Abolition of dopaminergic insulin secretion by beta-adrenergic antagonism.

abstract：:Thyroid hormone entry into the thymocyte, a thyroid hormone target, was investigated by incubating the cells with tracer amounts of [125I]L-T3. At 37 C T3 uptake was linear with time up to 2 min, and then approached a plateau. The specific T3 uptake, obtained by subtracting the uptake in the presence of excess unlabel...

journal_title：Endocrinology

authors： Centanni M,Mancini G,Andreoli M

更新日期：1989-05-01 00:00:00

abstract：:Tuberoinfundibular peptide is a recently discovered agonist for the PTH receptor-2; the latter has a wide distribution including the external zone of the median eminence of the hypothalamus, suggesting a role in neuroendocrine function. We have investigated the effects of tuberoinfundibular peptide on the hypothalamo-...

journal_title：Endocrinology

authors： Ward HL,Small CJ,Murphy KG,Kennedy AR,Ghatei MA,Bloom SR

更新日期：2001-08-01 00:00:00

abstract：:As human pregnancy advances, CRH increases exponentially and is hypothesized to trigger the transition from myometrial quiescence to active contractions at labor. Paradoxically, CRH stimulates cAMP production, suggesting it should cause relaxation. To evaluate CRH as a mediator of quiescence, the effect of CRH on cont...

journal_title：Endocrinology

authors： Tyson EK,Smith R,Read M

更新日期：2009-12-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-(OH)2D3 differentially affect the specific activity of alkaline phosphatase (ALPase) and phospholipase-A2 (PLA2) of plasma membranes and extracellular matrix vesicles produced by costochondral reserve zone and growth zone cartilage chondrocytes in culture. In the prese...

journal_title：Endocrinology

authors： Schwartz Z,Schlader DL,Swain LD,Boyan BD

更新日期：1988-12-01 00:00:00

abstract：:To determine whether altered noradrenergic activation of the hypothalamo-pituitary-adrenal (HPA) axis contributes to the attenuated neuroendocrine response to stress observed during lactation, the effect of intracerebroventricular injection of the alpha1-agonist methoxamine (100 microg) was compared between virgin and...

journal_title：Endocrinology

authors： Windle RJ,Brady MM,Kunanandam T,Da Costa AP,Wilson BC,Harbuz M,Lightman SL,Ingram CD

更新日期：1997-09-01 00:00:00

abstract：:Uterine estrogen receptor (ER) and ER mRNA were measured in cycling and ovariectomized (OVX) estrogen-treated mice to probe the physiological regulation of the intracellular distribution and biosynthesis of ER. On proestrus, when plasma estradiol (E2) levels are highest, the cell nuclear ER concentration was 2.4-fold ...

journal_title：Endocrinology

authors： Bergman MD,Schachter BS,Karelus K,Combatsiaris EP,Garcia T,Nelson JF

更新日期：1992-04-01 00:00:00

abstract：:Poor growth before birth is associated with impaired insulin sensitivity later in life, increasing the risk of type 2 diabetes. The tissue sites at which insulin resistance first develops after intrauterine growth restriction (IUGR), and its molecular basis, are unclear. We have therefore characterized the effects of ...

journal_title：Endocrinology

authors： De Blasio MJ,Gatford KL,Harland ML,Robinson JS,Owens JA

更新日期：2012-05-01 00:00:00

abstract：:Decidual/trophoblast PRL-related protein (d/tPRP) is a member of the PRL gene family and is dually expressed in uterine and placental tissues in a highly coordinated pattern during pregnancy. In the present study, we describe the isolation and characterization of the d/tPRP gene. A lambda DASH II Wistar-Kyoto rat geno...

journal_title：Endocrinology

authors： Orwig KE,Dai G,Rasmussen CA,Soares MJ

更新日期：1997-06-01 00:00:00

abstract：:Testosterone propionate causes a striking increase in in vivo uptake of 2-deoxyglucose by the levator ani muscle of immature male rats. Autoradiography showed the labeled 2-deoxyglucose to be uniformly distributed over the entire muscle. Liquid scintillation counting of whole muscles allowed quantification of 2-deoxyg...

