Pulsatility of immunoreactive somatomedin-C in chronically cannulated rats.

abstract：:Active immunization against GRF at 6 months of age delays puberty in beef heifers. The objectives of the present study were to determine whether active immunization against GRF at an earlier age would affect normal onset of puberty and follicular growth and to determine whether these changes were related to alteration...

journal_title：Endocrinology

authors： Cohick WS,Armstrong JD,Whitacre MD,Lucy MC,Harvey RW,Campbell RM

更新日期：1996-05-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:We have designed a new experimental system based on in vitro reconstituted thyroid follicles (RTF) to study the relative implication of macropinocytosis and micropinocytosis processes in the internalization of thyroglobulin (Tg). Thyrocytes cultured in the presence of TSH reorganize in histiotypic and functional folli...

journal_title：Endocrinology

authors： Bernier-Valentin F,Kostrouch Z,Rabilloud R,Rousset B

更新日期：1991-10-01 00:00:00

abstract：:Ionic mechanisms play an important role in the regulation of hormone secretion. The GHRH-induced GH release by human GH-secreting cells is transmitted through protein kinase A (PKA), which activates nonselective cation current (NSCC) and induces membrane depolarization, intracellular Ca2+ increase, and GH secretion. T...

journal_title：Endocrinology

authors： Yasufuku-Takano J,Takano K,Takei T,Fukumoto S,Teramoto A,Takakura K,Yamashita N,Fujita T

更新日期：1999-05-01 00:00:00

abstract：:The mechanisms by which bacterial endotoxin [lipopolysaccharide (LPS)] stimulates the hypothalamo-pituitary-adrenal axis (HPAA) have not been elucidated. The present study was designed to investigate the involvement of macrophages in plasma ACTH and corticosterone responses to LPS administration in rats using selectiv...

journal_title：Endocrinology

authors： Derijk R,Van Rooijen N,Tilders FJ,Besedovsky HO,Del Rey A,Berkenbosch F

更新日期：1991-07-01 00:00:00

abstract：:Hypophyseotropic dopamine exerts a tonic inhibitory tone on pituitary lactotrophs by the activation of dopamine D2 receptors (D2R). Ablation of D2R through gene knock-out approaches results in hyperprolactinemia and prolactinomas. This phenotype is more severe and develops more rapidly in female mice. We tested whethe...

journal_title：Endocrinology

authors： Hentges ST,Low MJ

更新日期：2002-12-01 00:00:00

abstract：:Nitrogenous compounds were studied for their effect on cGMP levels in the thyroid. Several agents, including sodium nitrite and hydroxylamine, could generate a rise of over 100-fold in cGMP. At a concentration of 20 mM, HN2OH and NaNO2 significantly reduced cAMP levels previously generated by 0.5 mU/ml TSH. If the sli...

journal_title：Endocrinology

authors： Spaulding SW

更新日期：1979-09-01 00:00:00

abstract：:The fate of cell-bound [125I]iodo-human GH ([125I]iodo-hGH) was studied in monolayer cultures of hepatocytes from pregnant and nonpregnant rats. Both the binding of [125I]iodo-hGH and its degradation were significantly higher in cells from pregnant than from nonpregnant rats. The positive correlation between the numbe...

journal_title：Endocrinology

authors： Wakai K,Tsushima T,Isozaki O,Sato Y,Sato K,Shizume K

更新日期：1984-05-01 00:00:00

abstract：:The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in R...

journal_title：Endocrinology

authors： Jouishomme H,Whitfield JF,Chakravarthy B,Durkin JP,Gagnon L,Isaacs RJ,MacLean S,Neugebauer W,Willick G,Rixon RH

更新日期：1992-01-01 00:00:00

abstract：:The preoptic area (POA) of the male dove is a known target area for separable behavioral actions of testosterone and 17 beta-estradiol (E2) and contains an active aromatase system. We have examined the regulatory influence of gonadal hormones on aromatase using an in vitro microassay that measures conversion of [1 alp...

