Maternal growth hormone treatment increases placental diffusion capacity but not fetal or placental growth in sheep.

abstract：:We have studied the two estrogen receptor (ER) subtypes, ER alpha and ER beta, and chimeric constructs with ER alpha and ER beta to examine the bioactivities of these receptors and their responses to estrogen and antiestrogen ligands. Transcriptional activity of ER beta is highly dependent on cell/promoter context and...

journal_title：Endocrinology

authors： McInerney EM,Weis KE,Sun J,Mosselman S,Katzenellenbogen BS

更新日期：1998-11-01 00:00:00

abstract：:An estrogen (E2)-dependent 90,000-92,000 M(r) protein is synthesized and released by the sheep oviduct in a temporally and regionally specific manner during the first few days of pregnancy, where it associates with the embryo. The present study was undertaken to further define the nature of this protein and its regula...

journal_title：Endocrinology

authors： DeSouza MM,Murray MK

更新日期：1995-06-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00

abstract：:Although LHRH can stimulate the release of both LH and FSH from the pituitary, there are a number of instances in which the secretion of LH and FSH are divergent. Previous studies from our laboratory have indicated that pulsatile LH and FSH secretion are independently regulated by gonadal factors. We have, therefore, ...

journal_title：Endocrinology

authors： Culler MD,Negro-Vilar A

更新日期：1986-02-01 00:00:00

abstract：:The preoptic area (POA) of the male dove is a known target area for separable behavioral actions of testosterone and 17 beta-estradiol (E2) and contains an active aromatase system. We have examined the regulatory influence of gonadal hormones on aromatase using an in vitro microassay that measures conversion of [1 alp...

journal_title：Endocrinology

authors： Hutchison JB,Steimer T

更新日期：1986-06-01 00:00:00

abstract：:One physiological role for endogenous opioid peptides is to attenuate the release of oxytocin (OT) from the hypothalamo-neurohypophysial system during dehydration and hemorrhage when vasopressin maintains fluid balance and blood pressure. During lactation, OT, which stimulates milk ejection, is released without vasopr...

journal_title：Endocrinology

authors： Hartman RD,Rosella-Dampman LM,Summy-Long JY

更新日期：1987-08-01 00:00:00

abstract：:Mouse uterine estrogen receptor (ER) was purified about 11,000-fold from normal mouse uteri by affinity chromatography. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified ER demonstrated a major component of 65,000 mol wt with minor fragments of the 54,000- and 37,000-dalton species, as judged b...

journal_title：Endocrinology

authors： Horigome T,Golding TS,Quarmby VE,Lubahn DB,McCarty K Sr,Korach KS

更新日期：1987-12-01 00:00:00

abstract：:Daily treatment with 1 mg of the GnRH antagonist [Ac-delta 3-Pro1,pC1-D-Phe2,D-Trp3,6,N alpha MeLeu7]-GnRH abolished mating behavior and disrupted spermatogenesis in male rats within 2 weeks. This was accompanied by a sharp decrease in plasma testosterone (T) levels as well as sexual organ weights while body weight re...

journal_title：Endocrinology

authors： Rivier C,Rivier J,Vale W

更新日期：1981-05-01 00:00:00

abstract：:Thyroid hormone (T3) is required for postnatal skeletal growth. It exerts its effect by binding to nuclear receptors, TRs including TRα1 and TRβ1, which are present in most cell types. These cell types include chondrocytes and osteoblasts, the interactions of which are known to regulate endochondral bone formation. In...

journal_title：Endocrinology

authors： Desjardin C,Charles C,Benoist-Lasselin C,Riviere J,Gilles M,Chassande O,Morgenthaler C,Laloé D,Lecardonnel J,Flamant F,Legeai-Mallet L,Schibler L

更新日期：2014-08-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:Hypoglycemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect of hypoglycemic episodes including a surge of sympathetic activity on the progression of neointima formation after vascular injury remains largely unknown. In this study, insulin was injected intraperi...

journal_title：Endocrinology

authors： Yasunari E,Mita T,Osonoi Y,Azuma K,Goto H,Ohmura C,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2014-06-01 00:00:00

abstract：:Estrogen receptor alpha and beta proteins (ERalpha and ERbeta) at various stages of development of the rat mammary gland were quantified by Western blotting. ERalpha and ERbeta recombinant proteins were used as standards, and their molar concentrations were measured by ligand binding assays. In 3-week-old pregnant, la...

journal_title：Endocrinology

authors： Saji S,Sakaguchi H,Andersson S,Warner M,Gustafsson J

更新日期：2001-07-01 00:00:00

abstract：:The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

journal_title：Endocrinology

authors： Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

更新日期：2020-03-01 00:00:00

abstract：:Chronic exposure to stressors impairs the function of multiple organ systems and has been implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and e...

