Abstract:
:An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular localization of the activator is determined by a radioactive assay of fractions prepared by sucrose density centrifugation. The distribution of activity parallels the distribution of two plasma membrane markers, Mg2+-ATPase and 5'-nucleotidase. Electron micrographic visualization of the gradient fractions containing the activator reveals a population of vesicles 0.2-0.5 micron in diameter.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Jazín EE,Dickerman HW,Henrikson KPdoi
10.1210/endo-122-2-500subject
Has Abstractpub_date
1988-02-01 00:00:00pages
500-3issue
2eissn
0013-7227issn
1945-7170journal_volume
122pub_type
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