Escape from the sodium-retaining action of intrarenal angiotensins II and III in the conscious dog.

abstract：:The effects of FFA on circulating LH and GH concentrations in ovariectomized ewe lambs were investigated. Lambs (n = 14) were weaned at 2.5 months, ovariectomized at 6.5 months, and used at 8.5 months of age. From weaning until day 0 of the experiment, lambs were fed to maintain body weights (23 kg). On day 0, serum F...

journal_title：Endocrinology

authors： Estienne MJ,Schillo KK,Hileman SM,Green MA,Hayes SH,Boling JA

更新日期：1990-04-01 00:00:00

abstract：:Somatostatin, also known as somatotropin release-inhibiting factor (SRIF), is secreted by pancreatic delta-cells and inhibits the secretion of both insulin and glucagon. SRIF initiates its actions by binding to a family of six G protein-coupled receptors (sst1, -2A, -2B, -3, -4, and -5) encoded by five genes. Messenge...

journal_title：Endocrinology

authors： Mitra SW,Mezey E,Hunyady B,Chamberlain L,Hayes E,Foor F,Wang Y,Schonbrunn A,Schaeffer JM

更新日期：1999-08-01 00:00:00

abstract：:In cultured rat pituitary cells, increases in the cytosolic calcium concentration ([Ca2+]i) and LH release are induced by activation of GnRH receptors as well as by nonreceptor-mediated stimuli. Treatment of pituitary cells with the myosin light chain kinase (MLCK) inhibitor, wortmannin, attenuated GnRH-induced LH rel...

journal_title：Endocrinology

authors： Rao K,Paik WY,Zheng L,Jobin RM,Tomić M,Jiang H,Nakanishi S,Stojilkovic SS

更新日期：1997-04-01 00:00:00

abstract：:We have investigated the adrenergic control of mitogen-activated protein kinase (MAPK) activity in brown adipocytes. Cold exposure in rats led to an activation of MAPK in brown adipose tissue, as determined by the gel mobility shift assay and in-gel kinase assay. In contrast, no activation was seen after surgical symp...

journal_title：Endocrinology

authors： Shimizu Y,Tanishita T,Minokoshi Y,Shimazu T

更新日期：1997-01-01 00:00:00

abstract：:Agouti-related protein (AgRP) expressed in the arcuate nucleus is a potent orexigenic neuropeptide, which increases food intake and reduces energy expenditure resulting in increases in body weight (BW). Glucocorticoids, key hormones that regulate energy balance, have been shown in rodents to regulate the expression of...

journal_title：Endocrinology

authors： Shibata M,Banno R,Sugiyama M,Tominaga T,Onoue T,Tsunekawa T,Azuma Y,Hagiwara D,Lu W,Ito Y,Goto M,Suga H,Sugimura Y,Oiso Y,Arima H

更新日期：2016-04-01 00:00:00

abstract：:PTH-related protein (PTHrP), the major mediator of hypercalcemia of malignancy, reduces tubular phosphate (Pi) reabsorption through its PTH-like renotropic actions. Another peptide detected in tumoral cells, transforming growth factor-beta (TGF beta), has been shown to considerably suppress the sodium-dependent Pi tra...

journal_title：Endocrinology

authors： Law F,Rizzoli R,Bonjour JP

更新日期：1993-07-01 00:00:00

abstract：:Various hormones and growth factors act at least in part by raising the cytosolic pH of the target cell. In the present studies we examined the influence of the muscarinic cholinergic agonist carbachol on intracellular pH (pHi) in chicken granulosa cells. The pHi in granulosa cells from the two largest preovulatory fo...

journal_title：Endocrinology

authors： Li M,Morley P,Schwartz JL,Whitfield JF,Tsang BK

更新日期：1992-07-01 00:00:00

abstract：:A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...

journal_title：Endocrinology

authors： Clark SA,Chick WL

更新日期：1990-04-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:The ability of cells to directly respond to glucocorticoids and aldosterone is a function of GR and MR expression, and coexpression of 11beta-hydroxysteroid dehydrogenases (11betaHSDs), which convert glucocorticoids and their 11-ketometabolites into either receptor inactive or active derivatives. The aim of the presen...

journal_title：Endocrinology

authors： Sheppard KE,Autelitano DJ

更新日期：2002-01-01 00:00:00

abstract：:Using a primary culture of neonatal rat heart, we investigated the properties of iodothyronine 5'-deiodinating activity in the heart. 125I- release from [125I] reverse T3 incubated with cell homogenates depended on the concentrations of protein and dithiothreitol, pH, incubation time, and temperature of the incubation...

journal_title：Endocrinology

authors： Mori Y,Nishikawa M,Toyoda N,Yonemoto T,Matsubara H,Inada M

更新日期：1991-06-01 00:00:00

abstract：:Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused b...

journal_title：Endocrinology

authors： Abe S,Namba N,Abe M,Fujiwara M,Aikawa T,Kogo M,Ozono K

更新日期：2012-08-01 00:00:00

abstract：:The direct effects of glucocorticoids on testicular LH receptor content and steroidogenesis were studied in vivo and in vitro. Immature hypophysectomized rats were treated with varying doses of dexamethasone, corticosterone, or a synthetic progestin, 17,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione (R5020). Some anim...

journal_title：Endocrinology

authors： Bambino TH,Hsueh AJ

更新日期：1981-06-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00

abstract：:To test the hypothesis that vitamin D-dependent calcium-binding protein (CaBP) and active calcium (Ca) transport in the small intestine of vitamin D-replete lactating rats are regulated by dietary Ca intake, pregnant rats were given a high Ca (1.6% Ca and 1.4% phosphorus) or low Ca (0.1% Ca and 0.4% phosphorus) diet s...