journal_title：Endocrinology

authors： Max SR,Toop J

更新日期：1983-07-01 00:00:00

abstract：:Involvement of ionized cytosolic calcium ([Ca2+]i) and protein kinase-C (PKC) in GnRH-stimulated LH release was assessed by correlating measurable changes in [Ca2+]i and LH release in PKC-depleted and nondepleted gonadotropes. Primary cultures of anterior pituitary cells were loaded with the calcium-sensitive fluoresc...

journal_title：Endocrinology

authors： Waters SB,Conn PM

更新日期：1992-04-01 00:00:00

abstract：:Alpha-calcitonin gene-related peptide (alphaCGRP) is released mainly from sensory and motor nerves in response to physiological stimuli. Despite well-documented pharmacological effects, its primary physiological role has thus far remained obscure. Increased lipid content, particularly in skeletal muscle and liver, is ...

journal_title：Endocrinology

authors： Danaher RN,Loomes KM,Leonard BL,Whiting L,Hay DL,Xu LY,Kraegen EW,Phillips AR,Cooper GJ

更新日期：2008-01-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) was partially purified from incubation medium of calf fetal testes and injected into a BALB/c mouse, whose splenocytes were fused with Sp2/Ag8 myeloma cells. Hybridomas were screened for specific antibody production by double antibody precipitation of labeled AMH, which was obtained by inc...

journal_title：Endocrinology

authors： Vigier B,Picard JY,Josso N

更新日期：1982-01-01 00:00:00

abstract：:Maintenance of male golden hamsters on short photoperiod leads to testicular regression due to pineal gland-mediated inhibition of the hypothalamo-hypophyseal reproductive system. This study clarifies the dynamics of the action of GnRH at the pituitary level after short photoperiod-induced gonadal regression. In Exp 1...

journal_title：Endocrinology

authors： Pieper DR

更新日期：1984-11-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:An estrogen (E2)-dependent 90,000-92,000 M(r) protein is synthesized and released by the sheep oviduct in a temporally and regionally specific manner during the first few days of pregnancy, where it associates with the embryo. The present study was undertaken to further define the nature of this protein and its regula...

journal_title：Endocrinology

authors： DeSouza MM,Murray MK

更新日期：1995-06-01 00:00:00

abstract：:We have tested the hypothesis that basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF beta) regulate the proliferation of osteoblast-like cells. Cells which migrated from central bone explants of fetal calf calvaria expressed markers characteristic of the osteoblast phenotype, including ost...

journal_title：Endocrinology

authors： Globus RK,Patterson-Buckendahl P,Gospodarowicz D

更新日期：1988-07-01 00:00:00

abstract：:The circadian rhythm of blood corticosterone was examined in rats whose feeding was restricted to a specific time of day. The peak of the corticosterone level was found just before feeding time regardless of whether, the rats were kept on a 12-h light, 12-h dark cycle or in constant light or were blinded. It took at l...

journal_title：Endocrinology

authors： Kato H,Saito M,Suda M

更新日期：1980-03-01 00:00:00

abstract：:The effect of amino acid substitutions introduced to the third alpha-helix in bovine GH (bGH) was investigated. A GH analog (bGH-M8), in which three amino acids were substituted to form an idealized amphiphilic alpha-helix, possessed the same specific binding affinity as wild-type bGH to cell membranes prepared from 3...

journal_title：Endocrinology

authors： Okada S,Chen WY,Wiehl P,Kelder B,Goodman HM,Guller S,Sonenberg M,Kopchick JJ

更新日期：1992-04-01 00:00:00

abstract：:The major changes in pancreatic islet function during pregnancy and after exposure to lactogens are an increase in beta-cell proliferation and enhanced insulin secretion. In this study we examined INS-1 cells as a potential model for further inquiry into PRL signaling in beta-cells. Proliferation of beta-cells, insuli...

journal_title：Endocrinology

authors： Stout LE,Svensson AM,Sorenson RL

更新日期：1997-04-01 00:00:00

abstract：:Up to now, no relevant tumor antigen has been identified in medullary thyroid carcinoma (MTC). The aim of the present study was to prove the concept of an immunization with an amino acid-modified calcitonin (CT) for the treatment of MTC in a transgenic mouse model. Amino acid-modified (human) CT has been chosen for va...

