Positive regulation of steroidogenic acute regulatory protein gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis.

abstract：:We tested the hypothesis that chronic maternal GH administration would increase fetal substrate supply, increase maternal and fetal insulin-like growth factor I (IGF-I) concentrations, and therefore enhance growth in the late gestation fetal sheep. Eleven ewes received bovine GH 0.1 mg/kg twice daily for 10 days, wher...

journal_title：Endocrinology

authors： Harding JE,Evans PC,Gluckman PD

更新日期：1997-12-01 00:00:00

abstract：:We have recently found that, in the frog adrenal gland, endozepines are present in chromaffin cells and we have shown that the triakontatetraneuropeptide TTN is a potent stimulator of corticosteroid secretion in vitro. In the present study, we have investigated the transduction mechanisms mediating the corticotropic e...

journal_title：Endocrinology

authors： Lesouhaitier O,Kodjo MK,Cartier F,Contesse V,Yon L,Delarue C,Vaudry H

更新日期：2000-01-01 00:00:00

abstract：:Some 17 alpha-alkylated androgens used as anabolic agents, such as stanozolol (ST) and danazol (DA), have specific effects on the liver that are not exerted by testosterone. This gives rise to the possibility that a steroid-binding protein, other than the androgen receptor, could modulate the intracellular actions of ...

journal_title：Endocrinology

authors： Fernández L,Chirino R,Boada LD,Navarro D,Cabrera N,del Rio I,Díaz-Chico BN

更新日期：1994-03-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is known to be involved in maintaining glucose homeostasis, and AVP-resistance is observed in poorly controlled non-insulin-dependent diabetes mellitus subjects, resulting in a lowered plasma volume. Recently we reported that V1a vasopressin receptor-deficient (V1aR(-/-)) mice exhibited a de...

journal_title：Endocrinology

authors： Aoyagi T,Birumachi J,Hiroyama M,Fujiwara Y,Sanbe A,Yamauchi J,Tanoue A

更新日期：2007-05-01 00:00:00

abstract：:Human pituitary prolactin (hPRL) contains a single major component. Upon iodination by a lactoperoxidase procedure approximately 50% of this component remains ulaltered in molecular size and net charge by the criteria of quantitative polyacrylamide gel electrophoresis (PAGE). Aminiotic fluid hPRL contains two componen...

journal_title：Endocrinology

authors： Rogol AD,Chrambach A

更新日期：1975-08-01 00:00:00

abstract：:The developmental patterns of thyroid-stimulating hormone (TSH) was examined in female Long-Evans rats by radioimmunoassay of pituitary and plasma from 5 through 80 days of age. The effects of hypothyroidism on normal TSH levels were examined in animals radiothyroidectomized at birth. Control animals showed a peak in ...

journal_title：Endocrinology

authors： Cons JM,Umezu M,Timiras PS

更新日期：1975-07-01 00:00:00

abstract：:Reports of estrone (E1) and dehydroepiandrosterone (DHEA) sulfatase (sulfohydrolase) activities within many human breast cancers have prompted us to undertake the identification and partial characterization of these enzyme activities within MCF-7 human breast cancer cells. Enzyme assays were performed within subcellul...

journal_title：Endocrinology

authors： MacIndoe JH

更新日期：1988-09-01 00:00:00

abstract：:Nowadays, we are bombarded with information on a large number of endocrine-disrupting chemicals. We hear and read about endocrine-disrupting chemicals on blogs, the web, news stories, television specials, advertisements, and of course scientific articles. Reports claim these ubiquitous compounds are responsible for in...

journal_title：Endocrinology

authors： Rissman EF

更新日期：2016-08-01 00:00:00

abstract：:The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. I...

journal_title：Endocrinology

authors： Moore XL,Tan SL,Lo CY,Fang L,Su YD,Gao XM,Woodcock EA,Summers RJ,Tregear GW,Bathgate RA,Du XJ

更新日期：2007-04-01 00:00:00

abstract：:In this study, we investigated the transcriptional regulation of the adrenergic induction of type II iodothyronine deiodinase (Dio2) in rat pinealocytes. Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and...

