Intermittent parathyroid hormone treatment increases osteoblast number, steady state messenger ribonucleic acid levels for osteocalcin, and bone formation in tibial metaphysis of hypophysectomized female rats.

abstract：:PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH ...

journal_title：Endocrinology

authors： Ben-awadh AN,Delgado-Calle J,Tu X,Kuhlenschmidt K,Allen MR,Plotkin LI,Bellido T

更新日期：2014-08-01 00:00:00

abstract：:Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...

journal_title：Endocrinology

authors： Tanaka M,Hayashida Y,Iguchi T,Nakao N,Nakai N,Nakashima K

更新日期：2001-08-01 00:00:00

abstract：:The objective of this study was to assess estrogen-dependent cellular mechanisms that could contribute to the acid pH of the vaginal lumen. Cultures of normal human cervical-vaginal epithelial (hECE) cells and endocervical cells were grown on filters, and acidification of the extracellular solutions on the luminal (L-...

journal_title：Endocrinology

authors： Gorodeski GI,Hopfer U,Liu CC,Margles E

更新日期：2005-02-01 00:00:00

abstract：:Monolayer cultures of mouse adrenal tumor cell line Y-1 have been used to investigate the effects of glucocorticoid on cell replication, [3H]thymidine incorporation into the trichloroacetic acid-precipitated cell fraction, steroidogenesis, and the ACTH receptors of adrenocortical cells. Corticosterone at a concentrati...

journal_title：Endocrinology

authors： Saito E,Mukai M,Muraki T,Ichikawa Y,Homma M

更新日期：1979-02-01 00:00:00

abstract：:Continuous labeling of primary cultures of human syncytiotrophoblasts with [125I]iodoepidermal growth factor (iodo-EGF) at 37 C revealed a progressive increase in intracellular EGF with 5% of total label observed in intracellular organelles at 2 min and 88% by 60 min. Detailed analysis by electron microscope radioauto...

journal_title：Endocrinology

authors： Lai WH,Guyda HJ,Bergeron JJ

更新日期：1986-01-01 00:00:00

abstract：:Light and electron microscopic triple immunostaining was performed on coronal vibratome sections prepared from the hypothalamus of ovariectomized (OVX) and OVX plus estrogen-treated African green monkeys (Cercopithecus aethiops). Immunoreactivity for progesterone receptors (PRs) and neuropeptide-Y (NPY) was visualized...

journal_title：Endocrinology

authors： Horvath TL,Shanabrough M,Naftolin F,Leranth C

更新日期：1993-07-01 00:00:00

abstract：:Slices of normal mammary tissue from pregnant and lactating mice and slices of neoplastic (MXT) mouse mammary tissue were superfused with estradiol (E2) and estrone (E1) each labeled with a different isotope. Isotope concentrations in tissue and perfusate at the steady state were used to calculate fractions and rates ...

journal_title：Endocrinology

authors： De Ryck LM,Raus JC

更新日期：1983-07-01 00:00:00

abstract：:The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cort...

journal_title：Endocrinology

authors： Soegiarto DW,Kiachopoulos S,Schipani E,Jüppner H,Erben RG,Lanske B

更新日期：2001-12-01 00:00:00

abstract：:We have previously shown that dopamine-evoked inhibition of corticosteroid production from adrenocortical cells is mediated through a decrease in prostaglandin biosynthesis. Since the catecholamine did not alter the stimulatory effect of arachidonic acid, it was proposed that dopamine may inhibit the formation of arac...

journal_title：Endocrinology

authors： Morra M,Leboulenger F,Desrues L,Tonon MC,Vaudry H

更新日期：1991-05-01 00:00:00

abstract：:We studied the role of aldosterone (aldo) in myocardial injury in a model of angiotensin (Ang) II-hypertension. Wistar rats were given 1% NaCl (salt) to drink and randomized into one of the following groups (n = 10; treatment, 21 d): 1) vehicle control (VEH); 2) Ang II infusion (25 ng/min, sc); 3) Ang II infusion plus...

