Lxrα regulates the androgen response in prostate epithelium.

abstract：:Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular nucleus, and to stimulate maternal behavior. We investigated oxytocin receptor (OTR) expression and activation perinatally. Using a (35)S-labeled riboprobe complem...

journal_title：Endocrinology

authors： Meddle SL,Bishop VR,Gkoumassi E,van Leeuwen FW,Douglas AJ

更新日期：2007-10-01 00:00:00

abstract：:The response of fat tissue to GH or insulin-like growth factor I (IGF-I) differs between humans with hypopituitarism and those with exogenous obesity; the effects of combined GH and IGF-I administration have not been compared in these two situations. In GH-deficient dwarf rats (who have a primary GH deficiency), the e...

journal_title：Endocrinology

authors： Dubuis JM,Deal C,Tsagaroulis P,Clark RG,Van Vliet G

更新日期：1996-07-01 00:00:00

abstract：:The DNA binding protein nuclear factor-kappaB (NF-kappaB) is a transcription factor translocated from the cytosol to the nucleus in response to stressors. Here we determined whether the known ability of alcohol to activate the hypothalamic-pituitary axis was mediated by NF-kappaB, tested the hypothesis that this pheno...

journal_title：Endocrinology

authors： Lee S,Rivier C

更新日期：2005-04-01 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta family of growth factors and a potent regulator of cellular activity. A number of binding proteins for activin A have been identified, including alpha 2-macroglobulin (alpha 2M). Alpha 2M has several conformational states that are known to have different gro...

journal_title：Endocrinology

authors： Niemuller CA,Randall KJ,Webb DJ,Gonias SL,LaMarre J

更新日期：1995-12-01 00:00:00

abstract：:It is widely accepted that expression of protooncogenes is coupled with cellular proliferation and differentiation. Since ACTH stimulates not only steroidogenesis but also cellular proliferation, we investigated whether ACTH affects the expression of c-fos, c-myc, and beta-actin genes. The effect of ACTH on adrenal gl...

journal_title：Endocrinology

authors： Imai T,Seo H,Murata Y,Ohno M,Satoh Y,Funahashi H,Takagi H,Matsui N

更新日期：1990-10-01 00:00:00

abstract：:The effect of 3 alpha-hydroxy-4-pregnen-20-one (3HP), a Sertoli cell steroid, on the secretion of gonadotropins from rat anterior pituitary cells in culture was examined and subsequently compared with the action of other gonadal steroids and steroids structurally related to 3HP. Pituitary cells from randomly cycling, ...

journal_title：Endocrinology

authors： Wood PH,Wiebe JP

更新日期：1989-07-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:Rat epididymal fat cells were isolated and incubated with 25 microunits insulin/ml for 15 minutes. Insulin induced a significant shift in the saturated/unsaturated fatty acid ratio of the cerebroside fraction isolated from fat cell ghosts. This change was due to a decrease of saturated fatty acids and an increase of u...

journal_title：Endocrinology

authors： Murray DK,Nelson DH

更新日期：1981-05-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a ...

journal_title：Endocrinology

authors： Stengel A,Goebel M,Million M,Stenzel-Poore MP,Kobelt P,Mönnikes H,Taché Y,Wang L

更新日期：2009-01-01 00:00:00

abstract：:Previous studies have shown that atrial natriuretic peptides (ANPs) inhibit the secretion of aldosterone by isolated rat adrenal glomerulosa cells stimulated by angiotensin II, ACTH, and potassium. Structure-function studies have concentrated on the significance of the C- and N-terminal chains for the biological activ...

journal_title：Endocrinology

authors： Craven TG,Kem DC,Schiebinger RJ

更新日期：1988-03-01 00:00:00

abstract：:Hypophyseotropic dopamine exerts a tonic inhibitory tone on pituitary lactotrophs by the activation of dopamine D2 receptors (D2R). Ablation of D2R through gene knock-out approaches results in hyperprolactinemia and prolactinomas. This phenotype is more severe and develops more rapidly in female mice. We tested whethe...

journal_title：Endocrinology

authors： Hentges ST,Low MJ

更新日期：2002-12-01 00:00:00

abstract：:The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...

journal_title：Endocrinology

authors： Wong EH,Tan CH,Khoo HE,Ng FH,Lim KL,Ciaraldi TP

更新日期：1995-04-01 00:00:00

abstract：:To determine the relationship between the concentrations of serum T3 and hepatic nuclear T3 receptor in a reversible nonthyroidal disease, we studied these parameters in rats with streptozotocin-induced diabetes mellitus, control rats, and rats that were weight-matched to the diabetic rats by food restriction. Results...

journal_title：Endocrinology

authors： Las MS,Surks MI

更新日期：1981-10-01 00:00:00

abstract：:Neuropeptide Y (NPY) is highly expressed in the hypothalamus, where it regulates feeding and energy homeostasis. Interestingly, NPY and its receptors are also expressed in peripheral tissues with roles in metabolism, including pancreatic islets. In islets, NPY is known to suppress insulin secretion acutely. In additio...

journal_title：Endocrinology

authors： Machida Y,Bruinsma C,Hallinger DR,Roper SM,Garcia E,Trevino MB,Nadler J,Ahima R,Imai Y

更新日期：2014-12-01 00:00:00

abstract：:The first mutation in a gene associated with a neuronal migration disorder was identified in patients with Kallmann Syndrome, characterized by hypogonadotropic hypogonadism and anosmia. This pathophysiological association results from a defect in the development of the GnRH and the olfactory system. A recent genetic s...