journal_title：Endocrinology

authors： Chik CL,Wloka MT,Price DM,Ho AK

更新日期：2007-07-01 00:00:00

abstract：:Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data in vivo. Hence, the objective of our study was to examine the...

journal_title：Endocrinology

authors： Audette MC,Challis JR,Jones RL,Sibley CP,Matthews SG

更新日期：2011-09-01 00:00:00

abstract：:Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin...

journal_title：Endocrinology

authors： Ismail F,Epstein S,Fallon MD,Thomas SB,Reinhardt TA

更新日期：1988-02-01 00:00:00

abstract：:Single-minded 1 (SIM1) mutations are associated with obesity in mice and humans. Haploinsufficiency of mouse Sim1 causes hyperphagic obesity with increased linear growth and enhanced sensitivity to a high-fat diet, a phenotype similar to that of agouti yellow and melanocortin 4 receptor knockout mice. To investigate t...

journal_title：Endocrinology

authors： Kublaoui BM,Holder JL Jr,Tolson KP,Gemelli T,Zinn AR

更新日期：2006-10-01 00:00:00

abstract：:Hypothalamic inflammation and gliosis are proposed to participate in the pathogenesis of high-fat diet-induced obesity. Because other factors and nutrients also induce weight gain and adiposity, we analyzed the inflammatory and glial responses to a sucrose (S)-enriched diet. Neonatal overnutrition (NON) exacerbates we...

journal_title：Endocrinology

authors： Fuente-Martín E,García-Cáceres C,Díaz F,Argente-Arizón P,Granado M,Barrios V,Argente J,Chowen JA

更新日期：2013-07-01 00:00:00

abstract：:T4 dynamically regulates the levels of type II iodothyronine 5'-deiodinase in the brain. Using an astrocyte cell culture model, we have shown that thyroxine increases inactivation of this enzyme through a mechanism using the actin cytoskeleton. In the absence of T4, the filamentous actin (F-actin) stress fibers are ab...

journal_title：Endocrinology

authors： Farwell AP,Leonard JL

更新日期：1992-08-01 00:00:00

abstract：:Complementary DNA-encoding proteins with high homology to steroidogenic acute regulatory proteins (StAR) of mammals were cloned from rainbow trout head kidney and a mixture of several brook trout tissues. A cDNA encoding an MLN64 homolog was also cloned from brook trout. The C-terminal domains of rainbow trout StAR an...

journal_title：Endocrinology

authors： Kusakabe M,Todo T,McQuillan HJ,Goetz FW,Young G

更新日期：2002-06-01 00:00:00

abstract：:The role of the carboxy-terminal domain of the Glut 1 glucose transporter was investigated using an antipeptide antibody to the C-terminal part of the molecule. The study was performed in fibroblasts transfected with the cDNA coding for the human insulin receptor. These cells acutely respond to insulin for glucose tra...

journal_title：Endocrinology

authors： Tanti JF,Gautier N,Cormont M,Baron V,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1992-11-01 00:00:00

abstract：:A cell-free system was used to characterize the binding reaction between the progesterone receptor and nuclear acceptor sites prepared from rat placenta. Two forms of receptor-acceptor complex were examined. One was extracted from nuclei by exposure to 0.6 M KCl; the other type was resistant to salt extraction. Kineti...

journal_title：Endocrinology

authors： Ogle TF

更新日期：1987-07-01 00:00:00

abstract：:We have demonstrated TSH binding sites in membranes prepared from guinea pig testis. The binding of TSH to testicular homogenate was localized to the interstitial tissue and showed similar characteristics to the binding of TSH to thyroid membranes with high affinity (Ka = 2.5 X 10(10) M-1) but limited capacity (approx...

journal_title：Endocrinology

authors： Davies TF,Smith BR,Hall R

更新日期：1978-07-01 00:00:00

abstract：:Vitellogenin (Vg) is a major yolk protein precursor in numerous oviparous animals. Numerous studies in bilateral oviparous animals have shown that Vg sequences are conserved across taxa and that Vgs are synthesized by somatic-cell lineages, transported to and accumulated in oocytes, and eventually used for supporting ...

