Positive and negative regulation of the rat vasopressin gene promoter.

abstract：:Pulmonary surfactant is a developmentally and hormonally regulated lipoprotein synthesized exclusively in alveolar type II cells. Surfactant protein-A (SP-A) gene transcription in human fetal lung in culture is stimulated by glucocorticoids and cAMP; cAMP also enhances the rate of type II cell differentiation. The CCA...

journal_title：Endocrinology

authors： Breed DR,Margraf LR,Alcorn JL,Mendelson CR

更新日期：1997-12-01 00:00:00

abstract：:A monoclonal antibody directed against bovine TSH was obtained by hybridoma technology. This antibody was specific for TSH and did not react with bovine LH and FSH. Affinity chromatography of crude TSH was performed on anti-TSH Sepharose. Bovine TSH was purified in a single step to near homogeneity by this technique, ...

journal_title：Endocrinology

authors： Lock AJ,van Denderen J,Aarden LA

更新日期：1988-01-01 00:00:00

abstract：:Mineralocorticoid and glucocorticoid hormones are metabolized as glucuronide conjugates. Using labeled [(14)C]uridine diphosphate glucuronic acid and microsomal preparations from human embryonic kidney 293 cells stably expressing the different human and monkey uridine diphosphate glucuronosyltransferase (UGT)2B enzyme...

journal_title：Endocrinology

authors： Girard C,Barbier O,Veilleux G,El-Alfy M,Bélanger A

更新日期：2003-06-01 00:00:00

abstract：:Swine granulosa cells cultured under serum-free conditions in vitro exhibit significant responsivity to the stimulatory actions of estradiol (E2) and FSH or LH. Under these conditions, granulosa cells harvested from either immature or mature Graafian follicles synthesized significantly increased quantities of progeste...

journal_title：Endocrinology

authors： Veldhuis JD,Gwynne JT,Strauss JF 3rd,Demers LM

更新日期：1984-06-01 00:00:00

abstract：:The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...

journal_title：Endocrinology

authors： Hauner H

更新日期：1990-08-01 00:00:00

abstract：:We and others have recently shown that 1alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] significantly inhibits cell proliferation and increases secretion of prostate-specific antigen (PSA) in LNCaP cells, an androgen-responsive human prostate cancer cell line. The present study was designed to investigate the possible int...

journal_title：Endocrinology

authors： Zhao XY,Ly LH,Peehl DM,Feldman D

更新日期：1997-08-01 00:00:00

abstract：:Evidence is presented that in vitamin D deficiency there are aberrations of estrogen metabolism in the laying hen. Five White Leghorn hens, 35 weeks of age, all laying soft shelled eggs as a result of complete withdrawal of supplemental vitamin D3 (D3) from the diet, were found to have a 3-fold higher molar ratio of p...

journal_title：Endocrinology

authors： Tsang CP,Grunder AA

更新日期：1984-12-01 00:00:00

abstract：:The hypothesis that hydrogen peroxide generation occurs in the corpora lutea of superovulated rats during luteolysis was tested using a peroxide-dependent inhibitor of catalase, 3-amino-1,2,4-triazole (AT). Luteal regression was induced during midpseudopregnancy by injection of 500 micrograms prostaglandin F2 alpha (P...

journal_title：Endocrinology

authors： Riley JC,Behrman HR

更新日期：1991-04-01 00:00:00

abstract：:Male and female Holtzman rats were raised from weaning on a vitamin D-deficient diet (-D). Control (+D) animals were raised on the same diet and orally given 70 IU vitamin D3 twice each week. Serum Ca levels fell at the same rate in -D males and females. In contrast, serum parathyroid hormone increased more rapidly in...

journal_title：Endocrinology

authors： Thomas ML,Forte LR

更新日期：1981-11-01 00:00:00

abstract：:Historically, much of the research on health effects of environmental pollutants focused on ascertaining whether compounds were carcinogenic. More recent findings show that environmental contaminants also exert insidious effects by disrupting hormone action. Of particular concern are findings that developmental exposu...

journal_title：Endocrinology

authors： Petersen SL,Krishnan S,Hudgens ED

更新日期：2006-06-01 00:00:00

abstract：:Although the extent of proptosis in exophthalmic Graves' disease has been measured directly and shown to correlate with serum content of a bioassayable exophthalmus-producing factor (EPS;1), a comparable relationship in an experimental model has not been reported. Progressive exophthalmos, measured from photographs an...

journal_title：Endocrinology

authors： Valk TW,Taylor RE Jr,Barker SB

更新日期：1975-01-01 00:00:00

abstract：:The effects of food restriction of the mother (65% restriction of ad libitum food intake) on fetal and maternal insulin secretion and islet function were studied at 21 days gestation in three different rat populations: 1) undernourished from 0-7 days gestation, 2) undernourished from 7-14 days gestation, and 3) undern...

journal_title：Endocrinology

authors： Alvarez C,Martín MA,Goya L,Bertin E,Portha B,Pascual-Leone AM

更新日期：1997-06-01 00:00:00

abstract：:1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] inhibits proliferation of normal and malignant prostate epithelial cells at least in part through inhibition of G1 to S phase cell cycle progression. The mechanisms of the antiproliferative effects of 1,25-(OH)2D3 have yet to be fully elucidated but are known to require the vita...

journal_title：Endocrinology

authors： Flores O,Burnstein KL

更新日期：2010-10-01 00:00:00

abstract：:The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...

