Pituitary corticotrope tumor (AtT20) cells as a model system for the study of early inhibition by glucocorticoids.

abstract：:Insulin-like growth factor-I (IGF-I) improves glucose metabolism and growth in patients with leprechaunism. We investigated signal transduction through IGF-I receptor in comparison with epidermal growth factor (EGF) receptor in early passages of cultured skin fibroblasts from a normal subject and a patient with leprec...

journal_title：Endocrinology

authors： Takahashi Y,Tobe K,Kadowaki H,Katsumata D,Fukushima Y,Yazaki Y,Akanuma Y,Kadowaki T

更新日期：1997-02-01 00:00:00

abstract：:Progesterone has the capacity to suppress hypothalamic dopaminergic neuronal activity on proestrous afternoon and prolong or amplify the preovulatory prolactin surge in rats. In the present study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling...

journal_title：Endocrinology

authors： Liu B,Arbogast LA

更新日期：2008-04-01 00:00:00

abstract：:The ALP1 [aci-reductone dioxygenase (ARD)-like protein 1] gene was identified in a comprehensive cDNA subtraction aimed at identifying genes regulated by androgens in the rat ventral prostate. ALP1 is homologous to the ARD/ARD' that were discovered in Klebsiella pneumoniae as enzymes that have the same polypeptide seq...

journal_title：Endocrinology

authors： Oram S,Jiang F,Cai X,Haleem R,Dincer Z,Wang Z

更新日期：2004-04-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:Treatment of 5-day cyclic rats with 10 or 100 microgram estradiol benzoate on the day of estrus induced a luteal phase in all animals studied. On the other hand, an injection with 1 microgram estradiol benzoate given on the same day failed to induce pseudopregnancy. When 10 mg progesterone were injected on the day of ...

journal_title：Endocrinology

authors： de Greef WJ,Zeilmaker GH

更新日期：1979-07-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:Cellular distribution of progestin receptor immunoreactivity (PR-IR) in paraffin-embedded rabbit oviduct tissue was determined using a monoclonal antibody and the indirect immunoperoxidase method. Ampullar and isthmic tissue from ovariectomized animals primed with 17 beta-estradiol or vehicle alone was examined. As ex...

journal_title：Endocrinology

authors： Hyde BA,Blaustein JD,Black DL

更新日期：1989-09-01 00:00:00

abstract：:The effects of estrogen on the synthesis of pituitary PRL mRNA and PRL and the release of PRL into plasma were investigated in male and female normal and hypogonadal (hpg) mice. Because the hpg mouse is totally deficient in hypothalamic GnRH, it provides an excellent model for investigating the effects of estrogen and...

journal_title：Endocrinology

authors： Stanley HF,Curtis A,Sheward WJ,Roberts JL,Fink G

更新日期：1986-12-01 00:00:00

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:The molecular links between membrane excitability and neurohormone synthesis were investigated using a simple model system: the bag cell neurons of Aplysia. We tested the hypothesis that the electrical afterdischarge, which leads to depletion of egg-laying hormone (ELH) by triggering secretion, rapidly stimulates ELH ...

journal_title：Endocrinology

authors： Lee W,Wayne NL

更新日期：1998-12-01 00:00:00

abstract：:Several studies have revealed a variety of interactions between PTH and ACTH. The existence of a significant area of homology in the bioactive regions of the two molecules has been proposed as a possible reason for such interactions. To clarify the relationship, corticosteroidogenic and cAMP accumulative effects of bo...

journal_title：Endocrinology

authors： Rafferty B,Zanelli JM,Rosenblatt M,Schulster D

更新日期：1983-09-01 00:00:00

abstract：:PTH and PTH-related peptide (PTHrP) have been shown to bind to and activate the same PTH/PTHrP receptor. Recent studies have demonstrated, however, the presence of additional receptors specific for each ligand. We used the PTHrP and PTH/PTHrP receptor gene knock-out models to investigate whether this receptor mediates...

journal_title：Endocrinology

authors： Lanske B,Divieti P,Kovacs CS,Pirro A,Landis WJ,Krane SM,Bringhurst FR,Kronenberg HM

更新日期：1998-12-01 00:00:00

abstract：:In order to elucidate the molecular mechanisms whereby ovarian hormones, and particularly estrogens, modulate fat cell metabolism, we investigated the effects of estradiol administration on c-fos and c-jun expressions in fat cells from ovariectomized (OVX) rats. Estradiol treatment resulted in a rapid increase in c-fo...

journal_title：Endocrinology

authors： Garcia E,Lacasa D,Giudicelli Y

更新日期：2000-08-01 00:00:00

abstract：:A model for the study of testicular function in experimental uremia induced by subtotal nephrectomy in mature male rats is described. Glomerular filtration rate was reduced by 87%, resulting in stable uremia for up to 13 weeks with characteristic biochemical changes and reduction in weight of testes, prostate, seminal...

journal_title：Endocrinology

authors： Handelsman DJ,Spaliviero JA,Turtle JR

更新日期：1985-11-01 00:00:00

abstract：:Molecular and cellular mechanisms involved in artificially induced ovarian differentiation were analyzed by exposing embryos of medaka (Oryzias latipes) to a potent nonsteroidal estrogen, diethylstilbestrol (DES). Embryos were exposed for short-exposure (SE) [from 0 to 8 d postfertilization (dpf)] and long-exposure (L...