journal_title：Endocrinology

authors： Shikina S,Chen CJ,Chung YJ,Shao ZF,Liou JY,Tseng HP,Lee YH,Chang CF

更新日期：2013-09-01 00:00:00

abstract：:The distribution of peptide YY (PYY)-like immunoreactivity (IR) in rat tissues was determined by specific RIA after extraction with boiled 1 N acetic acid. The high concentration of PYY-IR was observed in the gastrointestinal tract, with concentrations gradually increasing from the duodenum to the end of colon. The co...

journal_title：Endocrinology

authors： Miyachi Y,Jitsuishi W,Miyoshi A,Fujita S,Mizuchi A,Tatemoto K

更新日期：1986-06-01 00:00:00

abstract：:Remodeling of maternal spiral arteries during pregnancy requires a subpopulation of extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown to promote trophoblast invasion, but its role in endovascular differ...

journal_title：Endocrinology

authors： Li Y,Zhu H,Klausen C,Peng B,Leung PC

更新日期：2015-11-01 00:00:00

abstract：:The ability of different LH-like hormones, such as hCG, PMSG/equine (e) CG, ovine (o) LH, eLH, and rat (r) LH, to bind to and stimulate steroidogenesis in two types of rat gonadal cells was studied under the same experimental conditions. In both Leydig and granulosa cells, the maximal steroidogenic responses elicited ...

journal_title：Endocrinology

authors： Rani CS,Moudgal NR

更新日期：1985-02-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:Recently, California condors (Gymnogyps californianus) have been reintroduced to coastal regions of California where they feed on marine mammal carcasses. There is evidence that coastal-dwelling condors experience reproductive issues, such as eggshell thinning, likely resulting from exposure to endocrine-disrupting ch...

journal_title：Endocrinology

authors： Felton RG,Steiner CC,Durrant BS,Keisler DH,Milnes MR,Tubbs CW

更新日期：2015-12-01 00:00:00

abstract：:The level of fructose 2,6-bisphosphate (F2,6P2), a potent stimulator of 6-phosphofructo-1-kinase and inhibitor of fructose 1,6-bisphosphatase, was measured in three different muscle types (tensor fascia latae, biceps femoris, and soleus) and in the liver of normal and diabetic rats. The mean (+/- SEM) content of F2,6P...

journal_title：Endocrinology

authors： Dall'Aglio E,Reaven GM,Azhar S

更新日期：1986-01-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (17HSD) catalyzes the reversible conversion of estrone into estradiol. The complementary DNA (cDNA) coding for rat 17HSD type 1 was cloned from a commercial rat ovarian cDNA library, using human 17HSD type 1 cDNA as a probe. The nucleotide sequence extends for 1160 basepairs (bp), ...

journal_title：Endocrinology

authors： Ghersevich S,Nokelainen P,Poutanen M,Orava M,Autio-Harmainen H,Rajaniemi H,Vihko R

更新日期：1994-10-01 00:00:00

abstract：:The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...

journal_title：Endocrinology

authors： Youssef A,Iosef C,Han VK

更新日期：2014-04-01 00:00:00

abstract：:3-Iodothyronamine (3-T1AM) is an endogenous thyroid hormone (TH)-derived metabolite that induces severe hypothermia in mice after systemic administration; however, the underlying mechanisms have remained enigmatic. We show here that the rapid 3-T1AM-induced loss in body temperature is a consequence of peripheral vasod...

journal_title：Endocrinology

authors： Gachkar S,Oelkrug R,Martinez-Sanchez N,Rial-Pensado E,Warner A,Hoefig CS,López M,Mittag J

更新日期：2017-06-01 00:00:00

abstract：:Kisspeptin neurons play an essential role in the regulation of fertility through direct regulation of the GnRH neurons. However, the relative contributions of the two functionally distinct kisspeptin neuron subpopulations to this critical regulation are not fully understood. Here we analyzed the specific projection pa...

journal_title：Endocrinology

authors： Yip SH,Boehm U,Herbison AE,Campbell RE

更新日期：2015-07-01 00:00:00