Insulin-like growth factor-1 regulation of alpha(1)-adrenergic receptor signaling is estradiol dependent in the preoptic area and hypothalamus of female rats.

abstract：:Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes. Hepatocytes were freshly isolated from Sprague-Dawley rats treated with dexamethasone (1 mg/kg) for 4 days and from untreated littermates. Dexamet...

journal_title：Endocrinology

authors： Karasik A,Kahn CR

更新日期：1988-11-01 00:00:00

abstract：:Since hypophysectomy and GH deficiency are associated with decreases in hypothalamic content and release of SRIF, it was of interest to determine whether these hormonal alterations also affect peripheral tissue levels of SRIF. Hypophysectomized (hypox) rats were studied at various times after surgery and compared with...

journal_title：Endocrinology

authors： Recant L,Voyles NR,Wilkins SD,Fairtile RD,King C

更新日期：1984-12-01 00:00:00

abstract：:We previously reported that TNF-alpha-induced apoptosis of lactotropes is estrogen dependent and predominant at proestrus. Here we observed that TNF-alpha (50 ng/ml) failed to induce apoptosis of anterior pituitary cells from ovariectomized rats cultured in the presence of progesterone (10(-6) m). However, progesteron...

journal_title：Endocrinology

authors： Candolfi M,Jaita G,Zaldivar V,Zárate S,Ferrari L,Pisera D,Castro MG,Seilicovich A

更新日期：2005-02-01 00:00:00

abstract：:The receptor for the orexigenic peptide, ghrelin, is one of the most constitutively active 7TM receptors known, as demonstrated under in vitro conditions. Change in expression of a constitutively active receptor is associated with change in signaling independent of the endogenous ligand. In the following study, we fou...

journal_title：Endocrinology

authors： Petersen PS,Woldbye DP,Madsen AN,Egerod KL,Jin C,Lang M,Rasmussen M,Beck-Sickinger AG,Holst B

更新日期：2009-11-01 00:00:00

abstract：:The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some anim...

journal_title：Endocrinology

authors： Bambino TH,Hsueh AJ

更新日期：1981-06-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...

journal_title：Endocrinology

authors： Urbano AG,Suárez-Peñaranda JM,Diéguez C,Alvarez CV

更新日期：2000-05-01 00:00:00

abstract：:A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...

journal_title：Endocrinology

authors： Mroczkowski B,Reich M

更新日期：1993-01-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:We recently identified a 32 K mol wt insulin-like growth factor (IGF)-binding protein (BP) which is markedly increased in the serum of streptozotocin-diabetic rats and recognized by antiserum against the human amniotic fluid IGFBP (hIGFBP-1). In the present study we sought to confirm that this protein represents the r...

journal_title：Endocrinology

authors： Unterman TG,Oehler DT,Gotway MB,Morris PW

更新日期：1990-08-01 00:00:00

abstract：:Initiation of folliculogenesis through the induction of primordial follicle development in the ovary has an important role in determining the fertility and reproductive fitness of most mammalian species. The factors that control this critical process are largely unknown. The hypothesis tested in the current study was ...

journal_title：Endocrinology

authors： Parrott JA,Skinner MK

更新日期：1999-09-01 00:00:00

abstract：:The site(s) of the negative feedback action of estrogen on gonadotropin secretion were studied in the ovariectomized rhesus monkey by observing the serum LH and FSH responses to intravenous GnRH injections at various times after implantation of Silastic capsules filled with estrogen. Circulating estrogen concentration...

journal_title：Endocrinology

authors： Weick RF,Pitelka V,Thompson DL

更新日期：1983-05-01 00:00:00

abstract：:The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various transcriptional coregulators of MR is essential for understanding the compl...

journal_title：Endocrinology

authors： Kuppusamy M,Gomez-Sanchez EP,Beloate LN,Plonczynski M,Naray-Fejes-Toth A,Fejes-Toth G,Gomez-Sanchez CE

更新日期：2017-07-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:Mitochondrial reactive oxygen species have been implicated in both diabetic complications and the progression of the underlying diabetic state. However, it is not clear whether mitochondria of diabetic origin are intrinsically altered to generate excess reactive oxygen species independent of the surrounding diabetic m...

journal_title：Endocrinology

authors： Herlein JA,Fink BD,O'Malley Y,Sivitz WI

更新日期：2009-01-01 00:00:00

abstract：:The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone (GHRH)-containing neurosecretory cells located in the hypothalamus. In this study we examined whether there is s...

journal_title：Endocrinology

authors： Argente J,Chowen JA,Zeitler P,Clifton DK,Steiner RA

更新日期：1991-05-01 00:00:00

abstract：:Sclerostin (SOST), a member of the cystine-knot superfamily, is essential for proper skeletogenesis because a loss-of-function mutation in the SOST gene results in sclerosteosis featured with massive bone growth in humans. To understand the function of SOST in developmental skeletal tissue formation, we examined SOST ...

journal_title：Endocrinology

authors： Ohyama Y,Nifuji A,Maeda Y,Amagasa T,Noda M

更新日期：2004-10-01 00:00:00

abstract：:We have measured the concentrations of vasopressin in sequential samples of cerebrospinal fluid (CSF) obtained from fetal lambs between 108 and 130 days gestation. There was a clear and significant (F = 4.46; P less than 0.005) rhythm in vasopressin concentrations in the CSF of nine fetuses, characterized by a mean tr...

