Purification of bovine thyroid-stimulating hormone by a monoclonal antibody.

abstract：:An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, decrease triglyceride accumulation in the adipocyte and...

journal_title：Endocrinology

authors： Ruderman NB,Saha AK,Kraegen EW

更新日期：2003-12-01 00:00:00

abstract：:The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well understood. To help define the role of this isoform in bone, we developed a transgenic mouse in which targeted expression of human mCSF-1 in osteoblasts was achieved under the control of t...

journal_title：Endocrinology

authors： Yao GQ,Wu JJ,Sun BH,Troiano N,Mitnick MA,Insogna K

更新日期：2003-08-01 00:00:00

abstract：:In previous studies we demonstrated a much greater rate of glucose cycling (glucose-->glucose-6-P-->glucose) in islets from ob/ob mice than from lean litter mates. Cycling was further augmented by dexamethasone treatment. To determine whether these findings could be accounted for by increased islet glucose-6-phosphata...

journal_title：Endocrinology

authors： Khan A,Hong-Lie C,Landau BR

更新日期：1995-05-01 00:00:00

abstract：:Corticosteroids stimulate and insulin inhibits energy acquisition (food intake); conversely, corticosteroids inhibit and insulin stimulates energy storage (body weight gain). Thus, together these hormones mediate long-term energy balance. This study tested whether the stimulatory action of corticosteroids on food inta...

journal_title：Endocrinology

authors： Santana P,Akana SF,Hanson ES,Strack AM,Sebastian RJ,Dallman MF

更新日期：1995-05-01 00:00:00

abstract：:It is well established that PRL secretion is under a tonic inhibition exercised by the hypothalamic dopamine (DA). One feature of this regulation is an immediate withdrawal reaction (elevation of PRL release) of mammotropes after disruption of hypothalamic influence. Although plasma PRL rises rapidly, the suckling sti...

journal_title：Endocrinology

authors： Murányi A,Gergely P,Fekete MI,Nagy GM

更新日期：1998-11-01 00:00:00

abstract：:Steroidogenic acute regulatory protein (StAR) synthesis and steroidogenesis are stimulated by activation of divergent signaling pathways in the adrenal cortex. The two major physiological regulators of aldosterone synthesis in the adrenal zona glomerulosa are angiotensin II (AII) and extracellular K+, which both media...

journal_title：Endocrinology

authors： Clark BJ,Combs R

更新日期：1999-10-01 00:00:00

abstract：:The effects of GH and PTH on cancellous histomorphometry were determined in the proximal tibial metaphysis of hypophysectomized (HYPOX) sexually mature female rats. HYPOX resulted in uterine atrophy and a loss in body weight. Longitudinal bone growth ceased and bone formation was greatly reduced. There were decreases ...

journal_title：Endocrinology

authors： Schmidt IU,Dobnig H,Turner RT

更新日期：1995-11-01 00:00:00

abstract：:To further characterize the effect of TSH administration on thyroid iodothyronine monodeiodinating activity, we have evaluated the in vitro conversion of T4 to T3 (outer ring deiodination) and T3 to 3,3'-diiodothyronine (T2; inner ring deiodination) by mouse thyroid, liver, and kidney homogenates, comparing tissues fr...

journal_title：Endocrinology

authors： Wu SY,Reggio R,Florsheim WH

更新日期：1985-03-01 00:00:00

abstract：:The present experiments investigated the time course of maternal modulation of GH secretion and examined the possible role of milk in the regulation of GH secretion in neonatal rats. Serum GH concentrations in neonatal rats were high at birth and declined over time postpartum. Separation of rat pups from their mothers...

journal_title：Endocrinology

authors： Kacsoh B,Terry LC,Meyers JS,Crowley WR,Grosvenor CE

更新日期：1989-09-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:Earlier studies have shown that lactation-induced bone loss in the rat is both PTH- and vitamin D-independent and have suggested the involvement of another, as yet unidentified, factor(s) in the altered calcium metabolism which accompanies lactation. In the present study, we investigated the possibility that PTH-relat...

journal_title：Endocrinology

authors： Yamamoto M,Duong LT,Fisher JE,Thiede MA,Caulfield MP,Rosenblatt M

更新日期：1991-11-01 00:00:00

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...

journal_title：Endocrinology

authors： Li MH,Yang HH,Li MR,Sun YL,Jiang XL,Xie QP,Wang TR,Shi HJ,Sun LN,Zhou LY,Wang DS

更新日期：2013-12-01 00:00:00

abstract：:In the pituitary, GABA regulates the release of several hormones via different receptors. GABA(C) receptors are heterooligomers that differ from GABA(A) receptors in that they contain p-subunits and are insensitive to bicuculline. However, molecular and functional evidence for the presence of GABA(C) receptors outside...

journal_title：Endocrinology

authors： Boue-Grabot E,Taupignon A,Tramu G,Garret M

更新日期：2000-05-01 00:00:00

abstract：:MCRs of testosterone (T) and 5 alpha-dihydrotestosterone (DHT) were determined in the morning and evening in four chronically chaired adult rhesus monkeys (Macaca mulatta) by means of steady state infusion of [4-14C]testosterone and [1,2-3H]dihydrotestosterone. Morning and evening MCRs were comparable for both T and D...

