragment of 1100 bp was obtained. The ...

journal_title：Endocrinology

authors： Calduch-Giner J,Duval H,Chesnel F,Boeuf G,Pérez-Sánchez J,Boujard D

更新日期：2001-07-01 00:00:00

abstract：:Studies were undertaken using the opiate receptor antagonist naloxone (NAL) to evaluate the relative influence of endogenous opioid peptides (EOP) on LH secretion in cycling and ovariectomized, steroid-treated adult rats. Intact animals received NAL (2 mg/kg, sc) or saline (control vehicle) at 0800 and 1400 h on estru...

journal_title：Endocrinology

authors： Gabriel SM,Simpkins JW,Kalra SP

更新日期：1983-11-01 00:00:00

abstract：:Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1986-12-01 00:00:00

abstract：:PTH-related protein (PTHrP) has been shown to be a major factor responsible for hypercalcemia of malignancy. PTHrP acts via the PTH/PTHrP receptor, and therefore, PTH antagonists might be expected to reverse the hypercalcemia in malignancy. In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [...

journal_title：Endocrinology

authors： Kukreja SC,D'Anza JJ,Wimbiscus SA,Fisher JE,McKee RL,Caulfield MP,Rosenblatt M

更新日期：1994-05-01 00:00:00

abstract：:The insulin-like growth factors (IGFs) stimulate the proliferation of human breast cancer cells, including the estrogen-dependent cell line MCF-7. These cells secrete regulatory IGF-binding proteins (IGFBPs) which may enhance or attenuate IGF-stimulated cell proliferation. In this study, we have used RIA to quantify t...

journal_title：Endocrinology

authors： Martin JL,Coverley JA,Pattison ST,Baxter RC

更新日期：1995-03-01 00:00:00

abstract：:As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen-induced renal tumors in hamsters, we have 1) determined steroid-17 beta-oxidoreductase activity of microsomes and cytosol prepared from hamster kidney and liver; 2) compared the rates of 2-, ...

journal_title：Endocrinology

authors： Zhu BT,Bui QD,Weisz J,Liehr JG

更新日期：1994-11-01 00:00:00

abstract：:Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...

journal_title：Endocrinology

authors： Briggs DI,Lockie SH,Wu Q,Lemus MB,Stark R,Andrews ZB

更新日期：2013-02-01 00:00:00

abstract：:Aldosterone selectivity in mineralocorticoid target tissues has been suggested to be due to 11 beta-hydroxysteroid dehydrogenase (11-OHSD), which, by inactivating the endogenous glucocorticoids cortisol and corticosterone (CS), would allow aldosterone to bind to the mineralocorticoid receptor that has equal affinity f...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Watlington CO,Fejes-Tóth G

更新日期：1991-07-01 00:00:00

abstract：:Osteoclast-like multinucleated giant cells are induced in bone marrow cultures by 1,25-dihydroxyvitamin D3 and other agents. These cells resemble osteoclasts in their morphology, their ability to resorb bone, and the possession of calcitonin receptors. We report here a biphasic effect of transforming growth factor-bet...

journal_title：Endocrinology

authors： Shinar DM,Rodan GA

更新日期：1990-06-01 00:00:00