Abstract:
:In the adrenal gland, neuroendocrine cells that synthesize catecholamines and epithelial cells that produce steroid hormones are united beneath a common organ capsule to function as a single stress-responsive organ. The functional anatomy of the steroid hormone-producing adrenal cortex and the catecholamine-producing medulla is ill defined at the level of small molecules. Here, we report a comprehensive high-resolution mass spectrometry imaging (MSI) map of the normal human adrenal gland. A large variety of biomolecules was accessible by matrix-assisted laser desorption/ionization-Fourier transform-ion cyclotron resonance MSI, including nucleoside phosphates indicative of oxidative phosphorylation, sterol and steroid metabolites, intermediates of glycolysis and the tricarboxylic acid cycle, lipids, and fatty acids. Statistical clustering analyses yielded a molecularly defined adrenal anatomy of 10 distinct molecular zones including a highly structured corticomedullary interface. By incorporating pathway information, activities of carbohydrate, amino acid, and lipid metabolism as well as endocrine bioactivity were revealed to be highly spatially organized, which could be visualized as different molecularly defined zones. Together, these findings provide a molecular definition of human adult adrenal gland structure beyond classical histological anatomy.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Sun N,Wu Y,Nanba K,Sbiera S,Kircher S,Kunzke T,Aichler M,Berezowska S,Reibetanz J,Rainey WE,Fassnacht M,Walch A,Kroiss Mdoi
10.1210/en.2018-00064subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1511-1524issue
3eissn
0013-7227issn
1945-7170pii
4828183journal_volume
159pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa175
更新日期:2020-11-01 00:00:00
abstract::In the setting of insulin resistance, agonists of peroxisome proliferator-activated receptor (PPAR)-gamma restore insulin action in muscle and promote lipid redistribution. Mice with muscle-specific knockout of PPARgamma (MuPPARgammaKO) develop excess adiposity, despite reduced food intake and normal glucose disposal ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0100
更新日期:2008-11-01 00:00:00
abstract::Basal hypothalamic deafferentation abolished the nycthemeral rhythm of both plasma TSH and corticosterone. ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-97-3-749
更新日期:1975-09-01 00:00:00
abstract::Gonadotropin subunit gene expression is regulated by gonadal, hypothalamic, and locally derived hormones. In particular, activin rapidly (within hours) acts at the gonadotrope to selectively increase the expression of FSH beta messenger RNA (mRNA). A family of activin receptors (ActRI, ActRII, and ActRIIB) has been id...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.135.3.8070390
更新日期:1994-09-01 00:00:00
abstract::The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low le...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.8.8344
更新日期:2001-08-01 00:00:00
abstract::Synthesis of uteroglobin in rabbit uterine epithelial cells during early pregnancy is induced by progesterone and apparently suppressed by estrogen. To assess whether the steroid hormones exert regulatory effects on the expression of the uteroglobin gene, we performed transcriptional rate assays in endometrial nuclei ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-3-871
更新日期:1983-03-01 00:00:00
abstract::Regularly menstruating female rhesus monkeys were implanted sc with Silastic tubing packed with estrone. The implants were replaced every 6-8 months to maintain the serum estrone and estradiol concentrations constantly elevated 1.5-2.5-fold, i.e. in the midfollicular phase range, for 4 yr. Increasing the estrone and e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-5-2373
更新日期:1989-05-01 00:00:00
abstract::Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0588
更新日期:2005-01-01 00:00:00
abstract::Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role of endogenous relaxin in the pathogenesis of primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old relaxin (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0814
更新日期:2007-02-01 00:00:00
abstract::We have investigated the production and actions of a growth regulatory protein, insulin-like growth factor binding protein (IGFBP)-3, in the androgen-responsive prostate carcinoma cell line LNCaP. Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.7.7534
更新日期:2000-07-01 00:00:00
abstract::Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00331
更新日期:2017-10-01 00:00:00
abstract::We have investigated the physiological regulation and functional significance of brain-derived neurotrophic factor (BDNF) in the endocrine melanotrope cells of the pituitary pars intermedia of the amphibian Xenopus laevis, which can adapt its skin color to the light intensity of its environment. In black-adapted anima...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.4.8721
更新日期:2002-04-01 00:00:00
abstract::IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.8.8970
更新日期:2002-08-01 00:00:00
abstract::There is growing international interest in how environmental conditions experienced during development can shape adult phenotypes and the extent to which such induced changes are adaptive. One physiological system that links an individual to changes in environmental circumstances during development is the hypothalamic...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1471