journal_title：Endocrinology

authors： Hutchins BI,Kotan LD,Taylor-Burds C,Ozkan Y,Cheng PJ,Gurbuz F,Tiong JD,Mengen E,Yuksel B,Topaloglu AK,Wray S

更新日期：2016-05-01 00:00:00

abstract：:We have recently reported that pretreatment with electroacupuncture (EA) at stomach meridian point 36 (St36) prevents the chronic cold-stress increase in the hypothalamus-pituitary-adrenal axis (HPA), an action that may be under central control. Given that treatment for stress-related symptoms usually begins after ons...

journal_title：Endocrinology

authors： Eshkevari L,Mulroney SE,Egan R,Lao L

更新日期：2015-10-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:The action of the cyclic peptide polymyxin B (a well known inhibitor of protein kinase C) on adrenal steroid synthesis was examined with Y-1 adrenal tumor cells. Polymyxin B produces a biphasic effect on the stimulation of steroid synthesis by 2 nM ACTH in these cells, with inhibition at low concentrations (less than ...

journal_title：Endocrinology

authors： Widmaier EP,Iida S,Hall PF

更新日期：1987-07-01 00:00:00

abstract：:It is established that androgens and unidentified Sertoli cell (SC)-derived factors can influence the development of adult Leydig cells (LC) in rodents, but the mechanisms are unclear. We evaluated adult LC development and function in SC-selective androgen receptor (AR) knockout (SCARKO) and complete AR knockout (ARKO...

journal_title：Endocrinology

authors： De Gendt K,Atanassova N,Tan KA,de França LR,Parreira GG,McKinnell C,Sharpe RM,Saunders PT,Mason JI,Hartung S,Ivell R,Denolet E,Verhoeven G

更新日期：2005-09-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:In an attempt to purify the thyroid receptor for TSH and to study interaction with the thyroid-stimulating antibody (TSAb) of graves' disease, we used both bovine and human thyroid glands. With either tissue, the 10,000 X g pellet of homogenized material was solubilized with 0.5% Triton N-101; excess Triton was remove...

journal_title：Endocrinology

authors： Koizumi Y,Zakarija M,McKenzie JM

更新日期：1982-04-01 00:00:00

abstract：:Although Na+/H+ exchange is important to maintenance of pH and volume and thus placental-fetal homeostasis, regulation of the Na+/H+ exchange system is incompletely understood. We previously showed that Na+/H+ exchanger (NHE)1 and -3 and their regulatory factors NHERF1 and -2 were expressed in human and nonhuman prima...

journal_title：Endocrinology

authors： Pepe GJ,Burch MG,Albrecht ED

更新日期：2006-06-01 00:00:00

abstract：:PRL and placental lactogen (PL) play key roles in maintaining the rodent corpus luteum through pregnancy. Suppressors of cytokine signaling (SOCS) have been shown to decrease cell sensitivity to cytokines, including PRL, and so here we have addressed the issue of whether luteolysis induced by prostaglandin F(2alpha) (...

journal_title：Endocrinology

authors： Curlewis JD,Tam SP,Lau P,Kusters DH,Barclay JL,Anderson ST,Waters MJ

更新日期：2002-10-01 00:00:00

abstract：:The PTH and PTH-related protein (PTHrP) system consists of two hormones, at least two G protein-coupled seven-transmembrane domain receptors, and at least two intracellular signal transduction pathways for each receptor. The PTH/PTHrP receptor is present in the conventional target tissues of PTH action, namely kidney ...

journal_title：Endocrinology

authors： Behar V,Nakamoto C,Greenberg Z,Bisello A,Suva LJ,Rosenblatt M,Chorev M

更新日期：1996-10-01 00:00:00

abstract：:In humans, there is a significant decrease in serum T(3) and increase in rT(3) at different time points after myocardial infarction, whereas serum TSH and T(4) remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by...

journal_title：Endocrinology

authors： Olivares EL,Marassi MP,Fortunato RS,da Silva AC,Costa-e-Sousa RH,Araújo IG,Mattos EC,Masuda MO,Mulcahey MA,Huang SA,Bianco AC,Carvalho DP

更新日期：2007-10-01 00:00:00

abstract：:The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

journal_title：Endocrinology

authors： Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

更新日期：2020-03-01 00:00:00

abstract：:The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient. Dual-labeling for LEP receptors (LEPRs) and gonadotropins or GH revealed a 2-fold increase in LEPR during proestrus, some of which was seen in LH gonadotropes....

journal_title：Endocrinology

authors： Akhter N,CarlLee T,Syed MM,Odle AK,Cozart MA,Haney AC,Allensworth-James ML,Beneš H,Childs GV

更新日期：2014-10-01 00:00:00

abstract：:Ovary-specific acidic protein (OSAP) is a novel molecule discovered from a genomic project designed to identify ovary-selective genes in mice. Whereas public databases suggest extraovarian expression of OSAP, its tissue distribution has not yet been well documented. Thus, the expression profile of mouse and human OSAP...

journal_title：Endocrinology

authors： Matsumoto T,Minegishi K,Ishimoto H,Tanaka M,Hennebold JD,Teranishi T,Hattori Y,Furuya M,Higuchi T,Asai S,Kim SH,Miyakoshi K,Yoshimura Y

更新日期：2009-07-01 00:00:00

abstract：:In the rat ovary, follicle cells produce and respond to activin, but as yet, the functional significance of the autocrine/paracrine effects of ovarian activin remains equivocal. To assess the effects of activin on folliculogenesis, normal cycling female rats were injected once every 8 h over a 40-h period with recombi...

journal_title：Endocrinology

authors： Erickson GF,Kokka S,Rivier C

更新日期：1995-11-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00