journal_title：Endocrinology

authors： Wuttke M,Papewalis C,Meyer Y,Kessler C,Jacobs B,Willenberg HS,Schinner S,Kouatchoua C,Baehring T,Scherbaum WA,Schott M

更新日期：2008-11-01 00:00:00

abstract：:Regulation of galanin gene expression in the anterior pituitary (AP) is positively influenced by estrogen in rodents and undetermined in humans. The objective of this study was to investigate the mechanism behind estrogen induction of galanin by identifying any putative estrogen receptor (ER) binding sequences within ...

journal_title：Endocrinology

authors： Howard G,Peng L,Hyde JF

更新日期：1997-11-01 00:00:00

abstract：:In fish spermatogenesis, the main action of progestins is generally regarded as the induction of sperm maturation. Our previous in vitro study demonstrated that a progestin, 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP), induced the initiation of meiosis in spermatogenesis in the Japanese eel (Anguilla japonica). In ...

journal_title：Endocrinology

authors： Ozaki Y,Higuchi M,Miura C,Yamaguchi S,Tozawa Y,Miura T

更新日期：2006-11-01 00:00:00

abstract：:In adult male rhesus monkeys, 1 day of fasting leads to a profound suppression of LH secretion that is rapidly reversed with refeeding. To test the hypothesis that changes in insulin secretion during fasting and refeeding mediate the changes in LH secretion, blood samples for LH measurement were obtained between 0900-...

journal_title：Endocrinology

authors： Williams NI,Lancas MJ,Cameron JL

更新日期：1996-06-01 00:00:00

abstract：:The antigenic epitopes of human GH (hGH) have been investigated using monoclonal antibodies (Mabs) to hGH. A panel of 12 Mabs was incorporated into two-site binding assays in order to investigate the antigenic surface of hGH. Nine reaction patterns were observed. The Mabs were further characterized in terms of their c...

journal_title：Endocrinology

authors： Strasburger CJ,Kostyo J,Vogel T,Barnard GJ,Kohen F

更新日期：1989-03-01 00:00:00

abstract：:We have analyzed the factors responsible for the circadian variation in rat hepatic mRNA-S14. Regulation of this sequence, which is found in lipogenic tissues and encodes a protein (S14) believed to be associated with fatty acid synthesis, is an excellent model of the interaction of thyroid hormone and dietary factors...

journal_title：Endocrinology

authors： Kinlaw WB,Fish LH,Schwartz HL,Oppenheimer JH

更新日期：1987-04-01 00:00:00

abstract：:We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the mechanisms involved are unknown. SK-N-MC cells were cultured with FGF-2 (50 ng/ml) and/or IGF-I (100 ng/ml) up to 48 h. Fluorescence-activated ce...

journal_title：Endocrinology

authors： Higgins S,Wong SH,Richner M,Rowe CL,Newgreen DF,Werther GA,Russo VC

更新日期：2009-09-01 00:00:00

abstract：:A myometrial explant culture system was developed to investigate the effect of progesterone and the antiprogestagen RU486 on prostacyclin (PGI2) and thromboxane A2 (TXA2) synthesis by the rat myometrium. After culture, eicosanoid synthesis was stimulated with arachidonic acid (AA) and the calcium ionophore A23187 (A23...

journal_title：Endocrinology

authors： Jeremy JY,Dandona P

更新日期：1986-08-01 00:00:00

abstract：:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...

journal_title：Endocrinology

authors： Larson KR,Russo KA,Fang Y,Mohajerani N,Goodson ML,Ryan KK

更新日期：2017-10-01 00:00:00

abstract：:The estrogen receptor (ER) mixed agonists tamoxifen and raloxifene have been shown to protect against bone loss in ovariectomized rats. However, the mechanism by which these compounds manifest their activity in bone is unknown. We have used a series of in vitro screens to select for compounds that are mechanistically ...

journal_title：Endocrinology

authors： Willson TM,Norris JD,Wagner BL,Asplin I,Baer P,Brown HR,Jones SA,Henke B,Sauls H,Wolfe S,Morris DC,McDonnell DP

更新日期：1997-09-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...

journal_title：Endocrinology

authors： Montuenga LM,Mariano JM,Prentice MA,Cuttitta F,Jakowlew SB

更新日期：1998-09-01 00:00:00