journal_title：Endocrinology

authors： Paul-Prasanth B,Shibata Y,Horiguchi R,Nagahama Y

更新日期：2011-02-01 00:00:00

abstract：:The cell of origin of human null cell pituitary adenomas is disputed. Although these tumors, by definition, do not produce any of the anterior pituitary hormones in vivo, they have been shown to express gonadotropin subunit genes, release gonadotropin hormones in vitro, and express the gonadotroph-associated transcrip...

journal_title：Endocrinology

authors： Kumar TR,Graham KE,Asa SL,Low MJ

更新日期：1998-07-01 00:00:00

abstract：:Thyroid hormone (TH) is required for frog metamorphosis, and corticosterone (CORT) increases TH signaling to accelerate metamorphic progression. However, a requirement for CORT in metamorphosis has been difficult to assess prior to the recent development of gene-editing technologies. We addressed this long-standing qu...

journal_title：Endocrinology

authors： Shewade LH,Schoephoerster JA,Patmann MD,Kulkarni SS,Buchholz DR

更新日期：2020-12-01 00:00:00

abstract：:Interferon-tau (IFNtau) is the embryonic signal responsible for pregnancy recognition in ruminants. The primary action of IFNtau is believed to be mediated through inhibition of prostaglandin F(2alpha) (PGF(2alpha)) released from the endometrial epithelial cells in response to oxytocin (OT). Our working hypothesis was...

journal_title：Endocrinology

authors： Krishnaswamy N,Danyod G,Chapdelaine P,Fortier MA

更新日期：2009-02-01 00:00:00

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:The effects of insulin and glucose, alone and combined, on diacylglycerol (DAG), protein kinase-C (PKC), and glucose transport were compared in rat adipocytes and solei incubated in medium containing 0-20 mM glucose. In both tissues insulin rapidly stimulated [3H]DAG production from [3H]glycerol; extracellular glucose...

journal_title：Endocrinology

authors： Hoffman JM,Ishizuka T,Farese RV

更新日期：1991-06-01 00:00:00

abstract：:Several novel cyclic MSH analogs were synthesized, and their binding properties were tested on cells transiently expressing the human melanocortin-1 (MC1), MC3, MC4, and MC5 receptors. We discovered a novel substance (HS024) that showed about 20-fold selectivity and very high affinity (Ki = 0.29 nM) for the MC4 recept...

journal_title：Endocrinology

authors： Kask A,Mutulis F,Muceniece R,Pähkla R,Mutule I,Wikberg JE,Rägo L,Schiöth HB

更新日期：1998-12-01 00:00:00

abstract：:An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular locali...

journal_title：Endocrinology

authors： Jazín EE,Dickerman HW,Henrikson KP

更新日期：1988-02-01 00:00:00

abstract：:Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Since low mol wt GTP-binding proteins (LMW-GTP-binding proteins) have been implicated in the regulation of vesicular trafficking, we have analyzed these proteins in adipocyt...

journal_title：Endocrinology

authors： Cormont M,Tanti JF,Grémeaux T,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1991-12-01 00:00:00

abstract：:Glucocorticoid (Gc) excess, from endogenous overproduction in disorders of the hypothalamic-pituitary-adrenal axis or exogenous medical therapy, is recognized to cause adverse metabolic side effects. The Gc receptor (GR) is widely expressed throughout the body, including brain regions such as the hypothalamus. However...

journal_title：Endocrinology

authors： Sefton C,Harno E,Davies A,Small H,Allen TJ,Wray JR,Lawrence CB,Coll AP,White A

更新日期：2016-11-01 00:00:00

abstract：:Effects of spironolactone, canrenone and canrenoate-K on adrenal cytochrome P450 (P450) and corticosteroid biosynthesis were examined by studying difference spectra, P450 reduction and corticoid hydroxylation in mitochondrial preparations isolated from zona fasciculata and zona glomerulosa of bovine adrenals and from ...

journal_title：Endocrinology

authors： Cheng SC,Suzuki K,Sadee W,Harding BW

更新日期：1976-10-01 00:00:00

abstract：:[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes. The digestion was performed at 37 C for 24 h under nitr...

journal_title：Endocrinology

authors： Tokuyama T,Yoshinari M,Rawitch AB,Taurog A

更新日期：1987-08-01 00:00:00

abstract：:Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...

journal_title：Endocrinology

authors： Karpuzoglu E,Fenaux JB,Phillips RA,Lengi AJ,Elvinger F,Ansar Ahmed S

更新日期：2006-02-01 00:00:00

abstract：:The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...

journal_title：Endocrinology

authors： Bianco AC,Silva JE

更新日期：1987-01-01 00:00:00

abstract：:The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...

journal_title：Endocrinology

authors： Packman PM,Rothchild JA

更新日期：1976-07-01 00:00:00

abstract：:Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...

journal_title：Endocrinology

authors： Habibi J,Hayden MR,Sowers JR,Pulakat L,Tilmon RD,Manrique C,Lastra G,Demarco VG,Whaley-Connell A

更新日期：2011-02-01 00:00:00