journal_title：Endocrinology

authors： Stark RI,Daniel SS

更新日期：1989-06-01 00:00:00

abstract：:Normal fetal preoptic area (POA), a site of GnRH production, was implanted into the third ventricle of adult female hypogonadal (hpg) mice. When the grafts were successful, the mice (genetically deficient in hypothalamic GnRH) responded with vaginal opening, cornified vaginal cells, ovarian and uterine development, an...

journal_title：Endocrinology

authors： Gibson MJ,Charlton HM,Perlow MJ,Zimmerman EA,Davies TF,Krieger DT

更新日期：1984-05-01 00:00:00

abstract：:Angiotensin II (Ang II) is one of numerous hormones recently shown to be synthesized and secreted by adipose cells. Although the function of Ang II in adipose tissue is unknown, several studies indirectly suggest that it may be involved in control of adiposity. Little is known, however, about direct actions of Ang II ...

journal_title：Endocrinology

authors： Jones BH,Standridge MK,Moustaid N

更新日期：1997-04-01 00:00:00

abstract：:We recently reported that bone morphogenetic proteins (BMPs) 2 and 4 can stimulate FSHbeta-subunit (Fshb) transcription alone and in synergy with activins. We further showed that BMP2 signals via the BMP type IA receptor (or activin receptor-like kinase 3) to mediate its effects. However, the intracellular mechanisms ...

journal_title：Endocrinology

authors： Ho CC,Bernard DJ

更新日期：2010-07-01 00:00:00

abstract：:We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the mechanisms involved are unknown. SK-N-MC cells were cultured with FGF-2 (50 ng/ml) and/or IGF-I (100 ng/ml) up to 48 h. Fluorescence-activated ce...

journal_title：Endocrinology

authors： Higgins S,Wong SH,Richner M,Rowe CL,Newgreen DF,Werther GA,Russo VC

更新日期：2009-09-01 00:00:00

abstract：:Recent studies from our laboratory (Endocrinology 136:4762-4768, 1995) demonstrating that the expression of cAMP-dependent nuclear transcription factor CREB (cAMP response element binding protein) is lost following ovulation in macaques has revealed a novel mechanism by which the cytoplasmic and nuclear actions the cA...

journal_title：Endocrinology

authors： Benyo DF,Zeleznik AJ

更新日期：1997-08-01 00:00:00

abstract：:A mitochondrial fraction prepared from homogenates of rat hypothalamic tissue was found by means of electron microscopy to be enriched with synaptosomes. The release of luteinizing hormone releasing hormone (LHRH) and thyrotropin releasing hormone (TRH) from this preparation was investigated. After incubation, the syn...

journal_title：Endocrinology

authors： Warberg J,Eskay RL,Barnea A,Reynolds RC,Porter JC

更新日期：1977-03-01 00:00:00

abstract：:Age-associated changes in the reproductive hormones-the gonadal steroid hormones and the gonadotropins-have been identified as potential risk factors for Alzheimer's disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotro...

journal_title：Endocrinology

authors： Barron AM,Verdile G,Taddei K,Bates KA,Martins RN

更新日期：2010-11-01 00:00:00

abstract：:The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined whether they are mediated through prostaglandin-dependent pathways. Bone resorption, collagen, and non-collagen protein synthesis and inositol phosphate (IP) produ...

journal_title：Endocrinology

authors： Tatrai A,Foster S,Lakatos P,Shankar G,Stern PH

更新日期：1992-08-01 00:00:00

abstract：:GnRH is detectable in the cerebrospinal fluid (CSF), but its source remains unidentified. Previous studies have harvested CSF for GnRH analysis from the median eminence region, but it is unknown whether GnRH in CSF is restricted to this region. If CSF-GnRH plays a physiological role, through volume transmission, to co...

journal_title：Endocrinology

authors： Caraty A,Skinner DC

更新日期：2008-10-01 00:00:00

abstract：:The ontogenic changes in the somatotroph's responsiveness to TRH were examined in enzymatically dissociated rat pituitary cells in primary monolayer culture. Exposure to TRH (10(-8) M) caused a significant increase in GH release in cultured pituitary cells from rats ranging in age from -1 day (20 days of gestational a...

journal_title：Endocrinology

authors： Welsh JB,Cuttler L,Szabo M

更新日期：1986-11-01 00:00:00

abstract：:Like insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-5 forms a ternary complex with insulin-like growth factor (IGF)-I or IGF-II, and the acid-labile subunit (ALS). The study of IGFBP-5/IGFBP-6 chimeric proteins with amino-terminal and middle domain swaps, has revealed the existence of a site in the midd...

journal_title：Endocrinology

authors： Twigg SM,Kiefer MC,Zapf J,Baxter RC

更新日期：2000-01-01 00:00:00

abstract：:We previously demonstrated that the mitochondrial peripheral-type benzodiazepine receptor (PBR) is coupled to hormone-activated steroidogenesis by regulating the intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. In the present study we examined whether PBR is the site of horm...

journal_title：Endocrinology

authors： Boujrad N,Gaillard JL,Garnier M,Papadopoulos V

更新日期：1994-10-01 00:00:00

abstract：:Physiological roles for PTH-related peptide (PTHrP) appear varied, but remain to be clarified. The peptide is present in large amounts in milk, and PTHrP mRNA has been shown to be present in high amounts in lactating mammary gland. Because PTHrP can cause smooth muscle relaxation, we hypothesized that the peptide migh...

journal_title：Endocrinology

authors： Seitz PK,Cooper KM,Ives KL,Ishizuka J,Townsend CM Jr,Rajaraman S,Cooper CW

更新日期：1993-09-01 00:00:00