The thyroid gland is required for reproductive neuroendocrine responses to photoperiod in the ewe.

Abstract:

:A study was conducted to determine the role of the thyroid gland in three neuroendocrine responses to photoperiod; secretion of melatonin, PRL, and LH. Ewes were thyroidectomized (THX) in midsummer or left thyroid intact, and both groups were moved indoors to artificial short days (8 h of light, 16 h of darkness) for 90 days. Thereafter, a subset of both THX and thyroid-intact ewes was challenged with long days (16 h of light, 8 h of darkness) for 120 days. The other ewes remained in short days so that neuroendocrine responses to the photoperiodic shift could be distinguished from hormonal changes that occur spontaneously. Blood was sampled twice weekly for determination of serum concentrations of LH and PRL and hourly for 48 h surrounding the photoperiodic switch for assay of melatonin. All ewes were ovariectomized and treated with constant release implants of estradiol, so that PRL and LH secretion would not be influenced by alterations in gonadal steroid secretion. There was no effect of thyroidectomy on the circadian pattern of circulating melatonin or on the change in this pattern after the shift from short to long days. Similarly, thyroidectomy did not alter the PRL response to this photoperiodic shift; long days caused PRL to increase whether the thyroid was present or absent. In marked contrast, thyroidectomy blocked the effect of long days on circulating LH, a hormone indicative of reproductive neuroendocrine activity. Specifically, long days induced a precipitous drop in LH in thyroid-intact ewes, but not in THX ewes. Thus, although the thyroid plays an obligatory role in photoperiodic inhibition of the reproductive neuroendocrine axis of ewes, it may not be required for photoneuroendocrine responses in terms of melatonin and PRL secretion. Our findings suggest that in the absence of the thyroid, the reproductive neuroendocrine axis is uncoupled from the photoperiodic influence between the pineal and the GnRH neurosecretory system.

journal_name

Endocrinology

journal_title

Endocrinology

authors

Dahl GE,Evans NP,Moenter SM,Karsch FJ

doi

10.1210/endo.135.1.8013340

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

10-5

issue

1

eissn

0013-7227

issn

1945-7170

journal_volume

135

pub_type

杂志文章
  • Antigen presentation by vaginal cells: role of TGFbeta as a mediator of estradiol inhibition of antigen presentation.

    abstract::Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.143.8.8938

    authors: Wira CR,Roche MA,Rossoll RM

    更新日期:2002-08-01 00:00:00

  • Antipeptide polyclonal antibodies specifically recognize each human thyroid hormone receptor isoform.

    abstract::We characterized four antipeptide polyclonal antibodies (abs) able to specifically recognize each thyroid hormone receptor (TR) isoform. The abs immunoprecipitated both the in vitro synthesized receptor and the receptor expressed in E. coli and their specificity was confirmed by competition studies and immunohistochem...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.131.5.1425440

    authors: Falcone M,Miyamoto T,Fierro-Renoy F,Macchia E,DeGroot LJ

    更新日期:1992-11-01 00:00:00

  • Glutamate-immunoreactive neurons and their gonadotropin-releasing hormone-neuronal interactions in the monkey hypothalamus.

    abstract::Glutamate (Glu) is the most prevalent excitatory neurotransmitter in the brain and has been implicated in the regulation of GnRH secretion in several mammalian species, including the monkey. To investigate the neuroanatomical basis for Glu-GnRH interactions, we performed an immunocytochemical study at both the light a...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.134.2.7905410

    authors: Goldsmith PC,Thind KK,Perera AD,Plant TM

    更新日期:1994-02-01 00:00:00

  • The androgen receptor of the testicular-feminized (Tfm) mutant mouse is smaller than the wild-type receptor.

    abstract::The physicochemical and immunological properties of androgen receptors from kidney and brain of testicular-feminized (Tfm) mutant mice and wild-type mice were compared. Analysis by gel filtration and sucrose density gradients revealed that the mol wt of the mutant receptor was 66K (38A; 3.8S) which was significantly s...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-124-2-771

    authors: Young CY,Johnson MP,Prescott JL,Tindall DJ

    更新日期:1989-02-01 00:00:00

  • Characterization and hormonal regulation of a rat ovarian insulin-like growth factor binding protein-5 endopeptidase: an FSH-inducible granulosa cell-derived metalloprotease.

