Abstract:
:The previously reported synchronous oscillations in plasma glucose and insulin levels have been further studied to determine whether the phenomenon can be attributed to cyclic secretion or degradation of the hormone. Plasma C-peptide concentrations were measured and found to cycle with the same period as plasma insulin suggesting that the oscillations of insulin arise from changing secretion rather than degradation. The amplitude of C-peptide oscillation was 50 percent that of insulin. Assuming first order kinetics and the same relative rates of disappearance as in humans, this difference in amplitudes in consistent with equal secretion rates for the two peptides.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Koerker DJ,Goodner CJ,Hansen BW,Brown AC,Rubenstein AHdoi
10.1210/endo-102-5-1649subject
Has Abstractpub_date
1978-05-01 00:00:00pages
1649-52issue
5eissn
0013-7227issn
1945-7170journal_volume
102pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-5-2244
更新日期:1989-11-01 00:00:00
abstract::We used the library subtraction technique to identify genes specifically expressed in the rat uterus during early pregnancy. One such gene was that for stathmin, a factor that is associated with tubulin binding and the destabilization of microtubules. Stathmin was expressed at higher levels in implantation sites than ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220834
更新日期:2003-04-01 00:00:00
abstract::Regulation of the lactogen specific binding sites of rat liver was studied in several different high lactogen states. The specific binding of [125I]iodo-hGH was determined as a measure of these sites. Hypophysectomy of pregnant rats produced a much smaller decrease in hepatic binding of [125I]iodo-hGH than was seen in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-5-1168
更新日期:1976-11-01 00:00:00
abstract::The pattern of glucagon gene expression and the posttranslational processing of proglucagon was studied in the fetal and neonatal rat. Pancreatic immunoreactive glucagon (IRG) and glucagon-like immunoreactivity (GLI) were low in both fetal pancreas and intestine, respectively. Immediately after birth, pancreatic IRG r...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2217
更新日期:1990-11-01 00:00:00
abstract::Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address this issue we compared plasma calcitriol levels and renal 25-h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-5-2118
更新日期:1989-05-01 00:00:00
abstract::In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract::GH is the major regulator of circulating IGF-I, which, in return, controls pituitary GH secretion by negative feedback. IGF-binding protein-1 (IGFBP-1) is believed to modify this feedback through its effects on free IGF-I. In the present study we investigated the potential influence of IGFBP-1 on GH secretion in the a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1742
更新日期:2004-09-01 00:00:00
abstract::Around the onset of labor, uterine sensitivity to oxytocin (OT) increases tremendously. Although this is considered to reflect OT receptor (OTR) augmentation in myometrium, neither spatial expression of OTR nor the level of the receptor message during the course of pregnancy have been investigated at the molecular lev...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.2.8593830
更新日期:1996-02-01 00:00:00
abstract::Mammalian ovaries contain sympathetic neurons expressing the low affinity neurotropin receptor (p75NTR). To date neither the role these neurons might play in ovarian physiology nor their embryological origin is known. Immunohistochemistry was used to detect postnatal changes in distribution and number of both p75NTR-p...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0394
更新日期:2006-08-01 00:00:00
abstract::Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa007
更新日期:2020-03-01 00:00:00
abstract::Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1090
更新日期:2009-03-01 00:00:00
abstract::Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1372
更新日期:2004-06-01 00:00:00
abstract::There is evidence that the IGF system plays an important role in the growth and function of the thyroid gland. Proteolysis is an important posttranslational process that modulates the affinity of IGF binding proteins (IGFBPs) to IGFs, thus regulating their activity. IGFBP-3 has been shown to be cleaved by members of t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1378
更新日期:2004-03-01 00:00:00
abstract::Exposure to environmental toxicants during fetal development alters gene expression and promotes disease later in life. Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer widely used for the manufacturing of consumer products. Exposure to DEHP has been associated with obesity, asthma, and low T levels. In utero expos...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1436