journal_title：Endocrinology

authors： Hutchison JB,Steimer T

更新日期：1986-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder whose etiology is presently unknown. Probably the most consistent and widespread deficit seen in this syndrome is that of the basal forebrain cholinergic system. We have previously demonstrated that estradiol (E2) modulates the function of these neur...

journal_title：Endocrinology

authors： Singh M,Meyer EM,Simpkins JW

更新日期：1995-05-01 00:00:00

abstract：:GnRH neurons active in the preovulatory LH surge have been identified in several species using the early intermediate gene product, Fos, but the GnRH neurons active during episodic LH secretion remain unknown. In this study, we have used Fos and Fos-related antigens (FRA) to determine whether a subset of GnRH neurons ...

journal_title：Endocrinology

authors： Boukhliq R,Goodman RL,Berriman SJ,Adrian B,Lehman MN

更新日期：1999-12-01 00:00:00

abstract：:This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH pulsatile release into hypophyseal portal blood. Using alert, normally behaving, ovariectomized ewes, we sampled hypophyseal portal blood at 10-min intervals beginni...

journal_title：Endocrinology

authors： Battaglia DF,Bowen JM,Krasa HB,Thrun LA,Viguié C,Karsch FJ

更新日期：1997-10-01 00:00:00

abstract：:Reactive oxygen species, such as superoxide, hydrogen peroxide, and lipid peroxides, impair luteal function. Vitamin E, a lipophilic antioxidant vitamin, provides a major avenue of protection by scavenging free radicals and terminating lipid peroxidation. We previously showed that ovarian vitamin E levels increase aft...

journal_title：Endocrinology

authors： Aten RF,Kolodecik TR,Behrman HR

更新日期：1994-08-01 00:00:00

abstract：:Excessive accumulation of body fat triggers insulin resistance and features of the metabolic syndrome. Recently, evidence has accumulated that obesity, type 2 diabetes, and metabolic syndrome are associated with reduced levels of serum prolactin (PRL) in humans and rodents, raising the question of whether low PRL leve...

journal_title：Endocrinology

authors： Ruiz-Herrera X,de Los Ríos EA,Díaz JM,Lerma-Alvarado RM,Martínez de la Escalera L,López-Barrera F,Lemini M,Arnold E,Martínez de la Escalera G,Clapp C,Macotela Y

更新日期：2017-01-01 00:00:00

abstract：:Extracts of rat pancreas contain significant amounts of an [3H]estradiol-binding protein. The amount of steroid-binding activity that could be measured varied considerably depending on the tonicity of the homogenizing medium. High speed supernatants of homogenates initially prepared in isotonic buffer contained about ...

journal_title：Endocrinology

authors： Grossman A,Richardson SB,Altszuler N,Lane B

更新日期：1985-06-01 00:00:00

abstract：:We recently described a novel GnRH receptor signaling pathway mediated by the prostaglandins (PGs) F(2alpha) and PGI(2), which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and inhibit LH but not FSH release. Here we further explore the cross talk between GnRH and the PG rec...

journal_title：Endocrinology

authors： Naidich M,Shterntal B,Furman R,Pawson AJ,Jabbour HN,Morgan K,Millar RP,Jia J,Tomic M,Stojilkovic S,Stern N,Naor Z

更新日期：2010-06-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:The response of fat tissue to GH or insulin-like growth factor I (IGF-I) differs between humans with hypopituitarism and those with exogenous obesity; the effects of combined GH and IGF-I administration have not been compared in these two situations. In GH-deficient dwarf rats (who have a primary GH deficiency), the e...

journal_title：Endocrinology

authors： Dubuis JM,Deal C,Tsagaroulis P,Clark RG,Van Vliet G

更新日期：1996-07-01 00:00:00

abstract：:Acute nephrectomy seriously impairs hypovolemic adrenal epinephrine (E) release in the anesthetized dog. That systemically delivered angiotensin II totally restores E release to acutely anephric dogs is equally clear, but the dose-response relationship of this angiotensin II effect is not known. Adrenal secretion rate...