    abstract::Previous studies established the existence of an FSH-inducible rat granulosa cell-derived insulin-like growth factor binding protein (IGFBP)-5 endopeptidase. It was the objective of this communication to characterize this activity in some detail. Exposure of [125I]rhIGFBP-5 substrate to media conditioned by FSH-treate...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.139.3.5845

    authors: Resnick CE,Fielder PJ,Rosenfeld RG,Adashi EY

    更新日期:1998-03-01 00:00:00

  • Cysteamine induces depletion of both immunological and biological prolactin activity in the anterior pituitary and blood of the rat.

    abstract::Previous studies have shown that cysteamine [2-aminoethanethiol (CSH)], given in vivo or in vitro, rapidly but reversibly depletes immunoreactive PRL from the anterior pituitary (AP) through a mechanism which, in vitro, does not appear to involve the dopamine (DA) receptor. In the present investigation, these effects ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-113-6-2161

    authors: Millard WJ,Sagar SM,Simpkins JW,Owens RE,Badger TM,Friesen HG,Martin JB

    更新日期:1983-12-01 00:00:00

  • Differences in the behavior of luteinizing hormones of various species at the rat gonadal cell receptor site.

    abstract::The ability of different LH-like hormones, such as hCG, PMSG/equine (e) CG, ovine (o) LH, eLH, and rat (r) LH, to bind to and stimulate steroidogenesis in two types of rat gonadal cells was studied under the same experimental conditions. In both Leydig and granulosa cells, the maximal steroidogenic responses elicited ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-116-2-597

    authors: Rani CS,Moudgal NR

    更新日期:1985-02-01 00:00:00

  • Serum bone gla protein and the vitamin D endocrine system in the oophorectomized rat.

    abstract::Because of the importance of estrogen in osteoporosis, the effects of decreased estrogen production using sensitive measurements of bone mineral metabolism were studied in oophorectomized rats. Serum levels of ionized calcium, bone gla protein (BGP), vitamin D metabolites (25-hydroxyvitamin D and 1,25-dihydroxyvitamin...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-122-2-624

    authors: Ismail F,Epstein S,Fallon MD,Thomas SB,Reinhardt TA

    更新日期:1988-02-01 00:00:00

  • Insulin-like growth factor II is a potent inhibitor of the aromatase activity of human placental cytotrophoblasts.

    abstract::The placenta is the primary source of estrogens and progesterone during pregnancy. Because pregnant diabetic women are reported to have lower serum estrogen and higher progesterone levels than nondiabetic pregnant women, and placental insulin-like growth factor II (IGF-II) production may be elevated during diabetic pr...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-127-5-2064

    authors: Nestler JE

    更新日期:1990-11-01 00:00:00

  • Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.

    abstract::Epidemiological evidence indicates that phytoestrogens inhibit cancer formation and growth, reduce cholesterol levels, and show benefits in treating osteoporosis. At least some of these activities are mediated through the interaction of phytoestrogens with estrogen receptors alpha and beta (ERalpha and ERbeta). Resver...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.141.10.7721

    authors: Bowers JL,Tyulmenkov VV,Jernigan SC,Klinge CM

    更新日期:2000-10-01 00:00:00

  • Gene expression of the six insulin-like growth factor binding proteins in the mouse conceptus during mid- and late gestation.

    abstract::The insulin-like growth factor-binding proteins (IGFBPs) comprise at least six distinct species that may modulate the action of IGFs. IGFs are important regulators of fetal growth and differentiation. To define sites of IGFBP mRNA synthesis, we have used in situ hybridization techniques in mouse conceptuses of differe...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.132.6.7684980

    authors: Schuller AG,Zwarthoff EC,Drop SL

    更新日期:1993-06-01 00:00:00

  • Adrenocorticotropin, beta-endorphin, and beta-lipotropin in normal thyroid and lung: possible implications for ectopic hormone secretion.

    abstract::The expression of the proopiomelanocortin (POMC) gene by normal lung and thyroid was examined by measurement of the content of ACTH, beta-lipotropin (beta LPH), and beta-endorphin (beta EP) in porcine lung and thyroid tissue. Acid extracts of normal porcine lung and thyroid tissue each contained appreciable amounts of...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-111-6-2097

    authors: Clements JA,Funder JW,Tracy K,Morgan FJ,Campbell DJ,Lewis P,Hearn MT

    更新日期:1982-12-01 00:00:00

  • Effects of progesterone and tamoxifen on glucocorticosteroid-induced egg-white protein synthesis in the chick oviduct.