journal_title：Endocrinology

authors： Bruns ME,Boass A,Toverud SU

更新日期：1987-07-01 00:00:00

abstract：:Isolated granulosa cells and theca from proestrous hamsters alone and in recombination, were cultured in order to study steroidogenic capacity of this tissue. Cells from medium size antral follicles (100-300 mum diam.) and large preovulatory follicles (500 plus mum diam.) were used. Steroids were measured by radioimmu...

journal_title：Endocrinology

authors： Makris A,Ryan KJ

更新日期：1975-03-01 00:00:00

abstract：:Recently, heterogeneity of POMC mRNA content between intermediate lobe melanotropes of the rat pituitary gland was demonstrated by in situ hybridization of tissue sections. In the present study the heterogeneity of POMC mRNA content in dispersed rat pituitary cells has been investigated. Acutely dispersed cells from a...

journal_title：Endocrinology

authors： Hatfield JM,Daikh DI,Adelman JP,Douglass J,Bond CT,Allen RG

更新日期：1989-03-01 00:00:00

abstract：:Four 1-yr-old, i.e. immature, monkeys (M. fascicularis) were treated with testosterone. For the first 21 weeks, they received testosterone capsules sc; thereafter for the remainder of 1 yr, they received weekly injections of 125 mg testosterone enanthate. Four similarly aged monkeys served as untreated controls. The t...

journal_title：Endocrinology

authors： Marshall GR,Wickings EJ,Nieschlag E

更新日期：1984-06-01 00:00:00

abstract：:Bisphenol-A (BPA) is a component of polycarbonate and other plastics to which humans are regularly exposed at low levels. BPA is characterized as an endocrine disruptor because of observations of its estrogenic activity in various experimental models. We have previously shown evidence of disrupted hypothalamic feeding...

journal_title：Endocrinology

authors： MacKay H,Patterson ZR,Abizaid A

更新日期：2017-04-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:Inhibins and activins are produced by a variety of tissues and may have important endocrine and paracrine roles in development, reproduction, and hematopoiesis. However, little is known regarding the physical properties or concentrations of inhibin and activin in biological fluids. Binding proteins for inhibin or acti...

journal_title：Endocrinology

authors： Krummen LA,Woodruff TK,DeGuzman G,Cox ET,Baly DL,Mann E,Garg S,Wong WL,Cossum P,Mather JP

更新日期：1993-01-01 00:00:00

abstract：:A study was conducted to determine the influence of conditions known to alter ACTH secretion on prolactin release by the pituitary. Dexamethasone or 0.9% NaCl was injected subcutaneously into intact male rats 4 hr before a 2-min ether stress. Other rats were submitted to the ether stress 2 weeks following adrenalectom...

journal_title：Endocrinology

authors： Harms PG,Langlier P,McCann SM

更新日期：1975-02-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...

journal_title：Endocrinology

authors： Antonipillai I,Vogelsang J,Horton R

更新日期：1986-07-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase. This study examined the role of microRNA miR-122 in LRBP-mediated LHR mRNA expression. Real-time PCR analysis of ovaries from pregnant mare serum g...

journal_title：Endocrinology

authors： Menon B,Sinden J,Franzo-Romain M,Botta RB,Menon KM

更新日期：2013-12-01 00:00:00

abstract：:T(4) must be activated by its monodeiodination to T(3) by type 1 or 2 iodothyronine deiodinase (D1 and D2). Recent studies show that despite an approximately 2000-fold higher Michaelis constant (K(m); T(4)) for D1 than for D2 using dithiothreitol (DTT) as cofactor, D1 expressed in intact cells produces T(3) at free T(...

journal_title：Endocrinology

authors： Goemann IM,Gereben B,Harney JW,Zhu B,Maia AL,Larsen PR

更新日期：2010-02-01 00:00:00

abstract：:Brain natriuretic peptide (BNP) and atrial natriuretic peptide (ANP) are present in brain regions regulating LH secretion. Similarities in the molecular structure of these peptides suggest similar physiological function within the brain. This study examined the effects of centrally administered BNP and ANP on LH secre...

journal_title：Endocrinology

authors： Zhang J,Yuen BH,Currie WD,Leung PC

更新日期：1991-08-01 00:00:00

abstract：:The binding characteristics of 125I-labeled Leu15-gastrin and the molecular identification of the gastrin receptor was investigated in dispersed guinea pig gastric glands. The binding of [125I]gastrin to gastric glands was temperature dependent, saturable, and specific. At 37 C, the binding was rapid, became maximal w...

journal_title：Endocrinology

authors： Ramani N,Praissman M

更新日期：1989-04-01 00:00:00

abstract：:Melanocortin receptor 4 (MCR4) and CB(1) cannabinoid receptors independently modulate food intake. Although an interaction between the cannabinoid and melanocortin systems has been found in recovery from hemorrhagic shock, the interaction between these systems in modulating food intake has not yet been examined. The p...

journal_title：Endocrinology

authors： Verty AN,McFarlane JR,McGregor IS,Mallet PE

更新日期：2004-07-01 00:00:00

abstract：:Activin A is a member of the transforming growth factor-beta family of growth factors and a potent regulator of cellular activity. A number of binding proteins for activin A have been identified, including alpha 2-macroglobulin (alpha 2M). Alpha 2M has several conformational states that are known to have different gro...

journal_title：Endocrinology

authors： Niemuller CA,Randall KJ,Webb DJ,Gonias SL,LaMarre J

更新日期：1995-12-01 00:00:00