Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db).

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the United States and is strongly associated with hepatic insulin resistance. We examined whether the thyroid hormone receptor-α (Thra) would be a potential therapeutic target to prevent diet-induced NAFLD and insulin resistance. Fo...

journal_title：Endocrinology

authors： Jornayvaz FR,Lee HY,Jurczak MJ,Alves TC,Guebre-Egziabher F,Guigni BA,Zhang D,Samuel VT,Silva JE,Shulman GI

更新日期：2012-02-01 00:00:00

abstract：:GnRH neurons active in the preovulatory LH surge have been identified in several species using the early intermediate gene product, Fos, but the GnRH neurons active during episodic LH secretion remain unknown. In this study, we have used Fos and Fos-related antigens (FRA) to determine whether a subset of GnRH neurons ...

journal_title：Endocrinology

authors： Boukhliq R,Goodman RL,Berriman SJ,Adrian B,Lehman MN

更新日期：1999-12-01 00:00:00

abstract：:We previously reported that interleukin-1alpha (IL-1alpha)-induced activation of protein kinase C (PKC) via phosphatidylcholine-specific phospholipase C (PC-PLC) limits IL-6 synthesis induced by IL-1alpha itself in osteoblast-like MC3T3-E1 cells. In the present study, we further investigated the mechanism behind IL-1a...

journal_title：Endocrinology

authors： Miwa M,Kozawa O,Tokuda H,Uematsu T

更新日期：1999-11-01 00:00:00

abstract：:The in vitro production of total corticosteroids, corticosterone (B), and cortisol (F) by cultured adrenocortical cells from fetuses (115-120 days old) and newborn lambs exposed to ACTH-(1-24) was investigated in relation to the time of culture. Corticosteroids were measured by using an antibody against F, whereas B a...

journal_title：Endocrinology

authors： Durand P,Cathiard AM,Saez JM

更新日期：1984-04-01 00:00:00

abstract：:Differentiation of endometrial stromal cells into decidual cells is a prerequisite for successful embryo implantation. Our previous studies in the mouse have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ superfamily, is essential for this differentiation process. BMP2 is markedly in...

journal_title：Endocrinology

authors： Li Q,Kannan A,Das A,Demayo FJ,Hornsby PJ,Young SL,Taylor RN,Bagchi MK,Bagchi IC

更新日期：2013-01-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:We have compared the physicochemical properties of rat uterine nuclear estrogen receptors (ER) labeled with (E2) or the high affinity antiestrogen 4-hydroxytamoxifen [OH Tam; 1-[4-(2-dimethylaminoethoxy)phenyl]-1-(4-hydroxyphenyl) 2-phenyl-but-1-(Z)ene]. Nuclear ER labeled in vivo with either ligand had sedimentation ...

journal_title：Endocrinology

authors： Attardi B,Happe HK

更新日期：1986-08-01 00:00:00

abstract：:Estrogens stimulate cell proliferation in typical estrogen-responsive tissues including the anterior pituitary gland. Here we report that 17-beta estradiol (E2) has estrogen receptor-mediated mitogenic and antimitogenic actions on rat lactotrophs in primary culture, depending on the cell context. E2 did not affect bas...

journal_title：Endocrinology

authors： Kawashima K,Yamakawa K,Takahashi W,Takizawa S,Yin P,Sugiyama N,Kanba S,Arita J

更新日期：2002-07-01 00:00:00

abstract：:Sex differences in vocal communication are prevalent in both the animals and humans. The mechanism(s) mediating gender differences in human language are unknown, although, sex hormones, principally androgens, play a central role in the development of vocalizations in a wide variety of animal species. The discovery of ...

journal_title：Endocrinology

authors： Bowers JM,Perez-Pouchoulen M,Roby CR,Ryan TE,McCarthy MM

更新日期：2014-12-01 00:00:00

abstract：:The role of nutrients and hormones in the regulation of glucagon release is investigated in pancreatic A cells purified by autofluorescence-activated cell sorting. Purified A cells lack secretory activity in 1-h incubation at 1.4 mM glucose. Their release mechanism can be activated by arginine, alanine, and glutamine,...

journal_title：Endocrinology

authors： Pipeleers DG,Schuit FC,Van Schravendijk CF,Van de Winkel M

更新日期：1985-09-01 00:00:00

abstract：:These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to estradiol. Serum LH levels were compared in juvenile, peripubertal, and adult female mice after ovariectomy and challenge with a variety of 4-day steroid treatments. Since male stimul...