    abstract::A single injection of either natural (cortisol, corticosterone) or synthetic [dexamethasone (DEX), triamcinolone acetonide] glucocorticosteroids to estradiol-primed, withdrawn chicks, resulted in a dose-dependent increase in the relative rates of ovalbumin and conalbumin synthesis. The simultaneous injection of equal ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-116-6-2384

    authors: Le Bouc Y,Groyer A,Cadepond F,Groyer-Schweizer G,Robel P,Baulieu EE

    更新日期:1985-06-01 00:00:00

  • Regulation of estrogen and progesterone receptor levels in mouse mammary epithelial cells grown in serum-free collagen gel cultures.

    abstract::The effect of collagenase dissociation of virgin mouse mammary glands on the level of mammary epithelial cytosolic estrogen receptors (ER) and progesterone receptors (PR) was assessed. After cell dissociation, ER was present in mammary epithelial cells at concentrations similar to those found in the whole gland. Howev...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-116-1-105

    authors: Edery M,Imagawa W,Larson L,Nandi S

    更新日期:1985-01-01 00:00:00

  • Localization of messenger ribonucleic acids for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor in the ovine ovary throughout the estrous cycle.

    abstract::The distribution pattern of messenger RNAs (mRNAs) for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor and the detection of IGF-binding sites in sections of ovine ovary were demonstrated using in situ hybridization and autoradiography. Ovaries were collected from 30 ewes at time points throug...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.136.12.7588270

    authors: Perks CM,Denning-Kendall PA,Gilmour RS,Wathes DC

    更新日期:1995-12-01 00:00:00

  • Clomiphene prevents cancellous bone loss from tibia of ovariectomized rats.

    abstract::Estrogen inhibits postmenopausal bone loss and decreases fracture risk. Unfortunately, estrogen replacement therapy has many undesirable side effects, the majority of which are due to stimulation of reproductive tissues. Tissue specific estrogen agonists provide a promising new alternative to natural estrogens for hor...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.138.5.5109

    authors: Jimenez MA,Magee DE,Bryant HU,Turner RT

    更新日期:1997-05-01 00:00:00

  • Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats.

    abstract::Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of these peptides and their regulated expression by ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2014-1200

    authors: Overgaard A,Ruiz-Pino F,Castellano JM,Tena-Sempere M,Mikkelsen JD

    更新日期:2014-10-01 00:00:00

  • Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes.

    abstract::The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. I...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2006-1324

    authors: Moore XL,Tan SL,Lo CY,Fang L,Su YD,Gao XM,Woodcock EA,Summers RJ,Tregear GW,Bathgate RA,Du XJ

    更新日期:2007-04-01 00:00:00

  • Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte.

    abstract::Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and diabetes later in life. We previously showed that prenatal exposure to the EDC tributyltin (TBT) results in increased adiposity in the offspring. These effects linger into adulthood and are propag...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2018-00056

    authors: Shoucri BM,Hung VT,Chamorro-García R,Shioda T,Blumberg B

    更新日期:2018-08-01 00:00:00

  • The Response of Prostate Smooth Muscle Cells to Testosterone Is Determined by the Subcellular Distribution of the Androgen Receptor.

    abstract::Androgen signaling in prostate smooth muscle cells (pSMCs) is critical for the maintenance of prostate homeostasis, the alterations of which are a central aspect in the development of pathological conditions. Testosterone can act through the classic androgen receptor (AR) in the cytoplasm, eliciting genomic signaling,...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2017-00718

    authors: Peinetti N,Scalerandi MV,Cuello Rubio MM,Leimgruber C,Nicola JP,Torres AI,Quintar AA,Maldonado CA

    更新日期:2018-02-01 00:00:00

  • Role of leptin in peroxisome proliferator-activated receptor gamma coactivator-1 expression.

    abstract::Peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1), a cold-induced protein expressed in brown adipose tissue (BAT), plays a role in adaptive thermogenesis by up-regulating uncoupling proteins (UCP). Here, we explore its relationship to the thermogenic actions of leptin, which also up-regulates UCPs...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.141.12.7804

    authors: Kakuma T,Wang ZW,Pan W,Unger RH,Zhou YT

    更新日期:2000-12-01 00:00:00

  • Atrial natriuretic peptides: the role of phenylalanine on biological activity.