journal_title：Endocrinology

authors： Rocha R,Martin-Berger CL,Yang P,Scherrer R,Delyani J,McMahon E

更新日期：2002-12-01 00:00:00

abstract：:In vivo studies have suggested that serotonin (5HT) influences anterior pituitary function at the hypothalamic level. The present in vitro study investigated the possibility that 5HT may act directly on the anterior pituitary. The high affinity uptake of [3H]5HT into adult rat anterior pituitary tissue was examined in...

journal_title：Endocrinology

authors： Johns MA,Azmitia EC,Krieger DT

更新日期：1982-03-01 00:00:00

abstract：:The effects of nerve activation and of the catecholamines epinephrine and norepinephrine on adrenal corticosteroid release were investigated in intact isolated perfused pig adrenals with preserved nerve supply. To study the contact zones of medullary and cortical tissues, porcine adrenals were examined on the histolog...

journal_title：Endocrinology

authors： Bornstein SR,Ehrhart-Bornstein M,Scherbaum WA,Pfeiffer EF,Holst JJ

更新日期：1990-08-01 00:00:00

abstract：:We examined the effects of bombesin on rat pancreatic digestive enzyme gene expression using cloned complementary DNA probes for amylase, trypsinogen I, chymotrypsinogen B, and lysophospholipase. Rats were injected sc three times daily with 5 nmol/kg body wt bombesin. Pancreata were investigated after 6, 12, 24, 48, a...

journal_title：Endocrinology

authors： Rosewicz S,Liehr RM,Solomon TE,Riecken EO,Logsdon CD

更新日期：1992-03-01 00:00:00

abstract：:It is unclear whether the maturation of corticotrophs from the fetal to the adult type in the fetal sheep pituitary in late gestation is associated with changes in the sensitivity of the fetal pituitary to corticotrophic secretagogues and in the form of ACTH-containing peptides (IR-ACTH) secreted into the circulation....

journal_title：Endocrinology

authors： Ozolins IZ,Antolovich GC,Browne CA,Perry RA,Robinson PM,Silver M,McMillen IC

更新日期：1991-10-01 00:00:00

abstract：:Age-associated changes in the reproductive hormones-the gonadal steroid hormones and the gonadotropins-have been identified as potential risk factors for Alzheimer's disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotro...

journal_title：Endocrinology

authors： Barron AM,Verdile G,Taddei K,Bates KA,Martins RN

更新日期：2010-11-01 00:00:00

abstract：:Local release of TGF-beta during times of high bone turnover leads to elevated levels within the bone microenvironment, and we have shown that TGF-beta suppresses osteoclast apoptosis. Therefore, understanding the influences of TGF-beta on bone resorbing osteoclasts is critical to the design of therapies to reduce exc...

journal_title：Endocrinology

authors： Ruan M,Pederson L,Bradley EW,Bamberger AM,Oursler MJ

更新日期：2010-04-01 00:00:00

abstract：:The issue of what starts the circadian clock ticking was addressed by studying the developmental appearance of the daily rhythm in the expression of two genes in the zebrafish pineal gland that are part of the circadian clock system. One encodes the photopigment exorhodopsin and the other the melatonin synthesizing en...

journal_title：Endocrinology

authors： Vuilleumier R,Besseau L,Boeuf G,Piparelli A,Gothilf Y,Gehring WG,Klein DC,Falcón J

更新日期：2006-05-01 00:00:00

abstract：:Human osteoblast-like cells (HOB) produce vascular endothelial growth factor (VEGF), the steady state level of which is stimulated by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. As osteoblasts and endothelial cells are proximally located in skeletal tissue, we investigated the anabolic effects of 1,25-(OH)2D3 and VEGF on...

journal_title：Endocrinology

authors： Wang DS,Miura M,Demura H,Sato K

更新日期：1997-07-01 00:00:00

abstract：:Oscillations in intracellular calcium levels have been described in GnRH-1 neurons in both prenatal and adult cells. However, differences have been reported in the mechanisms underlying these [Ca(2+)](i) oscillations, dependent on the model used. The goal of this study was to address whether these changes depend on th...

journal_title：Endocrinology

authors： Constantin S,Klenke U,Wray S

更新日期：2010-08-01 00:00:00

abstract：:By the use of sucrose density gradient and protamine sulfate analyses, the cytosol fraction of rat lung has been found to contain binding activities for both androgenic and estrogenic steroids. These activities are present in lungs of rats of both sexes and at all ages examined. Both activities interacted stereospecif...