journal_title：Endocrinology

authors： Bronson FH

更新日期：1981-02-01 00:00:00

abstract：:Arachidonic acid metabolites have been implicated in the regulation of ACTH secretion. To define further which eicosanoid(s) is primarily involved, we examined the effects of both inhibitors of the three arachidonate metabolic pathways (cyclooxygenase, lipoxygenase, and epoxygenase) and specific eicosanoid products on...

journal_title：Endocrinology

authors： Won JG,Orth DN

更新日期：1994-10-01 00:00:00

abstract：:Newborn male rats were treated SC with dexamethasone phosphate (100 microgram) or dexamethasone acetate (100 microgram) on postnatal day 1, dexamethasone phosphate (5.0 microgram) opn postnatal days 1, 2, 3, or the corresponding drug vehicle. All animals were sacrificed 65-70 days later at previously determined daily ...

journal_title：Endocrinology

authors： Poland RE,Rubin RT,Weichsel ME Jr

更新日期：1981-03-01 00:00:00

abstract：:The objective of these experiments was to investigate the influence of activation of three second messenger systems (protein kinase-C, adenylate cyclase-cAMP, and calcium mobilization) on the secretion of pancreastatin (PST) and chromogranin-A (CGA) by a human pancreatic carcinoid cell line (BON) in tissue culture. St...

journal_title：Endocrinology

authors： Jeng YJ,Townsend CM Jr,Nagasawa S,Chuo S,Kern K,Yanaihara N,Ferrar RS,Hill FL,Thompson JC,Greeley GH Jr

更新日期：1991-01-01 00:00:00

abstract：:Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...

journal_title：Endocrinology

authors： Tse A,Lee AK

更新日期：1998-05-01 00:00:00

abstract：:The binding properties of the gamma-emitting 125I-labeled 11 beta-methoxy analog of 16 alpha-iodoestradiol, 11 beta-methoxy-16 alpha-iodoestradiol (MIE2), were characterized for its use in vivo as a ligand for the measurement and localization of estrogen-binding sites. In binding displacement studies, MIE2 bound to ra...

journal_title：Endocrinology

authors： Brown TJ,MacLusky NJ,Toran-Allerand CD,Zielinski JE,Hochberg RB

更新日期：1989-05-01 00:00:00

abstract：:Leptin, a pleiotropic adipokine, is a central regulator of appetite and weight and a key immunomodulatory protein. Although inborn leptin deficiency causes weight gain, it is unclear whether induced leptin deficiency in adult wild-type animals would be orexigenic. Previous work with a potent competitive leptin antagon...

journal_title：Endocrinology

authors： Elinav E,Niv-Spector L,Katz M,Price TO,Ali M,Yacobovitz M,Solomon G,Reicher S,Lynch JL,Halpern Z,Banks WA,Gertler A

更新日期：2009-07-01 00:00:00

abstract：:In different types of mammalian cells, insulin has been shown to promote the release of an inositol phosphate glycan (InsP-glycan) through the hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-PtdIns). This InsP-glycan, which has been demonstrated to be taken up by intact cells, may mediate some of the biologica...

journal_title：Endocrinology

authors： Sánchez-Gutiérrez JC,Sánchez-Arias JA,Valle JC,Guadaño A,Samper B,Mato JM,Felíu JE

更新日期：1994-03-01 00:00:00

abstract：:Four different GnRHs and one GnRH receptor are reported to be expressed in various mammals, whereas 13 GnRHs and numerous GnRH receptors have been identified in various nonmammalian vertebrates. The nucleotide sequencing of the human genome provided the opportunity to determine which of these peptides and receptors mi...

journal_title：Endocrinology

authors： Neill JD

更新日期：2002-03-01 00:00:00

abstract：:To investigate the possibility that a common phenomenon might exist by which glucocorticoids influence responses to thyroid hormones, the cytosol levels of four proteins were measured after 2 days of treatment with L-T3 (T3; 50 micrograms/100 g. day 2) and/or cortisone (2 mg/100 g./day) in adult male hypothyroid rats....

