Sex-Specific Modulation of Fetal Adipogenesis by Gestational Bisphenol A and Bisphenol S Exposure.

abstract：:Basal or hypothalamic extract-induced ACTH or TSH secretory capacity as well as intracellular ACTH content were assessed in cultured rat adenohypophyseal cells after various pretreatments of the donor animals. Medium and intracellular ACTH or TSH were measured by radioimmunoassay. Ten-day to 2-month adrenalectomy enha...

journal_title：Endocrinology

authors： Yasuda N,Takebe K,Greer MA

更新日期：1976-03-01 00:00:00

abstract：:Immunohistochemical localization of two estrogen receptor (ER) subtypes, ER beta and ER alpha, was performed in neonatal, early postnatal, immature, and adult rats to determine whether ER alpha and ER beta are differentially expressed in the ovary. ER beta and ER alpha were visualized using a polyclonal anti-ER beta a...

journal_title：Endocrinology

authors： Sar M,Welsch F

更新日期：1999-02-01 00:00:00

abstract：:To determine the relationship between the concentrations of serum T3 and hepatic nuclear T3 receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results...

journal_title：Endocrinology

authors： Las MS,Surks MI

更新日期：1981-10-01 00:00:00

abstract：:Cannabinoids (CBs) exert untoward effects on reproduction by reducing LH secretion and suppressing gonadal function. Recent evidence suggests these effects are due primarily to hypothalamic dysfunction; however, the mechanism is obscure. Using immortalized hypothalamic GnRH neurons, we find these cells produce and sec...

journal_title：Endocrinology

authors： Gammon CM,Freeman GM Jr,Xie W,Petersen SL,Wetsel WC

更新日期：2005-10-01 00:00:00

abstract：:The biological activity of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], 23(S)25(R)-1 alpha,25(OH)2D3-26,23-lactone, and three intermediate metabolites of the lactone in vivo and in vitro was comparatively examined. The three intermediate metabolites, 1 alpha,25(R)26(OH)3D3, 1 alpha,23(S)25(R)26(OH)4D3, and 23(S...

journal_title：Endocrinology

authors： Ishizuka S,Sumitani K,Hiura K,Kawata T,Okawa M,Hakeda Y,Kumegawa M

更新日期：1990-08-01 00:00:00

abstract：:Apoptosis is the process of cellular self-destruction, and genes such as bcl-2 and bax are known to inhibit and promote apoptosis, respectively. In this study, we show that apoptosis can be induced in pancreatic beta-cell lines, and we investigate the apoptotic pathways through the bcl-2 and bax genes and intracellula...

journal_title：Endocrinology

authors： Mizuno N,Yoshitomi H,Ishida H,Kuromi H,Kawaki J,Seino Y,Seino S

更新日期：1998-03-01 00:00:00

abstract：:The membrane fraction from the ovaries of pseudopregnant rats exhibits specific, high affinity binding of high density lipoproteins (HDL). Previous studies have indicated that HDL binding in this tissue is up-regulated by hCG and may be involved in supplying cholesterol as substrate for steroid hormone production. To ...

journal_title：Endocrinology

authors： Ferreri K,Menon KM

更新日期：1990-04-01 00:00:00

abstract：:The binding of oxytocin (OT) to receptors in rabbit amnion cells stimulates PGE2 release. We previously studied the binding characteristics, changes in receptor concentration during pregnancy, and agonist specificity of OT action on amnion cells. In this study the molecular size of OT receptors in rabbit amnion was es...

journal_title：Endocrinology

authors： Hinko A,Soloff MS,Potier M

更新日期：1992-06-01 00:00:00

abstract：:Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at...

journal_title：Endocrinology

authors： Otsuka N,Tong ZB,Vanevski K,Tu W,Cheng MH,Nelson LM

更新日期：2011-06-01 00:00:00

abstract：:A thyroid transcription factor-1 (TTF-1)-binding element in the rat TSH receptor (TSHR) promoter, between -189 and -175 basepairs (bp), is important for both thyroid-specific expression and thyroid-specific TSH/cAMP autoregulation of the TSHR. The identification of an up-stream TTF-1-binding site and its relationship ...

journal_title：Endocrinology

authors： Ohmori M,Shimura H,Shimura Y,Ikuyama S,Kohn LD

更新日期：1995-01-01 00:00:00

abstract：:The effects of insulin and glucose, alone and combined, on diacylglycerol (DAG), protein kinase-C (PKC), and glucose transport were compared in rat adipocytes and solei incubated in medium containing 0-20 mM glucose. In both tissues insulin rapidly stimulated [3H]DAG production from [3H]glycerol; extracellular glucose...

journal_title：Endocrinology

authors： Hoffman JM,Ishizuka T,Farese RV

更新日期：1991-06-01 00:00:00

abstract：:We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Here we delineated whether increased glucose flux through the hexosamine biosynthesis pathway (HBP) ca...

journal_title：Endocrinology

authors： Bhonagiri P,Pattar GR,Horvath EM,Habegger KM,McCarthy AM,Elmendorf JS

更新日期：2009-04-01 00:00:00

abstract：:The involvement of IGF-I in mammary carcinogenesis is well established, but the role of GH, as an autocrine growth factor for breast cancers is poorly understood. The goal of our study was to investigate whether antagonists of GHRH can interfere with the effects of GH and IGF-I in MXT mouse mammary cancers. GHRH antag...

journal_title：Endocrinology

authors： Szepeshazi K,Schally AV,Armatis P,Groot K,Hebert F,Feil A,Varga JL,Halmos G

更新日期：2001-10-01 00:00:00

abstract：:The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...

