Abstract:
:Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrate stimulation of bone resorption by PDGF in a specific cell type known to resorb bone in vivo and in vitro.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Key LL Jr,Carnes DL Jr,Weichselbaum R,Anast CSdoi
10.1210/endo-112-2-761subject
Has Abstractpub_date
1983-02-01 00:00:00pages
761-2issue
2eissn
0013-7227issn
1945-7170journal_volume
112pub_type
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