journal_title：Endocrinology

authors： Borrow AP,Bales NJ,Stover SA,Handa RJ

更新日期：2018-07-01 00:00:00

abstract：:The possible role of atrial natriuretic factor (ANF) in the regulation of adrenal sensitivity to angiotensin II (AII) was investigated in vivo and in vitro by analyzing the characteristics of the inhibitory effect of ANF on aldosterone production stimulated by AII and other stimuli. In isolated adrenal glomerulosa cel...

journal_title：Endocrinology

authors： Aguilera G

更新日期：1987-01-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：UNLABELLED:Triple A syndrome is a rare, autosomal recessive cause of adrenal failure. Additional features include alacrima, achalasia of the esophageal cardia, and progressive neurodegenerative disease. The AAAS gene product is the nuclear pore complex protein alacrima-achalasia-adrenal insufficiency neurological disor...

journal_title：Endocrinology

authors： Prasad R,Metherell LA,Clark AJ,Storr HL

更新日期：2013-09-01 00:00:00

abstract：:Prolactin (PRL) is a vertebrate hormone with diverse actions in osmoregulation, metabolism, reproduction, and in growth and development. Osmoregulation is fundamental to maintaining the functional structure of the macromolecules that conduct the business of life. In teleost fish, PRL plays a critical role in osmoregul...

journal_title：Endocrinology

authors： Yamaguchi Y,Moriyama S,Lerner DT,Grau EG,Seale AP

更新日期：2016-09-01 00:00:00

abstract：:Follistatin (FS), which binds to the inhibin/activin beta A- or beta B-subunit is localized with and modulates the biological actions of activin in many systems. However, in contrast to the wide distribution of the activin beta-subunit proteins and messenger RNAs (mRNA) in the brain, demonstration of FS mRNA signal ha...

journal_title：Endocrinology

authors： Macconell LA,Barth S,Roberts VJ

更新日期：1996-05-01 00:00:00

abstract：:The hippocampus is essentially involved in learning and memory processes. Its functions are affected by various neuromodulators, including 17beta-estradiol, testosterone, and retinoid. Brain-synthesized steroid hormones act as autocrine and paracrine modulators. The regulatory mechanism underlying brain steroidogenesi...

journal_title：Endocrinology

authors： Munetsuna E,Hojo Y,Hattori M,Ishii H,Kawato S,Ishida A,Kominami SA,Yamazaki T

更新日期：2009-09-01 00:00:00

abstract：:Prostacyclin (PGI2) (1-5 micrograms in 3 microliters 0.05 M Tris/HCl buffer, pH 7.5) and its stable metabolite, 6-oxo-PGF1 alpha, were microinjected into the third ventricle of ovariectomized rats, and plasma FSH, GH, PRL, and TSH levels were measured by RIA. Control animals received 3 microliters buffer. Injection of...

journal_title：Endocrinology

authors： Ottlecz A,Samson WK,McCann SM

更新日期：1984-02-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:Newly discovered kisspeptin (metastin), encoded by the Kiss1/KISS1 gene, is considered as a major gatekeeper of puberty through the regulation of GnRH. In the present study, we cloned a novel kisspeptin gene (kiss2) in the zebrafish Danio rerio and the medaka Oryzias latipes, which encodes a sequence of 125 and 115 am...

journal_title：Endocrinology

authors： Kitahashi T,Ogawa S,Parhar IS

更新日期：2009-02-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00

abstract：:The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain express...

journal_title：Endocrinology

authors： Couse JF,Yates MM,Rodriguez KF,Johnson JA,Poirier D,Korach KS

更新日期：2006-08-01 00:00:00

abstract：:In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Rusvai E,Fejes-Tóth G

更新日期：1994-04-01 00:00:00

abstract：:A highly conserved region in the PTH promoter was identified using the basic local alignment search tool (BLAST) 2 Sequences comparison. Strong specific complexes were observed with a DNA probe that contained much of the computer-derived conserved sequence in the EMSA using bovine parathyroid gland (bPTG) nuclear extr...

journal_title：Endocrinology

authors： Alimov AP,Langub MC,Malluche HH,Koszewski NJ

更新日期：2003-07-01 00:00:00

abstract：:Within the preoptic region, nitric oxide (NO) production varies during the ovarian cycle and has the ability to impact hypothalamic reproductive function. One mechanism for the regulation of NO release mediated by estrogens during the estrous cycle includes physical association of the calcium-activated neuronal NO syn...

journal_title：Endocrinology

authors： Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V

更新日期：2010-06-01 00:00:00

abstract：:Patients with Graves' disease and exophthalmos demonstrate delayed hypersensitivity to antigens present in extracts of certain normal human tissue; namely,thyroid gland and retroorbital tissue. The delayed hypersensitivity can be assayed in vitro by quantitating the amount of a lymphokine, migration inhibition factor ...

journal_title：Endocrinology

authors： Mullin BR,Levinson RE,Friedman A,Henson DE,Winand RJ,Kohn LD

更新日期：1977-02-01 00:00:00