journal_title：Endocrinology

authors： Badder EM,Duarte B,Seaton JF,Hamaji M,Harrison TS

更新日期：1985-11-01 00:00:00

abstract：:An immunomodulatory role for LHRH was suggested when we reported the presence of immunoactive and bioactive LHRH and its mRNA in rat splenic and thymic lymphocytes. In this paper we report that human peripheral T-cells as well as its subsets CD4+ and CD8+ contained immunoactive and bioactive LHRH. Furthermore, analysi...

journal_title：Endocrinology

authors： Azad N,La Paglia N,Jurgens KA,Kirsteins L,Emanuele NV,Kelley MR,Lawrence AM,Mohagheghpour N

更新日期：1993-07-01 00:00:00

abstract：:High fat feeding is associated with impaired insulin action, an obese body composition, and down-regulation of glucose transporter-4 (GLUT4) expression in adipocytes. We recently showed that overexpression of GLUT4 selectively in adipocytes of transgenic mice using the aP2 (fatty acid-binding protein) promoter/enhance...

journal_title：Endocrinology

authors： Gnudi L,Tozzo E,Shepherd PR,Bliss JL,Kahn BB

更新日期：1995-03-01 00:00:00

abstract：:The effect of diabetes mellitus on the synthesis and secretion of thyroid hormone ws investigated in mice with streptozotocin-induced diabetes. Thyroid glands were labeled in vivo with 131I for 2 h. In control animals, TSH stimulated the synthesis of PB127I and 131I-labeled iodothyronines and simultaneously decreased ...

journal_title：Endocrinology

authors： Bagchi N,Brown TR,Shivers B,Lucas S,Mack RE

更新日期：1981-11-01 00:00:00

abstract：:Arginine-vasopressin (AVP) is known to be involved in maintaining glucose homeostasis, and AVP-resistance is observed in poorly controlled non-insulin-dependent diabetes mellitus subjects, resulting in a lowered plasma volume. Recently we reported that V1a vasopressin receptor-deficient (V1aR(-/-)) mice exhibited a de...

journal_title：Endocrinology

authors： Aoyagi T,Birumachi J,Hiroyama M,Fujiwara Y,Sanbe A,Yamauchi J,Tanoue A

更新日期：2007-05-01 00:00:00

abstract：:Rats were made unilaterally cryptorchid by cutting the gubernaculum testis at birth. At 100 days age, the rats were injected with 600 IU/kg hCG. A biphasic testosterone response was seen in the scrotal (Scr) testis in response to hCG, with maxima at 1 h and 3 days after injection. The acute peak of testosterone was of...

journal_title：Endocrinology

authors： Huhtaniemi I,Bergh A,Nikula H,Damber JE

更新日期：1984-08-01 00:00:00

abstract：:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evalua...

journal_title：Endocrinology

authors： Montgomery DW,Krumenacker JS,Buckley AR

更新日期：1998-02-01 00:00:00

abstract：:High-density lipoprotein mediates a normal physiological process called reverse cholesterol transport. This process enables the transfer of cholesterol from peripheral tissues to the liver for further metabolism and eventual secretion in the form of bile. The scavenger receptor of the B class (SR-BI), human homolog of...

journal_title：Endocrinology

authors： Cao WM,Murao K,Imachi H,Yu X,Dobashi H,Yoshida K,Muraoka T,Kotsuna N,Nagao S,Wong NC,Ishida T

更新日期：2004-12-01 00:00:00

abstract：:Mammalian ovaries contain sympathetic neurons expressing the low affinity neurotropin receptor (p75NTR). To date neither the role these neurons might play in ovarian physiology nor their embryological origin is known. Immunohistochemistry was used to detect postnatal changes in distribution and number of both p75NTR-p...

journal_title：Endocrinology

authors： Dees WL,Hiney JK,McArthur NH,Johnson GA,Dissen GA,Ojeda SR

更新日期：2006-08-01 00:00:00

abstract：:PTH-related protein (PTHrP) is expressed in a stretch-responsive manner in several types of smooth muscle. We previously demonstrated the production of PTHrP in adult rat heart muscle. In this study, we demonstrate the production of PTHrP in the cardiovascular systems of several mammalian species, including human. We ...

journal_title：Endocrinology

authors： Burton DW,Brandt DW,Deftos LJ

更新日期：1994-07-01 00:00:00