更新日期:2015-01-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.5.7548
更新日期:2000-05-01 00:00:00
abstract::The procession of round spermatids through stages VII and VIII of the rat spermatogenic cycle is critically dependent on testosterone (T). When intratesticular T levels are reduced, round spermatids appear to slough from the seminiferous epithelium, resulting in the disappearance of elongated spermatids. We hypothesiz...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.9.8756560
更新日期:1996-09-01 00:00:00
abstract::The specific uptake by rat liver of human (hGH) and bovine (bGH) GHs labeled with 125I was studied by an in vivo procedure. A significant reduction of the uptake was observed when labeled hormones were injected together with different amounts of the corresponding native GH. This reduction was dose dependent, and the c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-103-4-1190
更新日期:1978-10-01 00:00:00
abstract::Acute leptin increase as well as endogenous hyperleptinemia evoked by high-fat diets (HF) activate fatty acid metabolism in nonadipose tissues. This supports the notion that hyperleptinemia is pivotal to prevent/delay steatosis during periods of positive energy balance. We have previously shown that long-term HF spare...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1170
更新日期:2010-03-01 00:00:00
abstract::The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Fur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1070
更新日期:2011-11-01 00:00:00
abstract::Most of the constitutive hepatic P450 isoforms expressed in the rat exhibit dramatic gender differences. Whereas only male hepatocytes contain CYP2A2, 2C11, and 3A2, only female hepatocytes express CYP2C12 and 3- to 4-fold greater levels of CYP2C7. This sexually dimorphic expression of hepatic P450 isoforms is regulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.3.6545
更新日期:1999-03-01 00:00:00
abstract::Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220075
更新日期:2002-09-01 00:00:00
abstract::Gap junctions were observed on the lateral plasma membrane of the typical thyroid epithelial cell in freeze-fracture preparations of rat thyroid gland. The gap junctions were 0.1 to 0.4 mum in diameter and were composed of closely packed, approximately 80 nm particles. They were located from 1 to 6 mum from the apical...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-3-800
更新日期:1976-03-01 00:00:00
abstract::Neuropeptide Y (NPY) peptide concentrations in the arcuate nucleus have recently been shown to be modulated by gonadal steroids in the male rat. The present study was designed to determine whether NPY messenger RNA (mRNA)-synthesizing cells in the arcuate nucleus (Arc) of the male rat are regulated by testosterone (T)...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.132.1.8419120
更新日期:1993-01-01 00:00:00
abstract::Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.1.7917
更新日期:2001-01-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1), in the form of either GLP-1-(7-36)amide or GLP-1-(7-37), has been shown to potently stimulate insulin release in a glucose-dependent manner and is suggested to be a physiological incretin. To explore the mechanisms by which GLP-1-(7-36)amide stimulates insulin release, we investigated ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.4.8404610
更新日期:1993-10-01 00:00:00
abstract::Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast cancer cells (HBCCs) through down-regulation of the long form of the PRL receptor (PRLr). Here we report that 1) anandamide and 2-AG inhibit th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.1.7239
更新日期:2000-01-01 00:00:00
abstract::Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered iron regulation hormone is predominantly expressed in the liver, and regulated by iron and hypoxia. As an antimicrobial peptide, this hormone is also elevated during infections and inflammation. In this ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1626
更新日期:2008-08-01 00:00:00
abstract::Female rats were ovariectomized and either sham-pinealectomized or pinealectomized on day 24 of age and exposed to a photoperiod of 12 h light: 12 h dark. In vivo and in vitro measures of adrenocortical function were made at 6, 7, and 8 weeks of age (18, 25, and 32 days post-pinealectomy, respectively). Pinealectomy d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-1-20
更新日期:1976-01-01 00:00:00
abstract::Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1059
更新日期:2008-05-01 00:00:00
abstract::IGF binding proteins-3 and -4, whether given in the perfused rat heart or given iv in the intact animal, cross the microvascular endothelium of the heart and distribute in subendothelial tissues. IGF binding protein-3, like IGF-I/II, localizes in cardiac muscle, with lesser concentrations in CT elements. In contrast, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.9.8353
更新日期:2001-09-01 00:00:00