To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals.

abstract：:Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...

journal_title：Endocrinology

authors： Ahluwalia A,Hoa N,Ge L,Blumberg B,Levin ER

更新日期：2020-11-01 00:00:00

abstract：:The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase)...

journal_title：Endocrinology

authors： Woitowich NC,Philibert KD,Leitermann RJ,Wungjiranirun M,Urban JH,Glucksman MJ

更新日期：2016-02-01 00:00:00

abstract：:In a previous study we found that PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and IGF-II from cultured neonatal mouse calvaria. Since IGF-I and IGF-II stimulate osteoblast proliferation and collagen synthesis, these results suggested that increased release of IGFs during resorpti...

journal_title：Endocrinology

authors： Linkhart TA,Keffer MJ

更新日期：1991-03-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:Age-related bone loss is an important risk factor for fractures in the elderly; it results from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein-coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrains bone formation in ...

journal_title：Endocrinology

authors： Millard SM,Wang L,Wattanachanya L,O'Carroll D,Fields AJ,Pang J,Kazakia G,Lotz JC,Nissenson RA

更新日期：2017-06-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:Serum triiodothyronine (T3) in rats did not change if food intake was restricted without altering the composition of the diet. Feeding a hypocaloric low-protein high-carbohydrate diet caused increases in serum T3, while feeding a hypocaloric high-protein low-carbohydrate diet caused decreases in serum T3. These change...

journal_title：Endocrinology

authors： Glass AR,Mellitt R,Burman KD,Wartofsky L,Swerdloff RS

更新日期：1978-06-01 00:00:00

abstract：:Renin-angiotensin system blockade improves glucose intolerance and insulin resistance, which contribute to the development of metabolic syndrome. However, the contribution of impaired insulin secretion to the pathogenesis of metabolic syndrome is not well defined. To assess the contributions of angiotensin receptor ty...

journal_title：Endocrinology

authors： Rodriguez R,Viscarra JA,Minas JN,Nakano D,Nishiyama A,Ortiz RM

更新日期：2012-04-01 00:00:00

abstract：:Retinoid X receptor (RXR) occupies a central position within the nuclear receptor superfamily, serving as an obligatory partner to numerous other nuclear receptors, including vitamin D receptor (VDR). In the current study, we examined whether phosphorylation of RXRα at serine 260 affects VDR/RXR and VDR interacting pr...

journal_title：Endocrinology

authors： Jusu S,Presley JF,Williams C,Das SK,Jean-Claude B,Kremer R

更新日期：2018-03-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:Maternal and fetal metabolism of vitamin D was examined in term pregnant rabbits fed a normal diet and in those supplemented with a large amount of vitamin D3. Term pregnant rabbits (27--30 days of gestation) fed the normal diet showed lower levels of plasma calcium, 25-hydroxyvitamin D3 (250HD3), and 24,25-dihydroxyv...

journal_title：Endocrinology

authors： Kubota M,Ohno J,Shiina Y,Suda T

更新日期：1982-06-01 00:00:00

abstract：:We studied the involvement of the cAMP pathway in the regulation of beta TC1 cell growth with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the activator of adenylate cyclase forskolin. We examined the effect of the increase in cAMP content on the serum-induced resumption of the cell cycle of ...

journal_title：Endocrinology

authors： Lavergne C,Breant B,Rosselin G

更新日期：1992-11-01 00:00:00

abstract：:A new perfusion system of isolated rat femora was established, and the effect of PTH or calcitonin (CT) on cAMP release from the adult bone was examined. Stimulation of cAMP release from the isolated perfused bone peaked rapidly between 5 and 10 min after human PTH (hPTH)-(1-34) or eel CT injection, respectively, and ...

journal_title：Endocrinology

authors： Sugimoto T,Fukase M,Tsutsumi M,Imai Y,Hishikawa R,Yoshimoto Y,Fujita T

更新日期：1985-11-01 00:00:00

abstract：:Beta-adrenergic agonists and antagonists are widely used in many clinical situations to regulate beta-adrenergic stimulation. However, responsiveness to beta-stimulation may be reduced by the process of desensitization. We have established an in vivo mammalian model system, the rat lung, to study the cellular and bioc...

journal_title：Endocrinology

authors： Strasser RH,Stiles GL,Lefkowitz RJ

更新日期：1984-10-01 00:00:00

abstract：:The ontogenic changes in the somatotroph's responsiveness to TRH were examined in enzymatically dissociated rat pituitary cells in primary monolayer culture. Exposure to TRH (10(-8) M) caused a significant increase in GH release in cultured pituitary cells from rats ranging in age from -1 day (20 days of gestational a...