journal_title：Endocrinology

authors： Morishige WK,Uetake CA

更新日期：1978-06-01 00:00:00

abstract：:Swine granulosa cells cultured under serum-free conditions in vitro exhibit significant responsivity to the stimulatory actions of estradiol (E2) and FSH or LH. Under these conditions, granulosa cells harvested from either immature or mature Graafian follicles synthesized significantly increased quantities of progeste...

journal_title：Endocrinology

authors： Veldhuis JD,Gwynne JT,Strauss JF 3rd,Demers LM

更新日期：1984-06-01 00:00:00

abstract：:The rapid and temporary suppression of reproductive behavior is often assumed to be an important feature of the adaptive acute stress response. However, how this suppression operates at the mechanistic level is poorly understood. The enzyme aromatase converts testosterone to estradiol in the brain to activate reproduc...

journal_title：Endocrinology

authors： Dickens MJ,Cornil CA,Balthazart J

更新日期：2011-11-01 00:00:00

abstract：:Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating d...

journal_title：Endocrinology

authors： Warden SJ,Robling AG,Sanders MS,Bliziotes MM,Turner CH

更新日期：2005-02-01 00:00:00

abstract：:Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3. T4 binding was not affected by the flavonoid EMD 21388...

journal_title：Endocrinology

authors： Benvenga S,Cahnmann HJ,Robbins J

更新日期：1993-09-01 00:00:00

abstract：:To define the specific role of IGF-I receptor (IGF-IR) in adipogenic and thermogenic differentiation of brown adipocytes during late fetal life, we have established immortalized brown adipocyte cell lines from fetuses of IGF-IR-deficient mice (IGF-IR(-/-)) as well as from wild-type mice (IGF-IR(+/+)). IGF-IR(-/-) cell...

journal_title：Endocrinology

authors： Mur C,Arribas M,Benito M,Valverde AM

更新日期：2003-02-01 00:00:00

abstract：:Adrenals express a high level of neutral cholesteryl ester hydrolase (CEH) activity, and male rats have greater activity than females; however, the identity of the enzyme(s) responsible for this activity and the basis for the sex differences are unknown. Using mice in which hormone-sensitive lipase (HSL) was inactivat...

journal_title：Endocrinology

authors： Kraemer FB,Shen WJ,Natu V,Patel S,Osuga J,Ishibashi S,Azhar S

更新日期：2002-03-01 00:00:00

abstract：:Insulin and protein kinase B (or Akt) play critical roles in cardiomyocytic growth and survival. High concentrations of glucocorticoids antagonize insulin's action. To examine whether endogenous glucocorticoids modulate insulin's effect on Akt signaling in the protein and glycogen synthetic pathways in myocardium, we ...

journal_title：Endocrinology

authors： Wu Y,Barrett EJ,Long W,Liu Z

更新日期：2004-03-01 00:00:00

abstract：:The short loop feedback effect of PRL was studied in young (4-5 months of age) and old (24-26 months of age) ovariectomized rats after a single iv injection of bovine PRL (bPRL, 500 micrograms/100 g BW) or BSA (500 micrograms/100 g BW). Blood samples were collected via intraatrial cannula every 20 min for assay of PRL...

journal_title：Endocrinology

authors： Sarkar DK,Miki N,Meites J

更新日期：1983-10-01 00:00:00

abstract：:A method to prepare suspension cultures of highly viable pinealocytes is described. Pineal glands of neonatal or adult rats can be used; the best yield is obtained from neonatal glands. Morphological examination of the cells indicates that they have a normal, healthy appearance and retain some structures typical of ne...

journal_title：Endocrinology

authors： Buda M,Klein DC

更新日期：1978-10-01 00:00:00

abstract：:131I therapy is a widely accepted treatment for differentiated thyroid cancers which can accumulate iodide. We evaluated the efficiency of 131I therapy against tumors which are transfected with the Na+/I- symporter (NIS) gene. We transfected the rat NIS cDNA expression vector into malignantly transformed rat thyroid c...

journal_title：Endocrinology

authors： Shimura H,Haraguchi K,Miyazaki A,Endo T,Onaya T

更新日期：1997-10-01 00:00:00