更新日期:2009-04-01 00:00:00
abstract::The preoptic area (POA) of the male dove is a known target area for separable behavioral actions of testosterone and 17 beta-estradiol (E2) and contains an active aromatase system. We have examined the regulatory influence of gonadal hormones on aromatase using an in vitro microassay that measures conversion of [1 alp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-6-2180
更新日期:1986-06-01 00:00:00
abstract::The question of whether maternal melatonin could be transported in milk to suckling rats was investigated because melatonin is probably not produced in these animals during the first 10 days of life. [3H]Melatonin was found to be rapidly transferred from the maternal circulation into lactating mammary tissue, and the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-102-2-582
更新日期:1978-02-01 00:00:00
abstract::Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1916
更新日期:2017-07-01 00:00:00
abstract::The hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), can efficiently increase cAMP levels in pituitary cells and release a number of pituitary hormones, suggesting an important physiological role for this peptide in pituitary function. Exposure of GH3 rat pituitary cells to PACAP resul...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.4.8625900
更新日期:1996-04-01 00:00:00
abstract::Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.7.8896
更新日期:2002-07-01 00:00:00
abstract::Prepubertal reproductive development in juvenile male Siberian hamsters can be strongly influenced by photoperiod information received during gestation. Information transmitted from the mother hamster to her fetuses appears to modify the photoperiodic mechanism of the developing hamsters so that they may respond diffe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.10.7664640
更新日期:1995-10-01 00:00:00
abstract::To examine the role of the kidney in the catabolism of gut glucagon-like immunoreactivity (GLI), we compared the plasma GLI responses of normal and nephrectomized dogs given intraduodenal glucose loads and studied the clearance of gut GLI by the isolated perfused rat kidney. Both basal and postload plasma samples were...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-6-2030
更新日期:1982-06-01 00:00:00
abstract::Basal serum gonadotropin levels were monitored weekly in female hamsters from birth to 10 weeks of age. Hamsters raised on three different photoperiods presented uniform pre- and postpubertal patterns of serum LH and FSH, suggesting that gonadotropin release in the young hamster occurs independently of ambient photope...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-4-1262
更新日期:1982-04-01 00:00:00
abstract::We are investigating the mechanisms by which aromatic hydrocarbons, such as 3-methylcholanthrene (MC), suppress hepatic cytochrome P450 2C11 (CYP2C11) gene expression. CYP2C11 is an enzyme expressed in the liver of male rats and is regulated by a pulsatile pattern of GH secretion. We have previously shown that MC atte...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220212
更新日期:2002-09-01 00:00:00
abstract::Estrogen-based hormone therapy (HT) in postmenopausal women may reduce the risk of Alzheimer's disease (AD), although HT remains controversial. One key concern with HT is the potential of adverse outcomes such as breast and uterine cancer. A promising strategy to maximize HT benefits and minimize HT risks is the use o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1346
更新日期:2008-05-01 00:00:00
abstract::The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component Brain and m...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1330
更新日期:2016-11-01 00:00:00
abstract::Bombesin was injected into the cerebral ventricle of male rats anesthetized with urethane to study its effect on plasma levels of immunoreactive somatostatin (IRS) in hypophysial portal and jugular blood. An intraventricular injection of bombesin (0.2 and 2 micrograms/rat) caused a significant and dose-related increas...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-109-1-229
更新日期:1981-07-01 00:00:00
abstract::PRL secretion in several physiological and experimental conditions, including early pregnancy, is linked to the daily photoperiod. The aim of this study was to examine the antepartum increase in PRL secretion for evidence of a circadian pattern of release, as seen during early pregnancy. During the last 3 days of preg...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-2-1199
更新日期:1990-02-01 00:00:00
abstract::Rat calvariae are known to secrete a bone-derived growth factor (BDGF) that stimulates bone DNA and collagen synthesis. BDGF was purified from calvarial culture medium with dialysis, gel filtration and HPLC. Amino acid composition of BDGF was compatible with murine beta 2 microglobulin (beta 2 m), and amino terminal s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-3-1198
更新日期:1987-09-01 00:00:00
abstract::We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-1-98
更新日期:1988-07-01 00:00:00
abstract::A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-6-1725
更新日期:1980-12-01 00:00:00