Thyroxine and 3,3',5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases.

abstract：:GH promotes not only longitudinal growth in children but is active throughout life in protein, fat, and carbohydrate metabolism. The multiple actions of GH start when GH binds to the cell surface-expressed GH receptor. Effectiveness of the hormone depends both on its presence in the circulation and the availability of...

journal_title：Endocrinology

authors： van Kerkhof P,Smeets M,Strous GJ

更新日期：2002-04-01 00:00:00

abstract：:It is unclear whether the maturation of corticotrophs from the fetal to the adult type in the fetal sheep pituitary in late gestation is associated with changes in the sensitivity of the fetal pituitary to corticotrophic secretagogues and in the form of ACTH-containing peptides (IR-ACTH) secreted into the circulation....

journal_title：Endocrinology

authors： Ozolins IZ,Antolovich GC,Browne CA,Perry RA,Robinson PM,Silver M,McMillen IC

更新日期：1991-10-01 00:00:00

abstract：:Glucose stimulation of pancreatic beta-cells triggers electrical activity (slow waves of membrane potential with superimposed spikes) that is best monitored with intracellular microelectrodes. Closure of ATP-sensitive K+ channels underlies the depolarization to the threshold potential and participates in the increase ...

journal_title：Endocrinology

authors： Henquin JC

更新日期：1998-03-01 00:00:00

abstract：:Pineal denervation by superior cervical ganglionectomy (Gx) decreased high affinity binding of estradiol (E2) to the pineal cytosol of female rats and of testosterone to the cytosol of male rats by 40 and 26% and by 75 and 80%, 5 and 14 days after sugery; hormone binding remained unchanged up to 24 h after surgery. Bi...

journal_title：Endocrinology

authors： Cardinali DP,Gómez E,Rosner JM

更新日期：1976-04-01 00:00:00

abstract：:The assembly of the developmentally arrested primordial follicle and the subsequent transition of the primordial follicle to the primary follicle are critical processes in normal ovarian physiology that remain to be elucidated. Ovarian follicles do not proliferate and the primordial follicles present in the neonate re...

journal_title：Endocrinology

authors： Kezele P,Skinner MK

更新日期：2003-08-01 00:00:00

abstract：:PTHrP is produced in vessels and acts as a local modulator of tone. We recently reported that PTHrP(1-34) is able to induce vasorelaxation in rat uterine arteries, but in pregnancy, this response is blunted and becomes strictly endothelium dependent. The present study aimed to get insights into the mechanisms involved...

journal_title：Endocrinology

authors： Meziani F,Tesse A,Welsch S,Kremer H,Barthelmebs M,Andriantsitohaina R,Schneider F,Gairard A

更新日期：2008-02-01 00:00:00

abstract：:Fasting in rodents is characterized by decreases in serum T4 and T3 levels but no compensatory increase in serum TSH level. The types 1 and 2 deiodinases (D1 and D2) are postulated to play key roles in mediating these changes. However, serum T4 and T3 levels in fasted 5'-deiodinase-deficient mice decreased by at least...

journal_title：Endocrinology

authors： Galton VA,Hernandez A,St Germain DL

更新日期：2014-08-01 00:00:00

abstract：:Mullerian inhibiting substance (MIS) is a 140-kilodalton homodimeric glycoprotein that causes regression of the Mullerian ducts in male embryos, and may also have a role in both males and females in the regulation of germ cell maturation. We examined the ontogeny of MIS messenger RNA (mRNA) in rat testes from midgesta...

journal_title：Endocrinology

authors： Lee MM,Cate RL,Donahoe PK,Waneck GL

更新日期：1992-02-01 00:00:00

abstract：:Studies in rodents demonstrate that the mitogen, IGF-I, stimulates intestinal peptide YY (PYY) expression. To investigate whether the stimulatory influence of IGF-I is exerted at the level of gene transcription, rat PYY 5'-upstream sequences (-2800/+37 bp, -770/+37 bp, -127/+37 bp) fused to the firefly luciferase (luc...

journal_title：Endocrinology

authors： Wang G,Leiter AB,Englander EW,Greeley GH Jr

更新日期：2004-02-01 00:00:00

abstract：:Cross talks between the vascular and immune system play a critical role in vascular diseases, in particular in atherosclerosis. The osteoclast-associated receptor (OSCAR) is a regulator of osteoclast differentiation and dendritic cell maturation. Whether OSCAR plays a role in vascular biology and has an impact on athe...

journal_title：Endocrinology

authors： Goettsch C,Rauner M,Sinningen K,Helas S,Al-Fakhri N,Nemeth K,Hamann C,Kopprasch S,Aikawa E,Bornstein SR,Schoppet M,Hofbauer LC

更新日期：2011-12-01 00:00:00

abstract：:Androgen regulation of ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) activities and accumulation of the mRNAs encoding these two enzymes in rodent kidney and accessory sex organs were studied. The ODC mRNA concentration and enzyme activity were increased by androgens in kidney, prosta...

journal_title：Endocrinology

authors： Crozat A,Palvimo JJ,Julkunen M,Jänne OA

更新日期：1992-03-01 00:00:00

abstract：:Aging of the female reproductive system in rats is marked by discrete stages in the disappearance of regular estrous cyclicity. We determined at which point in the transition to acyclicity changes in the LH pulse generator could be detected by comparing pulsatile LH release in ovariectomized young rats to three groups...

