Abstract:
:In vitro antiglucocorticoids (cortexolone and progesterone) were evaluated as in vivo antagonists of dexamethasone-induced increases in liver tyrosine amino transferase (TAT; EC 2.6.1.5), tryptophan oxygenase (TPO; EC 1.13.1.12), and glycogen deposition. Cortexolone antagonized the TPO and glycogen responses to dexamethasone in the liver of adrenalectomized rats but did not significantly influence the induced TAT activity. Progesterone, although toxic at levels approaching those used for cortexolone, was capable of antagonizing the glycogen increase. A new antagonist, 6 beta-bromoprogesterone, was found to be nontoxic and was more potent than cortexolone in blocking the TPO and glycogen responses. These results demonstrate that in vivo antiglucocorticoid activity can be evaluated and suggested significant differences between the sensitivity of TAT induction and that of glycogen or TPO.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Naylor PH,Gilani SS,Milholland RJ,Rosen Fdoi
10.1210/endo-107-1-117subject
Has Abstractpub_date
1980-07-01 00:00:00pages
117-21issue
1eissn
0013-7227issn
1945-7170journal_volume
107pub_type
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