journal_title：Endocrinology

authors： Welsh JB,Cuttler L,Szabo M

更新日期：1986-11-01 00:00:00

abstract：:Protein synthesis in bovine pituitaries was measured by incubation of tissue slices with radioactive amino acids, followed by gel electrophoresis. PRL and GH syntheses were estimated by determining the amount of radioactivity comigrating with standards of these hormones. Pituitary tissue removed from adult animals dem...

journal_title：Endocrinology

authors： Baxter LA,Gorski J

更新日期：1981-08-01 00:00:00

abstract：:The present study investigates the effect of different endocrine manipulations on the gamma-aminobutyric acid (GABA)-ergic system in the rat fallopian tube. Either hypophysectomy or ovariectomy induced a significant decrease of glutamic acid decarboxylase (GAD) activity and of GABA levels in in situ tubes. This effect...

journal_title：Endocrinology

authors： Celotti F,Apud JA,Melcangi RC,Masotto C,Tappaz M,Racagni G

更新日期：1986-01-01 00:00:00

abstract：:Rabbit hearts perfused by the Langendorff technique were studied. The addition of ovine prolactin (NIH-P-S-10) to the perfusate in a concentration of 50 ng/ml produced rapid increases in both the amplitude and rate of contraction in 33 adult male hearts studied in winter. Prepubertal male animals showed no response, a...

journal_title：Endocrinology

authors： Nassar BA,Horrobin DF,Tynan M,Manku MS,Davies PA

更新日期：1975-10-01 00:00:00

abstract：:We studied the effects of 17 beta-estradiol (E2) and PTH on alkaline phosphatase activity in SaOS-2 cells that had been passaged and grown continually in the presence (SaOS + Dex) or absence (SaOS - Dex) of 10(-8) M dexamethasone (Dex). We showed that the more differentiated SaOS + Dex cells had higher alkaline phosph...

journal_title：Endocrinology

authors： Rao LG,Wylie JN,Sutherland MS,Murray TM

更新日期：1994-02-01 00:00:00

abstract：:The action of the cyclic peptide polymyxin B (a well known inhibitor of protein kinase C) on adrenal steroid synthesis was examined with Y-1 adrenal tumor cells. Polymyxin B produces a biphasic effect on the stimulation of steroid synthesis by 2 nM ACTH in these cells, with inhibition at low concentrations (less than ...

journal_title：Endocrinology

authors： Widmaier EP,Iida S,Hall PF

更新日期：1987-07-01 00:00:00

abstract：:Although estrogens are neuroprotective in young adult animal models of stroke, clinical trials demonstrate that estrogens increase the incidence and severity of stroke in aged women. We have previously shown that experimental stroke pathophysiology differs between young adult and aged rats. The aim of this study was t...

journal_title：Endocrinology

authors： Leon RL,Li X,Huber JD,Rosen CL

更新日期：2012-07-01 00:00:00

abstract：:Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....

journal_title：Endocrinology

authors： Sellix MT,Murphy ZC,Menaker M

更新日期：2013-04-01 00:00:00

abstract：:PGs are important mediators of the ovulatory process and prostaglandin G/H synthase-2 (PGHS-2) is a key rate-limiting enzyme in the PG biosynthetic pathway. To determine whether PGHS-2 is regulated in equine follicles before ovulation and, if so, to characterize its time course of induction, preovulatory follicles wer...

journal_title：Endocrinology

authors： Sirois J,Doré M

更新日期：1997-10-01 00:00:00

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...

journal_title：Endocrinology

authors： Shih CH,Chen SL,Yen CC,Huang YH,Chen CD,Lee YS,Lin KH

更新日期：2004-06-01 00:00:00

abstract：:This study determined whether a rise in tonic secretion of LH occurred before long day-induced precocious puberty of the female ferret. Twenty immature females were assigned to 1 of 2 photoperiods at 15 weeks of age. Ten ferrets were placed in a long day, stimulatory photoperiod (16 h of light, 8 h of darkness) to ind...

journal_title：Endocrinology

authors： Ryan KD,Robinson SL

更新日期：1985-05-01 00:00:00

abstract：:We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...

journal_title：Endocrinology

authors： Song SY,Asakai R,Kenmotsu N,Taoka M,Isobe T,Yamakuni T

更新日期：1996-04-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:Kallikreins are a multigene subfamily of serine proteases that may have a role in processing precursors of polypeptide hormones and growth factors. The epidermal growth factor (EGF) immunoreactivity in mouse milk is derived from the membrane-bound EGF precursor located on the lumenal border of the alveolar cells in th...

journal_title：Endocrinology

authors： Jahnke GD,Chao J,Walker MP,Diaugustine RP

更新日期：1994-11-01 00:00:00