journal_title：Endocrinology

authors： Shapiro LE,Sachchidananda J

更新日期：1982-08-01 00:00:00

abstract：:The secretion of neurohypophyseal hormone and ACTH in the rat has been shown to exhibit circadian rhythms, with high values during the day and low values throughout the night. The neurohypophyseal hormone daily rhythm is altered by exposure to constant light and by pinealectomy. It was, thus, proposed that the observe...

journal_title：Endocrinology

authors： Yasin SA,Costa A,Besser GM,Hucks D,Grossman A,Forsling ML

更新日期：1993-03-01 00:00:00

abstract：:As human pregnancy advances, CRH increases exponentially and is hypothesized to trigger the transition from myometrial quiescence to active contractions at labor. Paradoxically, CRH stimulates cAMP production, suggesting it should cause relaxation. To evaluate CRH as a mediator of quiescence, the effect of CRH on cont...

journal_title：Endocrinology

authors： Tyson EK,Smith R,Read M

更新日期：2009-12-01 00:00:00

abstract：:Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL leve...

journal_title：Endocrinology

authors： Ruiz-Herrera X,de Los Ríos EA,Díaz JM,Lerma-Alvarado RM,Martínez de la Escalera L,López-Barrera F,Lemini M,Arnold E,Martínez de la Escalera G,Clapp C,Macotela Y

更新日期：2017-01-01 00:00:00

abstract：:Acidosis has been implicated in the pathogenesis of various metabolic bone diseases. Experimental acid ingestion is known to stimulate the release of bone mineral in humans and increase osteoclastic resorption surfaces in animals, but the mechanism has remained unclear. We have investigated the effect of medium pH on ...

journal_title：Endocrinology

authors： Arnett TR,Dempster DW

更新日期：1986-07-01 00:00:00

abstract：:Increasing adiposity predisposes to the development of the metabolic syndrome, in part, through adipose tissue dysregulation and inflammation. In addition, offspring nutrient-restricted (NR) in utero can exhibit an increased risk of early-onset insulin resistance and obesity, although the mechanisms remain unclear. We...

journal_title：Endocrinology

authors： Sharkey D,Symonds ME,Budge H

更新日期：2009-08-01 00:00:00

abstract：:The xenoestrogen bisphenol A (BPA) has been shown to mimic estrogen both in vivo and in vitro. BPA stimulates PRL secretion and the expression of a PRL regulating factor from the posterior pituitary in the estrogen-sensitive Fischer 344 rat (F344), but not in Sprague-Dawley (SD) rats. The goal of the present studies w...

journal_title：Endocrinology

authors： Steinmetz R,Mitchner NA,Grant A,Allen DL,Bigsby RM,Ben-Jonathan N

更新日期：1998-06-01 00:00:00

abstract：:Brown adipose tissue (BAT) thermogenesis is activated by the sympathetic nervous system. BAT responses to norepinephrine are blunted in hypothyroidism and are rapidly restored by thyroid hormone. We examined in rats the effects of thyroid hormone on BAT beta 1- and beta 2-adrenergic receptors (AR) expression and capac...

journal_title：Endocrinology

authors： Rubio A,Raasmaja A,Maia AL,Kim KR,Silva JE

更新日期：1995-08-01 00:00:00

abstract：:Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the N222D mutation. Me...

journal_title：Endocrinology

authors： Prabhu Y,Blanco EH,Liu M,Peinado JR,Wheeler MC,Gekakis N,Arvan P,Lindberg I

更新日期：2014-07-01 00:00:00

abstract：:Three transforming growth factor-beta protein isoforms (TGFbeta1, TGFbeta2, and TGFbeta3) have been identified in mammals. These isoforms appear to have similar actions on cell growth in various tissues. In rat pituitary tissue, TGFbeta1 is localized in PRL-secreting lactotropes and has been shown to act on lactotrope...

journal_title：Endocrinology

authors： Hentges S,Pastorcic M,De A,Boyadjieva N,Sarkar DK

更新日期：2000-04-01 00:00:00

abstract：:IGF binding protein-3 (IGFBP-3), the most abundant circulating IGF binding protein, inhibits cell growth and induces apoptosis by both IGF-I-dependent and -independent pathways. The ability of IGFBP-3 to inhibit tumor growth has been demonstrated in many cancers including prostate cancer (PCa). High concentrations of ...

journal_title：Endocrinology

authors： Peng L,Malloy PJ,Wang J,Feldman D

更新日期：2006-10-01 00:00:00