journal_title：Endocrinology

authors： Scarbrough K,Wise PM

更新日期：1990-02-01 00:00:00

abstract：:Plasma immunoreactive PRL responses to indoleamines and their metabolites were studied in urethane-anesthetized rats. All drugs were injected into the lateral ventricle and blood samples were serially collected from a jugular vein. Serotonin and melatonin caused a significant increase in plasma PRL with peak values at...

journal_title：Endocrinology

authors： Iwasaki Y,Kato Y,Ohgo S,Abe H,Imura H,Hirata F,Senoh S,Tokuyama T,Hayaishi O

更新日期：1978-07-01 00:00:00

abstract：:A study was conducted to determine the role of the thyroid gland in three neuroendocrine responses to photoperiod; secretion of melatonin, PRL, and LH. Ewes were thyroidectomized (THX) in midsummer or left thyroid intact, and both groups were moved indoors to artificial short days (8 h of light, 16 h of darkness) for ...

journal_title：Endocrinology

authors： Dahl GE,Evans NP,Moenter SM,Karsch FJ

更新日期：1994-07-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：:The importance of thyroid hormone (TH) in wound healing is not well understood. To gain insight, we evaluated the impact of TH deficiency on wound-healing genes in cultured keratinocytes. By RT-PCR, keratin 6a (K6a) and 16 (K16) gene expression in TH replete cells was 3.8- (P < 0.005) and 1.9-fold (P < 0.05) greater, ...

journal_title：Endocrinology

authors： Safer JD,Crawford TM,Holick MF

更新日期：2004-05-01 00:00:00

abstract：:Changes in several extracellular matrix proteins, such as fibronectin in fetal membrane and cervical collagens, occur at term and preterm delivery. However, no studies have evaluated changes in extracellular matrix proteins, in relation to myometrial activation recorded using invasive techniques during parturition in ...

journal_title：Endocrinology

authors： Wu WX,Zhang Q,Ma XH,Unno N,Nathanielsz PW

更新日期：1999-05-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...

journal_title：Endocrinology

authors： Zimmermann RC,Xiao E,Bohlen P,Ferin M

更新日期：2002-07-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00

abstract：:PRL receptor (PRL-R) expression has been analyzed in human hematopoietic tissues using flow cytofluorometric analysis with a series of biotinylated monoclonal antibodies (mAbs) directed against the extracellular domain of the rat liver PRL-R. In the thymus, more than 75% of cells were labeled by the anti-PRL-R mAb. Re...

journal_title：Endocrinology

authors： Dardenne M,de Moraes Mdo C,Kelly PA,Gagnerault MC

更新日期：1994-05-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00

abstract：:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities ...

journal_title：Endocrinology

authors： Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll AP

更新日期：2006-12-01 00:00:00

abstract：:The rat esophagus shares some cellular features with skin squamous epithelium and striated muscle that express high levels of corticotropin-releasing factor type 2 (CRF2) receptors or their cognate ligand urocortin (Ucn) 1, 2, and 3. We investigated the expression and cell signaling of CRF2 receptors and ligands in th...

journal_title：Endocrinology

authors： Wu SV,Yuan PQ,Wang L,Peng YL,Chen CY,Taché Y

更新日期：2007-04-01 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes expressed in hypoxic conditions. In vascular smooth muscle cells, the vasoactive hormone angiotensin II (Ang II) is a very potent inducer and activator of HIF-1. As opposed to hypoxia, which induces HIF-1alpha by ...

journal_title：Endocrinology

authors： Lauzier MC,Pagé EL,Michaud MD,Richard DE

更新日期：2007-08-01 00:00:00

abstract：:When colonic crypt cells isolated from intact rats are incubated with [3H]corticosterone specific nuclear binding is displaced by neither aldosterone nor the antiglucocorticoid RU38486, suggesting that [3H]corticosterone is binding to a site distinct from classical mineralocorticoid and glucocorticoid receptors. TLC r...

journal_title：Endocrinology

authors： Sheppard KE,Funder JW

更新日期：1996-08-01 00:00:00

abstract：:Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...

journal_title：Endocrinology

authors： Briggs DI,Lockie SH,Wu Q,Lemus MB,Stark R,Andrews ZB

更新日期：2013-02-01 00:00:00

abstract：:The binding characteristics of Sertoli Cell Factor (SCF) to the anterior pituitaries were examined using tissue homogenates and cultured cells. Tritium-labeled SCF (3H-SCF), synthesized by rat Sertoli cells in vitro in the presence of 3H-leucine and partly purified by Sephadex gel chromatography, was used to the ligan...

journal_title：Endocrinology

authors： Steinberger A,Seethalakshmi L,Kessler M,Steinberger E

更新日期：1982-08-01 00:00:00

abstract：:The physiology and regulation of steroid synthesis in the brain have emerged as important for understanding brain function. Neurosteroids, those steroids synthesized de novo in nervous tissue, have been associated with numerous central nervous system functions, including myelination, mental retardation, and epilepsy. ...

journal_title：Endocrinology

authors： Micevych P,Sinchak K

更新日期：2008-06-01 00:00:00

abstract：:Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities. Furthermore, interactions between PTH and gp130 signaling have suggested that gp130 signaling might influence calcium homeostasis. We, therefore, examined th...

journal_title：Endocrinology

authors： Shin HI,Divieti P,Sims NA,Kobayashi T,Miao D,Karaplis AC,Baron R,Bringhurst R,Kronenberg HM

更新日期：2004-03-01 00:00:00