Abstract:
:During luteinization of bovine granulosa cells in vitro in the presence of insulin, or insulin plus forskolin, there is a massive upregulation not only of progesterone production, but also of the gene for the peptide hormone oxytocin, with secretion of the peptide into the medium. By using the progesterone receptor antagonists, RU486 or onapristone, we have shown that this upregulation of the oxytocin gene is mediated by an autocrine loop involving endogenous progesterone and the progesterone receptor in the granulosa cells. The inhibition of oxytocin gene expression by the anti-gestagens can be reversed by medroxyprogesterone acetate but not by dexamethasone, showing that the effect is due to the endogenous progesterone. Since oxytocin also appears to be involved in a positive feedback loop regulating steroid output, these results show that endogenous progesterone itself is a key feedback element in the cascade of events termed luteinization, and that possibly anti-gestagens can influence ovarian function in vivo by directly disrupting this process.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Lioutas C,Einspanier A,Kascheike B,Walther N,Ivell Rdoi
10.1210/endo.138.11.5650subject
Has Abstractpub_date
1997-11-01 00:00:00pages
5059-62issue
11eissn
0013-7227issn
1945-7170journal_volume
138pub_type
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