journal_title：Endocrinology

authors： Sholl SA,Toivola PT,Robinson JA

更新日期：1979-08-01 00:00:00

abstract：:While the potential role of insulin-like growth factor (IGF)-I in ovarian physiology has been extensively studied, relatively limited attention has been paid to IGF-II the very presence of which in the mature rat ovary has been questioned. In the present study, we have reevaluated rat ovarian IGF-II gene expression, i...

journal_title：Endocrinology

authors： Hernandez ER,Roberts CT Jr,Hurwitz A,LeRoith D,Adashi EY

更新日期：1990-12-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR). EMD 21388 also inhibits the binding of T4 to human, dog, and rat serum TTR in vitro and w...

journal_title：Endocrinology

authors： Lueprasitsakul W,Alex S,Fang SL,Pino S,Irmscher K,Köhrle J,Braverman LE

更新日期：1990-06-01 00:00:00

abstract：:A basic somatomedin preparation results in a 2-fold stimulation of incorporation of both [3H]leucine into protein and 35SO4 into glycosaminoglycans by cultured chick sternal chondrocytes. The stimulation is seen in the presence of 20 mM 4-methylumbelliferyl-beta-D-xyloside alone but is not observable in the presence o...

journal_title：Endocrinology

authors： Kemp SF,Hintz RL

更新日期：1980-03-01 00:00:00

abstract：:We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily. They form heterodimer with a retinoid X receptor, recruit transcriptional cofactor...

journal_title：Endocrinology

authors： Lim HJ,Moon I,Han K

更新日期：2004-06-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that is thought to play a major role in the regulation of growth and differentiation of thyroid cells. However, little is known of its detailed mechanisms of action in thyrocytes. We have therefore studied the molecular mechanisms of TGF-beta1 ...

journal_title：Endocrinology

authors： Kang HC,Ohmori M,Harii N,Endo T,Onaya T

更新日期：2001-01-01 00:00:00

abstract：:Besides its role in body weight control leptin may also act as a vasoactive hormone. This study was designed to investigate whether leptin modifies angiotensin II (ANG II)-induced vascular responses. The expression of functional leptin receptors (OB-Rb) was detected in vascular smooth muscle cells (VSMCs) from adult W...

journal_title：Endocrinology

authors： Fortuño A,Rodríguez A,Gómez-Ambrosi J,Muñiz P,Salvador J,Díez J,Frühbeck G

更新日期：2002-09-01 00:00:00

abstract：:Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This response, which can be reversed by elevation of intraoocyte cAMP levels, is associated with interruption of gap junctional communication (GJC) within the ovarian follicle. In the present study, we examined the hypothesis that disruptio...

journal_title：Endocrinology

authors： Sela-Abramovich S,Edry I,Galiani D,Nevo N,Dekel N

更新日期：2006-05-01 00:00:00

abstract：:Osteocalcin (OC) is one of the abundant non-collagenous bone matrix proteins produced exclusively by osteoblasts, and its serum level is used as an indicator of bone metabolism in patients. Transforming growth factor-beta (TGF beta) is abundant in bones and platelets, promotes wound healing in vivo, and is a potent st...

journal_title：Endocrinology

authors： Noda M

更新日期：1989-02-01 00:00:00

abstract：:The present studies demonstrate that the murine adrenocortical tumor cell line Y-1 releases a digoxin-like immunoreactive material into both serum-supplemented nutrient medium and minimal Krebs-Ringer bicarbonate medium. Release of pregnenolone into minimal medium from these cells was consistently inhibited by additio...

journal_title：Endocrinology

authors： Doris PA,Kilgore MW,Durham D,Alberts D,Stocco DM

更新日期：1989-11-01 00:00:00

abstract：:Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose-dependent manner. Bone resorption in response to PDGF was time-dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrat...

journal_title：Endocrinology

authors： Key LL Jr,Carnes DL Jr,Weichselbaum R,Anast CS

更新日期：1983-02-01 00:00:00

abstract：:The purpose of these studies was to determine whether changes in FSH receptors correlated with FSH-induced attenuation of FSH-responsive adenylyl cyclase in immature porcine granulosa cells. Cells were incubated with FSH (1-1000 ng/ml) for up to 24 h, treated with acidified medium (pH 3.5) to remove FSH bound to cells...

journal_title：Endocrinology

authors： Ford KA,LaBarbera AR

更新日期：1988-11-01 00:00:00

abstract：:Obesity and its associated comorbidities are of major worldwide concern. It is now recognized that there are a number of metabolically distinct pathways of obesity development. The present paper investigates the effect of moderate daily exercise on the underlying mechanisms of one such pathway to obesity, through inte...

journal_title：Endocrinology

authors： Miles JL,Huber K,Thompson NM,Davison M,Breier BH

更新日期：2009-01-01 00:00:00

abstract：:Inflammation can interfere with endometrial receptivity. We examined how interleukin 1β (IL-1β) affects expression of the uterine gap junction protein connexin 43 (Cx43), which is known to be critical for embryonic implantation. We used an in vitro model of human endometrial stromal cells (ESCs), Western blotting, and...

journal_title：Endocrinology

authors： Yu J,Berga SL,Zou W,Yook DG,Pan JC,Andrade AA,Zhao L,Sidell N,Bagchi IC,Bagchi MK,Taylor RN

更新日期：2017-12-01 00:00:00