journal_title：Endocrinology

authors： Hauner H

更新日期：1990-08-01 00:00:00

abstract：:Spontaneously hypertensive (SH) rats, extensively used as experimental models of essential human hypertension, display important alterations in the neuroendocrine reproductive axis, which manifest as markedly delayed puberty onset in females but whose basis remains largely unknown. We analyze herein in female SH rats:...

journal_title：Endocrinology

authors： Pinilla L,Castellano JM,Romero M,Tena-Sempere M,Gaytán F,Aguilar E

更新日期：2009-06-01 00:00:00

abstract：:The DNA binding protein nuclear factor-kappaB (NF-kappaB) is a transcription factor translocated from the cytosol to the nucleus in response to stressors. Here we determined whether the known ability of alcohol to activate the hypothalamic-pituitary axis was mediated by NF-kappaB, tested the hypothesis that this pheno...

journal_title：Endocrinology

authors： Lee S,Rivier C

更新日期：2005-04-01 00:00:00

abstract：:Complementary DNAs encoding two forms of cocaine- and amphetamine-regulated transcript (CART) peptide precursors were identified from goldfish brain and named CART I and CART II. Each cDNA contains a signal peptide sequence, the putative CART-like peptide, and a carboxy-terminal extension peptide. Form I encodes a 117...

journal_title：Endocrinology

authors： Volkoff H,Peter RE

更新日期：2001-12-01 00:00:00

abstract：:The effect of an activator of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the 5'-deiodinase (5'D) activity was studied in rat astroglial cells cultured in chemically defined medium. TPA promoted a large increase in the type II 5'D activity, which was maximal 5-10 h after addition of TPA and then d...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Gavaret JM,Toru-Delbauffe D,Jacquemin C,Pierre M

更新日期：1989-09-01 00:00:00

abstract：:Nitric oxide (NO) has emerged as an intracellular and intercellular messenger in a number of biological systems. In the present study, we demonstrated that NO was produced by cultured rat Leydig cells, and that inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) was expressed in Leydig cells. NO was measured a...

journal_title：Endocrinology

authors： Tatsumi N,Fujisawa M,Kanzaki M,Okuda Y,Okada H,Arakawa S,Kamidono S

更新日期：1997-03-01 00:00:00

abstract：:We investigated the effect of glucocorticoid on the generation of osteoclasts. In mouse bone marrow culture systems, dexamethasone, a synthetic glucocorticoid analog, enhanced osteoclast-like cell formation induced by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] in a dose-dependent manner. Conversely, dexamethasone inhibit...

journal_title：Endocrinology

authors： Shuto T,Kukita T,Hirata M,Jimi E,Koga T

更新日期：1994-03-01 00:00:00

abstract：:Daily treatment with 1 mg of the GnRH antagonist [Ac-delta 3-Pro1,pC1-D-Phe2,D-Trp3,6,N alpha MeLeu7]-GnRH abolished mating behavior and disrupted spermatogenesis in male rats within 2 weeks. This was accompanied by a sharp decrease in plasma testosterone (T) levels as well as sexual organ weights while body weight re...

journal_title：Endocrinology

authors： Rivier C,Rivier J,Vale W

更新日期：1981-05-01 00:00:00

abstract：:Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in oste...

journal_title：Endocrinology

authors： McCarthy TL,Centrella M,Canalis E

更新日期：1989-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a cold-induced protein expressed in brown adipose tissue (BAT), plays a role in adaptive thermogenesis by up-regulating uncoupling proteins (UCP). Here, we explore its relationship to the thermogenic actions of leptin, which also up-regulates UCPs...

journal_title：Endocrinology

authors： Kakuma T,Wang ZW,Pan W,Unger RH,Zhou YT

更新日期：2000-12-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) receptor is a transmembrane tyrosine kinase that mediates the growth-promoting effects of IGF-I and IGF-II. Changes in IGF-I receptor messenger RNA levels are reflected in cell surface receptor number, and modulation of IGF-I receptor levels affects tumorigenicity in numerous c...

journal_title：Endocrinology

authors： Tajinda K,Carroll J,Roberts CT Jr

更新日期：1999-10-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cance...

journal_title：Endocrinology

authors： Li J,Feng Q,Kim JM,Schneiderman D,Liston P,Li M,Vanderhyden B,Faught W,Fung MF,Senterman M,Korneluk RG,Tsang BK

更新日期：2001-01-01 00:00:00

abstract：:Animals shipped from commercial suppliers to laboratories are exposed to a wide variety of stressors. Female C57Bl6/J mice shipped during the peripubertal/adolescent period (6 wk old) display lower levels of female sexual behavior in response to estradiol and progesterone injections after ovariectomy when tested in ad...

journal_title：Endocrinology

authors： Laroche J,Gasbarro L,Herman JP,Blaustein JD

更新日期：2009-05-01 00:00:00

abstract：:We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in the model. Female GH-deficient dwarf rats fed a high-fat diet became obese and insulin-resistant compared with chow-fed controls. They were treated with recombi...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Carlsson B,Carmignac D,Robinson IC

更新日期：1996-05-01 00:00:00

abstract：:Studies in rodents demonstrate that the mitogen, IGF-I, stimulates intestinal peptide YY (PYY) expression. To investigate whether the stimulatory influence of IGF-I is exerted at the level of gene transcription, rat PYY 5'-upstream sequences (-2800/+37 bp, -770/+37 bp, -127/+37 bp) fused to the firefly luciferase (luc...

journal_title：Endocrinology

authors： Wang G,Leiter AB,Englander EW,Greeley GH Jr

更新日期：2004-02-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00