    abstract::Previous studies have shown that atrial natriuretic peptides (ANPs) inhibit the secretion of aldosterone by isolated rat adrenal glomerulosa cells stimulated by angiotensin II, ACTH, and potassium. Structure-function studies have concentrated on the significance of the C- and N-terminal chains for the biological activ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-122-3-826

    authors: Craven TG,Kem DC,Schiebinger RJ

    更新日期:1988-03-01 00:00:00

  • Somatostatin-like immunoreactivity in transplantable medullary carcinoma of rat thyroid: partial chromatographic and biological characterization.

    abstract::Somatostatin-like immunoreactivity (SRIF-LI) has previously been demonstrated immunohistochemically in rat thyroid parafollicular cells. Studies were therefore performed to determine whether SRIF-LI was present in a transplantable medullary carcinoma of the thyroid (MCT) in the WAG/Rij strain of rat. SRIF-LI was found...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-107-5-1418

    authors: Berelowitz M,Cibelius M,Szabo M,Frohman LA,Epstein S,Bell NH

    更新日期:1980-11-01 00:00:00

  • β-Catenin Directs Long-Chain Fatty Acid Catabolism in the Osteoblasts of Male Mice.

    abstract::Wnt-initiated signaling through a frizzled receptor and the low-density lipoprotein-related receptor-5 coreceptor instructs key anabolic events during skeletal development, homeostasis, and repair. Recent studies indicate that Wnt signaling also regulates the intermediary metabolism of osteoblastic cells, inducing glu...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2017-00850

    authors: Frey JL,Kim SP,Li Z,Wolfgang MJ,Riddle RC

    更新日期:2018-01-01 00:00:00

  • Sertoli cell function varies along the seminiferous tubule: the proportion and response of transferrin secretors differ between stage-associated tubule segments.

    abstract::Recent studies from our laboratory demonstrated clearly that only a portion of all Sertoli cells secrete transferrin (TF). These findings raised the possibility that differences in the functional type of Sertoli cells from one location to another may account in part for the stage-related variation in TF release along ...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-128-4-1869

    authors: Garza MM,Schwarz LK,Bonner JM,Boockfor FR

    更新日期:1991-04-01 00:00:00

  • Estrogen action on growth hormone in pituitary cell cultures from adult and juvenile macaques.

    abstract::Basal growth hormone (GH) levels are higher in female than male primates, and estradiol (E) treatment of gonadectomized primates increases serum GH. To determine if the effect of E is mediated at the level of the somatotroph, we verified the effect of E-treatment on serum GH in spayed macaques, and then examined the e...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-129-4-2110

    authors: Bethea CL

    更新日期:1991-10-01 00:00:00

  • Analysis of gamma-aminobutyric acidB receptor function in the in vitro and in vivo regulation of alpha-melanotropin-stimulating hormone secretion from melanotrope cells of Xenopus laevis.

    abstract::The activity of many endocrine cells is regulated by gamma-aminobutyric acid (GABA). The effects of GABA are mediated by GABAA and/or GABAB receptors. While GABAB receptors in the central nervous system have now been extensively characterized, little is known of the function and pharmacology of GABAB receptors on endo...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo.132.2.8381070

    authors: De Koning HP,Jenks BG,Roubos EW

    更新日期:1993-02-01 00:00:00

  • Suppression of luteinizing hormone secretion by atrial and brain natriuretic peptides in ovariectomized rats.

    abstract::Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are present in brain regions regulating LH secretion. Similarities in the molecular structure of these peptides suggest similar physiological function within the brain. This study examined the effects of centrally administered BNP and ANP on LH secre...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-129-2-801

    authors: Zhang J,Yuen BH,Currie WD,Leung PC

    更新日期:1991-08-01 00:00:00

  • Role of atrial natriuretic factor in renin release.

    abstract::Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/endo-119-1-318

    authors: Antonipillai I,Vogelsang J,Horton R

    更新日期:1986-07-01 00:00:00

  • Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic beta-cells.

    abstract::Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

    journal_title:Endocrinology

    pub_type: 杂志文章

    doi:10.1210/en.2008-0186

    authors: Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

    更新日期:2008-11-01 00:00:00