journal_title：Endocrinology

authors： Lippert RN,Ellacott KL,Cone RD

更新日期：2014-05-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00

abstract：:[14C]-3-O-Methyl-D-glucose transport in response to GH stimulation was measured in freshly prepared and cultured hepatocytes from hypophysectomized (hypox) adult female rats. Sugar transport in freshly isolated hepatocytes from hypox animals was stimulated by 10(-9) M human GH (hGH) and 10(-9) M rat GH (rGH) during 0-...

journal_title：Endocrinology

authors： Fix JA,Moore WV

更新日期：1981-01-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1) enhances insulin biosynthesis and secretion as well as transcription of the insulin, GLUT2 and glucokinase genes. The latter are also regulated by the PDX-1 homeoprotein. We investigated the possibility that GLP-1 may be having its long-term pleiotropic effects through a hitherto unknow...

journal_title：Endocrinology

authors： Wang X,Cahill CM,Piñeyro MA,Zhou J,Doyle ME,Egan JM

更新日期：1999-10-01 00:00:00

abstract：:Thyroid hormone entry into the thymocyte, a thyroid hormone target, was investigated by incubating the cells with tracer amounts of [125I]L-T3. At 37 C T3 uptake was linear with time up to 2 min, and then approached a plateau. The specific T3 uptake, obtained by subtracting the uptake in the presence of excess unlabel...

journal_title：Endocrinology

authors： Centanni M,Mancini G,Andreoli M

更新日期：1989-05-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:It is well established that in the pituitary gland corticotropin-releasing hormone (CRH) stimulates the release of beta-endorphin (beta-E) via a cAMP-linked mechanism. Studies of the mechanisms underlying the CRH stimulation of beta-E release from rat hypothalamic slices perifused in vitro are reported in this paper. ...

journal_title：Endocrinology

authors： Burns G,Almeida OF,Passarelli F,Herz A

更新日期：1989-09-01 00:00:00

abstract：:The prevailing view of sexual differentiation of mammalian brain is that androgen synthesized in the fetal and neonatal testis and aromatized centrally during a perinatal sensitive period is the sole source of brain estradiol and the primary determinant of sex differences. Subregions of the diencephalon are among the ...

journal_title：Endocrinology

authors： Konkle AT,McCarthy MM

更新日期：2011-01-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...

journal_title：Endocrinology

authors： Gallardo N,Arribas C,Villar M,Ros M,Carrascosa JM,Martínez C,Andrés A

更新日期：2005-11-01 00:00:00

abstract：:T4-binding globulin (TBG), the principal carrier of thyroid hormone in serum, is a glycoprotein containing 20% carbohydrate. The importance of the carbohydrate moiety has been previously studied by enzymatic deglycosylation, which showed that deglycosylated TBG retains its original immunological an T4-binding properti...

journal_title：Endocrinology

authors： Murata Y,Magner JA,Refetoff S

更新日期：1986-04-01 00:00:00

abstract：:In a previous paper, we demonstrated that an inhibitory action of excess iodide on thyrotropin-induced thyroid hormone secretion occurs at a site subsequent to the generation of cyclic AMP. In the present study, however, we have found that thyroidal cyclic AMP formation induced by thyrotropin in vitro was markedly inh...

journal_title：Endocrinology

authors： Hashizume K,Akasu F,Takazawa K,Endo W,Onaya T

更新日期：1976-12-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-(OH)2D3 differentially affect the specific activity of alkaline phosphatase (ALPase) and phospholipase-A2 (PLA2) of plasma membranes and extracellular matrix vesicles produced by costochondral reserve zone and growth zone cartilage chondrocytes in culture. In the prese...

journal_title：Endocrinology

authors： Schwartz Z,Schlader DL,Swain LD,Boyan BD

更新日期：1988-12-01 00:00:00

abstract：:During in vitro maturation of porcine cumulus cell-oocyte complexes and in vitro luteinization of porcine granulosa cells, FSH induces the expression of the protease TNFα-converting enzyme/A disintegrin and metalloproteinase domain 17 (TACE/ADAM17) and the epidermal growth factor (EGF)-like factors, which activate the...

journal_title：Endocrinology

authors： Yamashita Y,Okamoto M,Ikeda M,Okamoto A,Sakai M,Gunji Y,Nishimura R,Hishinuma M,Shimada M

更新日期：2014-03-01 00:00:00

abstract：:Activating ras point mutations are frequently found in skeletal muscle tumors such as rhabdomyosarcomas. In this study we investigated the impact of two different H-ras mutants in skeletal muscle differentiation: RasV12, a constitutively active form, and RasV12C40, a mutant deficient in Raf1 activation. Stably transfe...

journal_title：Endocrinology

authors： De Alvaro C,Nieto-Vazquez I,Rojas JM,Lorenzo M

更新日期：2008-02-01 00:00:00

abstract：:Exposure to testosterone (T) during d 30-90 of fetal life results in low-birth-weight offspring, hypergonadotropism, multifollicular ovaries, and early cessation of cyclicity. The multifollicular phenotype may result from failure of follicles to regress and consequent follicular persistence or, alternatively, increase...

journal_title：Endocrinology

authors： Steckler T,Wang J,Bartol FF,Roy SK,Padmanabhan V

更新日期：2005-07-01 00:00:00

abstract：:The rapid, nongenomic effects of estrogen are increasingly recognized as playing an important role in several aspects of estrogen action. Rapid activation of the mitogen-activated protein kinase (MAPK) signaling pathway by estrogen is among the more recently identified of these effects. To explore the role of estrogen...

journal_title：Endocrinology

authors： Wade CB,Robinson S,Shapiro RA,Dorsa DM

更新日期：2001-06-01 00:00:00